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1. 发明申请

WO2013126762A1 MULTI-FOCAL STRUCTURED ILLUMINATION MICROSCOPY SYSTEMS AND METHODS 审中-公开
标题翻译：多功能结构照明微观系统及方法
公开(公告)号：WO2013126762A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027413
申请日：2013-02-22
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH , SHROFF, Hari , YORK, Andrew
发明人： SHROFF, Hari , YORK, Andrew
IPC分类号： G02B21/00
CPC分类号： G02B21/0072 , G01N21/6458 , G01N2021/6478 , G01N2201/0633 , G02B21/0032 , G02B21/0036 , G02B21/004 , G02B21/0076
摘要： A multi-focal selective illumination microscopy (SIM) system for generating multi-focal patterns of a sample is disclosed. The multi-focal SIM system performs a focusing, scaling and summing operation on each multi-focal pattern in a sequence of multi-focal patterns that completely scan the sample to produce a high resolution composite image.
摘要翻译：公开了一种用于产生样品的多焦点图案的多焦点选择性照明显微镜（SIM）系统。多焦点SIM卡系统以完全扫描样本以产生高分辨率合成图像的多焦点图案序列对每个多焦点图案进行聚焦，缩放和求和操作。

2. 发明申请

WO2010084478A3 HIGH-RESOLUTION MICROSCOPY AND PHOTOLITHOGRAPHY DEVICES USING FOCUSING MICROMIRRORS 审中-公开
标题翻译：采用聚焦微反射镜的高分辨率显微镜和光刻装置
公开(公告)号：WO2010084478A3
公开(公告)日：2010-10-28
申请号：PCT/IB2010050300
申请日：2010-01-23
申请人： ECOLE POLYTECH , RACHET BASTIEN , MERENDA FABRICE , SALATHE RENE
发明人： RACHET BASTIEN , MERENDA FABRICE , SALATHE RENE
IPC分类号： G02B21/00
CPC分类号： G03F7/70191 , G02B21/0032 , G02B21/004 , G02B21/0076 , G02B26/0833
摘要： The invention relates to large-field high-resolution microscopy and photolithography setups operating with polychromatic light. It includes the use of a plurality of focusing micromirrors.
摘要翻译：本发明涉及用多色光操作的大视场高分辨率显微镜和光刻设备。它包括使用多个聚焦微镜。

3. 发明申请

WO2009138512A1 OPTICAL STIMULATION OF PHOTOSENSITIZED CELLS 审中-公开
标题翻译：光敏细胞的光学刺激
公开(公告)号：WO2009138512A1
公开(公告)日：2009-11-19
申请号：PCT/EP2009/055992
申请日：2009-05-18
申请人： IMPERIAL INNOVATIONS LIMITED , GROSSMAN, Nir , DEGENAAR, Patrick , NIKOLIC, Konstantin , NEIL, Mark , KENNEDY, Gordon , POHER, Vincent
发明人： GROSSMAN, Nir , DEGENAAR, Patrick , NIKOLIC, Konstantin , NEIL, Mark , KENNEDY, Gordon , POHER, Vincent
IPC分类号： G02B21/00 , G02B21/16
CPC分类号： G02B21/004 , G01N21/6458 , G02B21/0032 , G02B21/0076 , G02B21/16
摘要： This invention describes a device for optical stimulation of cells and other biological structures. It has an ability to target multiple cells and/or multiple sub-cellular targets. The stimulation optical pattern on each cell can be independently controlled with individual frequencies. The light sensitivity of the cells can be imparted as a result of genetic expression of surface and/or subsurface proteins, chemical modification of existing proteins, or via the release of caged entities which in turn act to stimulate the cell through chemical means. The embodiment is capable of functioning on neurons but can also be used for other cells. It can perform optimal stimulation with sub-cellular resolutions, record the activity of the targeted cells and perform processing to ensure calibration.
摘要翻译：本发明描述了用于光学刺激细胞和其他生物结构的装置。它具有靶向多个细胞和/或多个亚细胞靶标的能力。每个单元上的刺激光学图案可以独立地用各个频率控制。由于表面和/或表面下蛋白质的遗传表达，现有蛋白质的化学修饰，或通过释放笼养的实体，细胞的光敏感性可以赋予细胞，而后者又通过化学方式刺激细胞。该实施例能够在神经元上起作用，但也可用于其他细胞。它可以用亚细胞分辨率执行最佳刺激，记录目标细胞的活性，并进行处理以确保校准。

4. 发明申请

WO0123913A3 OPTICAL CONFOCAL DEVICE HAVING A COMMON LIGHT DIRECTING MEANS 审中-公开
标题翻译：具有通用指示手段的光学协同设备
公开(公告)号：WO0123913A3
公开(公告)日：2008-03-06
申请号：PCT/US0026713
申请日：2000-09-28
申请人： NEW DIMENSION RES & INSTR INC
发明人： HANG ZHIJIANG , LAZAREV VICTOR , WEBB ROBERT H
IPC分类号： H01J3/14 , A61B3/12 , G02B21/00
CPC分类号： G02B21/0056 , A61B3/1225 , G02B21/0032 , G02B21/004 , G02B21/0072 , G02B21/0076
摘要： A confocal scanning imaging device for viewing an object includes an array of independently addressable microlasers and an array of detectors for detecting light from an object to which light from the microlasers has been directed. The array of microlasers and the array of detectors are combined into a single array, such as on a single chip, and in a pattern constructed and arranged so that different detectors are adjacent to each microlaser so that light from an illuminated object may be directed back to the vicinity of the illuminating microlaser and be detected by the adjacent detector(s). An optical arrangement directs light generated by the microlasers onto an object and directs light from an object so illuminated onto detectors adjacent to the illuminating microlaser. The optical arrangement includes a bilens and a matching lens system including two objective lenses. A microlens collimates light generated by the microlasers.
摘要翻译：用于观看物体的共焦扫描成像装置包括可独立寻址的微型激光器的阵列和用于检测来自微型激光器的光的物体的光的检测器阵列。微阵列和检测器阵列被组合成单个阵列，例如在单个芯片上，并且以构造和布置的图案组合，使得不同的检测器与每个微激光器相邻，使得来自被照射物体的光可以被引导回到照明微型激光器的附近，并由相邻的检测器检测。光学装置将由微型激光器产生的光引导到物体上并将来自被照射到物体上的光引导到与照明微激光器相邻的检测器上。光学装置包括双相和包括两个物镜的匹配透镜系统。微透镜校准微量元件产生的光。

5. 发明申请

WO2007113473A1 CONFOCAL MICROSCOPY WITH A TWO-DIMENSIONAL ARRAY OF LIGHT EMITTING DIODES 审中-公开
标题翻译：具有二维发光二极管阵列的共焦显微镜
公开(公告)号：WO2007113473A1
公开(公告)日：2007-10-11
申请号：PCT/GB2007/001033
申请日：2007-03-20
申请人： IMPERIAL INNOVATIONS LIMITED , FRENCH, Paul, Michael, William , DUNSBY, Christopher, William , NEIL, Mark, Andrew, Aquilla
发明人： FRENCH, Paul, Michael, William , DUNSBY, Christopher, William , NEIL, Mark, Andrew, Aquilla
IPC分类号： G02B21/00 , G02B23/24 , G06K9/00 , C12M1/34
CPC分类号： G02B21/004 , G02B21/008
摘要： A confocal microscope (2) uses as a light source a two-dimensional array of light emitting diodes (4). A two-dimensional array of detector cells (18) in the form of a CCD camera array or a CMOS camera array is provided. A sequence of illumination patterns are generated by the array of light emitting diodes (4). A corresponding sequence of detection patterns are read from the two-dimensional array of detector cells (18). The light emitting diodes may be AlGaInN light emitting diodes generating light in the wavelength 250nm to 500nm. The confocal microscope (2) may be fitted to the tip of an endoscope (30).
摘要翻译：共焦显微镜（2）使用发光二极管（2）的二维阵列作为光源。提供了CCD照相机阵列或CMOS照相机阵列形式的检测器单元（18）的二维阵列。一系列照明图案由发光二极管阵列（4）产生。从检测器单元（18）的二维阵列中读取相应的检测图案序列。发光二极管可以是产生波长为250nm至500nm的光的AlGaInN发光二极管。共焦显微镜（2）可以安装在内窥镜（30）的前端。

6. 发明申请

WO03008940A9 CONFOCAL 3D INSPECTION SYSTEM AND PROCESS 审中-公开
标题翻译： CONFOCAL 3D检查系统和过程
公开(公告)号：WO03008940A9
公开(公告)日：2004-06-24
申请号：PCT/US0222546
申请日：2002-07-16
申请人： AUGUST TECHNOLOGY CORP
发明人： WATKINS CORY , VAUGHNN DAVID , BLAIR ALAN
IPC分类号： G01N21/95 , G01N21/956 , G02B13/22 , G02B21/00 , G02B21/16 , G03B15/00 , H01L21/60 , H01L21/66 , H05K3/00 , G01N21/00 , G06K9/62 , H04N7/18
CPC分类号： G02B21/008 , G01N21/9501 , G02B13/22 , G02B21/0024 , G02B21/004 , G02B21/16
摘要： A confocal three dimensional inspection system (120), and process for use thereof, allows for rapid inspecting of bumps and other three dimensional (3D) features on wafers (S), other semiconductor substrates (S) and other large format micro topographies. The sensor eliminates out of focus light using a confocal principal to create a narrow depth response in the micron range.
摘要翻译：共焦三维检查系统（120）及其使用方法允许快速检查晶片（S），其它半导体衬底（S）和其他大幅面微观形貌上的凸起和其它三维（3D）特征。该传感器消除了使用共焦原理的聚焦光，以在微米范围内产生较窄的深度响应。

7. 发明申请

WO03087773A2 MULTIPLEXED CAPILLARY ELECTROPHORESIS SYSTEMS 审中-公开
标题翻译：多重毛细管电泳系统
公开(公告)号：WO03087773A2
公开(公告)日：2003-10-23
申请号：PCT/US0311454
申请日：2003-04-14
申请人： AMERSHAM BIOSCIENCES SV CORP , HUTTERER KATARIINA MARIA , OLSON NELS A , JOVANOVICH STEVAN BOGDAN , ROACH DAVID JOHN , ARMSTRONG THOMAS M , BURGI DEAN , DOLNIK VLADISLAV
发明人： HUTTERER KATARIINA MARIA , OLSON NELS A , JOVANOVICH STEVAN BOGDAN , ROACH DAVID JOHN , ARMSTRONG THOMAS M , BURGI DEAN , DOLNIK VLADISLAV
IPC分类号： G01N21/64 , G01N27/447 , G01N27/453 , G01N30/46 , G02B21/00 , G01N
CPC分类号： G01N27/44782 , G01N21/6486 , G01N27/44721 , G01N27/44743 , G01N27/44773 , G01N30/463 , G01N2021/6439 , G02B21/0028 , G02B21/004 , G02B21/0076
摘要： Multi-capillary systems for high-throughput electrophoretic separation and detection of biomolecules are disclosed. One embodiment of the invention uses galactomannans as a size-sieving matrix for multi-channel electrophoretic separations of biomolecules. Multi-color detection for the simultaneous analysis of controls and standards in the same channels as the samples, and endogenous fluorescence detection are also disclosed. Another embodiment of the invention is a two dimensional system for separation of complex samples, using multiplexed capillary electrophoresis system as the second dimension, with a fraction collection step connecting the two separation steps. The systems allow for separations to be accomplished with a highly parallel manner, or in a two-dimensional format.
摘要翻译：公开了用于高通量电泳分离和生物分子检测的多毛细管系统。本发明的一个实施方案使用半乳甘露聚糖作为尺寸筛选基质用于生物分子的多通道电泳分离。还公开了用于同时分析与样品相同通道中的对照和标准物以及内源性荧光检测的多色检测。本发明的另一个实施方案是使用多重毛细管电泳系统作为第二维度分离复杂样品的二维系统，连接两个分离步骤的级分收集步骤。这些系统允许以高度平行的方式或以二维格式来实现分离。

8. 发明申请

WO98035204A1 BACKGROUND COMPENSATION FOR CONFOCAL INTERFERENCE MICROSCOPY 审中-公开
标题翻译：协调干扰显微镜的背景补偿
公开(公告)号：WO98035204A1
公开(公告)日：1998-08-13
申请号：PCT/US1998/001214
申请日：1998-01-22
IPC分类号： G01B9/02 , G01B9/04 , G01B11/00 , G02B21/00 , G11B7/005 , G11B7/14
CPC分类号： G02B21/0056 , G01B9/02027 , G01B9/02042 , G01B9/02056 , G01B2290/45 , G02B21/004 , G02B21/006 , G02B21/0068 , G02B21/008 , G11B7/005 , G11B7/14
摘要： A system discriminates an in-focus image from an out-of-focus image so as to reduce both systematic and statistical errors in a measurement of the in-focus image. The system produces a probe beam (p22B) and a reference beam (R22B) from a point source (10), and antisymmetric spatial properties are produced in the reference beam (R22B). An in-focus return probe beam (P32A) is produced as a result of directing a probe beam (P22B) into an in-focus image point (28), and antisymmetric spatial properties are produced in the in-focus return probe beam (P32B). The reference beam (R32C) is interfered with a beam from an out-of-focus image point (58), and the reference beam (R32C) is interfered with the in-focus return beam (P32C). The reference beam (R32D) is detected by a single-pixel detector (114) as a square of an amplitude of the reference beam (R32D), and the in-focus return probe beam (P32D) is detected by the detector (114) as an interference term between a return reference beam (R32D) and the in-focus return probe beam (P32D). An amplitude of an interference term between an amplitude of the out-of-focus image beam (B52D) and an amplitude of the return reference beam (R32D) is substantially reduced, resulting in reducing both systematic and statistical errors in data produced by the detector (114). In the described embodiment, the beam from the out-of-focus image point (58) is an out-of-focus return probe beam (B52D).
摘要翻译：系统鉴别对焦图像与离焦图像，以减少对焦图像的测量中的系统误差和统计误差。系统从点源（10）产生探测光束（p22B）和参考光束（R22B），并且在参考光束（R22B）中产生反对称空间特性。通过将探测光束（P22B）引导到对焦图像点（28）中，产生对焦返回探测光束（P32A），并且在对焦返回探测光束（P32B）中产生反对称空间特性）。参考光束（R32C）会干扰来自离焦图像点（58）的光束，参考光束（R32C）会干扰对焦返回光束（P32C）。参考光束（R32D）由单像素检测器（114）检测为参考光束（R32D）的振幅的平方，并且检测器（114）检测对焦返回探测光束（P32D）作为返回参考光束（R32D）和对焦返回探测光束（P32D）之间的干涉项。离焦图像光束（B52D）的振幅与返回参考光束（R32D）的幅度之间的干涉项的幅度大大降低，导致减少由检测器产生的数据中的系统误差和统计误差（114）。在所描述的实施例中，来自离焦图像点（58）的光束是离焦返回探测光束（B52D）。

9. 发明申请

WO9828655A2 LIGHT MODULATED CONFOCAL OPTICAL INSTRUMENTS AND METHOD 审中-公开
标题翻译：光调制协调光学仪器和方法
公开(公告)号：WO9828655A2
公开(公告)日：1998-07-02
申请号：PCT/US9722969
申请日：1997-12-19
申请人： BIOPHYSICA TECHNOLOGIES INC
发明人： KRAUSE ANDREW W , LIANG MINHUA , STEHR ROBERT L
IPC分类号： G01M11/02 , G02B21/00 , G02B26/02 , G02B26/08 , G02F
CPC分类号： G01M11/0264 , G02B21/004 , G02B21/0048 , G02B21/0056 , G02B21/0068 , G02B21/0072 , G02B21/0076 , G02B26/02 , G02B26/0833 , G02B26/0841
摘要： The confocal imaging system and method involve the imaging of a specimen under observation by projecting a light pattern of illumination spots simultaneously on the specimen. This is accomplished by a pattern array unit which transforms light from a light source into a desired pattern of illumination spots, and reflects or rejects light outside the pattern. Light detected from the specimen is confined to a pattern conforming to the pattern of the illumination spots by the same pattern array unit which rejects light beyond the pattern, and rejected light from the pattern array unit is transmitted back to the light source. Image signals are created from the received light and stored, and the stored image signals are combined to form a complete image frame.
摘要翻译：共聚焦成像系统和方法涉及通过在样本上同时投射照明斑点的光图案而在观察下进行成像。这是通过将来自光源的光转换成期望的照明点图案的图案阵列单元来实现的，并且反射或拒绝图案外部的光。从样本检测到的光被限制为符合照明点的图案的图案，其通过相同的图案阵列单元，其拒绝超出图案的光，并且来自图案阵列单元的拒绝光被传输回到光源。从接收到的光创建图像信号并存储，并且存储的图像信号被组合以形成完整的图像帧。

10. 发明申请

WO1997048968A1 CONFOCAL OPTICAL APPARATUS 审中-公开
标题翻译：共焦光学装置
公开(公告)号：WO1997048968A1
公开(公告)日：1997-12-24
申请号：PCT/JP1997001944
申请日：1997-06-06
申请人： KOMATSU LTD. , TADA, Shigeyuki , TANAKA, Hiroshi , ENDOH, Takayoshi , MORIYA, Masato
发明人： KOMATSU LTD.
IPC分类号： G01B11/24
CPC分类号： G01B11/026 , G01B11/24 , G02B21/004
摘要： A confocal optical system is disposed one-dimensionally or two-dimensionally. Reflected light from an object (11, 12) is detected by a photodetector array (4) through a light receiving pin-hole array and the peak processing of the luminous intensity of the light received by the photodetector array is performed to measure the height of the object. If the received luminous intensity of the photodetector array exceeds a luminous power which is fixed within the dynamic range (Vs) of the photodetector array, the peak processing is made ineffective.
摘要翻译：共焦光学系统被一维或二维地设置。通过光接收针孔阵列由光电检测器阵列（4）检测来自物体（11,12）的反射光，并且执行由光电检测器阵列接收的光的发光强度的峰值处理，以测量物体。如果光电检测器阵列的接收到的发光强度超过光电检测器阵列的动态范围（Vs）内的光功率，则峰值处理无效。

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