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1. 发明申请

WO2008091195A1 NOVEL HETEROARYL SUBSTITUTED IMIDAZO [1,2 -A] PYRIDINE DERIVATIVES 审中-公开
标题翻译：新戊酰基取代的咪唑并[1,2-A]吡啶衍生物
公开(公告)号：WO2008091195A1
公开(公告)日：2008-07-31
申请号：PCT/SE2008/000045
申请日：2008-01-21
申请人： ASTRAZENECA AB , EDIN, Michaela , MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , WENSBO, David
发明人： EDIN, Michaela , MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , WENSBO, David
IPC分类号： C07D471/04 , A61K31/437 , A61K51/00 , A61P25/28 , A61K101/00
CPC分类号： C07D471/04 , A61K49/10 , A61K51/041 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463
摘要： The present invention relates to novel heteroaryl substituted imidazopyridine derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted imidazopyridine derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的咪唑并吡啶衍生物，其前体和具有结构式（Ia）的这类化合物及其药学上可接受的盐，组合物和使用方法的治疗用途。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的咪唑并吡啶衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的抗原异常诊断以及阿尔茨海默病治疗剂的临床疗效的测定方法。

2. 发明申请

WO2007074786A1 コンフォーメーション病診断プローブ审中-公开
标题翻译：探讨一致性疾病的诊断
公开(公告)号：WO2007074786A1
公开(公告)日：2007-07-05
申请号：PCT/JP2006/325804
申请日：2006-12-25
申请人：国立大学法人東北大学 , 工藤幸司 , 荒井啓行 , 岡村信行 , 丸山将浩 , 古本祥三 , 堂浦克美
发明人：工藤幸司 , 荒井啓行 , 岡村信行 , 丸山将浩 , 古本祥三 , 堂浦克美
IPC分类号： C07D277/84 , A61K31/4245 , A61K31/4439 , A61K31/5377 , A61K51/00 , A61P25/14 , A61P25/16 , A61P25/28 , C07D401/06 , C07D405/06 , C07D413/04 , C07D417/06
CPC分类号： C07D417/06 , A61K51/04 , A61K51/0431 , A61K51/0446 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463 , A61K51/0465 , A61K51/0468
摘要：　コンフォーメーション病の早期診断に有用なプローブ化合物、それを含むコンフォーメーション病診断用組成物およびキット、ならびにコンフォーメーション病治療および／または予防用医薬組成物などが本発明により提供される。
摘要翻译：公开的是：用于构象疾病早期诊断的探针化合物; 用于诊断构象疾病的组合物或试剂盒，其包含所述探针化合物; 用于构象疾病的治疗和/或预防组合物; 和别的。

3. 发明申请

WO2007005935A2 NOREPINEPHRINE TRANSPORTER RADIOTRACERS AND METHODS OF SYNTHESES THEREOF 审中-公开
标题翻译： NOREPINEPHRINE TRANSPORTER RADIOTRACERS及其合成方法
公开(公告)号：WO2007005935A2
公开(公告)日：2007-01-11
申请号：PCT/US2006026138
申请日：2006-07-06
申请人： MOLECULAR NEUROIMAGING LLC , TAMAGNAN GILLES D , ALAGILLE DAVID
发明人： TAMAGNAN GILLES D , ALAGILLE DAVID
IPC分类号： A61K51/00
CPC分类号： A61K51/0463
摘要： The present invention provides compounds and radiotracers thereof for locating, diagnosing, identifying, evaluating, detecting or quantitating NET by in vivo imaging. The invention also provides methods for locating, diagnosing, identifying, evaluating, detecting or quantitating NET, using radiotracers of high-affinity or labeled compounds of the invention, which exhibit low toxicity, can cross the blood-brain barrier and, preferably, distinguish among normal and abnormal brains. For example, a radiotracer of the invention can be administered to a patient in an amount suitable for in vivo imaging thereof. Preferably, radiotracers of the invention can also be used to locate, diagnosis, identify, evaluate, detect and quantitate NET in such diseases, disorders, conditions or maladies as, without limitation, depression, anxiety, ADHD and drug dependency.
摘要翻译：本发明提供了用于通过体内成像定位，诊断，鉴定，评价，检测或定量NET的化合物和放射性示踪剂。本发明还提供了用于定位，诊断，鉴定，评价，检测或定量测定NET的方法，使用显示低毒性的本发明的高亲和性或标记化合物的放射性示踪剂可以穿过血脑屏障，并且优选区分正常和异常的大脑。例如，本发明的放射性示踪剂可以以适于其体内成像的量给予患者。优选地，本发明的放射性示踪剂还可以用于定位，诊断，鉴定，评估，检测和定量这些疾病，病症，病症或疾病中的NET，而不限于抑郁，焦虑，ADHD和药物依赖性。

4. 发明申请

WO2004000205A2 NOVEL TETRACYCLIC ARYLCARBONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：具有丝氨酸蛋白酶受体亲和力的新型四氢叶酸吲哚酚作为治疗药物有用，其制备方法和含有它们的药物组合物
公开(公告)号：WO2004000205A2
公开(公告)日：2003-12-31
申请号：PCT/IN2003/000223
申请日：2003-06-19
申请人： SUVEN PHARMACEUTICALS LTD. , JASTI, Venkateswarlu , RAMAKRISHNA, Venkata, Satya, Nirogi , KAMBHAMPATI, Rama, Sastri , BATTULA, Srinivasa, Reddy , RAO, Venkata, Satya, Veerabhadra, Vadlamudi
发明人： JASTI, Venkateswarlu , RAMAKRISHNA, Venkata, Satya, Nirogi , KAMBHAMPATI, Rama, Sastri , BATTULA, Srinivasa, Reddy , RAO, Venkata, Satya, Veerabhadra, Vadlamudi
IPC分类号： A61K
CPC分类号： C07D487/04 , A61K51/0446 , A61K51/0459 , A61K51/0463 , C07D471/04
摘要： The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylcarbonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy
摘要翻译：本发明涉及新的四环芳基羰基吲哚，它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的溶剂化物，本文所述的新中间体和含有它们的药学上可接受的组合物。本发明特别涉及通式（I）的新型四环芳基羰基吲哚，它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物，本文所述的新中间体和药学上可接受的含有它们的组合物。本发明还涉及制备这种通式（I）化合物的方法，含有这种化合物的有效量的组合物和这种化合物/组合物在治疗中的用途

5. 发明申请

WO0217969A9 REAGENTS AND METHODS FOR THE DIAGNOSIS OF CMV DISSEMINATION 审中-公开
标题翻译：用于诊断CMV分布的试剂和方法
公开(公告)号：WO0217969A9
公开(公告)日：2003-09-12
申请号：PCT/US0127269
申请日：2001-08-30
申请人： CHEMOCENTRYX INC , SCHALL THOMAS J , MCMASTER BRIAN E , DAIRAGHI DANIEL J
发明人： SCHALL THOMAS J , MCMASTER BRIAN E , DAIRAGHI DANIEL J
IPC分类号： A61K51/04 , A61K51/08 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6863 , A61K51/0446 , A61K51/0455 , A61K51/0459 , A61K51/0463 , A61K51/0468 , A61K51/08 , G01N33/56994 , G01N2500/02
摘要： Methods are provided for detecting the spread of cytomegalovirus in a host infected with CMV, by administering to the host a detectable and labeled amount of a non-endogenous compound which binds to US28 or a US28 fragment. Typically, the methods use a labeled form of IBZM.
摘要翻译：通过向宿主施用可检测和标记量的与US28或US28片段结合的非内源性化合物，提供了检测巨细胞病毒在感染CMV的宿主中扩散的方法。通常，这些方法使用标记形式的IBZM。

6. 发明申请

WO2017023999A1 METHYLSULFONAMIDE DERIVATIVES AND USES RELATED THERETO 审中-公开
标题翻译：甲磺酰胺衍生物及其相关用途
公开(公告)号：WO2017023999A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045288
申请日：2016-08-03
申请人： EMORY UNIVERSITY
发明人： SHIM, Hyunsuk , GOODMAN, Mark M. , SHETTY, Dinesh , OUM, Yoon Hyeun
IPC分类号： A61P35/04 , A61K51/04
CPC分类号： A61K51/0463 , A61K51/0453 , A61K51/0459
摘要： This disclosure relates to methylsulfonamide derivatives and uses as imaging agents and other uses related to CXCR4 inhibition. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein, derivatives, or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for imaging to study CXCR4 related conditions.
摘要翻译：本公开涉及甲基磺酰胺衍生物并用作显像剂和与CXCR4抑制相关的其它用途。在某些实施方案中，本公开涉及包含本文公开的化合物，衍生物或其药学上可接受的盐或前药的药物组合物。在某些实施方案中，本文公开的组合物用于成像以研究CXCR4相关病症。

7. 发明申请

WO2014118039A1 RADIOLABELED COMPOUNDS 审中-公开
标题翻译：放射性化合物
公开(公告)号：WO2014118039A1
公开(公告)日：2014-08-07
申请号：PCT/EP2014/051180
申请日：2014-01-22
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BORRONI, Edilio , FLOHR, Alexander , GOBBI, Luca , HARTUNG, Thomas , HOAREAU, Raphael , HONER, Michael , MARTARELLO, Laurent
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P35/00 , A61P9/00 , A61K51/04 , C07B59/00 , G01N33/60
CPC分类号： C07D471/04 , A61K51/0453 , A61K51/0455 , A61K51/0463 , C07B59/002 , C07B2200/05 , G01N33/60
摘要： The present invention relates to radiolabeled compounds of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as defined herein.
摘要翻译：本发明涉及放射性标记的式（I）化合物，其中R 1，R 2，R 3和R 4如本文所定义。

8. 发明申请

WO2010105315A3 REPORTER GENE CONSTRUCTS FOR PET 审中-公开
标题翻译：报告基因构建PET
公开(公告)号：WO2010105315A3
公开(公告)日：2010-11-18
申请号：PCT/BE2010000022
申请日：2010-03-22
申请人： KATHOLIEKE UNIVERSIFEIT LEUVEN , BAEKELANDT VEERLE , BORMANS GUY , DEBYSER ZEGER , DEROOSE CHRISTOPHE , EVENS NELE , TOELEN JAAN , VANDEPUTTE CAROLINE , VAN LAERE KOENRAAD , VERBRUGGEN ALFONS
发明人： BAEKELANDT VEERLE , BORMANS GUY , DEBYSER ZEGER , DEROOSE CHRISTOPHE , EVENS NELE , TOELEN JAAN , VANDEPUTTE CAROLINE , VAN LAERE KOENRAAD , VERBRUGGEN ALFONS
IPC分类号： C07K14/705 , C12Q1/68
CPC分类号： C07K14/70571 , A61K51/0455 , A61K51/0463 , C12Q1/6897
摘要： The present invention relates to the field of in vivo molecular imaging and, more particularly to a method for reporter gene imaging via positron emission tomography (PET), which can be applied in nervous system (brain, cerebrum, cerebellum, medulla, pons, spinal cord, sciatic nerve) and particularly in the brain. The present invention also involves type 2 cannabinoid receptor (CB2) based reporter gene constructs and a reporter probe or tracer (reporter system) for use in a molecular imaging therapy for instance by PET. The reporter gene encodes the reporter protein to which the reporter probe binds.
摘要翻译：本发明涉及体内分子成像领域，更具体地说，涉及通过正电子发射断层摄影（PET）的报告基因成像方法，其可应用于神经系统（脑，大脑，小脑，髓质，脑脊髓，脊髓）绳，坐骨神经），特别是在脑中。本发明还涉及基于2型大麻素受体（CB2）的报告基因构建体和用于例如PET的分子成像治疗的报道探针或示踪剂（报道系统）。报告基因编码报告基因探针结合的报道蛋白。

9. 发明申请

WO2010120337A1 MITOCHONDRIAL INHIBITORS TO TREAT HUMAN DISEASE 审中-公开
标题翻译：麻醉抑制剂治疗人类疾病
公开(公告)号：WO2010120337A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/000787
申请日：2010-03-16
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , JUBINSKY, Paul , DAS, Bhaskar, Chandra , SHORT, Mary, K.
发明人： JUBINSKY, Paul , DAS, Bhaskar, Chandra , SHORT, Mary, K.
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： C07D265/36 , A61K51/0406 , A61K51/0421 , A61K51/0463 , C07B2200/05 , C07C279/22 , C07C2601/16 , C07D311/60 , C07D311/64 , G01N2333/535
摘要： The present invention relates to inhibitors of mitochondria-associated, granulocyte- macrophage colony stimulating factor signaling molecule (Magmas), and related compositions and uses thereof.
摘要翻译：本发明涉及线粒体相关的，粒细胞 - 巨噬细胞集落刺激因子信号分子（Magmas）的抑制剂及其相关组合物和用途。

10. 发明申请

WO2010059905A3 IMAGING LIGANDS FOR THE DOPAMINE D2 RECEPTOR 审中-公开
标题翻译：多巴胺D2受体的成像配体
公开(公告)号：WO2010059905A3
公开(公告)日：2010-08-26
申请号：PCT/US2009065268
申请日：2009-11-20
申请人： GEN ELECTRIC , HAMMERSMITH IMANET LTD , HEGDE RAVI , ATREYA CHANDAN , SHAN BO , ADAK SUDESHNA
发明人： HEGDE RAVI , ATREYA CHANDAN , SHAN BO , ADAK SUDESHNA
IPC分类号： A61K51/04 , A61K101/02
CPC分类号： A61K51/0463
摘要： Naphthoxazine derivatives which are selective ligands for the dopamine D2 receptor and which carry an 18F radiolabel suitable for imaging with PET are described. The compounds of the present invention are thus useful for in vivo diagnostics and in vivo imaging of the dopamine D2 receptor.
摘要翻译：描述了作为多巴胺D2受体的选择性配体并且携带适合于PET成像的18F放射性标记物的萘并恶嗪衍生物。因此，本发明的化合物可用于多巴胺D2受体的体内诊断和体内成像。

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