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1. 发明申请

WO2017117538A1 META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS 审中-公开
标题翻译： META-AZACYCLIC氨基苯甲酸衍生物作为PAN整合素拮抗剂
公开(公告)号：WO2017117538A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069511
申请日：2016-12-30
申请人： SAINT LOUIS UNIVERSITY
发明人： RUMINSKI, Peter, G. , GRIGGS, David, W.
IPC分类号： C07D239/16 , C07D239/14 , C07D239/02 , C07D401/12 , C07D233/28 , A61K31/44
CPC分类号： C07D239/14 , C07D233/28 , C07D239/02 , C07D239/16 , C07D401/12
摘要： The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
摘要翻译：本公开提供了下式的药剂：其中变量如本文所定义。还提供了包含此类药剂的药物组合物，试剂盒和制造品。还提供了使用药剂治疗各种疾病和病症的方法。

2. 发明申请

WO2014145004A1 PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES 审中-公开
标题翻译：吡咯烷酮和类似物展示抗癌和抗增生活性
公开(公告)号：WO2014145004A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029638
申请日：2014-03-14
申请人： DECIPHERA PHARMACEUTICALS, LLC
发明人： FLYNN, Daniel L. , KAUFMAN, Michael D.
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02 , C07D401/00 , A01N43/40
CPC分类号： C07D401/14 , A61K31/505 , C07D239/02 , C07D401/00
摘要： Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Formula (I). Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.
摘要翻译：公开了可用于治疗哺乳动物癌症，特别是根据式I的人类癌症的化合物。式（I）。还公开了使用本文公开的化合物的药物组合物和治疗方法。

3. 发明申请

WO2008083256A3 OPHTHALMIC AND OTIC COMPOSITIONS OF FACIALLY AMPHIPHILIC POLYMERS AND OLIGOMERS AND USES THEREOF 审中-公开
标题翻译：面向两性聚合物和低聚物的眼科和耳用组合物及其用途
公开(公告)号：WO2008083256A3
公开(公告)日：2008-12-24
申请号：PCT/US2007089001
申请日：2007-12-28
申请人： POLYMEDIX INC , SCOTT RICHARD W
发明人： SCOTT RICHARD W
IPC分类号： A61K31/33
CPC分类号： A61K31/506 , A61K9/0046 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K9/08 , A61K31/573 , A61K31/74 , A61K47/06 , A61K47/183 , A61K47/186 , A61K47/38 , C07D239/02 , C07D239/24 , C07D239/28 , C07D403/14 , A61K2300/00
摘要： The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.
摘要翻译：本发明公开了表面两亲抗微生物聚合物和低聚物的眼用和耳用组合物及其用途，包括它们在治疗和预防人和动物眼部感染和耳部感染的方法中的用途。

4. 发明申请

WO2008083256A2 OPHTHALMIC AND OTIC COMPOSITIONS OF FACIALLY AMPHIPHILIC POLYMERS AND OLIGOMERS AND USES THEREOF 审中-公开
标题翻译：全氟代聚合物和低聚物的透明和油性组合物及其用途
公开(公告)号：WO2008083256A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/089001
申请日：2007-12-28
申请人： POLYMEDIX, INC. , SCOTT, Richard, W.
发明人： SCOTT, Richard, W.
IPC分类号： A61P27/02 , A61K31/74
CPC分类号： A61K31/506 , A61K9/0046 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K9/08 , A61K31/573 , A61K31/74 , A61K47/06 , A61K47/183 , A61K47/186 , A61K47/38 , C07D239/02 , C07D239/24 , C07D239/28 , C07D403/14 , Y02A50/473 , A61K2300/00
摘要： The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.
摘要翻译：本发明公开了表面两亲性抗微生物聚合物和低聚物及其用途的眼科和耳用组合物及其用途，包括其用于治疗和预防人和动物眼科感染和耳部感染的方法。

5. 发明申请

WO2003106401A1 N-BRIDGED SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： N-桥选择性受体调节剂及其使用方法
公开(公告)号：WO2003106401A1
公开(公告)日：2003-12-24
申请号：PCT/US2003/016219
申请日：2003-06-17
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James , MILLER, Duane, D. , MARHEFKA, Craig, A. , GAO, Wenqing
发明人： DALTON, James , MILLER, Duane, D. , MARHEFKA, Craig, A. , GAO, Wenqing
IPC分类号： C07C233/05
CPC分类号： C07D211/72 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/65 , C07C237/10 , C07C255/60 , C07D233/44 , C07D239/02
摘要： This invention provides a class of androgen receptor targeting agents (ARTA) The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy, and/or g) decreasing the incidence of, halting or causing a regression of prostate cancer.
摘要翻译：本发明提供了一类雄激素受体靶向剂（ARTA）。该药物定义了一种新的化合物亚类，它们是选择性雄激素受体调节剂（SARM）。已经发现几种SARM化合物对雄激素受体具有非甾类化合物的意想不到的雄激素和合成代谢活性。已经发现其他SARM化合物对雄激素受体具有非甾类配体的意想不到的抗雄激素活性。 SARM化合物，单独或作为组合物，可用于a）男性避孕; b）治疗各种激素相关病症，例如与老年雄性雄激素降低有关的病症（ADAM），如疲劳，抑郁，性欲降低，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血，肥胖，肌营养不良，骨质减少，骨质疏松症，良性前列腺增生，情绪和认知和前列腺癌的改变; c）治疗与雄激素降解有关的疾病（ADIF），如性功能障碍，性欲降低，性腺机能减退，肌肉减少症，骨质减少症，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖，子宫内膜异位症，乳腺癌，子宫癌和卵巢癌; d）治疗和/或预防急性和/或慢性肌肉消瘦病症; e）预防和/或治疗干眼症状; f）口服雄激素替代疗法，和/或g）降低前列腺癌的发作，停止或导致消退。

6. 发明申请

WO2015158233A1 2，3，4，6-四取代苯-1，5-二胺衍生物、其制法与医药上的用途审中-公开
公开(公告)号：WO2015158233A1
公开(公告)日：2015-10-22
申请号：PCT/CN2015/076451
申请日：2015-04-13
申请人：上海海雁医药科技有限公司
发明人：兰炯 , 金云舟 , 周福生 , 何琦 , 何向宇 , 吕强
IPC分类号： C07C211/51 , C07C211/54 , C07D239/02 , A61K31/16 , A61K31/505
CPC分类号： C07D471/04 , A61K31/16 , A61K31/505 , A61K31/506 , A61K31/55 , A61K45/06 , C07C211/51 , C07C211/54 , C07D239/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要：本发明涉及2，3，4，6-四取代苯-1，5-二胺衍生物、其制法与医药上的用途。具体地，本发明公开了式（I）化合物或其药学上可接受的盐、立体异构体、溶剂化合物或前药，及其制备方法和应用，式中各基团的定义详见说明书。

7. 发明申请

WO2015048634A1 COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT 审中-公开
标题翻译：组合物，使用方法和治疗方法
公开(公告)号：WO2015048634A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/058031
申请日：2014-09-29
申请人： THE UNIVERSITY OF NEW ORLEANS , BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
发明人： JURSIC, Branko, S. , NEUMANN, Donna, M.
IPC分类号： A61K31/515 , A61K31/15 , A01N43/54 , A61P31/00
CPC分类号： A61K31/515 , A01N43/54 , A01N47/24 , C07D239/02 , C07D239/62
摘要： Embodiments of the present disclosure provide for compositions including an antimicrobial agent, pharmaceutical compositions including the antimicrobial agent, methods of treatment of an infection, methods of treatment using compositions or pharmaceutical compositions, and the like.
摘要翻译：本公开的实施方案提供了包含抗微生物剂，包括抗微生物剂的药物组合物，感染治疗方法，使用组合物或药物组合物的治疗方法等的组合物。

8. 发明申请

WO2007126988A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂及其使用方法
公开(公告)号：WO2007126988A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007813
申请日：2007-03-29
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , MARHEFKA, Craig, A. , GAO, Wenqing
发明人： DALTON, James, T. , MILLER, Duane, D. , MARHEFKA, Craig, A. , GAO, Wenqing
IPC分类号： A61K31/66 , A61K31/277 , A61K31/433 , A61K31/426 , A61K31/421 , A61K31/557 , A61K31/275
CPC分类号： A61K31/275 , A61K31/277 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/505 , A61K31/557 , A61K31/65 , A61K31/66 , C07C255/60 , C07D211/72 , C07D233/44 , C07D239/02
摘要： This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia , suppressing spermatogenesis, treating a subject having a hormone related condition, treating a subject suffering from prostate cancer, delaying the progression of prostate cancer, preventing the recurrence of prostate cancer, and treating the recurrence of prostate cancer.
摘要翻译：本发明提供一类雄激素受体靶向剂（ARTA）。这些化合物是选择性雄激素受体调节剂（SARM），其用于除其他外抑制精子发生，治疗具有激素相关病症的受试者，治疗患有前列腺癌的受试者，延缓前列腺癌的进展，预防前列腺癌的复发，并治疗前列腺癌的复发。

9. 发明申请

WO2012055483A1 NON-METAL TANNING PROCESS 审中-公开
标题翻译：非金属鞣制工艺
公开(公告)号：WO2012055483A1
公开(公告)日：2012-05-03
申请号：PCT/EP2011/004975
申请日：2011-10-05
申请人： CLARIANT INTERNATIONAL LTD , REINEKING, Claus , GAMARINO, Roberta , TRIMARCO, Licia , QUAGLIERINI, Maurizio , GISLER, Markus , NUSSER, Rainer
发明人： REINEKING, Claus , GAMARINO, Roberta , TRIMARCO, Licia , QUAGLIERINI, Maurizio , GISLER, Markus , NUSSER, Rainer
IPC分类号： C14C3/26
CPC分类号： C14C3/00 , C07D237/00 , C07D237/06 , C07D239/02 , C07D247/02 , C14C3/02 , C14C3/04 , C14C3/26
摘要： Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or pelt with a tanning agent (A), the tanning agent (A) being at least a mixture of compounds of formula (I) and formula (II), wherein Hal signifies fluorine or chlorine, R1 signifies hydrogen, C 1-8 -alkyl or an alkyleneoxy radical of formula (III), - (- C 2-3 alkylene - O -) q - H (III) R2 signifies a) phenyl, mono- or di-substituted with SO 3 M or COOM and optionally substituted also with hydroxyl or C 1-4 -alkyl or C 1-4 alkoxy, or b) naphthyl, mono- or di- or tri-substituted with SO 3 M and optionally substituted also with hydroxyl, or c) C 1-8 -alkylene, substituted with (S0 3 M) or (COOM), or d) a radical of formula (IV), - (- C 2-3 alkylene - O -) p - Y (IV) e) or a radical of formula (IVa), -(C 2-3 alkylene - O) p -C 2-3 alkylene - SO 2 CH 2 CH2O -Y (IVa) m signifies 1 or 2, P signifies 0 or 1, Y signifies hydrogen or -SO 3 M, q is of from 1 to 10, M signifies hydrogen or an alkali metal cation or an ammonium cation, the ammonium cation being a protonated tertiary amine or a quaternary ammonium cation, R3 signifies hydrogen or chlorine, in a tanning bath, the tanning bath having a pH of from 6 to 10 at the beginning of tanning step.
摘要翻译：鞣制的皮革，皮肤或毛皮是通过非金属鞣制制成的，包括用鞣剂（A）鞣制皮肤，皮肤或皮肤的步骤，鞣制剂（A）至少是式 I）和式（II），其中Hal表示氟或氯，R1表示氢，C1-8 - 烷基或式（III）的亚烷基氧基， - （ - C2-3亚烷基-O - ）q-H（III ）R2表示a）苯基，被SO 3 M或COOM单取代或二取代，并任选也被羟基或C 1-4 - 烷基或C 1-4烷氧基取代，或b）萘基，被SO 3 M单取代或二取代或三取代或任选地被羟基取代，或c）被（S03M）或（COOM）取代的C 1-8 - 亚烷基，或d）式（Ⅳ）基团， - （ - C 2-3亚烷基-O - ） - Y（IV）e）或式（Ⅳa）基团， - （C2-3亚烷基-O）p -C2-3亚烷基-SO2CH2CH2O -Y（Ⅳa）m表示1或2，P表示0或1，Y 表示氢或-SO 3 M，q为1至10，M表示氢或碱金属铵阳离子是质子化叔胺或季铵阳离子，R3表示氢或氯，在鞣制浴中，鞣制浴在鞣制步骤开始时pH为6至10。

10. 发明申请

WO2007126988A3 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂及其使用方法
公开(公告)号：WO2007126988A3
公开(公告)日：2008-09-04
申请号：PCT/US2007007813
申请日：2007-03-29
申请人： UNIV TENNESSEE RES FOUNDATION , DALTON JAMES T , MILLER DUANE D , MARHEFKA CRAIG A , GAO WENQING
发明人： DALTON JAMES T , MILLER DUANE D , MARHEFKA CRAIG A , GAO WENQING
IPC分类号： A61K31/165 , A61K31/275 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/65 , C07C51/16 , C07C233/05 , C07D211/72 , C07D233/44 , C07D239/02
CPC分类号： A61K31/275 , A61K31/277 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/505 , A61K31/557 , A61K31/65 , A61K31/66 , C07C255/60 , C07D211/72 , C07D233/44 , C07D239/02
摘要： This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia, suppressing spermatogenesis, treating a subject having a hormone related condition, treating a subject suffering from prostate cancer, delaying the progression of prostate cancer, preventing the recurrence of prostate cancer, and treating the recurrence of prostate cancer.
摘要翻译：本发明提供一类雄激素受体靶向剂（ARTA）。这些化合物是选择性雄激素受体调节剂（SARM），其用于除其他外抑制精子发生，治疗具有激素相关病症的受试者，治疗患有前列腺癌的受试者，延缓前列腺癌的进展，预防前列腺癌的复发，并治疗前列腺癌的复发。

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