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1. 发明申请

WO2016005866A1 PORTABLE ELECTRONIC SYSTEM FOR THE ANALYSIS OF TIME-VARIABLE GASEOUS FLOWS 审中-公开
标题翻译：便携式电子系统用于时变气流分析
公开(公告)号：WO2016005866A1
公开(公告)日：2016-01-14
申请号：PCT/IB2015/054994
申请日：2015-07-02
申请人： NANOTECH ANALYSIS S.R.L.S.
发明人： MENSA, Gianpiero , CORREALE, Raffaele
IPC分类号： G01N1/22 , H01J49/04 , B01L3/00 , H01J49/00 , G01N30/72
CPC分类号： G01N30/722 , G01N30/7206 , H01J49/0018 , H01J49/0427
摘要： A portable system 1 for analyzing gaseous flows that vary over time is described, the system comprising a sampling chamber 18, a gas sampling module 7, an ion filtering module 8 and an ion detecting module 9. The sampling chamber 18 is suitable to be kept at a controlled sampling pressure Pc, and is configured to receive at least one gaseous flow F having a gaseous composition to be analyzed that is variable over time. The gas sampling module 7, arranged in fluidic communication with the sampling chamber 18, is configured to adjust an input gaseous flow Fi of gas particles from the sampling chamber 18, and an output gaseous flow Fo from the sampling module 7, so as to reproduce inside the sampling module 7 a gaseous composition representative of the gaseous composition to be analyzed. The gas sampling module 7 is further configured to ionize said gas particles and to emit the produced ions, so as to generate an ion flow I having an ion composition representative of the gaseous composition to be analyzed. The sampling module 7 is also suitable to maintain inside it a controlled ionization pressure Pi, and it is also configured in such a way that the input gaseous flow Fi comprises a plurality of micro-flows at a molecular or predominantly molecular regime, at the sampling pressure Pc, and the output gaseous flow Fo is a flow at a molecular or predominantly molecular regime, at the ionization pressure Pi. The ion filtering module 8 is operatively connected to the sampling module 7 to receive the ion flow I, and is configured to controllably select at least one type of ion present in the ion flow I and to generate a corresponding at least one homogeneous ion beam l', having an intensity representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The ion detecting module 9 is operatively connected to the ion filtering module 8 to receive the at least one ion beam l', and is configured to measure the intensity of the at least one ion beam l' and to generate a corresponding electric signal S representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed.
摘要翻译：描述了用于分析随时间变化的气流的便携式系统1，该系统包括采样室18，气体采样模块7，离子过滤模块8和离子检测模块9.采样室18适于保持以受控采样压力Pc，并且被配置为接收具有随时间变化的要分析的气体组成的至少一个气态流F。配置成与采样室18流体连通的气体采样模块7配置成调节来自采样室18的气体颗粒的输入气流F 1和来自采样模块7的输出气流Fo，以便再现采样模块7内部是表示要分析的气体组成的气态组成。气体采样模块7进一步配置为离子化所述气体颗粒并发射产生的离子，以产生具有代表要分析的气体组成的离子组成的离子流I. 采样模块7也适合于在其内部保持受控的电离压力Pi，并且其还被配置成使得输入气流F i在分子或主要是分子状态下包含多个微流，在采样压力Pc，并且输出气流Fo是在电离压力Pi处的分子或主要分子状态的流。离子过滤模块8可操作地连接到采样模块7以接收离子流I，并且被配置为可控地选择存在于离子流I中的至少一种离子，并产生相应的至少一个均匀离子束l '，具有代表待分析的气体组合物中相应气体颗粒的浓度的强度。离子检测模块9可操作地连接到离子过滤模块8以接收至少一个离子束1'，并且被配置为测量至少一个离子束1'的强度并产生相应的电信号S代表在待分析的气体组合物中的相应气体颗粒的浓度。

2. 发明申请

WO1996009642A1 MASS SPECTROMETER FOR GAS TENSION MEASURER 审中-公开
标题翻译：用于气体张力测量仪的质谱仪
公开(公告)号：WO1996009642A1
公开(公告)日：1996-03-28
申请号：PCT/US1995012181
申请日：1995-09-25
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BAUMGARDNER, James, E. , NEUFELD, Gordon, R.
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
IPC分类号： H01J49/04
CPC分类号： H01J49/0427
摘要： A novel mass spectrometer probe (14) is disclosed. The probe comprises a tubing (20) having one end (14b) adapted for connection to a spectrometer (12) and a second probe tip (14c) having a pore (24) cut therethrough, the pore being sealed with a membrane (26) such that the membrane eliminates water from the mass spectrometer system and admits low molecule weight gases into the system.
摘要翻译：公开了一种新型的质谱仪探头（14）。探针包括管（20），其具有适于连接到光谱仪（12）的一端（14b）和具有从其切入的孔（24）的第二探针尖端（14c），所述孔用膜（26）密封，使得膜从质谱仪系统中消除水，并将低分子量气体引入系统。

3. 发明申请

WO2016005864A1 PORTABLE ELECTRONIC DEVICE FOR THE ANALYSIS OF A GASEOUS COMPOSITION 审中-公开
标题翻译：用于气相组分分析的便携式电子设备
公开(公告)号：WO2016005864A1
公开(公告)日：2016-01-14
申请号：PCT/IB2015/054992
申请日：2015-07-02
申请人： NANOTECH ANALYSIS S.R.L.S.
发明人： MENSA, Gianpiero , CORREALE, Raffaele
IPC分类号： G01N1/22 , H01J49/04 , B01L3/00 , H01J49/00
CPC分类号： H01J49/0422 , G01N33/0016 , H01J49/0022 , H01J49/0427 , H01J49/147 , H01J49/24
摘要： An electronic device 1 for analyzing a gas composition, which is present in an environment A at an environment pressure Pa, is described. The device 1 is portable and comprises a gas sampling module 7, an ion filtering module 8 and an ion detecting module 9. The sampling module 7 is configured to adjust an input gaseous flow Fi of gaseous particles from the environment A and an output gaseous flow Fo so as to reproduce inside the sampling module 7 a gas composition representative of the gas composition to be analyzed. In addition, the sampling module 7 is configured to ionize said gaseous particles and to emit the ions produced, so as to generate an ion flow I having an ion composition representative of the gas composition to be analyzed. The ion filtering module 8 is operatively connected to the sampling module 7 to receive the ion flow I, and is configured to controllably select at least one type of ions present in the ion flow I and to generate a corresponding at least one homogeneous ion beam I', having an intensity representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The ion detecting module 9 is operatively connected to the ion filtering module 8 to receive the at least one ion beam I', and is configured to measure the intensity of such least one ion beam I' and to generate a corresponding electric signal S representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The device 1 further comprises pumping means 95, configured to extract gas from the device 1, so as to control an ionization pressure Pi that is present inside the sampling module 7. The sampling module 7 is configured in such a way that the input gaseous flow Fi comprises a plurality of micro-flows at a molecular or predominantly molecular regime, at the environment pressure Pa, and the output gaseous flow Fo is a flow at a molecular or predominantly molecular regime, at the ionization pressure Pi.
摘要翻译：描述用于分析环境A中环境压力Pa下存在的气体组成的电子设备1。设备1是便携式的，并且包括气体采样模块7，离子过滤模块8和离子检测模块9.采样模块7被配置为调节来自环境A的气态颗粒的输入气流F i和输出气流 Fo，以在采样模块7内再现代表待分析的气体成分的气体组成。此外，采样模块7被配置为离子化所述气态颗粒并发射产生的离子，以产生具有代表要分析的气体组成的离子组成的离子流I. 离子过滤模块8可操作地连接到采样模块7以接收离子流I，并且被配置为可控地选择存在于离子流I中的至少一种类型的离子并且产生相应的至少一个均匀离子束I '，具有代表待分析的气体组合物中相应气体颗粒的浓度的强度。离子检测模块9可操作地连接到离子过滤模块8以接收至少一个离子束I'，并且被配置为测量这样的至少一个离子束I'的强度并产生代表待分析的气体组合物中相应气体颗粒的浓度。装置1还包括泵送装置95，其被配置为从装置1提取气体，以便控制存在于采样模块7内的电离压力Pi。采样模块7被配置成使得输入气流 Fi在环境压力Pa下包含分子或主要分子状态的多个微流，并且输出气流Fo是在电离压力Pi处的分子或主要分子状态的流。

4. 发明申请

WO2015038898A1 CHEMICAL ANALYZER WITH MEMBRANE 审中-公开
标题翻译：化学分析仪与膜
公开(公告)号：WO2015038898A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/055405
申请日：2014-09-12
申请人： INFICON INC.
发明人： WRIGHT, Kenneth, Charles , VERBECK, Guido, F.
IPC分类号： B01L7/00
CPC分类号： H01J49/0427 , H01J49/0495 , H01J49/4215
摘要： A system for analyzing an analyte is described herein. The system includes a chamber having an inlet and a semi-permeable membrane arranged to seal the inlet. The semi-permeable membrane includes a cross-linked mixture of a first compound and a second compound. The system can also include a radiation source arranged in the vacuum chamber, the radiation source spaced apart from the semi-permeable membrane and adapted to irradiate the semi-permeable membrane with electromagnetic radiation at a frequency at least partially absorbed by the semi-permeable membrane.
摘要翻译：本文描述了用于分析分析物的系统。该系统包括具有入口和半透膜的室，该室被设置成密封入口。半透膜包括第一化合物和第二化合物的交联混合物。该系统还可以包括布置在真空室中的辐射源，辐射源与半透膜间隔开并且适于以至少部分被半透膜吸收的频率的电磁辐射照射半透膜。

5. 发明申请

WO2005078429A3 MASS SPECTROMETER SYSTEM 审中-公开
标题翻译：质谱仪系统
公开(公告)号：WO2005078429A3
公开(公告)日：2005-12-29
申请号：PCT/EP2005050132
申请日：2005-01-13
申请人： MICROSAIC SYSTEMS LTD , FINLAY ALAN
发明人： FINLAY ALAN
IPC分类号： H01J49/04
CPC分类号： H01J49/0495 , H01J49/0022 , H01J49/0427
摘要： A portable mass spectrometer system is described. The system includes a mass spectrometer device incorporated within an evacuated chamber. The chamber includes a permeable membrane located between the mass spectrometer device and an entrance port to the chamber. Located between the membrane and the entrance port is a valve. The valve is provided in an normally closed state and has an open state, such that, in use, the adoption of the open state allows the flow of the sample into the chamber through the membrane and into contact with the spectrometer device.
摘要翻译：描述了便携式质谱仪系统。该系统包括并入真空室内的质谱仪装置。腔室包括位于质谱仪装置和腔室入口之间的可渗透膜。位于膜和入口之间的是一个阀门。阀处于常闭状态并且具有打开状态，使得在使用中采用打开状态允许样品通过膜流入腔室并与光谱仪装置接触。

6. 发明申请

WO2005078429A2 MASS SPECTROMETER SYSTEM 审中-公开
标题翻译：质谱分析系统
公开(公告)号：WO2005078429A2
公开(公告)日：2005-08-25
申请号：PCT/EP2005/050132
申请日：2005-01-13
申请人： MICROSAIC SYSTEMS LIMITED , FINLAY, Alan
发明人： FINLAY, Alan
IPC分类号： G01N30/00
CPC分类号： H01J49/0495 , H01J49/0022 , H01J49/0427
摘要： A portable mass spectrometer system is described. The system includes a mass spectrometer device incorporated within an evacuated chamber. The chamber includes a permeable membrane located between the mass spectrometer device and an entrance port to the chamber. Located between the membrane and the entrance port is a valve. The valve is provided in an normally closed state and has an open state, such that, in use, the adoption of the open state allows the flow of the sample into the chamber through the membrane and into contact with the spectrometer device.
摘要翻译：描述了一种便携式质谱仪系统。该系统包括结合在真空室内的质谱仪装置。腔室包括位于质谱仪装置和腔室入口之间的可渗透膜。位于膜和入口之间的是一个阀门。该阀以常闭状态提供并且具有打开状态，使得在使用中采用打开状态允许样品通过隔膜流入腔室并与分光计装置接触。

7. 发明申请

WO2003038086A1 SOFT IONIZATION DEVICE AND APPLICATIONS THEREOF 审中-公开
标题翻译：软离子化装置及其应用
公开(公告)号：WO2003038086A1
公开(公告)日：2003-05-08
申请号：PCT/US2002/020353
申请日：2002-06-25
申请人： IONFINITY LLC , HARTLEY, Frank, T.
发明人： HARTLEY, Frank, T.
IPC分类号： C12N13/00
CPC分类号： H01J49/168 , G01N2223/612 , H01J3/027 , H01J3/04 , H01J27/02 , H01J27/26 , H01J37/08 , H01J49/0018 , H01J49/0427 , H01J2237/061 , H01J2237/0815 , H01J2237/317
摘要： A soft ionization device is disclosed that comprises a series of electrodes (120, 122) having spacing less than the means free path of the molecules to be ionized. In some embodiments, the soft ionization device (99) is used in various applications that require ion or electron sources such as biological or chemical reactors, ion milling, and numerous replacements for conventional hot cathode systems. In another embodiment, a valence spectrometer is disclosed that is configured to variably ionize molecules (301) by their valiancy. In other embodiments, the ionization device is coupled to a spectrometer for the characterization of biological matter. Also disclosed is a preconditioner for preparing biological matter to be ionized.
摘要翻译：公开了一种软电离装置，其包括具有小于待离子化分子的装置自由路径的间隔的一系列电极（120,122）。在一些实施例中，软电离装置（99）用于需要离子或电子源（例如生物或化学反应器，离子铣削）和常规热阴极系统的大量替代品的各种应用中。在另一个实施方案中，公开了一种价态光谱仪，其被配置为可变地以分子（301）离子化分子（301）。在其它实施方案中，将离子化装置耦合到用于表征生物物质的光谱仪。还公开了用于制备待离子化的生物物质的预处理剂。

8. 发明申请

WO2016075208A1 A DEVICE FOR EXTRACTING VOLATILE SPECIES FROM A LIQUID 审中-公开
标题翻译：从液体中提取挥发性物质的装置
公开(公告)号：WO2016075208A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076358
申请日：2015-11-11
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： TRIMARCO, Daniel Bøndergaard , VESBORG, Peter Christian Kjærgaard , PEDESEN, Thomas , HANSEN, Ole , CHORKENDORFF, Ib
IPC分类号： H01J49/04 , G01N1/22
CPC分类号： H01J49/0427 , G01N1/4005 , G01N2001/4016 , G01N2001/4066 , H01J49/0018 , H01J49/0404
摘要： The invention relates to a device (10) for extracting volatile species from a liquid (20) connected to an inlet of an analysis instrument, such as a mass spectrometer (MS). The device has a chamber (4), a membrane (5) forming a barrier for the liquid at zero differential pressure between the inside and the outside of the chamber, and allowing passage of the volatile species at zero differential pressure between the inside and the outside of the chamber. The device has an inlet capillary channel (3) to feed in a carrier gas and prevent back-diffusion from the chamber, and an outlet capillary channel (6) which provides a significant pressure reduction, e.g. from atmospheric pressure in the chamber (4) to near-vacuum suitable for an MS. The invention combines the best of two worlds, i.e. the fast time-response of a DEMS system and the high sensitivity of a MIMS system, since a differential pumping stage is not needed.
摘要翻译：本发明涉及一种用于从连接到诸如质谱仪（MS）的分析仪器的入口的液体（20）中提取挥发性物质的装置（10）。该装置具有腔室（4），膜（5），其在腔室的内部和外部之间在零差压下形成用于液体的阻挡层，并且允许在零和压力之间的内部和在室外。该装置具有入口毛细通道（3），以进料载气并防止反向扩散室，以及出口毛细通道（6），其提供显着的减压，例如，从腔室（4）中的大气压到适合于MS的接近真空。本发明结合了两个世界中最好的，即DEMS系统的快速时间响应和MIMS系统的高灵敏度，因为不需要差分泵送阶段。

9. 发明申请

WO2014041045A1 SYSTEM AND METHOD FOR ELUTING AND TESTING SUBSTANCE FROM EXHALED AEROSOL SAMPLE 审中-公开
标题翻译：用于从外部气溶胶样品中测量和测试物质的系统和方法
公开(公告)号：WO2014041045A1
公开(公告)日：2014-03-20
申请号：PCT/EP2013/068860
申请日：2013-09-11
申请人： SENSA BUES AB
发明人： BECK, Olof
IPC分类号： G01N33/497 , A61B5/097 , A61B5/08
CPC分类号： G01N33/497 , A61B5/082 , A61B5/097 , A61B5/4845 , H01J49/0427
摘要： A method recovering one or more nonvolatile compounds from an exhaled aerosol collected on an electrostatic filter membrane (205) comprises eluting the nonvolatile compounds from the filter with a polar solvent and collecting the eluate. The method is useful for processing samples collected from a portable breath analysis device comprising a sampling filter membrane for analysis.
摘要翻译：收集在静电过滤膜（205）上的呼出气溶胶中回收一种或多种非挥发性化合物的方法包括用极性溶剂从过滤器中洗脱不挥发性化合物并收集洗脱液。该方法对于处理从包含用于分析的取样滤膜的便携式呼吸分析装置收集的样品是有用的。

10. 发明申请

WO2012054534A1 SURFACE SAMPLING SYSTEMS FOR COLLECTING VOLATILIZED SAMPLES 审中-公开
标题翻译：用于收集挥发性样品的表面采样系统
公开(公告)号：WO2012054534A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056779
申请日：2011-10-18
申请人： UT-BATTELLE, LLC , THOMPSON, Cyril, V.
发明人： THOMPSON, Cyril, V.
IPC分类号： G01N1/02 , G01N1/24 , G01N35/10 , H01J49/04
CPC分类号： H01J49/0468 , G01N1/02 , G01N2001/007 , G01N2001/022 , G01N2001/028 , G01N2001/2291 , G01N2030/126 , H01J49/0427
摘要： The sampling system includes a transfer tube and a sampling head configured to volatilize a sample from a test surface. The transfer tube has an inlet end for receiving a volatized sample into an interior of the transfer tube and an outlet end for directing the volatized sample from the interior of the transfer tube. The sampling head is coupled to the inlet end of the transfer tube and has a volatilized sample receiving area defined by a distal end that is configured to be brought into contact with the test surface and an opening in the sampling head that is in fluid communication with the inlet end of the transfer tube. The distal end of the sampling head includes a porous metallic membrane.
摘要翻译：采样系统包括传送管和被配置成从测试表面挥发样品的采样头。转移管具有用于将挥发的样品接收到转移管的内部的入口端和用于引导来自转移管内部的挥发的样品的出口端。采样头耦合到传送管的入口端，并且具有由远端限定的挥发的样品接收区域，该远端构造成与测试表面接触，并且采样头中的开口与流体连通输送管的入口端。采样头的远端包括多孔金属膜。

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