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1. 发明申请

WO2005030705A9 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2005030705A9
公开(公告)日：2006-04-20
申请号：PCT/US2004031591
申请日：2004-09-24
申请人： METHYLGENE INC , MORADEI OSCAR , PAQUIN ISABELLE , LEIT SILVANA , FRECHETTE SYLVIE , VAISBURG ARKADII , BESTERMAN JEFFREY M , TESSIER PIERRE , MALLAIS TAMMY C
发明人： MORADEI OSCAR , PAQUIN ISABELLE , LEIT SILVANA , FRECHETTE SYLVIE , VAISBURG ARKADII , BESTERMAN JEFFREY M , TESSIER PIERRE , MALLAIS TAMMY C
IPC分类号： A61P35/00 , C07C233/25 , C07C235/58 , C07C237/20 , C07C237/40 , C07C255/60 , C07C323/42 , C07D207/32 , C07D207/325 , C07D207/327 , C07D207/335 , C07D209/08 , C07D213/73 , C07D233/54 , C07D233/84 , C07D249/06 , C07D257/04 , C07D263/56 , C07D263/57 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D307/52 , C07D307/54 , C07D307/84 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/58 , C07D333/60 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07F7/18 , A61K31/16 , A61K31/33 , A61K31/381
CPC分类号： C07F7/1856 , C07C233/25 , C07C235/58 , C07C237/20 , C07C237/40 , C07C255/60 , C07C323/42 , C07D207/325 , C07D207/327 , C07D207/335 , C07D209/08 , C07D213/73 , C07D233/54 , C07D233/84 , C07D249/06 , C07D257/04 , C07D263/57 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D307/52 , C07D307/54 , C07D307/84 , C07D319/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/58 , C07D333/60 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译：本发明涉及抑制组蛋白脱乙酰酶。本发明提供了抑制组蛋白脱乙酰酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

2. 发明申请

WO00046182A1 METHOD OF PREPARING ALKYLATED SALICYLAMIDES 审中-公开
标题翻译：制备烷基磺酰胺的方法
公开(公告)号：WO00046182A1
公开(公告)日：2000-08-10
申请号：PCT/US2000/003189
申请日：2000-02-04
IPC分类号： A61K9/00 , A61K9/20 , A61K47/18 , C07C231/00 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/58 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68 , C07C229/14
CPC分类号： A61K9/0014 , A61K9/0031 , A61K9/2013 , A61K47/18 , A61K47/183 , C07C231/00 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68 , C07C235/58
摘要： The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a "protected/activated salicylamide"). The method comprises the steps of (a) alkylating the protected/activated salicylamide with an alkylating agent to form a protected/activated alkylated salicylamide, and (b) deprotecting and deactivating the protected/activated alkylated salicylamide, simultaneously or in any order, to form the alkylated salicylamide. The alkylated salicylamides prepared by this method are suitable for use in compositions for delivering active agents via oral or other routes of administration to animals.
摘要翻译：本发明涉及由保护和活化的水杨酰胺（以下称为“保护/活化的水杨酰胺”）制备烷基化水杨酰胺的方法。该方法包括以下步骤：（a）用烷基化剂烷基化保护/活化的水杨酰胺以形成受保护/活化的烷基化水杨酰胺，和（b）同时或以任何顺序使受保护/活化的烷基化水杨酰胺脱保护和失活以形成烷基化水杨酰胺。通过该方法制备的烷基化水杨酰胺适合用于通过口服或其它给药途径向动物递送活性剂的组合物。

3. 发明申请

WO2006121391A1 NEW COMPOUNDS I 审中-公开
标题翻译：新化合物
公开(公告)号：WO2006121391A1
公开(公告)日：2006-11-16
申请号：PCT/SE2006/000548
申请日：2006-05-08
申请人： ASTRAZENECA AB , JONASSON, Catrin , MOLIN, Håkan (DECEASED) , ROTTICCI, Didier
发明人： JONASSON, Catrin , MOLIN, Håkan (DECEASED) , ROTTICCI, Didier
IPC分类号： C07C43/253 , A61K31/22 , A61K31/275 , A61K31/41 , A61P29/00 , C07C235/58 , C07C235/84 , C07C255/56 , C07C257/04
CPC分类号： C07C255/56 , C07C43/2055 , C07C235/58 , C07C235/84
摘要： A compound of formula (I), or pharmaceutically acceptable salts thereof wherein X is selected from hydrogen, halo, -CN, -CON 2, -CON(C 1 - 6 alkyl)H, -CON(C 1 - 6 alkyl) 2 and heterocyclic groups; R1 is selected from C 1 - 6 alkyl and C 3 - 6 cycloalkyl; whereby Z is -OH, M is selected from C(O)- , -CH(OR a ) , N(R a ) , and S(O) r -, wherein R a is hydrogen or C 1 - 6 alkyl and r is 0, 1 or 2, R2 is selected from C 1 - 6 alkyl, C 3 - 6 cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl, R2 is substituted with halo, -NO 2 , -CN, -OH, -CF 3 , -OCF 3 , -NH 2 , and/or -CONH 2 , when Y is -C 1 - 6 alkyl; or Z is -C 1 - 6 alkoxy, M is bond, R2 is selected from C 1 - 6 alkyl, C 3 - 6 cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl, when Y is -C 1 - 6 alkoxy.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中X选自氢，卤素，-CN，-CON 2，-CON（C 1 - C 1-6烷基）H，-CON（C 1 -C 6烷基）2和杂环基; R 1选自C 1 -C 6烷基和C 3 -C 6环烷基; R 3选自C 1 -C 6烷基和C 3 -C 6环烷基; 其中Z是-OH，M选自C（O） - ， - CH（OR a），N（R a）和S（O）其中R a为氢或C 1 -C 6烷基，r为0,1或2，R 2为选自C 1 -C 6烷基，C 3 -C 6环烷基，杂环烷基，芳基，烷基芳基和杂芳基，R 2被卤素取代，-NO 2 2，-CN，-OH，-CF 3，-OCF 3，-NH 2，当Y是-C 1 -C 6烷基时，R 2是亚烷基，或者-CONH 2，或Z是-C 1 -C 6烷氧基，M是键，R 2选自C 1 -C 6 - 烷基，C 3 -C 6环烷基，杂环烷基，芳基，烷基芳基和杂芳基，当Y是-C 1 -C 6 - / SUB>烷氧基。

4. 发明申请

WO1997015551A1 N-[(FLUOROALKOXY)PHENOXYALKYL]BENZAMIDE COMPOUNDS, INTERMEDIATES THEREOF, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL AND HORTICULTURAL PESTICIDES 审中-公开
标题翻译： N - [（氟代烷氧基）苯氧基]苯并噻唑化合物，其中间体，其制备方法，以及农业和农业用农药
公开(公告)号：WO1997015551A1
公开(公告)日：1997-05-01
申请号：PCT/JP1996003090
申请日：1996-10-24
申请人： UBE INDUSTRIES, LTD. , FUJII, Katsutoshi , HATANO, Koji , SHIKITA, Shoji , TANAKA, Tatsumi
发明人： UBE INDUSTRIES, LTD.
IPC分类号： C07C233/69
CPC分类号： C07C327/48 , A01N37/20 , A01N37/40 , A01N37/48 , A01N39/00 , C07C233/69 , C07C235/48 , C07C235/58 , C07C255/57 , Y10S424/10
摘要： N-[(Fluoroalkoxy)phenoxyalkyl]benzamide compounds represented by general formula (1); and agricultural and horticultural pesticides containing these compounds as the active ingredient which are useful as a nematicide, miticide, insecticide, etc., wherein R and R may be either the same or different and each represents hydrogen, halogeno, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, cyano, nitro or hydroxy; R represents hydrogen, halogeno, C1-4 alkyl or C1-4 alkoxy; A represents oxygen or sulfur; x is an integer of from 1 to 4; y is an integer of from 0 to 6; z is an integer of from 2 to 9; and m is an integer of from 0 to 2, provided that 2x + 1 = y + z + m.
摘要翻译：由通式（1）表示的N - [（氟烷氧基）苯氧基烷基]苯甲酰胺化合物; 含有这些化合物作为活性成分的农业和园艺农药可用作杀线虫剂，杀螨剂，杀虫剂等，其中R 1和R 3可以相同或不同，各自表示氢，卤素， C 1-4烷基，C 1-4烷氧基，C 1-4卤代烷基，C 1-4卤代烷氧基，氰基，硝基或羟基; R 2表示氢，卤代，C 1-4烷基或C 1-4烷氧基; A代表氧或硫; x是1至4的整数; y为0〜6的整数; z为2〜9的整数; 并且m是0-2的整数，条件是2x + 1 = y + z + m。

5. 发明申请

WO2016196751A1 PHYSIOLOGICAL COOLING COMPOUNDS 审中-公开
标题翻译：生理冷却化合物
公开(公告)号：WO2016196751A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035453
申请日：2016-06-02
申请人： PINOVA HOLDINGS, INC.
发明人： KOLOMEYER, Gennadiy , SITKO, David , SNOW, Joe
IPC分类号： C07C233/58 , A01N37/18 , A01N37/20 , A01N37/22
CPC分类号： C07C233/58 , A23G3/36 , A23G3/364 , A23G4/06 , A23G4/12 , A23V2002/00 , A61K8/42 , A61K2800/244 , A61K2800/40 , A61K2800/592 , A61Q11/00 , C07C51/60 , C07C231/02 , C07C233/05 , C07C2601/14 , C07C235/58
摘要： Physiological cooling compounds of Structure 1, where R 1 is p-menthyl or 2,3,4-trimethylpent-3-yl group and R 2 -R 8 are hydrogen or alkyl groups. The combination of R 2 -R 8 is such that the N-alkyl group is a branched C 5 alkyl or branched or linear C 6 -C 8 alkyl group. The new carboxamides are valuable sensory ingredients which provide long-lasting cooling sensation and freshness in personal care, oral care, cosmetic products, pharmaceutical preparations, confectionary, food and beverages.
摘要翻译：结构1的生理学冷却化合物，其中R 1是对 - 薄荷基或2,3,4-三甲基戊-3-基和R 2 -R 8是氢或烷基。 R2-R8的组合使得N-烷基是支链C5烷基或支链或直链C6-C8烷基。新的甲酰胺是有价值的感官成分，可在个人护理，口腔护理，化妆品，药物制剂，糖果，食品和饮料中提供持久的凉爽感和新鲜感。

6. 发明申请

WO00059863A1 DISODIUM SALTS, MONOHYDRATES, AND ETHANOL SOLVATES 审中-公开
标题翻译：二盐，单盐和乙醇溶剂
公开(公告)号：WO00059863A1
公开(公告)日：2000-10-12
申请号：PCT/US2000/009390
申请日：2000-04-05
IPC分类号： A61K47/16 , A61K9/08 , A61K9/20 , A61K9/48 , A61K38/22 , A61K47/12 , A61K47/18 , A61P3/14 , C07C231/00 , C07C231/12 , C07C235/58 , C07C235/60 , C07D265/26 , C07C229/00
CPC分类号： C07C231/00 , A61K9/2013 , A61K47/183 , C07C235/60 , C07D265/26 , C07C235/58
摘要： The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have formula (I) wherein R , R , R , and R are indepedently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of formula (I) above. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC),N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
摘要翻译：发明人已经发现，某些递送剂的二钠盐比相应的单钠盐具有惊人的更大的递送活性剂的功效。此外，本发明人已经发现，这些递送剂的二钠盐与乙醇形成溶剂合物并且与水合。递送剂具有式（I），其中R 1，R 2，R 3和R 4独立地为氢，卤素，C 1 -C 4烷基或C 1 -C 4烷氧基; R 5为取代或未取代的C 2 -C 16亚烷基，取代或未取代的C 2 -C 16亚烯基，取代或未取代的C 1 -C 12烷基（亚芳基）或取代或未取代的芳基（C 1 -C 12亚烷基）。本发明的水合物和溶剂合物对于递送活性剂（例如肝素和降钙素）比其相应的单钠盐和游离酸具有惊人的更大的功效。本发明提供上述式（I）的递送剂的二钠盐的醇溶剂合物，例如乙醇溶剂合物。优选的递送剂包括但不限于N-（5-氯水杨酰基）-8-氨基辛酸（5-CNAC），N-（10- [2-羟基苯甲酰基]氨基）癸酸（SNAD）和N - （8- [2-羟基苯甲酰基]氨基）辛酸酯（SNAC）。本发明还提供了制备二钠盐，乙醇溶剂化物和水合物的方法以及含有二钠盐，乙醇溶剂化物和/或水合物的组合物。

7. 发明申请

WO1997008135A1 ACYLAMINOSALICYLIC ACID AMIDES AND THEIR USES AS PESTICIDES 审中-公开
标题翻译： Acylaminosalicylamides及其作为农药
公开(公告)号：WO1997008135A1
公开(公告)日：1997-03-06
申请号：PCT/EP1996003637
申请日：1996-08-19
申请人： BAYER AKTIENGESELLSCHAFT , SEITZ, Thomas , NAUMANN, Klaus , TIEMANN, Ralf , STENZEL, Klaus , HÄNSSLER, Gerd , DUTZMANN, Stefan
发明人： BAYER AKTIENGESELLSCHAFT
IPC分类号： C07C237/44
CPC分类号： C07C237/44 , C07C235/58 , C07C235/62 , C07C235/64
摘要： Known and new acylaminosalicylic acid amides are disclosed having the general formula (I), as well as several processes for producing the same, their use as pesticides, new intermediate products and several processes for preparing said intermediate products. In the formula (I), A stands for a simple bond or for an alkylene chain; R stands for hydrogen, alkyl or alkoxy; R stands for optionally substituted cycloalkyl, cycloalkenyl, aryl or heterocyclyl.
摘要翻译：本发明涉及已知的和新acylaminosalicylamides通式（I），它们的制备和它们作为农药，以及新的中间体和几个过程用于其制备中使用的几种方法，其中A表示单键或亚烷基链，R <1 >是氢，烷基或烷氧基，R <2>是任选取代的环烷基，环烯基，芳基或杂环基。

8. 发明申请

WO2015073864A8 EBNA1 INHIBITORS AND THEIR METHOD OF USE 审中-公开
标题翻译： EBNA1抑制剂及其使用方法
公开(公告)号：WO2015073864A8
公开(公告)日：2016-01-07
申请号：PCT/US2014065765
申请日：2014-11-14
申请人： WISTAR INST
发明人： MESSICK TROY E , SMITH GARRY R , REITZ ALLEN B , LIEBERMAN PAUL M
IPC分类号： C07C229/56
CPC分类号： C07D207/327 , C07C53/18 , C07C63/66 , C07C65/19 , C07C65/28 , C07C211/27 , C07C217/84 , C07C229/56 , C07C229/64 , C07C233/11 , C07C233/64 , C07C233/65 , C07C235/58 , C07C255/54 , C07C255/55 , C07C311/08 , C07C311/16 , C07C311/17 , C07C317/14 , C07C317/44 , C07C2601/02 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/70 , C07D213/55 , C07D213/64 , C07D213/74 , C07D215/14 , C07D231/12 , C07D235/06 , C07D239/26 , C07D249/06 , C07D277/30 , C07D295/155 , C07D307/79 , C07D333/54 , C07D401/04 , C07D401/10 , C07D403/10 , C07D409/10 , C07D417/10 , C07D471/04 , C07D487/04
摘要： Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.
摘要翻译：本发明的药物组合物包含可用于治疗由EBNA1活性引起的疾病如EB病毒，感染性单核细胞增多症，慢性疲劳综合征，多发性硬化症，系统性红斑狼疮和类风湿性关节炎的EBNA1抑制剂。本发明的药物组合物还包含可用于治疗潜伏性爱泼斯坦 - 巴尔病毒（EBV）感染引起的疾病的EBNA1抑制剂。本发明的药物组合物还包含可用于治疗由溶血性爱泼斯坦 - 巴尔病毒（EBV）感染引起的疾病的EBNA1抑制剂。

9. 发明申请

WO2015073864A1 EBNA1 INHIBITORS AND THEIR METHOD OF USE 审中-公开
标题翻译： EBNA1抑制剂及其使用方法
公开(公告)号：WO2015073864A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065765
申请日：2014-11-14
申请人： THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人： MESSICK, Troy, E. , SMITH, Garry, R. , REITZ, Allen, B. , LIEBERMAN, Paul, M.
IPC分类号： C07C229/56
CPC分类号： C07D207/327 , C07C53/18 , C07C63/66 , C07C65/19 , C07C65/28 , C07C211/27 , C07C217/84 , C07C229/56 , C07C229/64 , C07C233/11 , C07C233/64 , C07C233/65 , C07C235/58 , C07C255/54 , C07C255/55 , C07C311/08 , C07C311/16 , C07C311/17 , C07C317/14 , C07C317/44 , C07C2601/02 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/70 , C07D213/55 , C07D213/64 , C07D213/74 , C07D215/14 , C07D231/12 , C07D235/06 , C07D239/26 , C07D249/06 , C07D277/30 , C07D295/155 , C07D307/79 , C07D333/54 , C07D401/04 , C07D401/10 , C07D403/10 , C07D409/10 , C07D417/10 , C07D471/04 , C07D487/04
摘要： Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.
摘要翻译：本发明的药物组合物包含可用于治疗由EBNA1活性引起的疾病如EB病毒，感染性单核细胞增多症，慢性疲劳综合征，多发性硬化症，系统性红斑狼疮和类风湿性关节炎的EBNA1抑制剂。本发明的药物组合物还包含可用于治疗潜伏性爱泼斯坦 - 巴尔病毒（EBV）感染引起的疾病的EBNA1抑制剂。本发明的药物组合物还包含可用于治疗由溶血性爱泼斯坦 - 巴尔病毒（EBV）感染引起的疾病的EBNA1抑制剂。

10. 发明申请

WO2005030705A1 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： HISTONE DEACETYLASE的抑制剂
公开(公告)号：WO2005030705A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031591
申请日：2004-09-24
申请人： METHYLGENE, INC. , MORADEI, Oscar , PAQUIN, Isabelle , LEIT, Silvana , FRECHETTE, Sylvie , VAISBURG, Arkadii , BESTERMAN, Jeffrey, M. , TESSIER, Pierre , MALLAIS, Tammy, C.
发明人： MORADEI, Oscar , PAQUIN, Isabelle , LEIT, Silvana , FRECHETTE, Sylvie , VAISBURG, Arkadii , BESTERMAN, Jeffrey, M. , TESSIER, Pierre , MALLAIS, Tammy, C.
IPC分类号： C07C237/40
CPC分类号： C07F7/1856 , C07C233/25 , C07C235/58 , C07C237/20 , C07C237/40 , C07C255/60 , C07C323/42 , C07D207/325 , C07D207/327 , C07D207/335 , C07D209/08 , C07D213/73 , C07D233/54 , C07D233/84 , C07D249/06 , C07D257/04 , C07D263/57 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D307/52 , C07D307/54 , C07D307/84 , C07D319/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/58 , C07D333/60 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译：本发明涉及抑制组蛋白脱乙酰酶。本发明提供了抑制组蛋白脱乙酰酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。

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