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    • 2. 发明申请
    • SYSTEM AND METHODS FOR TREATMENT OF WOUNDS WITH NEGATIVE PRESSURE AND PEROXY PYRUVIC ACID
    • 用负压和过氧化酸处理伤口的系统和方法
    • WO2017117270A1
    • 2017-07-06
    • PCT/US2016/068968
    • 2016-12-28
    • KCI LICENSING, INC.
    • INGRAM, Shannon, C.CARROLL, Christopher, A.
    • A61M1/00
    • A61M1/0084A01N37/16A61F13/00017A61F13/00063A61F13/00068A61L26/0066A61L26/0085A61L2300/212A61M1/0023A61M1/0058A61M1/0088A61M2205/3344A61M2205/50A61M2205/502A61M2205/52
    • In one example embodiment, a system for treating a tissue site is disclosed comprising a dressing adapted to contact the tissue site and provide a fluid seal between a therapeutic environment and a local external environment, and a solution source fluidly coupled to the dressing and adapted to deliver an antimicrobial solution comprising a peroxy a-keto carboxylic acid, such as peroxy pyruvic acid, to the tissue interface. The system may further comprise a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment after delivery of the antimicrobial fluid to the therapeutic environment. In another example embodiment, a method for treating a tissue site is disclosed comprising positioning a tissue interface to contact the tissue site, covering the tissue interface and the tissue site with a drape to provide a fluid seal between the therapeutic environment and the local external environment, and delivering an antimicrobial solution comprising peroxy a-keto carboxylic acid to the therapeutic environment before providing negative pressure to the therapeutic environment.
    • 在一个示例性实施例中,公开了一种用于治疗组织部位的系统,该系统包括适于接触组织部位并提供治疗环境和局部外部环境之间的流体密封的敷料以及溶液源 流体地偶联至敷料并且适于将包含过氧α-酮羧酸(例如过氧丙酮酸)的抗微生物溶液递送至组织界面。 该系统可以进一步包括负压源,该负压源流体连接到敷料并且适于在将抗微生物流体输送到治疗环境之后向治疗环境提供负压。 在另一个示例性实施例中,公开了一种用于治疗组织部位的方法,包括:定位组织部位以接触组织部位,用盖布覆盖组织部位和组织部位以在治疗环境和局部外部环境之间提供流体密封 并且在向治疗环境提供负压之前将包含过氧α-酮羧酸的抗微生物溶液递送至治疗环境。
    • 8. 发明申请
    • CONTROLLED OXYGEN/ANTI-MICROBIAL RELEASE FILMS
    • 控制氧/抗微生物膜
    • WO1994026317A1
    • 1994-11-24
    • PCT/US1994005570
    • 1994-05-18
    • STERIS CORPORATION
    • STERIS CORPORATIONMALCHESKY, Paul, S.KRALOVIC, Raymond, C.
    • A61L02/16
    • A61L2/208A01N25/34A01N31/08A01N37/16A01N59/00A01N59/14A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26A61L11/00A61L15/44A61L15/46A61L31/16A61L2202/24A61L2300/212A61L2300/404A61L2300/45A61L2300/608A61L2300/62B65D77/225B65D81/3216A01N2300/00A01N37/40
    • A film for releasing at least one of an antimicrobial agent, oxygen, and a medicament inlcudes a flexible, porous layer (18) such as a woven, non-woven, or knitted cloth or a layer of open cell foam. A first dry reagent (12) and a second dry reagent (14) which react in the presence of a dilutant to form the anti-microbial agent, oxygen, or medicament attached to the flexible, porous layer. In one preferred embodiment, the two dry reagents are disposed on opposite sides of the flexible, porous layer such that the flexible porous layer keeps the two apart and prevents a premature reaction. Porous outer layers (20, 22) prevent the powdered reagents from being wiped off while permitting dilutant access. In a preferred embodiment, the powdered reagents include acetylsalicylic acid and a perborate which react in the presence of water to generate peracetic acid (an antimicrobial agent which breaks down in a matter of minutes to hours into oxygen) and salicylic acid (a topical keratotic). The rate at which the reaction occurs and the peracetic acid breaks down into oxygen is controlled by buffering the pH of the powdered reagents, by selectively micro-encapsulating the powdered reagents, by controlling the porosity of the layers, or the like. Optionally, surfactants, detergents, emollients, gels, and the like can be added to the dry reagents. Alternately, a single reagent which releases oxygen or forms a strong oxidant may be used.
    • 用于释放抗微生物剂,氧气和药物中的至少一种的膜包括柔性多孔层(18),例如纺织,无纺布或针织布或开孔泡沫层。 第一干试剂(12)和第二干试剂(14),其在稀释剂存在下反应以形成附着在柔性多孔层上的抗微生物剂,氧或药物。 在一个优选实施方案中,两个干试剂设置在柔性多孔层的相对侧上,使得柔性多孔层将两者分开并防止过早反应。 多孔外层(20,22)防止粉末试剂被擦除,同时允许稀释剂进入。 在优选的实施方案中,粉末试剂包括乙酰水杨酸和过水硼酸盐,其在水存在下反应以产生过乙酸(在几分钟至几分钟内分解成氧气的抗微生物剂)和水杨酸(局部角质形成) 。 反应发生的速率和过乙酸分解成氧气是通过缓冲粉末试剂的pH,通过选择性微囊化粉末试剂,通过控制层的孔隙率等来控制的。 任选地,可以将表面活性剂,洗涤剂,润肤剂,凝胶等添加到干试剂中。 或者,可以使用释放氧气或形成强氧化剂的单一试剂。