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1. 发明申请

WO1993007113A1 ALKOXYPHENYLALKYLAMINE DERIVATIVE 审中-公开
标题翻译：烷氧基苯胺衍生物
公开(公告)号：WO1993007113A1
公开(公告)日：1993-04-15
申请号：PCT/JP1992001259
申请日：1992-09-30
申请人： TAISHO PHARMACEUTICAL CO., LTD. , NAKAZATO, Atsuro , SEKIGUCHI, Yoshinori , OHTA, Koumei , KAWASHIMA, Yutaka , HATAYAMA, Katsuo
发明人： TAISHO PHARMACEUTICAL CO., LTD.
IPC分类号： C07C217/56
CPC分类号： C07D213/74 , C07C217/56 , C07C217/60 , C07C217/62 , C07C229/14 , C07D239/42 , C07D295/096 , C07D333/16
摘要： An alkoxyphenylalkylamine derivative represented by general formula (I) and a salt thereof, wherein X and X may be the same or different from each other and each represents hydrogen, halogen, hydroxyl, or C1 to C5 alkoxy which may be substituted by phenyl; R and R may be the same or different from each other and each represents hydrogen or C1 to C7 alkyl which may be terminated with hydroxyl, carboxyl or alkoxycarbonyl, or alternatively R and R are combined with the adjacent nitrogen atoms to represent optionally substituted pyrrolidine, piperidino, piperazino, etc.; A represents phenyl which may be substituted by one to three arbitrary substituents selected among halogen, hydroxyl and C1 to C5 alkoxy, or similarly substituted thienyl; m represents an integer of 2 to 5; and n represents an integer of 1 to 7. The above compounds are useful in treating schizophrenia without causing extrapyramidal disorder and in treating problematic behaviours accompanying cerebrovascular disorder or senile dementia.
摘要翻译：由通式（I）表示的烷氧基苯基烷基胺衍生物及其盐，其中X 1和X 2可以彼此相同或不同，各自表示氢，卤素，羟基或C 1至C 5烷氧基，其可以被苯基取代; R 1和R 2可以彼此相同或不同，并且各自表示氢或可以被羟基，羧基或烷氧基羰基封端的C 1 -C 7烷基，或者R 1和R 2可以是与相邻的氮原子结合以代表任选取代的吡咯烷，哌啶子基，哌嗪基等; A表示可以被一至三个选自卤素，羟基和C 1至C 5烷氧基的任意取代基取代的苯基，或类似取代的噻吩基; m表示2〜5的整数，并且n表示1〜7的整数。上述化合物可用于治疗精神分裂症而不引起锥体外系紊乱，并且用于治疗伴有脑血管障碍或老年痴呆的问题行为。

2. 发明申请

WO01005743A1 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES 审中-公开
标题翻译： 3-氨基-2-苄基-1-苯基 - 丙烷衍生物
公开(公告)号：WO01005743A1
公开(公告)日：2001-01-25
申请号：PCT/EP2000/005820
申请日：2000-06-23
IPC分类号： C07D319/18 , A61K31/137 , A61K31/255 , A61K31/277 , A61K31/357 , A61P1/04 , A61P1/12 , A61P9/10 , A61P11/00 , A61P11/14 , A61P13/02 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/32 , A61P29/00 , A61P37/08 , C07B61/00 , C07C213/00 , C07C213/02 , C07C215/30 , C07C215/54 , C07C215/62 , C07C217/56 , C07C217/62 , C07C217/66 , C07C217/72 , C07C221/00 , C07C225/16 , C07C253/30 , C07C255/58 , C07C319/20 , C07C323/32 , C07F9/40
CPC分类号： C07C323/32 , C07C215/30 , C07C215/54 , C07C215/62 , C07C217/56 , C07C217/66 , C07C225/16 , C07C2603/26 , C07F9/4021
摘要： The invention relates to substituted 3-amino-2-benzyl-1-phenyl-propane derivatives, to methods for producing them, to medicaments containing these compounds and to the use of these substances for producing medicaments.
摘要翻译：本发明涉及取代的3-氨基-2-苄基-1-苯基 - 丙烷衍生物，它们的制备方法，含有这些化合物，和用于生产药物的用途，这些物质的药物。

3. 发明申请

WO98037062A1 NOVEL NONYLPHENOL NONIONIC GEMINI SURFACTANTS 审中-公开
标题翻译：新型非离子酚非离子型GEMINI表面活性剂
公开(公告)号：WO98037062A1
公开(公告)日：1998-08-27
申请号：PCT/US1998/003103
申请日：1998-02-20
IPC分类号： B01F17/00 , B01F17/42 , C07C45/46 , C07C45/71 , C07C49/84 , C07C211/07 , C07C215/48 , C07C217/56 , C07C317/18 , C07C317/22 , C11D1/44 , C11D1/72 , C11D3/20 , C07C317/06 , C07C321/06
CPC分类号： A61K8/39 , A61Q5/02 , A61Q19/10 , B01F17/0028 , C07C45/46 , C07C45/71 , C07C49/84 , C07C215/48 , C07C217/56 , C07C317/18 , C11D1/44 , C11D1/72 , C07C49/83
摘要： Novel nonylphenol nonionic gemini surfactants are extremely effective emulsifiers for oil-in-water emulsions that provide improved detergency at even low concentration levels and are characterized by formula (I), wherein R and R1 are both either H or a C4-C2 alkyl, aryl, or alkylaryl with the stipulation that they cannot both be H at the same time; and R2 is independently -COR3CO-, -CH2N(R4)CH2-; CH2N(R5)R6(R5)NCH2-, or R7-D-R7 wherein R3 independently represents a C1-C6 alkyl, branched alkyl or aryl; R4 represents a C1 to C4 alkyl, aryl, alkylaryl, hydroxy alkyl, haloalkyl or H, R5 represents a C1 to C10 alkyl or aryl and R6 independently represents a C1 to C10 alkyl, aryl, or alkylaryl, R7 is a C2 to C4 alkyl and D independently represents -S-, -SO- and SO2 with the stipulation that R5 and R6 can form a heterocyclic ring; EO represents ethylene oxy-radicals, x and y are whole numbers and x+y equals a number from 2 to 200 inclusive.
摘要翻译：新型壬基酚非离子双子表面活性剂是用于水包油乳液的非常有效的乳化剂，其在甚至低浓度水平下提供改善的去污力，并且由式（I）表征，其中R和R 1都是H或C 1 -C 2烷基，芳基或烷基芳基，其规定不能同时为H; 且R 2独立地为-COR 3 CO - ， - CH 2 N（R 4）CH 2 - ; CH2N（R5）R6（R5）NCH2-或R7-D-R7，其中R3独立地表示C1-C6烷基，支链烷基或芳基; R4代表C1至C4烷基，芳基，烷基芳基，羟基烷基，卤代烷基或H，R5代表C1至C10烷基或芳基，R6独立代表C1至C10烷基，芳基或烷基芳基，R7为C2至C4烷基和D独立地表示-S-，-SO-和SO2，其中R5和R6可以形成杂环; EO表示乙烯氧基，x和y是整数，x + y等于包括2〜200的数。

4. 发明申请

WO2012059585A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED N-(BENZYL)CYCLOPROPANAMINES BY IMINE HYDROGENATION 审中-公开
标题翻译：制备取代的N-（苄基）环丙基亚胺的方法
公开(公告)号：WO2012059585A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069426
申请日：2011-11-04
申请人： BAYER CROPSCIENCE AG , LUI, Norbert , MORADI, Wahed Ahmed , MÜLLER, Thomas Norbert
发明人： LUI, Norbert , MORADI, Wahed Ahmed , MÜLLER, Thomas Norbert
IPC分类号： C07C209/52 , C07C211/35
CPC分类号： C07C209/52 , C07C211/35 , C07C213/02 , C07C217/58 , C07C227/04 , C07C251/24 , C07C2601/02 , C07C229/38 , C07C217/56
摘要： The present invention relates to a process for the preparation of substituted N-(benzyl)cyclopropanamines of the general formula (II) starting from N-[(aryl)methylene]cyclopropanamine derivatives. The present invention further provides the N-[(aryl)methylene]cyclopropanamine derivatives used as starting compounds in this process according to the invention, and their use for the preparation of substituted N-(benzyl)cyclopropanamines.
摘要翻译：本发明涉及由N - [（芳基）亚甲基]环丙胺衍生物制备由通式（II）取代的N-（苄基）环丙胺。本发明还提供在本发明方法中用作起始化合物的N - [（芳基）亚甲基]环丙胺衍生物及其用于制备取代的N-（苄基）环丙胺的用途。

5. 发明申请

WO9918941A3 Ih-MODULATORS 审中-公开
标题翻译： IH-调节剂
公开(公告)号：WO9918941A3
公开(公告)日：2000-01-13
申请号：PCT/EP9806651
申请日：1998-10-14
申请人： AKZO NOBEL NV , DIJCKS FREDERICUS ANTONIUS , GROVE SIMON JAMES ANTHONY , CARLYLE IAN CRAIG , THORN SIMON NICHOLAS , RAE DUNCAN ROBERTSON , RUIGT GERARDUS STEPHANUS FRANC , LEYSEN DIRK
发明人： DIJCKS FREDERICUS ANTONIUS , GROVE SIMON JAMES ANTHONY , CARLYLE IAN CRAIG , THORN SIMON NICHOLAS , RAE DUNCAN ROBERTSON , RUIGT GERARDUS STEPHANUS FRANC , LEYSEN DIRK
IPC分类号： G01N33/50 , A61K31/00 , A61K31/085 , A61K31/121 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K45/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07C47/55 , C07C47/575 , C07C211/28 , C07C211/29 , C07C217/56 , C07C255/58 , C07D213/48 , C07D213/61 , C07D215/12 , C07D217/14 , C07D231/56 , C07D239/26 , C07D261/08 , C07D261/20 , C07D263/56 , C07D263/57 , C07D277/28 , C07D277/66 , C07D307/52 , C07D307/80 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/56 , C07D333/58 , C07D413/04 , C07D498/04 , G01N33/15 , A61K31/34 , A61K31/38 , A61K31/425 , A61K31/435
CPC分类号： C07D413/04 , A61K31/00 , A61K31/085 , A61K31/121 , A61K31/137 , A61K31/15 , A61K31/381 , A61K31/416 , A61K31/423 , A61K31/426 , A61K31/437 , A61K31/472 , C07C211/28 , C07C211/29 , C07C217/56 , C07C255/58 , C07D213/61 , C07D215/12 , C07D217/14 , C07D231/56 , C07D239/26 , C07D261/08 , C07D261/20 , C07D263/57 , C07D277/28 , C07D277/66 , C07D307/52 , C07D307/80 , C07D307/81 , C07D333/20 , C07D333/28 , C07D333/58
摘要： The present invention relates to the use of an Ih channel modulator in the manufacture of a medicament for use in psychiatry. To certain novel methanamine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly for use in psychiatry.
摘要翻译：本发明涉及Ih通道调节剂在制造用于精神病学的药物中的用途。某些新的甲胺衍生物，其制备方法，含有它们的药物制剂及其在药物治疗中的用途，特别是用于精神病学。

6. 发明申请

WO1990004583A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：WO1990004583A1
公开(公告)日：1990-05-03
申请号：PCT/EP1989001230
申请日：1989-10-16
申请人： PFIZER LIMITED , PFIZER INC. , ALKER, David , BASS, Robert, John , CROSS, Peter, Edward
发明人： PFIZER LIMITED , PFIZER INC.
IPC分类号： C07C217/60
CPC分类号： C07D307/79 , C07C217/10 , C07C217/52 , C07C217/56 , C07C225/16 , C07C229/38 , C07C237/32 , C07C255/58 , C07C311/05 , C07C311/08 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2603/32 , C07D317/58 , C07D319/18 , C07D333/20 , C07D337/12
摘要： A muscarinic receptor antagonist, useful in treating irritable bowel syndrome, of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is a group of formula (α) or (β), where Z and Z1 are each independently hydrogen, halo or C¿1?-C4 alkyl; X is -(CH2)2-, -CH=CH-, -CH2-S-, -CH2-O-, -S- or -O-; Y is a direct link, O or S; R?2 and R3¿ are each independently C¿1?-C4 alkyl or together represent -(CH2)p- where p is 2, 3, 4 or 5; R?4¿ is H or C¿1?-C4 alkyl; m is 1, 2 or 3, with the proviso that when m is 1, Y is a direct link; and R is a group of formula (γ), (δ), (ε), (ζ), where either R?5 and R6¿ are certain specified optional substituents, or R?5 and R6¿, when attached to adjacent carbon atoms, together represent a group of the formula -O(CH¿2?)rO-, where r is 1, 2 or 3, -O(CH2)2- or -(CH2)3-; R?7¿ is H, C¿1?-C4 alkyl or -CONH2; and R?8¿ is H, C¿1?-C4 alkyl or C1-C4 alkoxy.

7. 发明申请

WO2012137047A1 A PROCESS FOR PREPARING FESOTERODINE 审中-公开
标题翻译：制备FESOTERODINE的方法
公开(公告)号：WO2012137047A1
公开(公告)日：2012-10-11
申请号：PCT/IB2011/055039
申请日：2011-11-11
申请人： ALEMBIC PHARMACEUTICALS LIMITED , RAMAN, Jayaraman, Venkat , PATEL, Samir , THAKOR, Indrajit , LADANI, Mahesh , PATIL, Chetan , PATEL, Ronak , RAVAL, Prashant , PAREKH, Viral , SHAH, Hiral
发明人： RAMAN, Jayaraman, Venkat , PATEL, Samir , THAKOR, Indrajit , LADANI, Mahesh , PATIL, Chetan , PATEL, Ronak , RAVAL, Prashant , PAREKH, Viral , SHAH, Hiral
IPC分类号： C07B57/00 , C07C213/08 , C07C217/54 , C07C219/28
CPC分类号： C07C227/36 , C07B57/00 , C07C57/15 , C07C213/08 , C07C217/56 , C07C217/62 , C07C219/28
摘要： The present invention relates to an improved process for the preparation of Fesoterodine and pharmaceutically acceptable salts thereof. The present invention particularly relates to a process for the preparation of fesoterodine and pharmaceutically acceptable salts thereof which involves use and preparation of R(+) benzyl tolterodine and fumarate salt of R(+)-[4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-phenyl]-methanol.
摘要翻译：本发明涉及一种制备非索罗定及其药学上可接受的盐的改进方法。本发明特别涉及制备非索特罗及其药学上可接受的盐的方法，其涉及使用和制备R（+） - [4-苄氧基-3-（3-二异丙基氨基） -1-苯基丙基） - 苯基] - 甲醇。

8. 发明申请

WO2008033455A2 BIPHENYL AND HETEROARYLPHENYL DERIVATIVES 审中-公开
标题翻译：苯乙烯和异丁基衍生物
公开(公告)号：WO2008033455A2
公开(公告)日：2008-03-20
申请号：PCT/US2007019915
申请日：2007-09-13
申请人： INST FOR PHARM DISCOVERY INC , VAN ZANDT MICHAEL C
发明人： VAN ZANDT MICHAEL C
IPC分类号： C07D213/32 , C07D213/74 , C07D213/79 , C07D213/80 , C07D215/16 , C07D231/14 , C07D233/90 , C07D277/28 , C07D277/64 , C07D285/06 , C07D401/10
CPC分类号： C07D417/12 , C07C217/48 , C07C217/56 , C07C229/16 , C07C233/47 , C07C255/57 , C07C323/52 , C07C323/59 , C07C323/62 , C07D207/327 , C07D213/32 , C07D213/74 , C07D213/79 , C07D213/80 , C07D215/16 , C07D231/14 , C07D233/90 , C07D277/28 , C07D277/64 , C07D285/06 , C07D401/10 , C07D401/12 , C07D403/10 , C07D417/06 , C07D417/10
摘要： Abstract of the Disclosure Disclosed are compounds and pharmaceutically acceptable salts of formula (I) : wherein A, B, D, L 1 L 2, R 2, R A , R B, X, m, n, and p are as defined herein, which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：披露的摘要公开了式（I）的化合物和药学上可接受的盐：其中A，B，D，L 1，L 2，R 2， R A，R B，X，m，n和p如本文所定义，其可用于治疗与胰岛素抵抗相关的代谢紊乱，瘦素抵抗或高血糖症。本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

9. 发明申请

WO00027790A1 MUTILIN COMPOUNDS 审中-公开
标题翻译： MUITLIN化合物
公开(公告)号：WO00027790A1
公开(公告)日：2000-05-18
申请号：PCT/EP1999/008705
申请日：1999-11-09
IPC分类号： C07C69/00 , C07C205/43 , C07C217/56 , C07C217/84 , C07C229/34 , C07C229/36 , C07C229/38 , C07C233/65 , C07C233/78 , C07C255/54 , C07C257/18 , C07C271/22 , C07D213/54 , C07D217/02 , C07D261/08 , C07D277/30 , C07D277/34 , C07D295/096 , C07D295/192 , C07D307/54 , C07D333/38 , C07D333/60 , C07D333/64 , C07D417/04 , C07D453/02 , C07D471/10 , C07D487/20 , C07C69/013 , A61K31/215 , A61K31/38 , A61K31/425 , A61K31/445 , A61K31/47 , C07C69/614 , C07C69/712 , C07C205/56 , C07C235/50 , C07D211/22 , C07D295/08 , C07D333/24
CPC分类号： C07D295/192 , C07C69/712 , C07C69/734 , C07C205/43 , C07C217/56 , C07C217/84 , C07C229/34 , C07C229/36 , C07C229/38 , C07C233/65 , C07C233/78 , C07C255/54 , C07C257/18 , C07C271/22 , C07C2603/82 , C07D213/54 , C07D217/02 , C07D261/08 , C07D277/30 , C07D277/34 , C07D295/096 , C07D307/54 , C07D333/38 , C07D333/60 , C07D333/64 , C07D417/04 , C07D453/02 , C07D471/10
摘要： A compound of formula (IA) or (IB): in which R is R (CH2)nO(CH2)m, R (CH2)p, Formula (II) or in which R is a spiro-fused mono- or bi-cyclic ring containing one or two basic nitrogen atoms; and X and X , which may be the same or different, are each -CH2- or -C=O, provided that at least one of X and X is -C=O; Y is -NH-, -CH2- or -CH2-CH2-; R is an optionally substituted aryl group or heteroaryl group linked via a carbon atom; m is 1, 2 or 3; n is 0, 1 or 2; and p is 1 to 4; R is vinyl or ethyl; R is H, OH or F, and R is H, or R is H and R is F. The compounds are useful for treating microbial infections in animals, especially in humans and in domesticated mammals.
摘要翻译：式（IA）或（IB）的化合物：其中R 1为R aA（CH 2）n O（CH 2）m，R AA（CH 2）p，式（II）或其中R为含有一个或两个碱性氮原子的螺稠合单环或双环; 和X 1和X 2可以相同或不同，分别为-CH 2 - 或-C = O，条件是X 1和X 2中的至少一个为-C = O ; Y是-NH-，-CH 2 - 或-CH 2 -CH 2 - ; R AA是通过碳原子连接的任选取代的芳基或杂芳基; m为1,2或3; n为0,1或2; p为1〜4; R 2是乙烯基或乙基; R 3是H，OH或F，R 4是H，或R 3是H，R 4是F.这些化合物可用于治疗动物，特别是人类和驯养哺乳动物。

10. 发明申请

WO99018941A2 Ih-MODULATORS 审中-公开
标题翻译： IH型调制器
公开(公告)号：WO99018941A2
公开(公告)日：1999-04-22
申请号：PCT/EP1998/006651
申请日：1998-10-14
IPC分类号： G01N33/50 , A61K31/00 , A61K31/085 , A61K31/121 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K45/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07C47/55 , C07C47/575 , C07C211/28 , C07C211/29 , C07C217/56 , C07C255/58 , C07D213/48 , C07D213/61 , C07D215/12 , C07D217/14 , C07D231/56 , C07D239/26 , C07D261/08 , C07D261/20 , C07D263/56 , C07D263/57 , C07D277/28 , C07D277/66 , C07D307/52 , C07D307/80 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/28 , C07D333/56 , C07D333/58 , C07D413/04 , C07D498/04 , G01N33/15
CPC分类号： C07D413/04 , A61K31/00 , A61K31/085 , A61K31/121 , A61K31/137 , A61K31/15 , A61K31/381 , A61K31/416 , A61K31/423 , A61K31/426 , A61K31/437 , A61K31/472 , C07C211/28 , C07C211/29 , C07C217/56 , C07C255/58 , C07D213/61 , C07D215/12 , C07D217/14 , C07D231/56 , C07D239/26 , C07D261/08 , C07D261/20 , C07D263/57 , C07D277/28 , C07D277/66 , C07D307/52 , C07D307/80 , C07D307/81 , C07D333/20 , C07D333/28 , C07D333/58
摘要： The present invention relates to the use of an Ih channel modulator in the manufacture of a medicament for use in psychiatry. To certain novel methanamine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly for use in psychiatry.
摘要翻译：本发明涉及Ih通道调节剂在制造用于精神病学的药物中的用途。某些新的甲胺衍生物，其制备方法，含有它们的药物制剂及其在药物治疗中的用途，特别是用于精神病学。

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