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    • 3. 发明申请
    • PROCESS FOR PREPARING UNSATURATED QUATERNARY AMMONIUM SALTS
    • 制备不稳定季铵盐的方法
    • WO1988006152A1
    • 1988-08-25
    • PCT/JP1988000165
    • 1988-02-18
    • KOHJIN CO., LTD.NAGATSU, YoshirouNAGAMOTO, AkiyoshiHARADA, KazuyaMUKOUYAMA, Hideaki
    • KOHJIN CO., LTD.
    • C07C93/193
    • C07C233/89
    • A process for preparing unsaturated quaternary ammonium salts, which comprises treating a cationic vinyl monomer represented by general formula (1) with an alkyl or aralkyl halide to prepare an unsaturated quaternary ammonium salt represented by general formula (2) using a reaction solvent comprising a mixture of water with an aprotic organic solvent in a specific mixing ratio and controlling a dissolved oxygen concentration in the system at a level of less than 1.8 ppm but not less than 0.3 ppm. In formula (1), R1 represents a hydrogen atom or a methyl group, R2 and R3 each independently represents a C1-4 alkyl group, A represents an oxygen atom or NH, and B represents a C1-4 alkylene group. In formula (2), R1, R2, R3, A, and B are as defined above, R4 represents a C1-4 alkyl group or a benzyl group, and X- represents a halide anion. In this process, the ammonium salt is not precipitated even when formed as the reaction proceeds, which permits smooth stirring of the system and heat removal therefrom and which prevents formation of substances causative of polymerization and gelation and inhibiting polymerization due to overheating. This process enables an excellent aqueous solution of the unsaturated quaternary ammonium salt to be industrially produced with ease. The salt can be used as a starting material for producing a high-molecular cationic polymer.
    • 5. 发明申请
    • SURFACTANT AMINES AND GLYCOSIDES
    • 表面活性剂和乳糖
    • WO98034943A1
    • 1998-08-13
    • PCT/NL1998/000077
    • 1998-02-10
    • B01F17/00B01F17/16B01F17/56C07C229/12C07C233/89C07H3/06C07H15/04C07H15/10
    • C07H15/10B01F17/0021B01F17/0042C07C229/12C07C233/89C07H3/06C07H15/04
    • Surface-active amines are described having the formula (1): R R R N -CHR -A -R wherein A represents a C7-C11 alkylene group; R represents hydroxymethyl, carbamoyl, carboxyl or (C1-C4alkoxy)carbonyl; R represents a C5-C9 alkyl group; R and R each represent hydrogen or a C1-C4 alkyl group, or R and R together with the nitrogen atom represent a pyrrolidino, piperidino or morpholino group; R represents a C1-C20 alkyl, alkenyl, alkynyl, cycloalkyl(alkyl), aralkyl or acyl group, which group may be interrupted by one or more oxygen atoms or imino groups, a C1-C3alkyl or C2-C3 alkanoyl group substituted by a carboxyl, phospho and/or sulpho group, or a sugar residue; wherein, if R represents hydrogen, the nitrogen atom may also be deprotonated. Surfactant alkylglycosides are also described. The compounds can be used as emulsifiers, in detergents and the like.
    • 描述具有式(1)的表面活性胺:R 10 R 11 R 12 N + CHR 2 -A 1 -R 1其中A 1表示 C7-C11亚烷基; R 1表示羟甲基,氨基甲酰基,羧基或(C 1 -C 4烷氧基)羰基; R 2表示C 5 -C 9烷基; R 10和R 11各自代表氢或C 1 -C 4烷基,或R 10和R 11与氮原子一起代表吡咯烷基,哌啶子基或吗啉代基; R 12表示可被一个或多个氧原子或亚氨基中断的C 1 -C 20烷基,烯基,炔基,环烷基(烷基),芳烷基或酰基,C 1 -C 3烷基或C 2 -C 3烷酰基 被羧基,磷酸基和/或磺基取代,或糖残基取代; 其中,如果R 10表示氢,则氮原子也可以去质子化。 还描述了表面活性剂烷基糖苷。 化合物可用作乳化剂,在洗涤剂等中。
    • 6. 发明申请
    • PREPARATION OF ANTIMICROBIAL SUBSTANCES
    • 用于生产抗生素
    • WO1995006028A1
    • 1995-03-02
    • PCT/EP1994002735
    • 1994-08-17
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIENHILL, KarlheinzKLUSCHANZOFF, HaraldSTEIN, SigridFRIESE, Carsten
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN
    • C07C231/02
    • C07C53/126C07C231/02C07C233/36C07C233/89C07C237/10C07C237/50
    • In order to prepare antimicrobial substances, compounds having the formulas (I): R -NR -CH2-CH2-CH2-NH and (II) or (III): R -CH2-COOH are dissolved in each other in a molar ratio from about 1 : 1 to 1 : 2 by adding portions of (II) to (I) while agitating them at temperatures from about 80 to 100 DEG C. In the formula (I), R stands for a linear alkyl residue with 6 to 22 carbon atoms, preferably with 12 to 14 carbon atoms, and R stands for H or for CH2-CH2-CH2-NH2, and in the formulas (II) or (III), R stands for an alkyl residue with 1 to 4 carbon atoms or preferably a hydrogen atom; 10 to 100 l/minute nitrogen are then continuously blown over the reaction water that results at the beginning of the reaction, at temperatures from about 120 to 150 DEG C, until one hour from the end of the reaction has elapsed. The thus obtained reaction products may be reacted with inorganic and organic acids into corresponding salts and with ethylene oxide or propylene oxide into the corresponding alkoxylation products. The alkoxylation products may in turn be converted into the corresponding salts of inorganic or organic acids. Said salts, alkoxylation products and salts of the alkoxylation products also have an antimicrobial activity.
    • 抗微生物得到的活性物质时的式I的化合物(I):R <1>是-NR <2> -CH2-CH2-CH2-NH,其中R <1>是具有6-22个碳原子的直链烷基, 优选为具有12 - 是14个碳原子,并且R <2>是H或是CH2-CH2-CH2-NH 2,和式(II)或(III)的化合物:R t <3> -CH 2 COOH, [R <3>是一个烷基具有1至4个碳原子或优选为氢原子,在约1的摩尔比:1至1:2,在搅拌下,在约80的温度至100℃通过分批加入的(II)至( I)成彼此溶解,然后在约120〜150℃下的温度下与反应的初始反应水生成物中,通过连续地使从约10至100升/分钟吹氮和吹出继续反应仍然约1小时后。 得到的反应产物可以用无机酸和有机酸被转化成相应的盐,并与环氧乙烷或环氧丙烷的烷氧基化对应,其中反过来烷氧基可被转换成的无机酸或有机酸的相应的盐。 说盐,以及烷氧基化的烷氧基化也有抗菌活性。