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    • 4. 发明申请
    • VACCINE FORMULATIONS THAT INDUCE A TH2 IMMUNE RESPONSE
    • 诱导TH2免疫应答的疫苗制剂
    • WO2015017280A1
    • 2015-02-05
    • PCT/US2014/048254
    • 2014-07-25
    • QANTU THERAPEUTICS, INC.
    • MARCIANI, Dante, J.
    • A61K39/00A61P25/28B01F17/56
    • A61K39/0007A61K39/39A61K2039/545A61K2039/55505A61K2039/55577A61K2039/57
    • The present invention relates to compositions and methods for the prevention and treatment of neurodegenerative diseases, such Alzheimer's disease, that are caused by misfolding, aggregating proteins. The compositions and methods of the present invention comprise a vaccine formulation comprising an antigen selected from the group consisting of i) amyloid-β or a peptide that has in its amino acid sequence part of the amyloid-β amino acid sequence, ii) hyperphosphorylated tau protein or one of its hyperphoshorylated peptides, or iii) a combination of antigens derived from groups i) and ii) and that are formulated with a non-acylated or deacylated, natural or synthetic, bidesmosidic triterpene glycoside carrying an aldehyde or ketone group, which acts as an adjuvant or immune agonist. These vaccine formulations are capable of stimulating a Th2 immunity or antibody response against antigens such as amyloid-β and tau derived antigens, but not a Th1 immune response.
    • 本发明涉及用于预防和治疗由错误折叠,聚集蛋白质引起的神经变性疾病(例如阿尔茨海默氏病)的组合物和方法。 本发明的组合物和方法包含疫苗制剂,其包含选自以下的抗原:i)淀粉样蛋白 - 或在其氨基酸序列中具有淀粉样蛋白的一部分的肽; 氨基酸序列,ii)过磷酸化tau蛋白或其高磷酸化肽之一,或iii)来自组i)和ii)的抗原的组合,并且与非酰化或去酰基化的天然或合成的双苷脂三萜糖苷配制 携带醛或酮基,其作为佐剂或免疫激动剂。 这些疫苗制剂能够刺激针对抗原的Th2免疫或抗体应答,例如淀粉样蛋白 - 和tau衍生的抗原,但不是Th1免疫应答。