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1. 发明申请

WO0205873A3 DEVICES AND METHODS FOR INFUSING A LIQUID INTO A CATHETER 审中-公开
标题翻译：用于将液体输入到导管器中的装置和方法
公开(公告)号：WO0205873A3
公开(公告)日：2002-09-06
申请号：PCT/US0141362
申请日：2001-07-13
申请人： ASH MEDICAL SYSTEMS INC , MANKUS RITA A , ASH STEPHEN R
发明人： MANKUS RITA A , ASH STEPHEN R
IPC分类号： A61J1/05 , A61J1/10 , A61M1/14 , A61M1/28 , A61M5/14 , A61M5/142 , A61M5/168 , A61M25/00 , A61M31/00 , A61M39/00 , A61M39/02 , A61M5/178
CPC分类号： A61M25/0017 , A61M1/285 , A61M5/1424 , A61M2005/1403 , A61M2202/0478
摘要： This invention generally relates to devices (1), methods and kits for use in connection with catheter, and more particularly to devices, methods and kits for infusing a liquid into a catheter, such as, for example, transcutaneous body access catheter. In one aspect, the invention involves infusing a lock solution into an indwelling catheter for preventing occlusion of the catheter and for inhibiting infection.
摘要翻译：本发明总体上涉及用于与导管结合使用的装置（1），方法和试剂盒，更具体地涉及用于将液体注入导管例如经皮体进入导管的装置，方法和试剂盒。一方面，本发明涉及将锁定溶液注入留置导管，以防止导管堵塞并抑制感染。

2. 发明申请

WO2016081653A1 GAS EXCHANGE COMPOSITE MEMBRANES AND METHODS OF USE THEREOF 审中-公开
标题翻译：气体交换复合膜及其使用方法
公开(公告)号：WO2016081653A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061422
申请日：2015-11-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： ROY, Shuvo , YEAGER, Torin , ABADA, Emily , DHARIA, Ajay S.
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/267 , A61M2202/0478 , A61M2207/00 , A61M2209/088 , B01D53/228 , B01D69/02 , B01D69/12 , B01D71/70 , B01D2257/104 , B01D2325/02 , B01D2325/04 , B01D2325/20
摘要： Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.
摘要翻译：本文提供气体交换复合膜及其制造方法。气体交换复合膜可以用于需要血氧饱和支持的受试者中与血液交换气体的方法，该方法也被公开。本文还提供了用于执行与血液交换气体的方法的系统和试剂盒。

3. 发明申请

WO2002062335A2 APPARATUS AND METHODS FOR PREVENTING OR TREATING FAILURE OF HEMODIALYSIS VASCULAR ACCESS AND OTHER VASCULAR GRAFTS 审中-公开
标题翻译：用于预防或治疗血液透析和血管收缩功能障碍的装置和方法
公开(公告)号：WO2002062335A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/001375
申请日：2002-01-16
申请人： VASCULAR THERAPIES, LLC
发明人： IYER, Sriram, S. , KIPSHIDZE, Nicholas, N. , NIKOLAYCHIK, Victor, V.
IPC分类号： A61K31/395
CPC分类号： A61K31/436 , A61K9/0024 , A61K31/122 , A61K31/337 , A61K31/395 , A61K31/573 , A61K31/727 , A61L27/20 , A61L27/225 , A61L27/44 , A61L27/54 , A61L31/16 , A61L2300/204 , A61L2300/252 , A61L2300/416 , A61M1/16 , A61M1/3655 , A61M39/0247 , A61M2039/0258 , A61M2039/0261 , A61M2202/0468 , A61M2202/0478
摘要： This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material. Methods of perivascular antiproliferative drug administration also are disclosed.
摘要翻译：用于预防，抑制（抑制）或治疗血液透析血管通路和其它血管移植物从血管或移植物腔内外并通过血管壁（血管外或血管周围）的失败的治疗性植入物，装置和方法。可植入装置包含可再吸收的基质材料（例如胶原，纤维蛋白，壳聚糖）和抗调节剂，例如3雷帕霉素，紫杉醇，他克莫司等和其它细胞周期抑制剂或类似功能的药剂。

4. 发明申请

WO99062583A1 SYSTEM FOR WITHDRAWAL OF BLOOD 审中-公开
标题翻译：撤回血液系统
公开(公告)号：WO99062583A1
公开(公告)日：1999-12-09
申请号：PCT/US1999/010485
申请日：1999-06-01
IPC分类号： A61B5/15 , A61M1/00 , A61M1/02 , A61M1/36 , A61M25/18 , A61M25/00
CPC分类号： A61M1/02 , A61M1/0001 , A61M1/0023 , A61M1/3672 , A61M2202/0478 , Y10T137/86823
摘要： The invention comprises a disposable tubing set (4) for connection to a rigid canister (2) that is maintained at a controlled reduced (vacuum) pressure. The set is used for collecting and anti-coagulating a patient's blood for later re-infusion into the same patient.
摘要翻译：本发明包括用于连接到刚性罐（2）的一次性管道组件（4），其保持在受控的减小（真空）压力。该组用于收集和抗凝血患者的血液，以便以后重新输注到同一患者。

5. 发明申请

WO1996025186A2 FEEDBACK CONTROLLED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：反馈控制药物递送系统
公开(公告)号：WO1996025186A2
公开(公告)日：1996-08-22
申请号：PCT/US1996001221
申请日：1996-01-30
申请人： GENSIA, INC.
发明人： GENSIA, INC. , HILLMAN, Robert, Steven , VALCKE, Christian, P. , GAUTHIER, Robert, T. , GORIN, Michael, Morduch
IPC分类号： A61M00/00
CPC分类号： G01N33/4905 , A61M5/1723 , A61M39/105 , A61M39/16 , A61M2005/1403 , A61M2202/0478 , A61M2230/20 , G01N33/48707 , G06F19/00 , A61M2202/0007
摘要： A feedback controlled drug delivery system includes automated blood sampling and analysis and dosing of the patient. Automated sampling is performed by direct analysis of patient blood, such as for measurement of its coagulation state. A novel manifold includes a fluid input port, a patient port adapted to output fluid and to receive a blood sample from the patient, and a fluid pathway connecting the fluid port and the patient port. A sample line is connected to the fluid pathway to provide the sample to an analyzer. In one aspect of this invention, the sample is forced through the sample line by isolating the patient port, such as by a valve, and non-drug fluid is forced into the manifold causing the blood to cross through the sample line. In another embodiment, an integrated assembly includes an integrated peristaltic pump, valve assembly, selectively movable actuator and integrated waste container. In one aspect, the peristaltic pump permits retraction of the rollers away from the inner circumference of the pump, so as to reduce deformation of the peri-pump tube and to permit sterilization.
摘要翻译：反馈控制的药物递送系统包括患者的自动血液取样和分析和给药。通过直接分析患者血液进行自动采样，例如用于测量其凝血状态。新颖的歧管包括流体输入端口，适于输出流体并从患者接收血液样本的患者端口以及连接流体端口和患者端口的流体通路。样品管线连接到流体通道以将样品提供给分析仪。在本发明的一个方面，样品通过例如通过阀门隔离患者端口而被迫通过样品管线，并且非药物流体被迫进入歧管中，导致血液穿过样品管线。在另一个实施例中，集成组件包括集成的蠕动泵，阀组件，选择性地可移动致动器和集成的废物容器。在一个方面，蠕动泵允许辊离开泵的内周回缩，以便减少周围泵管的变形并允许灭菌。

6. 发明申请

WO2019147903A1 FLUSH SYRINGE WITH SHIELDED TIP 审中-公开
公开(公告)号：WO2019147903A1
公开(公告)日：2019-08-01
申请号：PCT/US2019/015097
申请日：2019-01-25
申请人： BECTON, DICKINSON AND COMPANY
发明人： MAHMOODIAN, Roza
IPC分类号： A61M5/31 , A61M39/20
CPC分类号： A61M5/3137 , A61M5/3134 , A61M5/3148 , A61M5/31511 , A61M39/20 , A61M2005/1403 , A61M2005/3104 , A61M2202/0478
摘要： Flush syringe assemblies are described herein. Such flush syringe assembly may include a barrel including a side wall defining a chamber, an open proximal end, a distal end having a distal wall with an elongate tip extending distally therefrom having a passageway therethrough in fluid communication with said chamber. A collar may 5 be mounted on the distal wall of the barrel and surrounding the elongate tip. The flush syringe assembly may also include a removable cap.

7. 发明申请

WO2016020062A1 VERFAHREN ZUM SPÜLEN EINES EXTRAKORPORALEN BLUTKREISLAUFS 审中-公开
标题翻译：方法用于冲洗体外血液回路
公开(公告)号：WO2016020062A1
公开(公告)日：2016-02-11
申请号：PCT/EP2015/001619
申请日：2015-08-05
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： WOJKE, Ralf , WIENEKE, Paul
IPC分类号： A61M1/36
CPC分类号： A61M1/3643 , A61M1/3644 , A61M1/3673 , A61M2202/0478
摘要： Die Erfindung betrifft ein Verfahren zum Spülen eines extrakorporalen Blutkreislaufs, vorzugsweise eines extrakorporalen Blutkreislaufs einer Dialysemaschine, mit einer Spülflüssigkeit, wobei die Spülflüssigkeit ein gerinnungshemmendes Mittel, vorzugsweise Heparin enthält. Die Erfindung betrifft ferner eine extrakorporale Blutbehandlungseinheit, vorzugsweise Dialysemaschine mit einem extrakorporalen Blutkreislauf und einer Steuereinheit, wobei die Steuereinheit ausgebildet ist, um ein Spülverfahren gemäß einem der vorhergehenden Ansprüche vor Beginn der Behandlung und/oder intermittierend während der Behandlung durchzuführen.
摘要翻译：本发明涉及一种方法，用于漂洗优选的透析机的体外血液回路用冲洗液，其中，所述冲洗液包括抗凝血剂，优选肝素体外血液回路。本发明还涉及一种体外血液处理单元，具有体外血液回路和控制单元优选透析机，其中，所述控制单元适于根据治疗的和/或治疗过程中间歇地开始前的前述权利要求中的任一项来执行漂洗过程。

8. 发明申请

WO2005102417A2 AN INFUSION DEVICE FOR MEDICAL FLUIDS. 审中-公开
标题翻译：医用流体输液装置。
公开(公告)号：WO2005102417A2
公开(公告)日：2005-11-03
申请号：PCT/IB2005000893
申请日：2005-04-06
申请人： GAMBRO LUNDIA AB , TONELLI CLAUDIO , LIGABUE ANDREA , CESTARI SILVANO
发明人： TONELLI CLAUDIO , LIGABUE ANDREA , CESTARI SILVANO
IPC分类号： A61M1/14 , A61M1/36 , A61M5/145 , A61M5/168 , A61M37/00 , B67D7/22 , B67D7/30
CPC分类号： A61M5/1456 , A61M1/3672 , A61M5/16854 , A61M2202/0478 , A61M2205/18 , A61M2205/332 , A61M2205/50 , A61M2205/52
摘要： The infusion device comprises a pusher for a plunger (10) of a syringe (6) containing a liquid to be infused. A load cell (14) measures the push force. An encoder associated to a motor (13) commanding the pusher measures the displacement of the pusher. A controller (15) signals an alarm when the ratio between the variation of the push force and the displacement exceeds a predetermined threshold. The device, which serves for infusing an anticoagulant into an extracorporeal blood circuit in a dialysis apparatus, is able to signal an onset of an anomalous situation of lack of infusion in good time.
摘要翻译：输注装置包括用于包含要注入的液体的注射器（6）的柱塞（10）的推动器。称重传感器（14）测量推力。与驱动推动器的马达（13）相关联的编码器测量推动器的位移。当推力和位移的变化之比超过预定阈值时，控制器（15）发出报警。用于在透析设备中将抗凝血剂注入体外血液回路中的装置能够及时发出缺乏输注的异常情况的发作。

9. 发明申请

WO9625186A3 FEEDBACK CONTROLLED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：反馈控制药物递送系统
公开(公告)号：WO9625186A3
公开(公告)日：1996-09-26
申请号：PCT/US9601221
申请日：1996-01-30
申请人： GENSIA INC
发明人： HILLMAN ROBERT STEVEN , VALCKE CHRISTIAN P , GAUTHIER ROBERT T , GORIN MICHAEL MORDUCH
IPC分类号： G01N33/48 , A61M1/02 , A61M5/00 , A61M5/14 , A61M5/172 , A61M39/16 , G01N33/487 , G01N33/49 , G01N35/00 , G01N35/04 , A61M
CPC分类号： G01N33/4905 , A61M5/1723 , A61M39/105 , A61M39/16 , A61M2005/1403 , A61M2202/0478 , A61M2230/20 , G01N33/48707 , A61M2202/0007
摘要： A feedback controlled drug delivery system includes the automated sampling and analysis of a patient sample and dosing the patient based on the analysis. Automated sampling may be performed by direct analysis of the patient sample, such as for the measurement of a blood sample coagulation state or a glucose level. The drug delivery system includes a sample set that has a bidirectional patient tube that allows for delivery of the patient sample to an analyzer, and at another time, the infusion of a therapeutic drug. A controller receives a measurement from the analyzer, and based on that measurement, adjusts the delivery of the therapeutic fluid. The sample set has a quick-clear Leur fitting that allows for more effectively clearing a first fluid from a Leur fitting when starting a second fluid. The system also has a reagent cassette holder that protects, using a foam gasket, a reagent on a sample slide. Further, the system provides an interlock apparatus that assures a sample tube is occluded by either or both a slide clamp and by a platen arm compressing the sample tube to a peristaltic pump.

10. 发明申请

WO2013188073A1 USE OF HEPARIN AND CARBOHYDRATES TO TREAT CANCER 审中-公开
标题翻译：使用肝素和碳水化合物治疗癌症
公开(公告)号：WO2013188073A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/042377
申请日：2013-05-23
申请人： EXTHERA MEDICAL, LLC
发明人： MCCREA, Keith , WARD, Robert , LARM, Olle
IPC分类号： A61M1/36 , A61K31/60
CPC分类号： A61M1/34 , A61K31/727 , A61M1/3679 , A61M2202/0478 , A61M2202/07 , A61M2205/3334 , A61M2205/7545
摘要： The method is described as the removal of mediators that contribute to the pathogenesis of cancer from blood by contacting the blood with a solid, essentially non-micro-porous substrate which has been surface treated with heparin, heparan sulfate and, optionally, other molecules or chemical groups (the adsorbent media or media) having a binding affinity to the mediator, and wherein the size of the interstitial channels within said substrate are balanced with the amount of interstitial substrate surface area such that high flow rates of blood past said substrate creates a flow transport that is characterized by convection transport more than Brownian diffusion transport.
摘要翻译：该方法描述为通过使血液与已经用肝素，硫酸乙酰肝素和任选的其它分子表面处理的固体，基本上非微孔的底物接触，从血液中除去有助于癌症发病的介质，或具有与介体结合亲和力的化学基团（吸附介质或介质），并且其中所述衬底内的间质通道的尺寸与间隙衬底表面积的量平衡，使得血液通过所述衬底的高流速产生流量运输的特点是对流运输超过布朗传播。

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