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1. 发明申请

WO2009095773A2 NOVEL HETEROCYCLES 审中-公开
标题翻译：新型杂环
公开(公告)号：WO2009095773A2
公开(公告)日：2009-08-06
申请号：PCT/IB2009/000157
申请日：2009-01-30
申请人： ORCHID RESEARCH LABORATORIES LIMITED , ORCHID RESEARCH LABORATORIES LIMITED , SRINIVAS, Visweswara, Akella, Satya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , SAPPANIMUTHU, Thirunavukkarasu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARASIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan , NARAYANAM, Maruthikumar , GADDE, Sathyanarayana , RAMACHANDRAN, Uma , BALASUBRAMANIAN, Gopalan , SURENDRAN, Narayanan , NARAYANAN, Shridhar , VISHWAKARMA, Lolaknath, Santosh , SAXENA, Sanjeev
发明人： SRINIVAS, Visweswara, Akella, Satya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , SAPPANIMUTHU, Thirunavukkarasu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARASIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan , NARAYANAM, Maruthikumar , GADDE, Sathyanarayana , RAMACHANDRAN, Uma , BALASUBRAMANIAN, Gopalan , SURENDRAN, Narayanan , NARAYANAN, Shridhar , VISHWAKARMA, Lolaknath, Santosh , SAXENA, Sanjeev
IPC分类号： C07D403/04 , C07D401/04 , C07D239/26
CPC分类号： C07D239/42 , A61K31/5377 , C07D265/28 , C07D401/04
摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 动脉粥样硬化; 癌症; 恶病质; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏性反应; 接触性皮炎; 肌肉退化; 哮喘; 慢性阻塞性肺病; 骨吸收疾病; 多发性硬化症败血症; 败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

2. 发明申请

WO2009053808A2 HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译： HISTONE脱乙酰酶抑制剂
公开(公告)号：WO2009053808A2
公开(公告)日：2009-04-30
申请号：PCT/IB2008002799
申请日：2008-10-21
申请人： ORCHID RES LAB LTD , RAJAGOPAL SRIDHARAN , KACHHADIA VIRENDRA , PONPANDIAN THANASEKARAN , KEERI ABDUL RAHEEM , ANANDHAN KARNAMBARAM , RAJAGOPAL SRIRAM , PRAVEEN RAJENDRAN , DAIVASIGAMANI PRABHU
发明人： RAJAGOPAL SRIDHARAN , KACHHADIA VIRENDRA , PONPANDIAN THANASEKARAN , KEERI ABDUL RAHEEM , ANANDHAN KARNAMBARAM , RAJAGOPAL SRIRAM , PRAVEEN RAJENDRAN , DAIVASIGAMANI PRABHU
IPC分类号： C07C259/06 , C07C235/84 , C07C259/10
CPC分类号： C07C259/06 , C07C233/44 , C07C237/38 , C07C237/40 , C07C259/10 , C07C2601/02 , C07C2601/08 , C07C2601/18 , C07D209/18 , C07D213/56 , C07D295/185 , C07D317/60 , C07D333/24
摘要： Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I).
摘要翻译：具有抑制酶活性的组蛋白脱乙酰酶（HDAC），其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，中间体，药学上可接受的盐，药物组合物，代谢物和前药的通式（I）的新型化合物。本发明更具体地提供了通式（I）的新型化合物。还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括施用有效量的新的式（I）化合物。

3. 发明申请

WO2008110891A3 NEW HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新型杂环化合物
公开(公告)号：WO2008110891A3
公开(公告)日：2009-02-19
申请号：PCT/IB2008000536
申请日：2008-03-07
申请人： ORCHID RES LAB LTD , SHARMA GANAPAVARAPU VEERA RAGH , REDDY GADDAM OM , RAJAGOPAL SRIRAM , RAMACHANDRAN UMA , NARAYANAN SUKUNATH , PICHIKA NAGALAKSHMI , NEMMARA VISWANATHAN VENKATESH , ANDIAPPAN LAVANYA , THIRUNAVUKKARASU SARAVANAN
发明人： SHARMA GANAPAVARAPU VEERA RAGHAVA , REDDY GADDAM OM , RAJAGOPAL SRIRAM , RAMACHANDRAN UMA , NARAYANAN SUKUNATH , PICHIKA NAGALAKSHMI , NEMMARA VISWANATHAN VENKATESH , ANDIAPPAN LAVANYA , THIRUNAVUKKARASU SARAVANAN
IPC分类号： C07D401/12
CPC分类号： C07D239/24 , C07D413/14
摘要： Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases and disorders by administering in a patient one or more TNF-a, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).
摘要翻译：本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R1，R2，R3，R4和R5 如本文所述。本文进一步描述的是通过在患者中给予一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂来治疗各种疾病和病症的式（I）的杂环化合物。本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化; 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏性反应; 接触性皮炎; 肌肉退化; 恶病质; 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症败血症; 败血性休克中毒性休克综合征; 发热和由于HIV-1介导的感染和疾病引起的肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒; 哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。

4. 发明申请

WO2007054776A3 STILBENE LIKE COMPOUNDS AS NOVEL HDAC INHIBITORS 审中-公开
标题翻译：作为HDAC抑制剂的新兴化合物
公开(公告)号：WO2007054776A3
公开(公告)日：2008-09-04
申请号：PCT/IB2006003114
申请日：2006-11-06
申请人： ORCHID RES LAB LTD , SRINIVAS AKELLA SATYA SURYA VI , BALAN URKALAN KAVERI , PUNTHALIR NARAYANA SWAMY , VELMURUGAN RAMA SWAMY , RAJAGOPAL SRIRAM , REDDY GADDAM OM , KACHHADIA VIRENDRA
发明人： SRINIVAS AKELLA SATYA SURYA VI , BALAN URKALAN KAVERI , PUNTHALIR NARAYANA SWAMY , VELMURUGAN RAMA SWAMY , RAJAGOPAL SRIRAM , REDDY GADDAM OM , KACHHADIA VIRENDRA
IPC分类号： C07C235/72 , A61K31/165 , C07C233/46 , C07C235/34 , C07D277/30 , C07D333/24
CPC分类号： C07C259/06 , C07C237/22 , C07C323/62 , C07D213/56 , C07D277/30 , C07D277/46 , C07D277/58 , C07D277/82 , C07D307/56 , C07D333/24 , C07D333/28 , C07D417/06
摘要： The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel stilbene like compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.
摘要翻译：本发明涉及通式（I）的新颖的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药。本发明更具体地提供了通式（I）的新颖的二苯乙烯类化合物。还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括给予有效量的如上所述的新的式（I）化合物。

5. 发明申请

WO2007017728A3 NOVEL HETEROCYCLIC COMPOUNDS 审中-公开
公开(公告)号：WO2007017728A3
公开(公告)日：2007-02-15
申请号：PCT/IB2006/002139
申请日：2006-08-04
申请人： ORCHID RESEARCH LABORATORIES LIMITED , SRINIVAS, Akella, Satya, Surya, Visweswara , MATHIYAZHAGAN, Kasinathan , SHARADA, Duddu, Savaraiah , PONPANDIAN, Thanasekaran , REVATHY, Kulasekharan , REDDY, Gaddam, Om , KAMARAJ, Mani , RAJAGOPAL, Sriram
发明人： SRINIVAS, Akella, Satya, Surya, Visweswara , MATHIYAZHAGAN, Kasinathan , SHARADA, Duddu, Savaraiah , PONPANDIAN, Thanasekaran , REVATHY, Kulasekharan , REDDY, Gaddam, Om , KAMARAJ, Mani , RAJAGOPAL, Sriram
IPC分类号： C07D417/12 , C07C271/10 , C07D277/38 , C07D333/16
摘要： The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their stereoisomers, their pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel heterocyclic compounds of the general formula (I).

6. 发明申请

WO2004069145A3 ANTICANCER COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
公开(公告)号：WO2004069145A3
公开(公告)日：2004-08-19
申请号：PCT/IB2004/000299
申请日：2004-02-06
申请人： DR. REDDY'S LABORATORIES LTD. , VEDULA, Manohar, Sharma , KATTUBOINA, Venkata, Adiseshu , IQBAL, Javed , RAMANUJAM, Rajagopalan , RAJAGOPAL, Sriram , MAMIDI, Naga, Venkata, Srinivasa, Rao , JOSYULA, Ramanatham , GUTTA, Madhusudhan
发明人： VEDULA, Manohar, Sharma , KATTUBOINA, Venkata, Adiseshu , IQBAL, Javed , RAMANUJAM, Rajagopalan , RAJAGOPAL, Sriram , MAMIDI, Naga, Venkata, Srinivasa, Rao , JOSYULA, Ramanatham , GUTTA, Madhusudhan
IPC分类号： C07D215/00
摘要： The present invention relates to novel anticancer agents, their pharmaceutically acceptable salts, their geometrical isomers and their pharmaceutically acceptable compositions containing them. the present invention more particularly relates to novel quinazoline compounds, their pharmaceutically acceptable salts and their pharmaceutically acceptable compositions containing them. the novel quinazoline compounds have the general formula (I), where all symbols are as defined in the specification.

7. 发明申请

WO2012120477A3 IMAGING SYSTEM SUBJECT SUPPORT 审中-公开
标题翻译：成像系统主题支持
公开(公告)号：WO2012120477A3
公开(公告)日：2012-11-15
申请号：PCT/IB2012051110
申请日：2012-03-09
申请人： KONINKL PHILIPS ELECTRONICS NV , DONG SHUFANG , NEMENZ TERRANCE JOSEPH , CUMPSON PATRICK , PETTINATO JEREMY DAVID , RAJAGOPAL SRIRAM
发明人： DONG SHUFANG , NEMENZ TERRANCE JOSEPH , CUMPSON PATRICK , PETTINATO JEREMY DAVID , RAJAGOPAL SRIRAM
IPC分类号： A61B6/10
CPC分类号： A61B6/105 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/04 , A61B6/102 , A61B6/4441 , A61B6/547 , A61B6/586
摘要： A method includes receiving a subject support motion disable signal indicative of at least one of power removal of an imaging system, a collision of a horizontally moving tabletop of the imaging system, a decoupling of a horizontal motion drive system configured to horizontally drive the tabletop, or a collision of a vertically moving subject support of the imaging system, wherein a vertical motion drive system drives the subject support vertical motion, and disabling, in response to receiving the subject support motion disable signal, at least one of tabletop horizontal motion or subject support vertical motion.
摘要翻译：一种方法包括接收指示成像系统的功率去除，成像系统的水平移动台面的碰撞，被配置为水平驱动桌面的水平运动驱动系统的去耦的对象支持运动禁止信号，或成像系统的垂直移动的被摄体支架的碰撞，其中垂直运动驱动系统驱动对象支架垂直运动，并且响应于接收到对象支持运动禁止信号而禁用桌面水平运动或被摄体中的至少一个支持垂直运动。

8. 发明申请

WO2009053808A3 HISTONE DEACETYLASE INHIBITORS 审中-公开
公开(公告)号：WO2009053808A3
公开(公告)日：2009-04-30
申请号：PCT/IB2008/002799
申请日：2008-10-21
申请人： ORCHID RESEARCH LABORATORIES LIMITED , RAJAGOPAL, Sridharan , KACHHADIA, Virendra , PONPANDIAN, Thanasekaran , KEERI, Abdul, Raheem , ANANDHAN, Karnambaram , RAJAGOPAL, Sriram , PRAVEEN, Rajendran , DAIVASIGAMANI, Prabhu
发明人： RAJAGOPAL, Sridharan , KACHHADIA, Virendra , PONPANDIAN, Thanasekaran , KEERI, Abdul, Raheem , ANANDHAN, Karnambaram , RAJAGOPAL, Sriram , PRAVEEN, Rajendran , DAIVASIGAMANI, Prabhu
IPC分类号： C07C259/06 , C07C259/10 , C07C235/84
摘要： Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I).

9. 发明申请

WO2008110891A2 NEW HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新的杂环化合物
公开(公告)号：WO2008110891A2
公开(公告)日：2008-09-18
申请号：PCT/IB2008/000536
申请日：2008-03-07
申请人： ORCHID RESEARCH LABORATORIES LIMITED, , SHARMA, Ganapavarapu, Veera, Raghava , REDDY, Gaddam, Om , RAJAGOPAL, Sriram , RAMACHANDRAN, Uma , NARAYANAN, Sukunath , PICHIKA, Nagalakshmi , NEMMARA VISWANATHAN, Venkatesh , ANDIAPPAN, Lavanya , THIRUNAVUKKARASU, Saravanan
发明人： SHARMA, Ganapavarapu, Veera, Raghava , REDDY, Gaddam, Om , RAJAGOPAL, Sriram , RAMACHANDRAN, Uma , NARAYANAN, Sukunath , PICHIKA, Nagalakshmi , NEMMARA VISWANATHAN, Venkatesh , ANDIAPPAN, Lavanya , THIRUNAVUKKARASU, Saravanan
IPC分类号： C07D401/12
CPC分类号： C07D239/24 , C07D413/14
摘要： Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases and disorders by administering in a patient one or more TNF-α, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).
摘要翻译：本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R 1， R 2，R 3，R 4和R 5如本文所述。本文进一步描述的是通过在患者中给予一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂来治疗各种疾病和病症的式（I）的杂环化合物。本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化; 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏性反应; 接触性皮炎; 肌肉退化; 恶病质; 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症败血症; 败血性休克中毒性休克综合征由于HIV-1介导的感染和疾病引起的发热和肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒; 哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。

10. 发明申请

WO2008087514A2 HDAC INHIBITORS 审中-公开
标题翻译： HDAC抑制剂
公开(公告)号：WO2008087514A2
公开(公告)日：2008-07-24
申请号：PCT/IB2008000045
申请日：2008-01-10
申请人： ORCHID RES LAB LTD , KACHHADIA VIRENDRA , PUNTHALIR NARAYANASWAMY , PONPANDIAN THANASEKARAN , DAIVASIGAMANI PRABHU , SRINIVAS AKELLA SATYA VISWESWA , RAMACHANDRAN UMA , RAJAGOPAL SRIRAM , REDDY GADDAM OM , RAJAGOPAL SRIDAHRAN , KEERI ABDUL RAHEEM
发明人： KACHHADIA VIRENDRA , PUNTHALIR NARAYANASWAMY , PONPANDIAN THANASEKARAN , DAIVASIGAMANI PRABHU , SRINIVAS AKELLA SATYA VISWESWA , RAMACHANDRAN UMA , RAJAGOPAL SRIRAM , REDDY GADDAM OM , RAJAGOPAL SRIDAHRAN , KEERI ABDUL RAHEEM
IPC分类号： C07D417/12 , C07C233/01 , C07C233/16 , C07C233/64 , C07D241/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/14
CPC分类号： C07D215/14 , C07C259/06 , C07D213/56 , C07D277/30 , C07D277/64 , C07D285/08 , C07D295/185 , C07D317/60 , C07D319/20 , C07D333/22
摘要： Novel compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof are described. These novel compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, cancer, psoriasis, proliferative conditions and conditions mediated by HDAC.
摘要翻译：描述了新的式（I）化合物，其衍生物，类似物，互变异构体形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，代谢物和前药。这些新型化合物可以抑制HDAC，并且可用作涉及细胞生长的疾病的治疗或改善剂，例如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症，癌症，牛皮癣，增殖性病症和由HDAC介导的病症。

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