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    • 1. 发明申请
    • DIRECTLY COMPRESSIBLE LACTITOL AND METHOD
    • 直接耐压的LACTITOL和方法
    • WO1998011878A1
    • 1998-03-26
    • PCT/FI1997000548
    • 1997-09-16
    • XYROFIN OYPEARSON, JulitaOLINGER, Philip
    • XYROFIN OY
    • A61K09/20
    • A61K9/2018Y10S514/952Y10S514/96
    • The invention relates to a directly compressible lactitol granulate and lactitol tablets made therefrom. The granulate comprises lactitol and a physiologically acceptable, non-cariogenic binder, which may be a non-cariogenic sugar alcohol, a polymerized reducing sugar, and alkali carboxymethylcellulose, a hydrogenated starch hydrolysate, a hydroxypropylcellulose, a physiologically acceptable cellulose derivative, polyvinylpyrrolidone, gum arabic or another physiologically acceptable gum. The preferred binder is lactitol. The invention also relates to a method of producing a directly compressible lactitol granulate, which can be used in tabletting contexts. The produced tablets exhibit high hardness and low friability. They are non-cariogenic and manifest the taste profile and metabolic properties of lactitol.
    • 本发明涉及由其制成的直接可压缩的乳糖醇颗粒和乳糖醇片剂。 该颗粒包括乳糖醇和生理上可接受的非致龋粘合剂,其可以是非致龋糖醇,聚合的还原糖和碱性羧甲基纤维素,氢化淀粉水解物,羟丙基纤维素,生理学上可接受的纤维素衍生物,聚乙烯吡咯烷酮,胶 阿拉伯胶或另一种生理上可接受的胶。 优选的粘合剂是乳糖醇。 本发明还涉及一种生产直接可压缩的乳糖醇颗粒的方法,其可用于压片上下文。 生产的片剂具有高硬度和低脆性。 它们是非龋齿的,并且表现出乳糖醇的味道特征和代谢性质。