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1. 发明申请

WO2009143890A1 LEBENSERHALTUNGSSYSTEM 审中-公开
标题翻译：生命保障系统
公开(公告)号：WO2009143890A1
公开(公告)日：2009-12-03
申请号：PCT/EP2008/056600
申请日：2008-05-29
申请人： SORIN GROUP DEUTSCHLAND GMBH , HAHN, Andreas , KNOTT, Erwin
发明人： HAHN, Andreas , KNOTT, Erwin
IPC分类号： A61M1/36
CPC分类号： A61M1/3621 , A47B2200/0078 , A61B5/00 , A61M1/3664 , A61M1/3666 , A61M2205/502 , A61M2209/08
摘要： Die Erfindung besieht sich auf ein Lebenserhaltungssystem, insbesondere eine Herz-Lungen-Maschine (2), das eine Mehrzahl medizinischer Geräte (4.1-4.4), ein Bedienpaneel (6) und eine ausgezeichnete Bedienposition (8) umfasst. Dabei weist das Bedienpaneel (6) separate Bedienelemente (10.1-10.4) zum Bedienen der medizinischen Geräte (4.1-4.4) auf und ist dadurch gekennzeichnet, dass das Bedienpaneel (6) im Wesentlichen flächig über eine Grundfläche (12) der Mehrzahl medizinischer Geräte (4.1-4,4) auskragend ausgebildet ist. Das Bedienpaneel (6) ist dabei derart auskragend ausgebildet, dass jedem Gerät (4.1-4,4) ein mit nur diesem der Geräte (4.1-4.4) und mit der Bedienposition (8) fluchtendes Bedienelement (10.1-10,4) zugeordnet ist.
摘要翻译：本发明将看到的生命维持系统，在具有多个医疗设备（4.1-4.4），控制面板特别是心脏 - 肺机（2）（6）和极好的操作位置（8）。在这种情况下，控制面板（6）个单独的控制元件（10.1-10.4）用于操作所述医疗装置（4.1-4.4），并且其特征在于所述控制面板（6）（在所述多个医疗设备中的一个区域（12）基本上是平的 4.1-4,4）的悬臂。控制面板（6）被设计成以突出方式，每个设备（4.1-4,4）一个仅与该设备（4.1-4.4），并与端部操作位置对准（8）的操作元件（10.1-10,4）与相关联的，

2. 发明申请

WO0226286A3 BLOOD PERFUSION SYSTEM 审中-公开
标题翻译：血液灌注系统
公开(公告)号：WO0226286A3
公开(公告)日：2002-09-12
申请号：PCT/US0130301
申请日：2001-09-26
申请人： COBE CARDIOVASCULAR INC
发明人： ELLINGBOE BRUCE , DALKE WILLIAM , INGEBRIGTSEN J , KAPPUS JOHN , KOLLAR KEVIN , LAWRENCE BRUCE , SCHWAB MIKE , CARSON GARY
IPC分类号： A61M1/36 , A61M37/00 , C02F9/00
CPC分类号： A61M1/32 , A61M1/322 , A61M1/3621 , A61M1/3624 , A61M1/3626 , A61M1/3632 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3663 , A61M1/3664 , A61M1/3666 , A61M1/3667 , A61M2205/123 , A61M2205/128 , A61M2205/3389 , A61M2205/505 , A61M2205/705 , A61M2205/707 , A61M2209/082
摘要： An extracorporeal blood perfusion system (1) includes a disposable assembly (100) and a control unit (10) having a control interface region (50). The interface region includes pump assemblies (31-36) for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood, and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface (50) is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display (54) may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.
摘要翻译：体外血液灌注系统（1）包括具有控制界面区域（50）的一次性组件（100）和控制单元（10）。界面区域包括用于选择性抽取静脉血，动脉血，心麻痹液，抽吸血液和从左心室移除的血液的泵组件（31-36）。阀组件控制通过组件和/或从患者流出的流体，并且传感器监测各种流体参数，包括各种流体回路内的温度和压力。用户接口（50）是用于实现控制单元和阀组件的操作的功能屏幕界面。屏幕界面可以是具有对应于组件接口区域的对象的触摸屏。可以选择性地控制显示器（54），以提供具有相应叙述指令的一次性组装部件的图形描绘。

3. 发明申请

WO0073763A3 SYSTEMS AND METHODS OF pH TISSUE MONITORING 审中-公开
标题翻译： pH组织监测系统与方法
公开(公告)号：WO0073763A3
公开(公告)日：2001-07-05
申请号：PCT/US0014766
申请日：2000-05-26
申请人： MONITORS INC E , KHURI SHUKRI F
发明人： KHURI SHUKRI F
IPC分类号： A61B5/0408 , A61B5/00 , A61B5/0478 , A61B5/0492 , A61B5/145 , A61B5/1473 , A61M1/36 , G01N33/487 , A01N1/02 , A61B17/00 , G01N27/416 , G01N33/49
CPC分类号： A61M1/3621 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/1495 , A61B5/413 , A61B5/6848 , A61B5/742 , A61M1/3613 , A61M1/3664
摘要： The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Real time tissue pH measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site.
摘要翻译：本发明涉及使用组织的pH测量作为用于控制诊断和/或外科手术的系统。本发明还涉及用于进行组织pH测量的装置。实时组织pH测量可以用作确定组织缺血段的方法，并为外科手术期间和之后的使用者提供行为进程。当发现局部缺血存在于组织中时，使用者可以将保存液体最佳地输送到感兴趣的部位和/或影响该过程的改变以提高部位的pH。

4. 发明申请

WO00073763A2 SYSTEMS AND METHODS OF pH TISSUE MONITORING 审中-公开
标题翻译： pH组织监测系统与方法
公开(公告)号：WO00073763A2
公开(公告)日：2000-12-07
申请号：PCT/US2000/014766
申请日：2000-05-26
IPC分类号： A61B5/0408 , A61B5/00 , A61B5/0478 , A61B5/0492 , A61B5/145 , A61B5/1473 , A61M1/36 , G01N33/487 , G01N
CPC分类号： A61M1/3621 , A61B5/14539 , A61B5/14542 , A61B5/1473 , A61B5/1495 , A61B5/413 , A61B5/6848 , A61B5/742 , A61M1/3613 , A61M1/3664
摘要： The invention relates to the use of pH measurements of tissue as a system for controlling diagnostic and/or surgical procedures. The invention also relates to an apparatus used to perform tissue pH measurements. Real time tissue pH measurements can be used as a method to determine ischemic segments of the tissue and provide the user with courses of conduct during and after a surgical procedure. When ischemia is found to be present in a tissue, a user can effect an optimal delivery of preservation fluids to the site of interest and/or effect a change in the conduct of the procedure to raise the pH of the site.
摘要翻译：本发明涉及使用组织的pH测量作为用于控制诊断和/或外科手术的系统。本发明还涉及用于进行组织pH测量的装置。实时组织pH测量可以用作确定组织缺血段的方法，并为外科手术期间和之后的使用者提供行为进程。当发现局部缺血存在于组织中时，使用者可以将保存液体最佳地输送到感兴趣的部位和/或影响该过程的改变以提高部位的pH。

5. 发明申请

WO2019086631A1 EXTRACORPOREAL BLOOD HEATING AND COOLING SYSTEM AND METHOD OF OPERATING AND MAINTAINING SAME 审中-公开
公开(公告)号：WO2019086631A1
公开(公告)日：2019-05-09
申请号：PCT/EP2018/080054
申请日：2018-11-02
申请人： MAQUET CARDIOPULMONARY GMBH
发明人： REICHL, Herwig Ernst
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/3664 , A61M1/1629 , A61M1/169 , A61M1/1698 , A61M1/32 , A61M1/3666 , A61M2202/0472 , A61M2205/0205 , A61M2205/025 , A61M2205/3368 , A61M2205/36 , A61M2205/3606 , A61M2205/366
摘要： An extracorporeal blood heating and cooling system that is connectable to an oxygenator of a cardiopulmonary bypass system, the heating and cooling system comprising: a heater-cooler unit; a coolant flow circuit that is configured to pass coolant through the heater-cooler unit and the oxygenator; and a cardioplegia coolant circuit that is configured to pass coolant through the heater-cooler unit and a cardioplegia heat exchanger; wherein when the heating and cooling system is in a purging mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-35 millimole/liter; wherein when the heating and cooling system is in a coolant mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-10 millimole/liter; and wherein when the heating and cooling system is in the coolant mode or the purging mode, a first and second plurality of coolant conduits within the oxygenator and the cardioplegia heat exchanger are capable of maintaining a trisodium phosphate concentration ratio across the wall of such coolant conduits of at least 100:1, from the interior to the exterior of each coolant conduit. Methods of purging and operating such extracorporeal blood heating and cooling systems are also disclosed.

6. 发明申请

WO2010009421A1 METHOD AND APPARATUS FOR MITIGATING ACUTE REOXYGENATION INJURY DURING PERCUTANEOUS CORONARY INTERVENTION 审中-公开
标题翻译：用于缓解冠状动脉介入治疗期间急性再氧化损伤的方法和装置
公开(公告)号：WO2010009421A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/051033
申请日：2009-07-17
申请人： RHEOXTECH, LLC , THOMAS, Neil, J. , VAISNYS, Gintaras, A.
发明人： THOMAS, Neil, J. , VAISNYS, Gintaras, A.
IPC分类号： A61M1/32
CPC分类号： A61M1/3613 , A61M1/1698 , A61M1/32 , A61M1/36 , A61M1/3664 , A61M1/3666 , A61M5/1723 , A61M25/10 , A61M25/104 , A61M2025/1095 , A61M2202/0439 , A61M2205/3306 , A61M2205/3375 , A61M2230/005 , A61M2230/205
摘要： A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based subsystem which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.
摘要翻译：描述了用于改善急性冠状动脉综合征期间缺血性心脏组织的管理的系统和方法。该系统结合了基于导管的子系统，其允许冠状动脉的同时气囊扩张以及在经皮冠状动脉介入期间输注精心控制的灌注液。该系统允许在经皮干预时调节氧气的水平。此外，提供导管和系统用于在干预期间施用具有改进的氧含量的流体，其包括上游流动控制构件以区分目标冠状动脉和心脏的其余部分的灌注。

7. 发明申请

WO2004091691A3 CONDENSED PERFUSION CIRCUIT FOR CARDIOPULMONARY BYPASS AND CARDIOPLEGIA 审中-公开
标题翻译：用于心脏旁路和心脏的冷凝灌注电路
公开(公告)号：WO2004091691A3
公开(公告)日：2005-05-06
申请号：PCT/US2004009639
申请日：2004-03-30
申请人： VK CARDIOVASCULAR TECH INC
发明人： VIJAY VENKATARAMANA , MCCUSKER KEVIN
IPC分类号： A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3664 , A61M1/1698 , A61M1/3606 , A61M1/3621 , A61M1/3627 , A61M1/3666 , A61M2202/047
摘要： A total condensed circuit for cardiopulmonary bypass and cardioplegia (100) are provided, as well as methods of using the same. The total circuit includes a cardiopulmonary bypass portion (104) including tubing (154) and components which together have a substantially short path length and priming volume preferably under 800 ml. Thus, the opportunity for an inflammatory response caused by blood contacting plasticizers is minimized. The bypass circuit (102) includes a shunt (136), which bypasses a blood reservoir of the total circuit. The cardioplegia circuit infuses cardioplegia fluid into blood pulled from an oxygenator (128) of the bypass circuit. According to the method, either or both of heart-lung bypass and cardioplegia can be performed with only minimal or no isotonic priming solution circulated into the patient. In addition, use of the shunt and reservoir together eliminate the possibility of air entering the circulation system upon kinking of the circuit.
摘要翻译：提供了用于心肺转流和心脏停搏（100）的总体冷凝回路，以及使用它们的方法。总电路包括包括管道（154）的心肺旁路部分（104）和一起具有基本上短的路径长度的组件，并且起泡体积优选低于800ml。因此，由血液接触增塑剂引起的炎症反应的机会被最小化。旁路电路（102）包括旁路（136），其旁路总电路的血液储存器。心麻痹电路将心麻痹液注入从旁路回路的氧合器（128）抽取的血液中。根据该方法，可以仅使用循环到患者中的最小或不等渗启动溶液来执行心肺旁路和心麻痹中的任一者或两者。此外，使用分流器和水箱一起消除了空气在电路扭结时进入循环系统的可能性。

8. 发明申请

WO2002072170A2 BALLOON CATHETER AND METHOD OF USE 审中-公开
标题翻译：气囊导管及使用方法
公开(公告)号：WO2002072170A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007070
申请日：2002-03-07
申请人： GALLAGHER, Robert, C.
发明人： GALLAGHER, Robert, C.
IPC分类号： A61M
CPC分类号： A61M1/3653 , A61M1/3613 , A61M1/3656 , A61M1/3659 , A61M1/3664
摘要： A retrograde venous cardioplegia balloon catheter (20) has a flexible cannula (22) on which is mounted an inflatable, tapered balloon (34) which divides the flexible cannula (22) into a proximal portion (22a) which is stiffer than a distal portion (22b). Balloon (34) may be inserted into a body opening, such as the ostium (46) of a human heart (52) to position soft, flexible distal portion (22b) within the coronary sinus (44). Balloon (34) is inflated to seal the ostium (46) and force may be applied by means of the stiff proximal portion (22a) to maintain the turgid balloon (34) in place to seal the ostium and leave substantially the entire coronary sinus (44) open to infusion by cardioplegia solution. A method of using the balloon catheter (20) includes positioning inflatable balloon (34) within the ostium (46) and imposing a force (e.g., by collapsing the right atrial wall) via distal portion (22b) on balloon (34) in its turgid condition, to maintain it in place within ostium (46).
摘要翻译：逆向静脉心脏停搏液气囊导管（20）具有柔性插管（22），柔性插管（22）上安装有可充气的锥形球囊（34），该球囊将柔性插管（22）分成近端部分）比远端部分（22b）更硬。球囊（34）可以插入身体开口（例如人类心脏（52）的开口（46））中，以将柔软的柔性远侧部分（22b）定位在冠状窦（44）内。球囊（34）充气以密封孔口（46），并且可以借助于刚性近端部分（22a）施加力以将turgid球囊（34）保持在适当位置以密封孔口并基本上留下整个冠状窦 44）可通过心麻痹溶液输注。使用球囊导管（20）的方法包括将可膨胀球囊（34）定位在孔口（46）内并通过其球囊（34）上的远端部分（22b）施加力（例如通过塌陷右心房壁） turgid条件下，将其保持在孔内（46）。

9. 发明申请

WO01017582A3 BIFURCATED SHUNT DRUG DELIVERY SYSTEM AND METHODS OF USE 审中-公开
标题翻译：分流分药物输送系统及使用方法
公开(公告)号：WO01017582A3
公开(公告)日：2001-09-13
申请号：PCT/US2000/024880
申请日：2000-09-11
IPC分类号： A61B17/00 , A61B17/12 , A61B17/34 , A61M1/36 , A61M39/02 , A61M39/10 , A61M5/00 , A61M25/00 , B65D69/00 , B65D71/00
CPC分类号： A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/3421 , A61B2017/00243 , A61B2017/00252 , A61B2017/12127 , A61M1/3613 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3664 , A61M39/0208
摘要： Bifurcated intraluminal shunt devices (10/10'/10''/10''') and methods of their use for delivering a drug or other fluid to a target vessel (11/12/13) of a patient while maintaining perfusion of blood through the vessel to reduce ischemia downstream of the vessel are disclosed.
摘要翻译：分叉管腔内分流器及其用于将药物或其他流体输送到患者的靶血管中同时保持血管在血管中灌注以减少血管的血流灌注船。

10. 发明申请

WO1996039211A1 METHOD AND SYSTEM FOR OBTAINING TARGET INFUSION DOSAGE 审中-公开
标题翻译：用于获取目标输注剂量的方法和系统
公开(公告)号：WO1996039211A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008808
申请日：1996-06-05
申请人： COBE LABORATORIES, INC.
发明人： COBE LABORATORIES, INC. , ELLINGBOE, Bruce, S.
IPC分类号： A61M05/168
CPC分类号： A61M5/16827 , A61M1/361 , A61M1/3664 , A61M5/1723 , A61M2205/366 , A61M2209/082 , Y10S128/03
摘要： A method and system are disclosed for more accurate administration of a composition being infused into a body fluid having formed elements. The improved accuracy is due to a correction factor that corrects for the relative impermeability of the formed elements to the infused composition. In one embodiment, the infusion system is a cardioplegia system in which a controller receives information pertaining to the hematocrit and initial blood potassium concentration and adjusts blood flow rate and crystalloid (KCl) solution flow rate so as to obtain the desired resulting potassium concentration in the cardioplegia. The invention further includes an infusion system that comprises a controller which uses an equation that relates the correction factor to an index of formed elements in the body fluid, such as the hematocrit. The equation is determined empirically from a series of experiments in which the resulting concentration of the substance infused into the body fluid is correlated to a formed element index of the body fluid, such as hematocrit.
摘要翻译：公开了一种方法和系统，用于更精确地施用注入具有形成元件的体液中的组合物。改进的精确度是由于校正因子，其校正了形成的元件对于输注的组合物的相对不渗透性。在一个实施例中，输注系统是心脏停搏系统，其中控制器接收关于血细胞比容和初始血液钾浓度的信息，并且调节血液流速和晶体（KCl）溶液流速，以获得所需的所得钾浓度停搏。本发明还包括输注系统，其包括控制器，该控制器使用将校正因子与体液中形成的元件的指数（例如血细胞比容）相关联的方程式。该方程式是从一系列实验确定的，其中输入体液中的物质的浓度与体液的形成的元素指数（例如血细胞比容）相关。

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