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    • 4. 发明申请
    • DOSAGE DEVICE
    • 剂量装置
    • WO99009823A1
    • 1999-03-04
    • PCT/GB1998/002521
    • 1998-08-21
    • A01N25/04A01N25/34A01P7/00
    • A01N25/34Y10S514/937Y10S514/951Y10S514/952Y10S514/96
    • A method of making a dosage device comprises mixing a suspension concentrate comprising at least one active ingredient which is in solid form at 25 DEG C, and which has an average particle size of less than 10 microns, in a carrier liquid in which the active ingredient is non-soluble or sparingly soluble, and a drying agent for the carrier liquid. The drying agent takes up at least some of the carrier liquid of the suspension concentrate, thereby to dry the active ingredient at least partly and to obtain a mixture comprising the active ingredient and the drying agent. The mixture is compressed into at least one unitary dosage device.
    • 制备剂量装置的方法包括在载体液体中混合包含至少一种在25℃下为固体形式且平均粒度小于10微米的活性成分的悬浮浓缩物,其中活性成分 是不可溶或微溶的,以及用于载液的干燥剂。 干燥剂吸收悬浮浓缩物的至少一些载液,从而至少部分干燥活性成分,并获得包含活性成分和干燥剂的混合物。 混合物被压缩成至少一个单位剂量装置。
    • 5. 发明申请
    • DIRECTLY COMPRESSIBLE LACTITOL AND METHOD
    • 直接耐压的LACTITOL和方法
    • WO1998011878A1
    • 1998-03-26
    • PCT/FI1997000548
    • 1997-09-16
    • XYROFIN OYPEARSON, JulitaOLINGER, Philip
    • XYROFIN OY
    • A61K09/20
    • A61K9/2018Y10S514/952Y10S514/96
    • The invention relates to a directly compressible lactitol granulate and lactitol tablets made therefrom. The granulate comprises lactitol and a physiologically acceptable, non-cariogenic binder, which may be a non-cariogenic sugar alcohol, a polymerized reducing sugar, and alkali carboxymethylcellulose, a hydrogenated starch hydrolysate, a hydroxypropylcellulose, a physiologically acceptable cellulose derivative, polyvinylpyrrolidone, gum arabic or another physiologically acceptable gum. The preferred binder is lactitol. The invention also relates to a method of producing a directly compressible lactitol granulate, which can be used in tabletting contexts. The produced tablets exhibit high hardness and low friability. They are non-cariogenic and manifest the taste profile and metabolic properties of lactitol.
    • 本发明涉及由其制成的直接可压缩的乳糖醇颗粒和乳糖醇片剂。 该颗粒包括乳糖醇和生理上可接受的非致龋粘合剂,其可以是非致龋糖醇,聚合的还原糖和碱性羧甲基纤维素,氢化淀粉水解物,羟丙基纤维素,生理学上可接受的纤维素衍生物,聚乙烯吡咯烷酮,胶 阿拉伯胶或另一种生理上可接受的胶。 优选的粘合剂是乳糖醇。 本发明还涉及一种生产直接可压缩的乳糖醇颗粒的方法,其可用于压片上下文。 生产的片剂具有高硬度和低脆性。 它们是非龋齿的,并且表现出乳糖醇的味道特征和代谢性质。