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    • 4. 发明申请
    • NOVEL PYRIMIDINE CARBOXAMIDES
    • 新型吡咯烷酮羧酰胺
    • WO2007031829A3
    • 2007-11-08
    • PCT/IB2006002461
    • 2006-09-07
    • ORCHID RES LAB LTDTADIPARTHI RAVIKUMARAGGARWAL PAWANPARAMESWARAN VENKATESANTHIRUNAVUKKARASU SAPPANIMUTHUBARIK RAJIBRAJAGOPAL SRIRAMREDDY GADDAM OM
    • TADIPARTHI RAVIKUMARAGGARWAL PAWANPARAMESWARAN VENKATESANTHIRUNAVUKKARASU SAPPANIMUTHUBARIK RAJIBRAJAGOPAL SRIRAMREDDY GADDAM OM
    • C07D239/28
    • C07D239/38C07D239/46C07D239/47C07D239/48C07D401/04
    • The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly relates to novel pyrimidine carboxamides of the general formula (I). Also included is a method of prophylaxis or treatment of a pain disorder, immunological diseases, inflammation, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
    • 本发明涉及通式(I)的新化合物,其衍生物,其类似物,其互变异构形式,其立体异构体,其多晶型物,其水合物,它们的溶剂化物,其药学上可接受的盐和组合物,其代谢物和前药。 本发明更具体地涉及通式(I)的新型嘧啶甲酰胺。 还包括预防或治疗疼痛障碍,免疫疾病,炎症,类风湿性关节炎的方法; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化; 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征(ARDS); 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏性反应; 接触性皮炎; 肌肉退化; 恶病质; 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 败血症; 败血性休克 中毒性休克综合征 发热和由于哺乳动物感染引起的肌痛,包括给予有效量的如上所述的式(I)化合物。
    • 8. 发明申请
    • PHENOXYPYRIMIDINE INSECTICIDES AND ACARICIDES
    • 苯氧基杀虫剂和杀螨剂
    • WO00049001A2
    • 2000-08-24
    • PCT/US2000/003180
    • 2000-02-08
    • C07D239/34C07D239/38C07D239/46C07D239/52C07D239/56C07D403/06C07D239/42
    • C07D239/34C07D239/38C07D239/46C07D239/52C07D239/56C07D403/06
    • Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as arthropodicides wherein Q is O, S, NR , OCR R , or NR CR R ; wherein when Q is OCR R or NR CR R , then Q is attached to the pyrimidine through the O or N atom respectively; Q is S, CR R , OCR R , SCR R or NR CR R ; wherein when Q is OCR R , SCR R or NR CR R then Q is attached to the pyrimidine through the O, S or N atom respectively; R and R are each independently H, C1-C4 alkyl, halogen, NR R , C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylthio or nitro; each R is independently H, halogen, C1-C4 alkyl, C1-C4 haloalkoxy, C1-C4 haloalkyl, C1-C4 alkoxy, SF5, S(O)nR , cyano or CO2R ; each R and each R is independently H, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 alkoxy, NR or S(O)nR ; p is 0-4; and J, R , R R , R , R , R , R , R , R and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling arthropods which involves contacting the arthropods or their environment with an effective amount of a compound of Formula (I).
    • 公开了式(I)化合物及其N-氧化物和农业上合适的盐,其可用作其中Q 1为O,S,NR 17,OCR 18 R 19或NR <17> CR <18> - [R <19>; 其中当Q 1是OCR 18 R 19或NR 17 CR 18 R 19时,则Q 1分别通过O或N原子连接到嘧啶上; Q 2是S,CR 3 R 4,OCR 18 R 19,SCR 18 R 19或NR 17 CR 18 R 19。 其中当Q 2是OCR 18 R 19时,SCR 18 R 19或NR 17 CR 18 R然后Q 2通过O连接到嘧啶上 ,S或N原子; R 1和R 2各自独立地为H,C 1 -C 4烷基,卤素,NR 7 R 8,C 1 -C 4烷氧基,C 1 -C 4卤代烷基,C 1 -C 4烷硫基或硝基; 每个R 5独立地是H,卤素,C 1 -C 4烷基,C 1 -C 4卤代烷氧基,C 1 -C 4卤代烷基,C 1 -C 4烷氧基,SF 5,S(O)n R 9,氰基或CO 2 R 11; 每个R 6和每个R 22独立地是H,卤素,氰基,C 1 -C 4烷基,C 1 -C 4卤代烷基,C 1 -C 4卤代烷氧基,C 1 -C 4烷氧基,NR 17或S(O) 9>; p为0-4; 和R 3,R 4,R 8,R 9,R 11,R 17,R 18,R 19和n分别为 在本公开中定义。 还公开了含有式(I)化合物和控制节肢动物的方法的组合物,其涉及将节肢动物或其环境与有效量的式(I)化合物接触。