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1. 发明申请

WO2006083301A2 IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES 审中-公开
标题翻译：包含HMGB1多肽的免疫组化
公开(公告)号：WO2006083301A2
公开(公告)日：2006-08-10
申请号：PCT/US2005021691
申请日：2005-06-16
申请人： MEDIMMUNE INC , LONG ISLAND JEWISH RES INST , MESSMER DAVORKA , TRACEY KEVIN , KIENER PETER , ALBAN SCOTT
发明人： MESSMER DAVORKA , TRACEY KEVIN , KIENER PETER , ALBAN SCOTT
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/23
摘要： The present invention relates to novel immunogenic compositions (e.g., vaccines), the production of such immunogenic compositions and methods of using such compositions. More specially, this invention provides unique immunogenic molecules comprising an HMGB1 polypeptide (e.g., an HMGB1 B-box polypeptide) and an antigen. Even more specificially, this invention provides novel fusion proteins comprising an isolated HMGB1 polypeptide and an antigen such that administration of these fusion proteins provides the two signals required for native T - cell activation.
摘要翻译：本发明涉及新的免疫原性组合物（例如疫苗），这种免疫原性组合物的生产和使用这些组合物的方法。更具体地，本发明提供了包含HMGB1多肽（例如，HMGB1B盒多肽）和抗原的独特的免疫原性分子。更具体地，本发明提供了包含分离的HMGB1多肽和抗原的新型融合蛋白，使得这些融合蛋白的施用提供了天然T细胞活化所需的两个信号。

2. 发明申请

WO2005097172A3 ADRENOMEDULLIN AND ADRENOMEDULLIN BINDING PROTEIN FOR ISCHEMIA/REPERFUSION TREATMENT 审中-公开
标题翻译： ADRENOMEDULLIN和ADRENOMEDULLIN结合蛋白进行ISCHEMIA / REPERFUSION治疗
公开(公告)号：WO2005097172A3
公开(公告)日：2006-03-30
申请号：PCT/US2005010822
申请日：2005-03-30
申请人： LONG ISLAND JEWISH RES INST , WANG PING
发明人： WANG PING
IPC分类号： A61K38/00 , A61K38/22
CPC分类号： A61K38/22 , A61K38/1709 , A61K2300/00
摘要： Methods of treating a mammal at risk for ischemia-reperfusion injury are provided. The methods comprise administering an adrenomedullin binding protein-1 (AMBP-1) to the mammal in sufficient amount to reduce the injury. Also provided are methods of treating a mammal at risk for ischemia-reperfusion injury to the bowel. The methods comprise administering adrenomedullin to the mammal in sufficient amount to reduce the injury.
摘要翻译：提供了治疗处于缺血 - 再灌注损伤风险的哺乳动物的方法。所述方法包括以足够的量向哺乳动物施用肾上腺髓质素结合蛋白-1（AMBP-1）以减少损伤。还提供了治疗对肠的缺血再灌注损伤有风险的哺乳动物的方法。所述方法包括给予哺乳动物足量的肾上腺髓质素以减少损伤。

3. 发明申请

WO0202593A3 MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF 审中-公开
标题翻译：细胞增殖和血管生成的调节剂，其使用和鉴定方法
公开(公告)号：WO0202593A3
公开(公告)日：2003-08-07
申请号：PCT/US0120849
申请日：2001-06-29
申请人： LONG ISLAND JEWISH RES INST , PILLARISETTI SIVARAM , GOLDBERG ITZHAK D
发明人： PILLARISETTI SIVARAM , GOLDBERG ITZHAK D
IPC分类号： C12N15/09 , A61K31/12 , A61K31/121 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/4704 , A61K31/505 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/16 , A61K45/00 , A61K48/00 , A61K49/00 , A61P7/00 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D215/22 , C07D239/42 , C07D261/18 , C07D409/06 , C07D413/06 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/475 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/11 , C12N15/63 , G01N33/68
CPC分类号： C07K14/4753 , A61K31/12 , A61K31/415 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/4704 , A61K31/505 , A61K38/00 , A61K48/00 , A61K49/0004 , C07D231/12 , C07D261/18 , C07D405/04 , C07D409/06 , C07D413/04 , C07D417/14 , C07D471/04 , C07K7/08 , C07K14/001
摘要： The invention is directed to small organic molecules and peptides having the ability to mimic or agonize hepatocyte growth factor/ scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
摘要翻译：本发明涉及具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性或抑制或拮抗HGF / SF活性的能力的小有机分子和肽，前者可用于促进例如血管生成用于促进伤口或组织愈合的组织或器官，或增加或恢复心肌梗死后心脏等缺血组织的血流。抑制细胞生长或增殖在治疗例如炎性关节和皮肤疾病等炎性疾病以及诸如癌症的增生性增生性疾病中是有益的。

4. 发明申请

WO0229105A9 INHIBITION OF TGF- beta AND USES THEREOF 审中-公开
标题翻译： TGF-β的抑制及其用途
公开(公告)号：WO0229105A9
公开(公告)日：2003-02-13
申请号：PCT/US0130872
申请日：2001-10-03
申请人： LONG ISLAND JEWISH RES INST
发明人： TABIBZADEH SIAMAK , MASON JAMES M
IPC分类号： A61K38/18 , C07K14/47 , C12Q1/68 , A01N37/18 , A61K38/00 , C07K1/00 , C07K14/00 , C07K17/00 , G01N33/574
CPC分类号： A61K38/1841 , C07K14/47 , C12Q1/6883 , Y10S514/899
摘要： The present invention provides a method for inhibiting activity of TGF- beta , comprising contacting tissue expressing TGF- beta with an amount of ebaf or an ebaf analogue. The present invention further provides a method for treating a condition associated with overactivity of TGF- beta , particularly fibrosis, a defect in cell proliferation, or a coagulation defect. The present invention also provides a method for inhibiting activity of TGF- beta , comprising contacting tissue expressing TGF- beta with a modulator of ebaf expression, or a modulator of expression of an ebaf analogue. The present invention is further directed to a method for treating fibrosis in a subject in need of treatment, comprising administering to the subject an amount of ebaf or an ebaf analogue effective to treat the fibrosis. Finally, the present invention provides a method for treating a defect in cell proliferation in a subject in need of treatment, comprising administering to the subject an amount of ebar or an ebaf analogue effective to treat the defect in cell proliferation.
摘要翻译：本发明提供了一种抑制TGF-β活性的方法，包括使表达TGF-β的组织与一定量的ebaf或ebaf类似物接触。本发明还提供了一种治疗与TGF-β过度活跃，特别是纤维化，细胞增殖缺陷或凝血缺陷有关的病症的方法。本发明还提供一种抑制TGF-β活性的方法，包括使表达TGF-β的组织与ebaf表达的调节剂或ebaf类似物的表达调节剂接触。本发明还涉及在需要治疗的受试者中治疗纤维化的方法，其包括对受试者施用一定量的有效治疗纤维化的ebaf或ebaf类似物。最后，本发明提供了一种治疗需要治疗的受试者的细胞增殖缺陷的方法，其包括对受试者施用一定量的有效治疗细胞增殖缺陷的ebar或ebaf类似物。

5. 发明申请

WO0018238A9 IDENTIFICATION OF DIFFERENTIALLY METHYLATED AND MUTATED NUCLEIC ACIDS 审中-公开
标题翻译：鉴定不同的甲基化和突变的核酸
公开(公告)号：WO0018238A9
公开(公告)日：2000-09-08
申请号：PCT/US9922518
申请日：1999-09-28
申请人： LONG ISLAND JEWISH RES INST
发明人： DUFFY HAO-PENG XU
IPC分类号： C12N9/64 , C12P21/04 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/68 , A01N61/00 , A61K31/00 , A61K39/395 , C07H21/04 , C07K16/00 , C12N1/20 , C12N5/02 , C12N15/00 , C12N15/74 , C12P19/34 , C12P21/06 , C12Q1/44 , C12Q1/48 , G01N33/53 , G01N33/573
CPC分类号： G01N33/6872 , A61K2039/505 , C12N9/6421 , C12Q1/683 , C12Q1/686 , G01N33/57415 , Y10S435/81 , C12Q2539/107 , C12Q2521/331 , C12Q2525/191 , C12Q2531/113 , C12Q2561/113 , C12Q2521/301 , C12Q2565/1015 , C12Q2537/159
摘要： The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and the methylation patterns of nucleic acids. Regions of the genome are differentially methylated or mutated in different cell types, including cancerous cell types. The TSP50 gene is thereby identified and found to be differentially expressed in breast cancer cells. The present invention provides methods and compositions for identifying aberrant expression of the TSP50 gene and of tsp50 protein. Antibodies of the present invention can be used for diagnosis and treatment of diseases characterized by aberrant tsp50 expression.
摘要翻译：本发明提供用于检测核酸的突变和甲基化模式的甲基 - （或突变 - ）差异显示（MDD）方法和核酸探针。基因组的区域在不同的细胞类型（包括癌细胞类型）中差异甲基化或突变。因此鉴定出TSP50基因，发现在乳腺癌细胞中差异表达。本发明提供用于鉴定TSP50基因和tsp50蛋白的异常表达的方法和组合物。本发明的抗体可用于诊断和治疗以异常tsp50表达为特征的疾病。

6. 发明申请

WO2006073484A2 TREATING INFLAMMATORY DISORDERS BY ELECTRICAL VAGUS NERVE STIMULATION 审中-公开
标题翻译：通过电气VAGUS神经刺激治疗炎症性疾病
公开(公告)号：WO2006073484A2
公开(公告)日：2006-07-13
申请号：PCT/US2005022409
申请日：2005-06-22
申请人： LONG ISLAND JEWISH RES INST , HUSTON JARED M , TRACEY KEVIN J
发明人： HUSTON JARED M , TRACEY KEVIN J
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/36114
摘要： A method and an apparatus for treating a patient suffering from, or at risk for, a condition mediated by the inflammatory cytokine cascade, by electrically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.
摘要翻译：通过以足以抑制炎性细胞因子级联的量的电刺激迷走神经活性来治疗患有由炎性细胞因子级联介导的或处于危险中的病症的患者的方法和装置。

7. 发明申请

WO2004048516A3 ELF3 GENE COMPOSITIONS AND METHODS 审中-公开
标题翻译： ELF3基因组成及方法
公开(公告)号：WO2004048516A3
公开(公告)日：2006-02-23
申请号：PCT/US0337200
申请日：2003-11-21
申请人： LONG ISLAND JEWISH RES INST , KAPLAN MARK H , WANG XUE-PING , DOSIK MICHAEL H
发明人： KAPLAN MARK H , WANG XUE-PING , DOSIK MICHAEL H
IPC分类号： C07K14/47 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07K14/4702 , C07K14/47 , C12Q1/6886 , C12Q1/701 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： ELF3 gene compositions associated with cancer are provided, including ELF3 mRNA intron retention, a novel ELF3 5' untranslated region, and a novel Alu, Alu kwd . Methods and kits using primers or probes to detect the presence of these ELF3 gene compositions are also provided. Methods for determining whether a cell comprises a virus are also provided.
摘要翻译：提供了与癌症相关的ELF3基因组合物，包括ELF3 mRNA内含子保留，新型ELF3 5'非翻译区和新型Alu，Alu 。还提供了使用引物或探针来检测这些ELF3基因组合物的存在的方法和试剂盒。还提供了用于确定细胞是否包含病毒的方法。

8. 发明申请

WO02092004A8 USE OF HMG FRAGMENT AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：使用HMG片作为抗炎剂
公开(公告)号：WO02092004A8
公开(公告)日：2003-11-27
申请号：PCT/US0215329
申请日：2002-05-15
申请人： LONG ISLAND JEWISH RES INST , GEN HOSPITAL CORP , UNIV PITTSBURGH , TRACEY KEVIN J , YANG HUAN , WARREN HOWLAND SHAW JR , FINK MITCHELL P
发明人： TRACEY KEVIN J , YANG HUAN , WARREN HOWLAND SHAW JR , FINK MITCHELL P
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P1/02 , A61P1/04 , A61P3/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P15/02 , A61P17/16 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/06 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C12N5/06 , C12N5/10 , C12P21/06 , C12Q1/02
CPC分类号： C07K14/4702 , A61K38/00
摘要： Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
摘要翻译：公开了用于抑制促炎细胞因子从脊椎动物细胞中释放并抑制患者炎性细胞因子级联的组合物和方法。组合物包含脊椎动物HMG A盒和特异性结合脊椎动物HMG B盒的抗体制剂。所述方法包括用足够量的组合物治疗细胞或患者以抑制促炎细胞因子的释放或抑制炎性细胞因子级联。

9. 发明申请

WO2004041115A3 NOVEL HUMAN ELASTASES AND STRESS URINARY INCONTINENCE 审中-公开
标题翻译：新的人类弹性和压力不均匀性
公开(公告)号：WO2004041115A3
公开(公告)日：2007-10-04
申请号：PCT/US0318696
申请日：2003-06-12
申请人： LONG ISLAND JEWISH RES INST , KUSHNER LESLIE , MATHRUBUTHAM MAHESH , RAO SRINIVASA K
发明人： KUSHNER LESLIE , MATHRUBUTHAM MAHESH , RAO SRINIVASA K
IPC分类号： C12N9/64 , A61K38/48 , C07K14/00 , C12N9/66 , C12Q1/37
CPC分类号： C12N9/6448 , A61K38/482 , C12Q1/37 , G01N2333/966
摘要： Novel elastases are provided that are associated with stress urinary incontinence. Also provided are methods for determining whether a woman has stress urinary incontinence, and methods for treating or preventing stress urinary incontinence.
摘要翻译：提供与压力性尿失禁相关的新型弹性蛋白酶。还提供了用于确定女性是否具有压力性尿失禁的方法，以及用于治疗或预防压力性尿失禁的方法。

10. 发明申请

WO2005034733A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA 审中-公开
标题翻译： B细胞慢性淋巴细胞性白血病的诊断和治疗方法和组合物
公开(公告)号：WO2005034733A3
公开(公告)日：2005-09-09
申请号：PCT/US2004033176
申请日：2004-10-08
申请人： LONG ISLAND JEWISH RES INST , MESSMER BRADLEY T , CHIORAZZI NICHOLAS , ALBESIANO EMILIA
发明人： MESSMER BRADLEY T , CHIORAZZI NICHOLAS , ALBESIANO EMILIA
IPC分类号： A61B20060101 , A61K38/00 , A61K39/395 , C07H21/04 , C07K14/00 , C07K16/00 , C12N15/00 , G01N33/68
CPC分类号： C07K16/00 , G01N33/6878
摘要： Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes. Methods of determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL that is susceptible to treatment directed to eliminating idiotype specific B cell receptor-bearing B-CLL cells are also provided, as are methods of following the progression of treatment of B-CLL in the patient. Additionally, methods of treating a patient having B-CLL are provided, as are methods of identifying a therapeutic agent for B-CLL.
摘要翻译：提供了分离和纯化的轻链抗体基因和重链抗体基因组合的制备物，其中轻链和重链抗体基因在多于一名患有B细胞慢性淋巴细胞白血病（B-CLL）的患者中相同。还提供了包含那些基因的载体和包含那些载体的细胞，由抗体基因编码的分离和纯化的抗体也是如此。另外提供了与抗体基因编码的抗体的抗原结合区结合的抗独特型抗体，肽和适体，以及包含多个结合位点的多聚体分子，所述多个结合位点结合由抗体结合区编码的抗体的抗原结合区抗体基因。还提供了确定患有B细胞慢性淋巴细胞白血病（B-CLL）的患者是否具有针对针对消除独特型特异性B细胞受体的B-CLL细胞的治疗敏感的B-CLL形式的方法，方法追踪患者中B-CLL治疗的进展。此外，提供了治疗患有B-CLL的患者的方法，以及鉴定B-CLL治疗剂的方法。

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