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1. 发明申请

WO1997040871A1 METHOD OF TREATING MOVEMENT DISORDERS BY BRAIN INFUSION 审中-公开
标题翻译：通过脑输液治疗运动障碍的方法
公开(公告)号：WO1997040871A1
公开(公告)日：1997-11-06
申请号：PCT/US1997006442
申请日：1997-04-18
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , TURNER, Mark, R. , WARD, Scott
IPC分类号： A61M05/142
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2202/0464 , A61M2210/0693
摘要： Techniques for infusing drugs into the brain to treat movement disorders resulting in abnormal motor behavior by means of an implantable pump and catheter. A sensor is used to detect the symptoms resulting from the motion disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the amount of drug delivered to the brain.
摘要翻译：将药物注入脑中以通过可植入泵和导管治疗运动障碍导致异常运动行为的技术。传感器用于检测运动障碍引起的症状。微处理器算法分析来自传感器的输出，以便调节输送到大脑的药物的量。

2. 发明申请

WO1997040874A1 TECHNIQUES OF TREATING NEURODEGENERATIVE DISORDERS BY BRAIN INFUSION 审中-公开
标题翻译：通过脑灌注治疗神经损伤性疾病的技术
公开(公告)号：WO1997040874A1
公开(公告)日：1997-11-06
申请号：PCT/US1997007192
申请日：1997-04-30
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , RISE, Mark, T.
IPC分类号： A61M05/172
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2210/0693
摘要： Techniques for infusing drugs into the brain to treat neurodegenerative disorders by means of an implantable pump and catheter. The drugs are capable of altering the level of excitation of neurons in the brain. A sensor is used to detect an attribute of the nervous system which reflects the hyperexcitation of the nerve cells projecting onto the degenerating nerve cells. A microprocessor algorithm analyzes the output from the sensor in order to regulate the amount of drug delivered to the brain.
摘要翻译：将药物注入脑中以通过可植入泵和导管治疗神经变性疾病的技术。这些药物能够改变大脑神经元的激发水平。传感器用于检测神经系统的属性，其反映突出到退化神经细胞上的神经细胞的过度兴奋。微处理器算法分析来自传感器的输出，以便调节输送到大脑的药物的量。

3. 发明申请

WO2005044252A1 PUMP SYSTEMS INCLUDING INJECTABLE GABAPENTIN COMPOSITIONS 审中-公开
标题翻译：包括可注射的加巴喷丁组合物的泵系统
公开(公告)号：WO2005044252A1
公开(公告)日：2005-05-19
申请号：PCT/US2004/034689
申请日：2004-10-21
申请人： MEDTRONIC, INC. , HILDEBRAND, Keith, R. , LANE, Deanna, S. , PAGE, Linda, M. , CLARAHAN, David, A. , ELSBERRY, Dennis, D. , RATNAYAKE, Jayantha, H.
发明人： HILDEBRAND, Keith, R. , LANE, Deanna, S. , PAGE, Linda, M. , CLARAHAN, David, A. , ELSBERRY, Dennis, D. , RATNAYAKE, Jayantha, H.
IPC分类号： A61K31/197
CPC分类号： A61M5/14276 , A61K31/197 , A61M2202/0464 , A61M2210/0693
摘要： A system including a reservoir, a pump coupled to the reservoir, a catheter coupled to the pump and adapted for delivering a therapeutic agent to a cerebrospinal fluid of a patient; and an injectable gabapentin composition housed in the reservoir and deliverable through the catheter, is discussed. The injectable gabapentin composition may have reduced tonicity. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9 % sodium chloride.
摘要翻译：一种系统，包括储存器，耦合到所述储存器的泵，耦合到所述泵且适于将治疗剂递送到患者的脑脊髓液的导管; 和容纳在贮存器中并可通过导管输送的可注射加巴喷丁组合物进行讨论。可注射加巴喷丁组合物可具有降低的张力。一种这样的可注射加巴喷丁组合物含有大于约30mg / ml的加巴喷丁并具有小于约900mOsm的张力。另一种这样注射的加巴喷丁组合物含有少于0.9％的氯化钠。

4. 发明申请

WO2005041976A2 INJECTABLE GABAPENTIN COMPOSITIONS 审中-公开
标题翻译：注射GABAPENTIN组合物
公开(公告)号：WO2005041976A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/034668
申请日：2004-10-21
申请人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , CLARAHAN, David, A. , PAGE, Linda, M. , LANE, Deanna, S. , HILDEBRAND, Keith, R. , RATNAYAKE, Jayantha, H.
发明人： ELSBERRY, Dennis, D. , CLARAHAN, David, A. , PAGE, Linda, M. , LANE, Deanna, S. , HILDEBRAND, Keith, R. , RATNAYAKE, Jayantha, H.
IPC分类号： A61K31/52
CPC分类号： A61K9/08
摘要： Injectable compositions containing gabapentin and having reduced tonicity are discussed. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride. A process for preparing injectable gabapentin compositions are also discussed. The process includes determining and optionally adjusting tonicity of a gabapentin composition.
摘要翻译：讨论含有加巴喷丁并具有降低的张力的可注射组合物。一种这样的可注射加巴喷丁组合物含有大于约30mg / ml的加巴喷丁并具有小于约900mOsm的张力。另一种这种注射加巴喷丁组合物含有少于0.9％的氯化钠。还讨论了制备可注射加巴喷丁组合物的方法。该方法包括确定并任选调节加巴喷丁组合物的张度。

5. 发明申请

WO2005041977A2 PROCESS FOR PRODUCING INJECTABLE GABAPENTIN COMPOSITIONS 审中-公开
标题翻译：生产注射用加巴喷丁组合物的方法
公开(公告)号：WO2005041977A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/034690
申请日：2004-10-21
申请人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , CLARAHAN, David, A. , PAGE, Linda, M. , LANE, Deanna, S. , HILDEBRAND, Keith, R. , RATNAYAKE, Jayantha, H.
发明人： ELSBERRY, Dennis, D. , CLARAHAN, David, A. , PAGE, Linda, M. , LANE, Deanna, S. , HILDEBRAND, Keith, R. , RATNAYAKE, Jayantha, H.
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , A61K9/0019 , A61K9/0085 , A61K31/195 , A61L2/0017 , A61L2/0023 , A61M5/14276 , A61M2202/0464 , A61M2210/0693
摘要： Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, which has previously been shown to be toxic. Surprisingly, heated injectable compositions containing gabapentin are found to be non-toxic when administered intrathecally. Thus, heating for the purposes of sterilization or to assure sterility provides a viable option in the production of injectable compositions containing gabapentin.
摘要翻译：讨论了含有加巴喷丁的可注射组合物以及制备含加巴喷丁的无菌可注射组合物的方法。该方法包括使组合物受热。加热导致加巴喷丁内酰胺的产生增加，之前已证明它是有毒的。令人惊讶的是，含有加巴喷丁的加热的可注射组合物在鞘内注射时发现无毒。因此，为了灭菌或保证无菌的目的而进行加热提供了生产含有加巴喷丁的可注射组合物的可行选择。

6. 发明申请

WO1996033761A1 INTRAPARENCHYMAL INFUSION CATHETER SYSTEM 审中-公开
标题翻译：肠内输注导管系统
公开(公告)号：WO1996033761A1
公开(公告)日：1996-10-31
申请号：PCT/US1996005163
申请日：1996-04-15
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D.
IPC分类号： A61M25/00
CPC分类号： A61M25/001 , A61M25/0009 , A61M25/0068 , A61M25/0069 , A61M2025/0057 , A61M2025/0073 , Y10S128/12
摘要： An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular portion terminating in a free distal end. The distal end of the catheter bears a rounded tip, a portion of which is slidably disposed within the lumen of the tubular portion. The tip is porous for discharging an agent or drug to a selected site. The tip has a microporosity of less than or equal to 0.22 microns. The tubular portion is composed from a material that will expand from its nominal size when exposed to a stimulus such as heat or a solvent and return to its nominal size when the stimulus is withdrawn. By expanding the tubular portion, a physician can select the amount of the tip that is exposed to the organism, thereby customizing the catheter to the structural size of the selected site within the body.
摘要翻译：用于将药物或其它试剂输送到诸如人的生物体中的选定部位的实质内输注导管系统包括可植入或设置在生物体外部的泵。导管联接到泵。导管包括终止于自由远端的柔性生物相容性管状部分。导管的远端具有圆形尖端，其一部分可滑动地设置在管状部分的内腔内。尖端是多孔的，用于将药剂或药物排出到选定的部位。尖端具有小于或等于0.22微米的微孔。管状部分由当暴露于诸如热或溶剂的刺激物时将从其标称尺寸膨胀的材料组成，并且当抽出刺激时返回其标称尺寸。通过扩大管状部分，医师可以选择暴露于生物体的尖端的量，从而将导管定制成体内所选部位的结构尺寸。

7. 发明申请

WO1996033756A1 BIORETENTIVE FILTERED INFUSION CATHETER 审中-公开
标题翻译：生物过滤过滤输液管
公开(公告)号：WO1996033756A1
公开(公告)日：1996-10-31
申请号：PCT/US1996005162
申请日：1996-04-15
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D.
IPC分类号： A61M05/142
CPC分类号： A61M5/14276 , A61M5/165 , A61M39/0208 , A61M2005/1652 , A61M2039/0241
摘要： A bioretentive filtered infusion catheter comprises a cylindrically shaped bioretentive filter inserted into a catheter lumen to prevent passage of microbial agents during a drug infusion process. Filter material placed within the catheter fluid flow path captures fluid contaminants. Alternatively, the filter material is disposed within a filtering assembly comprising a fluid conduit adapted for use with a previously implanted infusion catheter or an infusion pump.
摘要翻译：生物永久性过滤输注导管包括插入导管腔中的圆柱形生物累积过滤器，以防止在药物注射过程中微生物剂通过。放置在导管流体流动路径内的过滤材料捕获流体污染物。或者，过滤材料设置在包括适于与先前植入的输注导管或输注泵一起使用的流体导管的过滤组件中。

8. 发明申请

WO2005042072A1 IMPLANTABLE INFUSION PUMP FOR THE ADMINISTRATION OF INTRATHECAL GABAPENTIN FOR TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的内分泌腺素治疗的可浸润输液泵
公开(公告)号：WO2005042072A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034779
申请日：2004-10-21
申请人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , HILDEBRAND, Keith, R. , LANE, Deanna, S. , PAGE, Linda, M. , CLARAHAN, david, A. , RATNAYAKE, Jayantha, H.
发明人： ELSBERRY, Dennis, D. , HILDEBRAND, Keith, R. , LANE, Deanna, S. , PAGE, Linda, M. , CLARAHAN, david, A. , RATNAYAKE, Jayantha, H.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M2005/1405 , A61M2202/0464
摘要： Methods for treating pain by administering gabapentin to cerebrospinal fluid of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable pump having a reservoir for housing a composition, a catheter having a proximal portion coupled to the pump and having a distal portion adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, is also discussed.
摘要翻译：讨论了通过给予加巴喷丁至患者脑脊液治疗疼痛的方法。还讨论了含有加巴喷丁的组合物，特别是可注射组合物。另外，包括具有用于容纳组合物的储存器的可植入泵的系统，具有耦合到泵的近端部分并具有适于将组合物施用于患者的脑脊液的远端部分的导管和含有加巴喷丁的组合物，还讨论了哪种组合物容纳在泵的储存器中。

9. 发明申请

WO1997040879A1 THERAPEUTIC METHOD FOR TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病的治疗方法
公开(公告)号：WO1997040879A1
公开(公告)日：1997-11-06
申请号：PCT/US1997007661
申请日：1997-04-18
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D.
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61M25/0069 , A61M25/007 , A61M2025/0057
摘要： A method and apparatus for treating Alzheimer's disease is disclosed. The method comprises delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action directly to the hippocampus or the lateral ventricle throuh an implanted catheter. The catheter has a flexible distal end that is implanted directly in the hippocampus or lateral ventricle as the preferred embodiment. The distal end has either a porous tip or a closed end. Where the distal end is closed, or a plurality of elution holes are present, indomethacin is delivered to the hippocampus or lateral ventricle through either the porous tip or the elution holes. The catheter is part of a system for delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action to the hippocampus or lateral ventricle that includes a pump coupled to the catheter for delivering the indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action through the catheter to the hippocampus or lateral ventricle.
摘要翻译：公开了一种治疗阿尔茨海默病的方法和装置。该方法包括将具有环加氧酶抑制剂作用的吲哚美辛或非甾体抗炎剂直接递送至植入导管的海马或侧脑室。作为优选实施例，导管具有直接植入海马或侧脑室的柔性远端。远端具有多孔尖端或封闭端。当远端封闭或多个洗脱孔存在时，吲哚美辛通过多孔尖端或洗脱孔输送到海马或侧脑室。导管是用于将具有环氧合酶抑制剂作用的吲哚美辛或非甾体抗炎药物输送到海马或侧脑室的系统的一部分，其包括耦合到导管的泵，用于递送具有环氧合酶抑制剂作用的吲哚美辛或非甾体抗炎剂导管到海马或侧脑室。

10. 发明申请

WO1997039797A1 METHOD OF TREATING MOVEMENT DISORDERS BY BRAIN STIMULATION AND DRUG INFUSION 审中-公开
标题翻译：通过脑刺激和药物输注治疗运动障碍的方法
公开(公告)号：WO1997039797A1
公开(公告)日：1997-10-30
申请号：PCT/US1997005522
申请日：1997-04-02
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , RISE, Mark, T. , KING, Gary, W.
IPC分类号： A61N01/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61N1/36067 , A61N1/36082
摘要： Techniques using one or more drugs and electrical stimulation for treating neural disorders, including movement disorders resulting in abnormal motor response, by means of an implantable signal generator and electrode and an implantable pump and catheter. A sensor is used to detect activity resulting from the neural disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation and drug dosage delivered to the neural tissue.
摘要翻译：通过可植入信号发生器和电极以及可植入泵和导管，使用一种或多种药物和电刺激来治疗神经障碍（包括导致运动反应异常的运动障碍）的技术。传感器用于检测由神经障碍引起的活动。微处理器算法分析传感器的输出，以调节传递到神经组织的刺激和药物剂量。

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