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1. 发明申请

WO2010115071A2 REMOTE CIRCUIT LOCKING SWITCH SYSTEM 审中-公开
标题翻译：远程电路锁定开关系统
公开(公告)号：WO2010115071A2
公开(公告)日：2010-10-07
申请号：PCT/US2010029735
申请日：2010-04-02
申请人： COMPANION DIAGNOSTIC INC , SELINFREUND RICHARD H , BERRY FRED
发明人： SELINFREUND RICHARD H , BERRY FRED
IPC分类号： H04B10/12 , H04B10/02
CPC分类号： G06F21/64 , G09C1/00 , H04B10/278 , H04L9/00 , H04L2209/12 , H04L2209/80
摘要： A method and apparatus for remotely controlling access to the components of an optically interconnected information processing infrastructure is presented. Access to the infrastructure is controlled independently of the infrastructure operating system.
摘要翻译：提出了用于远程控制对光学互连信息处理基础设施的组件的访问的方法和装置。对基础架构的访问独立于基础设施操作系统进行控制。

2. 发明申请

WO2010011460A1 DISEASE SPECIFIC DIAGNOSTIC AID 审中-公开
标题翻译：疾病特异性诊断
公开(公告)号：WO2010011460A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/048463
申请日：2009-06-24
申请人： SIEMENS HEALTHCARE DIAGNOSTIC INC. , PUGIA, Michael, J.
发明人： PUGIA, Michael, J.
IPC分类号： G01N33/50
CPC分类号： G01N33/54386 , G01N2800/042 , G01N2800/347
摘要： A disease specific panel having at least one primary test for different analytes that are relevant for either early detection of a primary disease or management of patients already diagnosed with said primary disease. The panel also includes at least one secondary test which is relevant for detection of a co-morbid condition or complications of the primary disease. Generally, the primary and secondary tests are disposed on a support surface. The disease specific panel is different from the prior art screening tests in that there are no tests included in the panel whose results are not relevant or do not relate to either primary disease or a co-morbid condition or complications of the primary disease. The disease specific panel may also include systems and methods utilizing algorithms for creating and outputting diagnostic aids, as well as warnings about the presence of possible sample interferants, especially those commonly associated with the subject disease of the panel.
摘要翻译：一种疾病特异性小组，其具有与早期检测原发性疾病或管理已经诊断为所述原发性疾病的患者相关的不同分析物的至少一种初级测试。该小组还包括至少一个与检测并发病症或原发性疾病并发症有关的二次检查。通常，初级和次级试验设置在支撑表面上。疾病特异性小组与现有技术的筛选试验不同，因为组合中没有包括结果不相关或与原发性疾病或并发病症或并发症无关的原发性疾病无关的检查。疾病特异性面板还可以包括利用用于创建和输出诊断帮助的算法的系统和方法，以及关于可能的样品干扰物（特别是通常与面板的主题疾病相关的那些）的存在的警告。

3. 发明申请

WO2009097673A1 SYNTHESIS OF SINGLE-STRANDED DNA 审中-公开
标题翻译：单链DNA的合成
公开(公告)号：WO2009097673A1
公开(公告)日：2009-08-13
申请号：PCT/CA2008/000224
申请日：2008-02-07
申请人： BIO-ID DIAGNOSTIC INC. , VINAYAGAMOORTHY, Thuraiayah
发明人： VINAYAGAMOORTHY, Thuraiayah
IPC分类号： C12P19/34 , C07H21/00 , C07H21/04 , C12N15/10 , C12Q1/68
CPC分类号： C12P19/34
摘要： A method of producing single-stranded DNA. In one form, the method involves providing a uracil-containing oligonucleotide template molecule having a sequence that is complementary to a part of a target single-stranded DNA molecule of length greater than the template molecule; providing one or more parts of the target molecule including a base sequence complementary to a part of the template molecule; annealing the part(s) of the target molecule to the template molecule and forming the complete target molecule by ligating together at least two adjacent parts of the target molecule while annealed to the template molecule, andlor extending at least one part of the target molecule to form a sequence complementary to a remainder of the template molecule by nucleotide polymerization, and then separating the template molecule from the target molecule. In another form, an intermediate molecule is annealed to the template and then enzymatically cut, and one part is then extended by DNA polymerization using monomers of increased molecular weight or ionic charge compared to the monomers used to form the intermediate molecule.
摘要翻译：一种单链DNA的制备方法。在一种形式中，该方法包括提供含有尿嘧啶的寡核苷酸模板分子，其具有与长度大于模板分子的目标单链DNA分子部分互补的序列; 提供靶分子的一个或多个部分，包括与模板分子的一部分互补的碱基序列; 将靶分子的部分退火至模板分子，并通过将靶分子的至少两个相邻部分与模板分子退火而形成完整的靶分子，同时将至少一部分目标分子延伸至通过核苷酸聚合形成与模板分子的其余部分互补的序列，然后将模板分子与靶分子分离。在另一种形式中，将中间体分子与模板退火，然后进行酶切，然后通过与用于形成中间分子的单体相比增加分子量或离子电荷的单体通过DNA聚合延伸一部分。

4. 发明申请

WO2019094315A1 D-DIMER-SPECIFIC APTAMERS AND METHODS OF USE IN DIAGNOSTICS, THERAPEUTIC AND THERANOSTIC PURPOSES 审中-公开
公开(公告)号：WO2019094315A1
公开(公告)日：2019-05-16
申请号：PCT/US2018/059149
申请日：2018-11-05
申请人： APTAMER DIAGNOSTIC, INC.
发明人： AYASS, Mohamad, Ammar , GRIKO, Natalya , LUBAG, Angelo , ABI MOSLEH, Lina
IPC分类号： C07H21/00 , C12N15/00 , C12N15/10 , C12N15/115 , C12P19/34 , C12Q1/68
摘要： Herein is described a number of DNA/RNA sequences (aptamers) that selectively bind D-dimer and related fibrin degradation products. In one aspect, the disclosed nucleic acids can be modified to incorporate a detectable tag (such as, for example, a latex bead, magnetic bead, fluorescence label; fluorescent probe, chemiluminescent labels, radiolabels, and/or nanoparticle probe). Disclosed herein are methods of detecting and/or treating deep venous thrombosis, pulmonary embolism, disseminated intravascular coagulation, and/or any inflammatory condition where the inflammation affects the vasculature, comprising using the one or more aptamers described herein. Further disclosed herein are kits for detecting the presence of D-dimer or deep venous thrombosis, pulmonary embolism, and/or disseminated intravascular coagulation.

5. 发明申请

WO2004106544A3 OPTICAL SENSORS BASED ON HYBRID APTAMER/CONJUGATED POLYMER COMPLEXES 审中-公开
标题翻译：基于混合APTAMER /共聚聚合物复合物的光学传感器
公开(公告)号：WO2004106544A3
公开(公告)日：2005-04-21
申请号：PCT/CA2004000824
申请日：2004-06-03
申请人： INFECTIO DIAGNOSTIC INC , UNIV LAVAL , LECLERC MARIO , HO HOANG-ANH , BOISSINOT MAURICE
发明人： LECLERC MARIO , HO HOANG-ANH , BOISSINOT MAURICE
IPC分类号： C12Q1/68 , C07D333/32 , C12N15/11
CPC分类号： C12Q1/6876 , C12Q1/6811 , C12Q1/6816 , C12Q1/6825 , C12Q2563/173 , C12Q2563/107 , C12Q2537/101 , C12Q2525/205
摘要： An optical sensor for detecting a target comprising a singlestranded aptamer complementary to said target, and a water-soluble cationic polythiophene derivative of the following formula (I) wherein "n" is an integer ranging from 6 to 100, is disclosed. The optical sensor allows for the detection of targets selected from the group consisting of potassium ions, small organic molecules, amino acids, proteins, whole cells and nucleotides. The detection is based on the formation of hybrid anionic aptamer/cationic polythiophene complexes.
摘要翻译：一种用于检测包含与所述靶互补的单链适配体的靶的光学传感器和下式（I）的水溶性阳离子聚噻吩衍生物，其中“n”为6至100的整数。光学传感器允许检测从由钾离子，小有机分子，氨基酸，蛋白质，全细胞和核苷酸组成的组中选择的靶标。检测是基于杂交阴性适体/阳离子聚噻吩复合物的形成。

6. 发明申请

WO2003050298A1 LOW MOLECULAR WEIGHT HEPARIN ASSAY, SYSTEM AND REAGENT THEREFOR 审中-公开
标题翻译：低分子量肝素测定，其系统和试剂
公开(公告)号：WO2003050298A1
公开(公告)日：2003-06-19
申请号：PCT/US2002/039308
申请日：2002-12-09
申请人： CARDIOVASCULAR DIAGNOSTIC, INC.
发明人： MIZE, Patrick, D.
IPC分类号： C12Q1/37
CPC分类号： G01N33/86 , C12Q1/56 , Y10S435/975
摘要： A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.
摘要翻译：提供了用于测量全血样品中的低分子量肝素的方法，试剂盒，系统和试剂，其涉及使用因子Xa活化剂，例如罗素的Viper Venom作为凝血测定引发剂。

7. 发明申请

WO0123604A3 HIGHLY CONSERVED GENES AND THEIR USE TO GENERATE PROBES AND PRIMERS FOR DETECTION OF MICROORGANISMS 审中-公开
标题翻译：高度遗传基因及其用于生成检测微生物的探针和引物
公开(公告)号：WO0123604A3
公开(公告)日：2002-08-08
申请号：PCT/CA0001150
申请日：2000-09-28
申请人： INFECTIO DIAGNOSTIC INC , BERGERON MICHEL G , BOISSINOT MAURICE , HULETSKY ANN , MENARD CHRISTIAN , OUELLETTE MARC , PICARD FRANCOIS J , ROY PAUL H
发明人： BERGERON MICHEL G , BOISSINOT MAURICE , HULETSKY ANN , MENARD CHRISTIAN , OUELLETTE MARC , PICARD FRANCOIS J , ROY PAUL H
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/00 , A61K39/002 , A61K39/02 , A61K48/00 , A61P31/04 , A61P31/10 , A61P33/00 , C07K7/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C07K14/00 , C12N15/63
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/6893 , C12Q2600/156 , C12Q2600/16
摘要： Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate a sequence repertory or bank and species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical microorganisms from specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention.
摘要翻译：使用四个高度保守的基因，编码翻译延伸因子Tu，翻译延伸因子G，质子转位ATP酶的催化亚单位和RecA重组酶，以产生序列汇编或银行和物种特异性，属特异性家族特异性，组特异性和通用核酸探针和扩增引物，以快速检测和鉴定来自标本的藻类，古细菌，真菌和寄生微生物进行诊断。相关的抗微生物剂抗性和毒素基因的检测也在本发明的范围内。

8. 发明申请

WO2005104702A3 AN AUTOMATED NON- INVASIVE REAL-TIME ACUTE RENAL FAILURE DETECTION SYSTEM 审中-公开
标题翻译：自动化非实时急性真核失效检测系统
公开(公告)号：WO2005104702A3
公开(公告)日：2006-02-09
申请号：PCT/US2005013852
申请日：2005-04-22
申请人： RENAL DIAGNOSTIC INC , TOWNSEND SETH , KOMANSKI CHRISTOPHER , BOYER RICHARD , TEDFORD NATHAN , FINE DEREK , STAR ROBERT
发明人： TOWNSEND SETH , KOMANSKI CHRISTOPHER , BOYER RICHARD , TEDFORD NATHAN , FINE DEREK , STAR ROBERT
IPC分类号： G01N35/08 , G01N21/00
CPC分类号： A61B5/201 , A61B5/14507 , A61B5/208 , A61B5/412
摘要： [0111] A real-time, non-invasive system and method for determining the level of an analyze of interest in the urine of a patient is disclosed. The system and method uses the measured level of an analyze of interest to detect the onset of acute renal failure (ARF) as early as possible to prevent that patient from developing the disease or mitigating the effects of the disease. The system and method may be used to monitor the recovery of a patient after an ARF diagnosis. Preferably, the analyze of interest is creatinine or urea. The system may be placed in the urine drain line of a patient between a Foley catheter or other urinary drain and a urine collection bag. The system makes substantially continuous measurements of the urine flow rate and the concentration of the analyze of interest to determine the mass excretion rate of the analyze so it may be monitored to detect if the patient experiences a delta change in the mass excretion rate of an analyze that is indicative of the onset of ARF or a change in renal function.
摘要翻译：公开了一种用于确定患者尿中感兴趣的分析水平的实时非侵入性系统和方法。该系统和方法使用测量的感兴趣的分析水平尽可能早地检测急性肾衰竭（ARF）的发作，以防止该患者发展该疾病或减轻该疾病的影响。该系统和方法可以用于在ARF诊断之后监视患者的恢复。优选地，感兴趣的分析是肌酐或尿素。该系统可以放置在患有Foley导尿管或其它排尿管和尿液收集袋之间的尿液排泄管线中。该系统基本上连续测量尿流速和感兴趣分析的浓度，以确定分析物的质量排泄率，以便可以监测其可以监测以检测患者是否经历分析的质量排泄速率的δ变化这表明ARF的发生或肾功能的变化。

9. 发明申请

WO2004055205A3 BIOLOGICAL REAGENTS AND METHODS TO VERIFY THE EFFICIENCY OF SAMPLE PREPARATION AND NUCLEIC ACID AMPLIFICATION AND/OR DETECTION 审中-公开
标题翻译：生物试剂和方法来验证样品制备和核酸扩增和/或检测的效率
公开(公告)号：WO2004055205A3
公开(公告)日：2004-08-26
申请号：PCT/CA0301925
申请日：2003-12-15
申请人： INFECTIO DIAGNOSTIC INC , GAYRAL JEAN-PIERRE , PICARD FRANCOIS , BOISSINOT MAURICE , BASTIEN MARTINE
发明人： GAYRAL JEAN-PIERRE , PICARD FRANCOIS , BOISSINOT MAURICE , BASTIEN MARTINE
IPC分类号： C12Q1/68
CPC分类号： C12N1/06 , C12N15/1003 , C12Q1/6806 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , C12Q2600/16 , C12Q2600/166 , C12Q2545/101
摘要： This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal control (IC) target for nucleic acid testing (NAT) assay; wherein the reagent is suitable to be added to a test sample undergoing sample preparation to release, concentrate and/or purify nucleic acids and amplification and/or detection of nucleic acids so as to be used to verify: (i) the efficiency of sample preparation; and (ii) the efficiency of nucleic acid amplification and/or detection. The present invention also relates to a method to verify or validate the preparation and amplification and/or detection of a nucleic acid target sequence in a sample spiked with a reagent of the present invention.
摘要翻译：本发明涉及试剂，其包含：细胞，病毒颗粒，细胞器，寄生虫，包含细胞器的细胞，包含病毒颗粒的细胞，包含寄生虫的细胞，包含细菌细胞的细胞及其任何组合，细胞，病毒颗粒，细胞器或寄生虫包括用作核酸测试（NAT）测定的内部对照（IC）靶的至少一个核酸序列; 其中所述试剂适于加入到经过样品制备以测试核酸的测试样品中以及核酸的扩增和/或检测，以便用于验证：（i）样品制备的效率 ; 和（ii）核酸扩增和/或检测的效率。本发明还涉及验证或验证掺有本发明试剂的样品中核酸靶序列的制备和扩增和/或检测的方法。

10. 发明申请

WO2007044029A3 METHOD AND APPARATUS FOR LOW QUANTITY DETECTION OF BIOPARTICLES IN SMALL SAMPLE VOLUMES 审中-公开
公开(公告)号：WO2007044029A3
公开(公告)日：2007-04-19
申请号：PCT/US2005/043664
申请日：2005-12-02
申请人： NANO SCIENCE DIAGNOSTIC, INC. , SATYANARAYANA, Srinagesh , DWARAKANATH, Sulatha
发明人： SATYANARAYANA, Srinagesh , DWARAKANATH, Sulatha
IPC分类号： B03C5/00 , B03C5/02 , G01J1/42
摘要： A novel apparatus and method is described for detection of very small quantities (a few hundred molecules) of bioparticles in nanoliter/picoliter quantities of a sample. The apparatus involves a very small and low cost apparatus that contains a fluorometer. The detection process uses the fluorescence of nanoparticles. Dielectrophoresis is used to concentrate, mix and position the target particles with regard to the light sensor such that maximum detection efficiency is achieved. This allows low cost implementation of low cost point of care tests for disease (animal and plant), infection, food-borne bacteria detection, nucleotide sequencing and pathogen detection (bioterrorism) inreal world applications.

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