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1. 发明申请

WO2015077401A1 COMPOSITIONS AND METHODS FOR MACROPHAGE CONVERSION 审中-公开
标题翻译：组合物和方法转化
公开(公告)号：WO2015077401A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/066517
申请日：2014-11-20
申请人： DREXEL UNIVERSITY
发明人： SPILLER, Kara L. , NASSIRI, Sina
IPC分类号： A61L27/40
CPC分类号： A61L26/0066 , A61K38/2026 , A61K38/2066 , A61L26/0023 , A61L26/0038 , A61L26/0047 , A61L26/008 , A61L27/20 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/426 , A61L2300/608 , A61L2300/622 , C08L5/04 , C08L5/08 , C08L89/00 , C08L89/04
摘要： The present invention describes methods and compositions of hydrogel microspheres for inducing macrophage conversion by sequentially converting a first population of wound macrophages in a wound to M2A macrophages by exposing the first population of wound macrophages to IL-4 and converting a second population of wound macrophages to M2C macrophages by exposing the second population of wound macrophages to IL-10. One aspect describes a method of inducing macrophage conversion in a wound. Another aspect describes compositions and methods of preparing a hydrogel microsphere for wound healing. Yet another aspect describes methods for treating a chronic wound with hydrogel microspheres.
摘要翻译：本发明描述了通过将伤口巨噬细胞的第一群暴露于IL-4并将第二组伤口巨噬细胞转化为第二组伤口巨噬细胞，将伤口巨噬细胞中的第一群伤口依次转化为M2A巨噬细胞来诱导巨噬细胞转化的水凝胶微球的方法和组合物 M2C巨噬细胞通过将第二组伤口巨噬细胞暴露于IL-10。一方面描述了在伤口中诱导巨噬细胞转化的方法。另一方面描述了制备用于伤口愈合的水凝胶微球的组合物和方法。另一方面描述了用水凝胶微球治疗慢性伤口的方法。

2. 发明申请

WO2013117298A1 BIODEGRADIERBARES VLIES FÜR MEDIZINISCHE ZWECKE 审中-公开
标题翻译：可生物降解的抓绒用于医疗目的
公开(公告)号：WO2013117298A1
公开(公告)日：2013-08-15
申请号：PCT/EP2013/000198
申请日：2013-01-23
申请人： HERAEUS MEDICAL GMBH , CARL FREUDENBERG KG
发明人： VOGT, Sebastian , COPANAKI, Ekaterini , GRAFAHREND, Dirk , REIBEL, Denis , NEUMÜLLER, Dirk
IPC分类号： A61L15/32 , A61L26/00 , A61F13/00
CPC分类号： A61L26/0038 , A61L24/0015 , A61L24/0042 , A61L24/08 , A61L24/102 , A61L24/104 , A61L26/0004 , A61L26/0066 , A61L2300/404 , A61L2300/418 , A61L2400/04 , D01D10/00 , C08L1/04 , C08L1/286 , C08L5/02
摘要： Die Erfindung betrifft ein biodegradierbares Vlies enthaltend (i) wenigstens ein Polymer zum Induzieren der primären Hämostase, (ii) wenigstens einen nichtproteinogenen, niedermolekularen, in Wasser löslichen Aktivator der sekundären Hämostase und (iii) wenigstens einen nicht-proteinogenen, niedermolekularen, in Wasser löslichen Inhibitor der Fibrinolyse. Die Erfindung betrifft auch ein Verfahren zur Herstellung eines biodegradierbaren Vlieses bei dem (i) ein fluidisiertes Faserrohmaterial gegebenenfalls mit Additiven in ein Behältnis gegeben wird, (ii) das Behältnis in Rotation versetzt wird, (iii) das fluidisierte Faserrohmaterial durch Zentrifugalkräfte aus dem Behältnis ausgetragen wird, wodurch Fasern oder Filamente gebildet werden, und (iv) aus den Fasern oder Filamenten ein biodegradierbares Vlies gebildet wird. Die Erfindung betrifft auch die Verwendung eines solchen biodegradierbaren Vlieses als lokales Hämostyptikum.
摘要翻译：本发明涉及一种可生物降解的无纺织物包括：（i）诱导初级止血中的至少一种聚合物，（ii）至少一种非蛋白原，低分子量，次级止血和（iii）至少一种非蛋白原，低分子量，水溶性的水溶性活化剂纤维蛋白溶解的抑制剂。本发明还涉及一种制造，其中（i）流化纤维原料任选地与添加剂加入在容器中的可生物降解的无纺织物的方法，（ii）所述容器被置于旋转，（iii）所述流化纤维原料通过离心力排出到容器的是，由此纤维或长丝而形成，和（iv）从所述纤维或长丝中形成生物降解的无纺。本发明还涉及使用这样的可生物降解的无纺织物作为本地止血剂。

3. 发明申请

WO2013028672A1 PROTECTIVE WOUND DRESSING DEVICE FOR ORAL AND PHARYNGEAL SPACE 审中-公开
标题翻译：用于口腔和皮肤空间的保护性接头装置
公开(公告)号：WO2013028672A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051691
申请日：2012-08-21
申请人： ETHICON, INC. , KEPLINGER, Scott, Alan
发明人： KEPLINGER, Scott, Alan
IPC分类号： A61L15/24 , A61L15/32 , A61L15/58 , A61L15/62 , A61L15/64 , A61L24/06 , A61L26/00 , A61F13/02
CPC分类号： A61L26/0052 , A61F13/122 , A61L15/24 , A61L15/32 , A61L15/58 , A61L15/62 , A61L15/64 , A61L24/06 , A61L26/0014 , A61L26/0038 , A61L2430/36 , C08L29/04 , C08L35/04
摘要： The present invention provides a wound dressing comprising a tessellated water-soluble molding matrix comprised of a polymer selected from the group consisting of polyvinyl alcohol, gelatin, and mixtures thereof and a 1,1-disubstituted ethylene monomer. The present invention further provides methods of using the wound dressing and kits containing the wound dressing.
摘要翻译：本发明提供了一种伤口敷料，其包括由选自聚乙烯醇，明胶及其混合物的聚合物和1,1-二取代的乙烯单体组成的镶嵌水溶性成型基质。本发明还提供使用伤口敷料和包含伤口敷料的试剂盒的方法。

4. 发明申请

WO1997041899A1 NEW MEDICAMENTS CONTAINING GELATIN CROSS-LINKED WITH OXIDIZED POLYSACCHARIDES 审中-公开
标题翻译：含有与氧化多糖交联的凝胶的新药
公开(公告)号：WO1997041899A1
公开(公告)日：1997-11-13
申请号：PCT/EP1997002279
申请日：1997-05-05
申请人： INNOGENETICS N.V. , SCHACHT, Etienne , DRAYE, Jean-Pierre , DELAEY, Bernard
发明人： INNOGENETICS N.V.
IPC分类号： A61L25/00
CPC分类号： A61L15/32 , A61K9/7007 , A61L15/44 , A61L15/46 , A61L26/0038
摘要： The present invention relates to a medicament comprising a biopolymer matrix comprising gelatin cross-linked with an oxidized polysaccharide. Preferably said oxidized polysaccharide comprises an oxidized dextran or an oxidized xanthan. Preferably said medicament is a wound dressing. Preferably said matrix is in the form of a hydrated film, a hydrated or dry foam, dry fibres which may be fabricated into a woven or non-woven tissue, hydrated or dry micro beads, dry powder; or said matrix is covered with a semipermeable film, so as to control the humidity of the wound covered with the dressing, with the permeability chosen so as to maintain this humidity within a therapeutically optimal window. The invention also relates to a controlled release device comprising a biopolymer matrix comprising gelatin cross-linked with an oxidized polysaccharide into which a therapeutically effective amount of a drug is non-covalently incorporated. Preferably also additional compounds are immobilized, said compounds having substantial affinity for the incorporated drug, so as to slow down the release of the drug from the matrix and/or stabilizing the drug. The present invention also relates to a wound dressing comprising such a slow or controlled release device. Preferably said matrix is covered with a semipermeable film, with a permeability chosen so as to control the humidity of the wound covered with the dressing, and to maintain the humidity within a therapeutically optimal window. Preferably multiple forms of said matrix are combined to form a wound dressing, each form having different properties with respect to chemical composition and physical and controlled release characteristics. Preferably into each of the multiple forms one or more different active factors are non-covalently incorporated. Preferably, the invention relates to a wound dressing wherein one or more of the active factors belong to any of the following groups: EGF-like factors, FGF-like factors, TGF- beta -like factors, IGF-like factors, PDGF-like factors, keratinocyte cell lysate. The invention further relates to methods of producing and using said wound dressings or said controlled or slow release devices as defined above.
摘要翻译：本发明涉及包含与氧化多糖交联的明胶的生物聚合物基质的药物。优选地，所述氧化多糖包含氧化葡聚糖或氧化黄原胶。优选地，所述药物是伤口敷料。优选地，所述基质是水合膜，水合或干燥泡沫的形式，干纤维可以制成机织或非织造组织，水合或干燥的微珠，干粉; 或所述基质被半透膜覆盖，以便控制被敷料覆盖的伤口的湿度，其中选择的渗透性将该湿度保持在治疗最佳窗口内。本发明还涉及包含生物聚合物基质的控释装置，其包含与氧化多糖交联的明胶，其中治疗有效量的药物非共价掺入其中。优选还可以固定另外的化合物，所述化合物对所掺入的药物具有显着的亲和力，从而减缓药物从基质的释放和/或稳定药物。本发明还涉及包含这种缓慢或控制释放装置的伤口敷料。优选地，所述基质被半透膜覆盖，其具有选择的渗透性，以便控制被敷料覆盖的伤口的湿度，并将湿度保持在治疗最佳窗口内。优选地，将多种形式的所述基质组合以形成伤口敷料，每种形式相对于化学组成和物理和控制释放特性具有不同的性质。优选地，在多种形式中的每一种中，非共价掺入一种或多种不同的活性因子。优选地，本发明涉及伤口敷料，其中一种或多种活性因子属于以下任一组：EGF样因子，FGF样因子，TGF-β样因子，IGF-样因子，PDGF样因子，角化细胞裂解物。本发明还涉及生产和使用如上所述的所述伤口敷料或所述受控或缓释装置的方法。

5. 发明申请

WO2015067603A1 PHARMACEUTICAL PREPARATION AND METHOD OF ITS PRODUCTION AND USE 审中-公开
标题翻译：药物制剂及其生产和使用方法
公开(公告)号：WO2015067603A1
公开(公告)日：2015-05-14
申请号：PCT/EP2014/073698
申请日：2014-11-04
申请人： INVENRES GMBH , GERASHCHENKO, Igor , CHEPLIAKA, Oleksii
发明人： GERASHCHENKO, Igor , CHEPLIAKA, Oleksii
IPC分类号： A61K9/14 , A61K9/00
CPC分类号： A61K9/143 , A61K9/0014 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1641 , A61K31/167 , A61K31/5415 , A61K38/48 , A61K45/06 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/60 , A61L26/0004 , A61L26/0019 , A61L26/0023 , A61L26/0038 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/412 , A61L2300/45 , A61L2300/606 , A61L2300/62 , A61L2400/04 , A61L2420/06 , A61L2430/34 , C08G77/04 , C08G77/06
摘要： Thus, the present invention provides a composition in powder form comprising highly dispersed silica particles, polymethylsiloxane particles, and at one or both of a cationic surfactant and an antimicrobial substance, wherein at least 25 % by weight of the cationic surfactant is present in primary polymethylsiloxane particles carrying the cationic surfactant on their surface and/or in agglomerates of these primary particles, and/or at least 25 % by weight, of the antimicrobial substance is present in primary highly dispersed silica particles carrying the antimicrobial substance on their surface and/or in agglomerates of these primary particles.
摘要翻译：因此，本发明提供粉末形式的组合物，其包含高度分散的二氧化硅颗粒，聚甲基硅氧烷颗粒，以及阳离子表面活性剂和抗微生物物质的一种或两种，其中至少25重量％的阳离子表面活性剂存在于初级聚甲基硅氧烷在其表面上和/或这些初级颗粒的附聚物和/或至少25重量％的抗微生物物质中携带阳离子表面活性剂的颗粒存在于其表面上携带抗微生物物质的初级高度分散的二氧化硅颗粒和/或在这些初级颗粒的附聚物中。

6. 发明申请

WO2013060769A3 HEMOSTATIC COMPOSITIONS 审中-公开
标题翻译：静脉内组合物
公开(公告)号：WO2013060769A3
公开(公告)日：2013-06-20
申请号：PCT/EP2012071135
申请日：2012-10-25
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： SANDERS PAUL J , DANDE PRASAD , NORDHAUS MARK A , DONOVAN SHANE
IPC分类号： A61L24/10 , A61L26/00
CPC分类号： C07K14/78 , A61L24/001 , A61L24/104 , A61L26/0038 , A61L26/0061 , A61L2400/04
摘要： The invention discloses a method for producing a hemostatic composition comprising mixing a biocompatible polymer suitable for use in hemostasis and a genipin-type crosslinker, crosslinking said polymer by said genipin-type crosslinker to obtain a crosslinked biocompatible polymer, and finishing said crosslinked polymer to a pharmaceutically acceptable hemostatic composition, new hemostatic compositions and methods for using such compositions.
摘要翻译：本发明公开了一种生产止血组合物的方法，该方法包括混合适用于止血的生物相容性聚合物和京尼平型交联剂，通过所述京尼平型交联剂交联所述聚合物以获得交联的生物相容性聚合物，并且将所述交联聚合物整理为药学上可接受的止血组合物，新的止血组合物和使用这种组合物的方法。

7. 发明申请

WO2012149494A2 COATING COMPOSITIONS, METHODS AND COATED DEVICES 审中-公开
标题翻译：涂料组合物，方法和涂层装置
公开(公告)号：WO2012149494A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035692
申请日：2012-04-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SHUKLA, Anita , HAMMOND, Paula, T.
发明人： SHUKLA, Anita , HAMMOND, Paula, T.
IPC分类号： A61F2/82 , B05D1/02 , A61F2/24
CPC分类号： A61L26/0066 , A61L26/0038 , A61L2300/406 , A61L2300/608 , A61L2400/04 , A61L2420/02 , A61L2420/08 , A61M25/0045
摘要： In various embodiments, the present disclosure provides a coated device comprising: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer associated with one another via a hydrogen bond, wherein the first layer comprises a first natural polymeric material and a hydrogen bond donor and wherein the second layer comprises a second natural polymeric material and a hydrogen bond acceptor; and an agent for delivery associated with the coated device such that, decomposition of one or more layers of the film results in release of the agent. In various embodiments, a coated device comprising: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a tetralayer with alternating layers of opposite charge; and an agent for delivery associated with the coated device such that, decomposition of one or more layers of the film results in release of the agent.
摘要翻译：在各种实施例中，本公开提供一种涂覆装置，包括：基底; 至少部分基材的薄膜包衣，该薄膜包括多层单元，该多层单元包括通过氢键彼此相连的第一层和第二层，其中第一层包含第一天然聚合材料和氢键供体，其中第二层包括第二天然聚合物材料和氢键受体; 以及与涂覆装置相关的递送剂，使得一层或多层薄膜的分解导致试剂的释放。在各种实施例中，涂覆的装置包括：基底; 至少部分基底的薄膜，该薄膜包括多层单元，该多层单元包括具有相反电荷的交替层的四联体层; 以及与涂覆装置相关的递送剂，使得一层或多层薄膜的分解导致试剂的释放。

8. 发明申请

WO2009153750A2 IMPROVED CROSS-LINKED COMPOSITIONS 审中-公开
标题翻译：改进的交联组合物
公开(公告)号：WO2009153750A2
公开(公告)日：2009-12-23
申请号：PCT/IB2009052605
申请日：2009-06-18
申请人： LIFEBOND LTD , PREISS-BLOOM ORAHN , ATTAR ISHAY , IRAM NATALIE , KOMLOS CHAGAI , HABER MEIR
发明人： PREISS-BLOOM ORAHN , ATTAR ISHAY , IRAM NATALIE , KOMLOS CHAGAI , HABER MEIR
CPC分类号： A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要： Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译：包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。组合物任选且优选在非磷酸缓冲溶剂中制备。任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。

9. 发明申请

WO2006002528A1 NON-ADHESIVE HYDROGELS 审中-公开
标题翻译：非粘合水凝胶
公开(公告)号：WO2006002528A1
公开(公告)日：2006-01-12
申请号：PCT/CA2005/001009
申请日：2005-06-28
申请人： COVALON TECHNOLOGIES INC. , DICOSMO, Frank , DITIZIO, Valerio
发明人： DICOSMO, Frank , DITIZIO, Valerio
IPC分类号： A61L15/60
CPC分类号： A61K47/42 , A61F13/00063 , A61F13/00991 , A61F2013/00157 , A61F2013/00221 , A61F2013/00268 , A61F2013/00519 , A61F2013/00885 , A61F2013/0091 , A61K9/0014 , A61K9/06 , A61K9/7015 , A61K31/00 , A61K33/38 , A61L15/14 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/60 , A61L26/0033 , A61L26/0038 , A61L26/0061 , A61L26/008 , C08J3/28
摘要： Substantially non-adhesive hydrogels are useful as wound dressings, wound barriers, therapeutic drug delivery devices and the like. The substantially non-adhesive hydrogels are synthesized by a method that comprises irradiating a solution comprising a biological polymer that is biodegradable and biocompatible, using ionizing radiation, whereby free radicals of the biological polymer are formed and cross-linking occurs between the biological polymer radicals to provide the hydrogel.
摘要翻译：基本上不粘合的水凝胶可用作伤口敷料，伤口，治疗药物递送装置等。基本上不粘合的水凝胶是通过一种方法合成的，该方法包括使用电离辐射照射包含可生物降解和生物相容的生物聚合物的溶液，由此形成生物聚合物的自由基，并且在生物聚合物自由基之间发生交联提供水凝胶。

10. 发明申请

WO2014202760A3 VACUUM EXPANDED DRY COMPOSITION AND SYRINGE FOR RETAINING SAME 审中-公开
标题翻译：真空膨胀干燥组合物和用于保持其的SYRINGE
公开(公告)号：WO2014202760A3
公开(公告)日：2015-02-26
申请号：PCT/EP2014063041
申请日：2014-06-20
申请人： FERROSAN MEDICAL DEVICES AS
发明人： LARSEN KRISTIAN , MORTENSEN MICHAEL WRANG
IPC分类号： A61B17/00 , A61M5/178
CPC分类号： A61B17/00491 , A61L26/0038 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/252 , A61L2300/254 , A61L2300/412 , A61L2300/418 , A61L2400/04 , A61L2400/06 , A61M5/19 , A61M5/2448 , A61M5/284 , A61M5/3135 , A61M39/22 , A61M2005/3123 , A61M2005/3132 , C08L89/06
摘要： The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum.
摘要翻译：本公开内容涉及一种在冷冻干燥所述糊料之前对糊料进行真空膨胀的方法，以实现干糊剂组合物，其在添加水性介质时有效地重构以形成可流动的糊剂。本公开还涉及一种用于在真空中保持干糊剂组合物的注射器。

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