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1. 发明申请

WO2016049770A1 MARKERS FOR MOOD DISORDERS 审中-公开
标题翻译：恶毒症状的标记
公开(公告)号：WO2016049770A1
公开(公告)日：2016-04-07
申请号：PCT/CA2015050990
申请日：2015-10-01
申请人： CAMH
发明人： MEYER JEFFREY , EVANS KEN , CHEN JIAN , ACKLOO SUZANNE , DHARSEE MOYEZ
IPC分类号： C12N9/02 , C07K7/06 , C07K7/08 , C07K16/40 , C12Q1/26 , C12Q1/37 , C40B30/04 , C40B40/10 , G01N33/48 , G01N33/483 , G01N33/68
CPC分类号： C07K7/06 , C07K7/08 , C12N9/0022 , C12Q1/26 , C12Y104/03004 , C40B40/10 , G01N2333/90638 , G01N2800/304
摘要： Disclosed is a method for diagnosing a mood disorder or susceptibility to a mood disorder, including depressive disorders and bipolar disorder, from a biological sample taken from a subject. The method includes detecting markers of monoamine oxidase-A (MAO-A) in the biological sample; determining MAO-A concentration from the markers; and correlating the MAO-A concentration in the biological sample to a control group which does not have a mood disorder in order to diagnose or determine susceptibility to the mood disorder in the subject. Also disclosed is a method of detecting peripheral markers of MAO-A for the diagnosis of a mood disorder or susceptibility to a mood disorder. Also provided are polypeptide markers.
摘要翻译：公开了从取自受试者的生物样品中诊断情绪障碍或对情绪障碍（包括抑郁障碍和双相情感障碍）的易感性的方法。该方法包括检测生物样品中单胺氧化酶-A（MAO-A）的标记; 确定标记物中的MAO-A浓度; 并将生物样品中的MAO-A浓度与不具有情绪障碍的对照组相关联，以诊断或确定受试者心情障碍的易感性。还公开了检测MAO-A的外周标志物用于诊断情绪障碍或对情绪障碍的易感性的方法。还提供多肽标记。

2. 发明申请

WO2015195703A1 METHODS, REAGENTS AND CELLS FOR BIOSYNTHESIZING COMPOUNDS 审中-公开
标题翻译：生物化学化合物的方法，试剂和细胞
公开(公告)号：WO2015195703A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036086
申请日：2015-06-16
申请人： INVISTA TECHNOLOGIES S.A R.L.
发明人： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck
IPC分类号： C12N1/32 , C12N9/00
CPC分类号： C12N9/0008 , C07C229/08 , C12N9/0022 , C12N9/0069 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/18 , C12P7/42 , C12P7/46 , C12P13/005 , C12Y102/01003 , C12Y102/01004 , C12Y104/03021 , C12Y113/12002 , C12Y206/01 , C12Y305/0103 , C12Y401/01
摘要： This document describes biochemical pathways for producing glutaric acid, 5 aminopentanoic acid, 5-hydroxypentanoic acid or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as cadaverine or 5-aminopentanamide.
摘要翻译：本文件描述了在C5主链基质如尸胺中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成戊二酸，5氨基戊酸，5-羟基戊酸或1,5-戊二醇的生化途径或5-氨基戊酰胺。

3. 发明申请

WO2013105588A1 フルクトシルバリルヒスチジンオキシダーゼ製剤の製造方法审中-公开
标题翻译：生产木瓜胆固醇氧化酶制剂的方法
公开(公告)号：WO2013105588A1
公开(公告)日：2013-07-18
申请号：PCT/JP2013/050259
申请日：2013-01-10
申请人：東洋紡株式会社
发明人：平尾　理恵 , 岸本　高英 , 柳谷　周作
IPC分类号： C12N9/04 , C12M1/34 , C12Q1/26
CPC分类号： C12N9/0032 , C12N9/0022 , C12Q1/26 , G01N33/723
摘要：【課題】安定性の高いＦＶＨＯ製剤、吸湿性の低いＦＶＨＯ乾燥製剤を提供する。【解決手段】リン酸、カゼインペプトン、Ｄ－グルコサミン塩酸塩、メリビオース、ソルボース、ラクトース、フルクトース、メレジトース、グルコノ－１，５－ラクトン、リビトール、ソルボースから選ばれるいずれか１つ以上を共存させる工程を含むことを特徴とするＦＶＨＯ製剤の製造方法、および、Ｂｉｃｉｎｅを共存させる工程を含むことを特徴とするＦＶＨＯ乾燥製剤の製造方法。
摘要翻译： [问题]提供：具有高稳定性的FVHO制剂; 和具有低吸湿性的干燥的FVHO制剂。 [解决方案]一种制备FVHO制剂的方法，其特征在于包括允许至少一种选自磷酸，酪蛋白胨，D-葡糖胺盐酸盐，蜜二糖，山梨糖，乳糖，果糖，松三糖，葡萄糖酸-1.5 β-内酯，核糖醇和山梨糖共同制备; 以及制备干燥的FVHO制剂的方法，其特征在于包括允许Bicine在制剂中共存的步骤。

4. 发明申请

WO2012127392A1 COMPOSITION COMPRISING DIAMINE OXIDASE FOR USE IN THE TREATMENT OR PREVENTION OF FIBROMYALGIA OR CHRONIC FATIGUE SYNDROME 审中-公开
标题翻译：包含DIAMINE氧化酶的组合物用于治疗或预防纤维瘤或慢性疲劳综合征
公开(公告)号：WO2012127392A1
公开(公告)日：2012-09-27
申请号：PCT/IB2012/051276
申请日：2012-03-16
申请人： DR HEALTHCARE ESPAÑA, S. L. , DUELO RIU, Carlos , DUELO RIU, Juan José
发明人： DUELO RIU, Carlos , DUELO RIU, Juan José
IPC分类号： A61K38/44 , A61K9/107 , A61K9/48 , A61K9/70 , C12N9/00 , A61P21/02 , A61P25/06 , A23L1/305 , A23L1/00
CPC分类号： A61K31/522 , A23L33/10 , A23L33/105 , A23L33/17 , A23P10/28 , A23P10/30 , A23P10/40 , A61K9/2018 , A61K9/48 , A61K9/5026 , A61K9/5047 , A61K38/44 , C12N9/0022 , C12Y104/03022
摘要： The present invention refers to a composition comprising diamine oxidase for use in the prevention or treatment of the symptoms and disorders caused by fibromyalgia or chronic fatigue syndrome.
摘要翻译：本发明涉及包含用于预防或治疗由纤维肌痛或慢性疲劳综合征引起的症状和障碍的二胺氧化酶的组合物。

5. 发明申请

WO2008109934A3 DEGRADATION OF COUMARIN BASED COMPOUNDS 审中-公开
标题翻译：香豆素类化合物的降解
公开(公告)号：WO2008109934A3
公开(公告)日：2008-12-18
申请号：PCT/AU2008000319
申请日：2008-03-07
申请人： COMMW SCIENT IND RES ORG , GRAINS RES & DEV CORP , TAYLOR MATTHEW C , TATTERSALL DAVID , BRIGGS LYNDALL J , FRENCH NIGEL , RUSSELL ROBYN J , OAKESHOTT JOHN G
发明人： TAYLOR MATTHEW C , TATTERSALL DAVID , BRIGGS LYNDALL J , FRENCH NIGEL , RUSSELL ROBYN J , OAKESHOTT JOHN G
IPC分类号： C12N9/02
CPC分类号： C12N9/0004 , C12N9/0022 , C12Y104/03005
摘要： The present invention relates to the identification of reductase enzymes that degrade coumarin based compounds such as aflatoxins. Methods, including those relying on transgenic organisms, are provided for degrading coumarin based compounds such as aflatoxins.
摘要翻译：本发明涉及鉴定降解基于香豆素的化合物如黄曲霉毒素的还原酶。提供了包括依赖于转基因生物的方法用于降解基于香豆素的化合物如黄曲霉毒素。

6. 发明申请

WO2007137755A1 PEG-MODIFIED ARGININE/LYSINE OXIDOREDUCTASE 审中-公开
标题翻译： PEG改性的ARGININE / LYSINE氧化还原酶
公开(公告)号：WO2007137755A1
公开(公告)日：2007-12-06
申请号：PCT/EP2007/004587
申请日：2007-05-23
申请人： APIT LABORATORIES GMBH , HOFMANN, Christian, J. , LINDEMANN, Michael
发明人： HOFMANN, Christian, J. , LINDEMANN, Michael
IPC分类号： A61K47/48
CPC分类号： C12N9/0022 , A61K47/60 , C12N9/96
摘要： The present invention is directed to an arginine/lysine oxidoreductase modified with polyethylene glycol and to a production method thereof and to methods of treating disorders responsive to a modification of amino acid levels reactive oxygen species and/or ammonium.
摘要翻译：本发明涉及用聚乙二醇修饰的精氨酸/赖氨酸氧化还原酶及其制备方法，以及治疗对氨基酸水平的活性氧和/或铵的修饰有反应的病症的方法。

7. 发明申请

WO2007059357A1 METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C) 审中-公开
标题翻译：调节RENALASE（单胺氧化酶C）
公开(公告)号：WO2007059357A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/045067
申请日：2006-11-21
申请人： YALE UNIVERSITY , DESIR, Gary, V. , XU, Jianchao
发明人： DESIR, Gary, V. , XU, Jianchao
IPC分类号： A61K38/44 , C12N9/02 , C07H21/04
CPC分类号： C12N9/0022 , A61K38/44 , C12Y104/00
摘要： The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.
摘要翻译：本发明提供了使用单胺氧化酶C（MAO-C）（也称为肾酶）作为其活性和非活性形式的治疗性蛋白质的方法。将非活性肾脏酶蛋白管理给具有较低肾素酶水平的个体可以用于为它们提供足够的蛋白质池，其可以根据需要被身体激活。活性肾病毒蛋白可以被给予需要立即降低儿茶酚胺水平的个体。肾脏酶抑制剂可用于增强肾上腺素能作用。

8. 发明申请

WO0243745A3 HISTAMINASE OF VEGETABLE ORIGIN FOR USE IN THE TREATMENT OF ALLERGIC AND SEPTIC SHOCK AND OF ALLERGIC ASTHMA 审中-公开
标题翻译：用于治疗过敏和休克和过敏性哮喘的蔬菜原液组胺酶
公开(公告)号：WO0243745A3
公开(公告)日：2003-04-10
申请号：PCT/EP0113770
申请日：2001-11-27
申请人： UNIV ROMA , UNIV DEGLI STUDI ROMA TRE , UNIV QUEBEC MONTREAL , MONDOVI BRUNO , BEFANI OLIVIA , FEDERICO RODOLFO , MATEESCU MIRCEA ALEXANDRU , MASINI EMANUELA , MANNAIONI PIER FRANCESCO , VANNACCI ALFREDO
发明人： MONDOVI BRUNO , BEFANI OLIVIA , FEDERICO RODOLFO , MATEESCU MIRCEA ALEXANDRU , MASINI EMANUELA , MANNAIONI PIER FRANCESCO , VANNACCI ALFREDO
IPC分类号： A61K38/44 , A61P17/04 , A61P37/08 , C12N9/06 , A61K35/78
CPC分类号： C12N9/0022 , A61K38/00 , C12Y104/03022
摘要： The present invention relates to a histaminase of vegetable origin to be used in the treatment of allergic and septic shock and inallergic asthma. The invention also regards the preparation of the histaminase for pharmaceutical use and the corresponding pharmaceutical compositions.
摘要翻译：本发明涉及用于治疗过敏性和败血性休克和过敏性哮喘的植物来源的组胺酶。本发明还涉及用于药物用途的组胺酶的制备和相应的药物组合物。

9. 发明申请

WO0218574A3 HUMAN INTERLEUKIN-FOUR INDUCED PROTEIN 审中-公开
标题翻译：人类白细胞介素-4诱导的蛋白质
公开(公告)号：WO0218574A3
公开(公告)日：2003-01-23
申请号：PCT/US0126462
申请日：2001-08-24
申请人： LONG ISLAND JEWISH RES INST
发明人： CHU CHARLES CHIYUAN , CHAVAN SANGEETA S , MASON JAMES M
IPC分类号： A61K38/00 , C12N9/06 , C12N15/12 , A61K31/7088 , C07K16/40 , C12N15/11 , C12Q1/26 , C12Q1/68 , G01N33/50 , G01N33/375
CPC分类号： C12N9/0022 , A61K38/00
摘要： The invention is directed to an isolated genomic polynucleotide sequence encoding interleukin-four induced protein as well as methods for obtaining said protein by expressing said polynucleotide sequences. The invention is also directed to constructs, vectors and hosts comprising such sequences, and oligonucleotide probes which hybridize to said polynucleotide sequence and kits comprising said probes. Additionally, the invention is directed to compositions comprising said polynucleotides and methods for using said compositions to treat, prevent or ameliorate pathological disorders, e.g., immune related disorders and novel methods of using the interleukin-four induced protein. The invention is also directed to methods for obtaining an antibody that binds to an epitope on said protein. The invention is further directed to a method for measuring the activity of said protein by measuring its L-amino acid oxidase activity.
摘要翻译：本发明涉及编码白细胞介素-4诱导的蛋白质的分离的基因组多核苷酸序列以及通过表达所述多核苷酸序列获得所述蛋白质的方法。本发明还涉及包含这些序列的构建体，载体和宿主以及与所述多核苷酸序列杂交的寡核苷酸探针和包含所述探针的试剂盒。另外，本发明涉及包含所述多核苷酸的组合物和使用所述组合物治疗，预防或改善病理学障碍（例如免疫相关病症）和使用白细胞介素-4诱导的蛋白质的新方法的方法。本发明还涉及获得与所述蛋白质上的表位结合的抗体的方法。本发明还涉及通过测量其L-氨基酸氧化酶活性来测量所述蛋白质的活性的方法。

10. 发明申请

WO2002062964A2 AP1 AMINE OXIDASE VARIANTS 审中-公开
标题翻译： AP1氨氧化物变体
公开(公告)号：WO2002062964A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/003883
申请日：2002-02-06
申请人： MAXYGEN, INC. , PIONEER HI-BRED INTERNATIONAL, INC. , CHATTERJEE, Ranjini , DUVICK, Jonathan, P. , ENGLISH, James
发明人： CHATTERJEE, Ranjini , DUVICK, Jonathan, P. , ENGLISH, James
IPC分类号： C12N
CPC分类号： C12N9/0022 , C12N15/8242 , C12N15/8282
摘要： New fumonisin detoxifying or fumonisin-derivative detoxifying homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, antibodies to the new homologues, and methods of using the homologues are also provided.
摘要翻译：提供新的伏马毒素解毒或伏马毒素衍生物解毒同系物（核酸和蛋白质）。还提供了包括这些新蛋白质，重组细胞，新同系物的抗体以及使用同源物的方法的组合物。

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