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1. 发明申请

WO2010105315A3 REPORTER GENE CONSTRUCTS FOR PET 审中-公开
标题翻译：报告基因构建PET
公开(公告)号：WO2010105315A3
公开(公告)日：2010-11-18
申请号：PCT/BE2010000022
申请日：2010-03-22
申请人： KATHOLIEKE UNIVERSIFEIT LEUVEN , BAEKELANDT VEERLE , BORMANS GUY , DEBYSER ZEGER , DEROOSE CHRISTOPHE , EVENS NELE , TOELEN JAAN , VANDEPUTTE CAROLINE , VAN LAERE KOENRAAD , VERBRUGGEN ALFONS
发明人： BAEKELANDT VEERLE , BORMANS GUY , DEBYSER ZEGER , DEROOSE CHRISTOPHE , EVENS NELE , TOELEN JAAN , VANDEPUTTE CAROLINE , VAN LAERE KOENRAAD , VERBRUGGEN ALFONS
IPC分类号： C07K14/705 , C12Q1/68
CPC分类号： C07K14/70571 , A61K51/0455 , A61K51/0463 , C12Q1/6897
摘要： The present invention relates to the field of in vivo molecular imaging and, more particularly to a method for reporter gene imaging via positron emission tomography (PET), which can be applied in nervous system (brain, cerebrum, cerebellum, medulla, pons, spinal cord, sciatic nerve) and particularly in the brain. The present invention also involves type 2 cannabinoid receptor (CB2) based reporter gene constructs and a reporter probe or tracer (reporter system) for use in a molecular imaging therapy for instance by PET. The reporter gene encodes the reporter protein to which the reporter probe binds.
摘要翻译：本发明涉及体内分子成像领域，更具体地说，涉及通过正电子发射断层摄影（PET）的报告基因成像方法，其可应用于神经系统（脑，大脑，小脑，髓质，脑脊髓，脊髓）绳，坐骨神经），特别是在脑中。本发明还涉及基于2型大麻素受体（CB2）的报告基因构建体和用于例如PET的分子成像治疗的报道探针或示踪剂（报道系统）。报告基因编码报告基因探针结合的报道蛋白。

2. 发明申请

WO2010094090A3 SYNUCLEINOPATHIES 审中-公开
标题翻译：突触核蛋白
公开(公告)号：WO2010094090A3
公开(公告)日：2010-10-14
申请号：PCT/BE2010000013
申请日：2010-02-18
申请人： KATHOLLEKE UNIVERSITEIT LEUVEN , UNIV GRAZ , BAEKELANDT VEERLE , BUETTNER SABRINA , GERARD MELANIE , MADEO FRANK , WINDERUCJX JORIS
发明人： BAEKELANDT VEERLE , BUETTNER SABRINA , GERARD MELANIE , MADEO FRANK , WINDERUCJX JORIS
IPC分类号： C07D307/68 , A61K31/341 , A61K31/415 , A61K31/4192 , A61P25/16 , A61P25/28
CPC分类号： C07D307/68
摘要： Present inventions demonstrates that NHE-1 inhibiting carbonylguanidine derivatives inhibit a-synuclein toxicity. Such compounds can be used in the treatment or prevention of synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA).
摘要翻译：本发明证明NHE-1抑制羰基胍衍生物抑制α-突触核蛋白毒性。此类化合物可用于治疗或预防突触核蛋白病，例如帕金森氏病（PD），路易体痴呆（DLB），纯自主神经衰竭（PAF）和多系统萎缩（MSA）。

3. 发明申请

WO2005109004A2 DISEASE RELATED PROTEIN AGGREGATION 审中-公开
标题翻译：疾病相关蛋白聚集
公开(公告)号：WO2005109004A2
公开(公告)日：2005-11-17
申请号：PCT/IB2005001234
申请日：2005-05-06
申请人： LEUVEN K U RES & DEV , BAEKELANDT VEERLE , DEBYSER ZEGER , ENGELBORGHS YVES , GERARD MELANIE
发明人： BAEKELANDT VEERLE , DEBYSER ZEGER , ENGELBORGHS YVES , GERARD MELANIE
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2333/99
摘要： Present invention demonstrates that the members of the FKBP family or FK506 Binding Proteins (FKBPs), more specifically FKBP12 or FKBP52 enhance the aggregation of alpha-SYN. Moreover, it was found that the effect of FKBP on alpha-SYN aggregation has its origin in the PPIase activity of the enzyme. Immunophilin ligands, specific inhibitors of the activity of FKBPs, inhibit stimulation of the aggregation of a alpha-SYN by FKBPs.
摘要翻译：本发明表明，FKBP家族成员或FK506结合蛋白（FKBPs），更具体地说FKBP12或FKBP52的成员增强了α-SYN的聚集。此外，发现FKBP对α-SYN聚集的作用起源于酶的PPIase活性。免疫荧光素配体，FKBPs活性的特异性抑制剂抑制FKBPs刺激α-SYN的聚集。

4. 发明申请

WO2010105315A2 REPORTER GENE CONSTRUCTS FOR PET 审中-公开
标题翻译：报告基因结构的PET
公开(公告)号：WO2010105315A2
公开(公告)日：2010-09-23
申请号：PCT/BE2010/000022
申请日：2010-03-22
申请人： KATHOLIEKE UNIVERSIFEIT LEUVEN , BAEKELANDT, Veerle , BORMANS, Guy , DEBYSER, Zeger , DEROOSE, Christophe , EVENS, Nele , TOELEN, Jaan , VANDEPUTTE, Caroline , VAN LAERE, Koenraad , VERBRUGGEN, Alfons
发明人： BAEKELANDT, Veerle , BORMANS, Guy , DEBYSER, Zeger , DEROOSE, Christophe , EVENS, Nele , TOELEN, Jaan , VANDEPUTTE, Caroline , VAN LAERE, Koenraad , VERBRUGGEN, Alfons
IPC分类号： C12Q1/68
CPC分类号： C07K14/70571 , A61K51/0455 , A61K51/0463 , C12Q1/6897
摘要： The present invention relates to the field of in vivo molecular imaging and, more particularly to a method for reporter gene imaging via positron emission tomography (PET), which can be applied in nervous system (brain, cerebrum, cerebellum, medulla, pons, spinal cord, sciatic nerve) and particularly in the brain. The present invention also involves type 2 cannabinoid receptor (CB2) based reporter gene constructs and a reporter probe or tracer (reporter system) for use in a molecular imaging therapy for instance by PET. The reporter gene encodes the reporter protein to which the reporter probe binds.
摘要翻译：本发明涉及体内分子成像领域，并且更具体地涉及经由正电子发射断层摄影术（PET）进行报道基因成像的方法，其可以应用于神经系统（脑，大脑），小脑，髓质，脑桥，脊髓，坐骨神经），特别是在大脑中。本发明还涉及基于2型大麻素受体（CB2）的报道基因构建体和报道探针或示踪剂（报道系统），用于例如通过PET的分子成像疗法。报道基因编码报道探针结合的报道蛋白。

5. 发明申请

WO2009021295A2 ALPHA SYNUCLEIN TOXICITY 审中-公开
标题翻译： ALPHA SYNUCLEIN毒性
公开(公告)号：WO2009021295A2
公开(公告)日：2009-02-19
申请号：PCT/BE2008/000062
申请日：2008-08-07
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN , UNIVERSITY OF GRAZ , BAEKELANDT, Veerle , BUETTNER, Sabrina , MADEO, Frank , WINDERICKX, Joris
发明人： BAEKELANDT, Veerle , BUETTNER, Sabrina , MADEO, Frank , WINDERICKX, Joris
IPC分类号： C07K16/00
CPC分类号： A61K39/3955 , A61K31/713 , A61K38/005 , A61K2039/505 , C07K16/40 , C12N15/1137 , C12N2310/14
摘要： Present inventions demonstrates that alpha synculein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of the endonuclease G apoptotic pathway attenuates or counteracts such alpha synuclein toxicity. The present invention compositions and methods for inhibition of α-synuclein toxicity. The inhibiting α-synuclein toxicity can be used in methods of treatment of synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA) and the manufacture of medicaments for such treatment. In particular The subject matter provided in herein relates to a pharmaceutical compositions containing inhibitors of endonuclease G, and their use in the treatment of synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, and multiple system atrophy and the manufacture of medicaments for such treatment. Furthermore the present invention relates to a method for the identification of compounds attenuating the synuclein toxicity, said method comprising evaluating the inhibitory action of said compound on the endonuclease G dependent apoptosis.
摘要翻译：本发明证明α-突触素毒性如α-突触核蛋白介导的细胞死亡，α突触核蛋白在细胞中诱导活性氧（ROS）需要促凋亡内切酶G，并且内切核酸酶G的缺失或内切核酸酶G凋亡通路的抑制减弱或抵抗这种α突触核蛋白毒性。本发明的组合物和抑制α-突触核蛋白毒性的方法。抑制性α-突触核蛋白毒性可用于治疗突触核蛋白病，如帕金森病（PD），路易体痴呆（DLB），纯自主神经功能衰竭（PAF）和多系统萎缩（MSA）药物用于治疗。特别地，本文提供的主题涉及含有内切核酸酶G抑制剂的药物组合物及其在治疗突触核蛋白病（例如帕金森病，路易体痴呆，纯粹的自主神经衰竭和多系统萎缩）中的用途，以及制造药物用于治疗。此外，本发明涉及鉴定减毒突触核蛋白毒性的化合物的方法，所述方法包括评价所述化合物对核酸内切酶G依赖性凋亡的抑制作用。

6. 发明申请

WO2010094090A2 SYNUCLEINOPATHIES 审中-公开
标题翻译：突触核蛋白
公开(公告)号：WO2010094090A2
公开(公告)日：2010-08-26
申请号：PCT/BE2010/000013
申请日：2010-02-18
申请人： KATHOLLEKE UNIVERSITEIT LEUVEN , UNIVERSITY OF GRAZ , BAEKELANDT, Veerle , BUETTNER, Sabrina , GERARD, Melanie , MADEO, Frank , WINDERUCJX, Joris
发明人： BAEKELANDT, Veerle , BUETTNER, Sabrina , GERARD, Melanie , MADEO, Frank , WINDERUCJX, Joris
IPC分类号： C07D307/68
CPC分类号： C07D307/68
摘要： Present inventions demonstrates that NHE-1 inhibiting carbonylguanidine derivatives inhibit α-synuclein toxicity. Such compounds can be used in the treatment or prevention of synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA).
摘要翻译：本发明显示NHE-1抑制性羰基胍衍生物抑制α-突触核蛋白毒性。这些化合物可用于治疗或预防突触核蛋白病，如帕金森病（PD），路易体痴呆（DLB），纯自主神经衰竭（PAF）和多系统萎缩（MSA）。

7. 发明申请

WO2009021295A3 INHIBITION OF ALPHA SYNUCLEIN TOXICITY 审中-公开
标题翻译：抑制ALPHA综合征毒性
公开(公告)号：WO2009021295A3
公开(公告)日：2009-05-14
申请号：PCT/BE2008000062
申请日：2008-08-07
申请人： UNIV LEUVEN KATH , UNIV GRAZ , BAEKELANDT VEERLE , BUETTNER SABRINA , MADEO FRANK , WINDERICKX JORIS
发明人： BAEKELANDT VEERLE , BUETTNER SABRINA , MADEO FRANK , WINDERICKX JORIS
IPC分类号： C07K16/40 , A61K38/00 , A61P25/16 , A61P25/28 , C12N15/113
CPC分类号： A61K39/3955 , A61K31/713 , A61K38/005 , A61K2039/505 , C07K16/40 , C12N15/1137 , C12N2310/14
摘要： Present inventions demonstrates that alpha synculein toxicity such as a-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of the endonuclease G apoptotic pathway attenuates or counteracts such alpha synuclein toxicity. The present invention compositions and methods for inhibition of a-synuclein toxicity. The inhibiting a-synuclein toxicity can be used in methods of treatment of synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA) and the manufacture of medicaments for such treatment. In particular The subject matter provided in herein relates to a pharmaceutical compositions containing inhibitors of endonuclease G, and their use in the treatment of synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, and multiple system atrophy and the manufacture of medicaments for such treatment. Furthermore the present invention relates to a method for the identification of compounds attenuating the synuclein toxicity, said method comprising evaluating the inhibitory action of said compound on the endonuclease G dependent apoptosis.
摘要翻译：本发明证明α-突触素毒性如α-突触核蛋白介导的细胞死亡，α突触核蛋白在细胞中诱导活性氧（ROS）需要促凋亡内切酶G，并且内切核酸酶G的缺失或内切核酸酶G凋亡通路的抑制减弱或抵抗这种α突触核蛋白毒性。本发明的组合物和抑制α-突触核蛋白毒性的方法。抑制性α-突触核蛋白毒性可用于治疗突触核蛋白病，如帕金森病（PD），路易体痴呆（DLB），纯自主神经功能衰竭（PAF）和多系统萎缩（MSA）药物用于治疗。特别地，本文提供的主题涉及含有内切核酸酶G抑制剂的药物组合物及其在治疗突触核蛋白病（例如帕金森病，路易体痴呆，纯粹的自主神经衰竭和多系统萎缩）中的用途，以及制造药物用于治疗。此外，本发明涉及鉴定减毒突触核蛋白毒性的化合物的方法，所述方法包括评估所述化合物对核酸内切酶G依赖性凋亡的抑制作用。

8. 发明申请

WO2005109004A3 DISEASE RELATED PROTEIN AGGREGATION 审中-公开
公开(公告)号：WO2005109004A3
公开(公告)日：2005-11-17
申请号：PCT/IB2005/001234
申请日：2005-05-06
申请人： K.U. LEUVEN RESEARCH AND DEVELOPMENT , BAEKELANDT, Veerle , DEBYSER, Zeger , ENGELBORGHS, Yves , GERARD, Melanie
发明人： BAEKELANDT, Veerle , DEBYSER, Zeger , ENGELBORGHS, Yves , GERARD, Melanie
IPC分类号： G01N33/68 , A61K39/395
摘要： Present invention demonstrates that the members of the FKBP family or FK506 Binding Proteins (FKBPs), more specifically FKBP12 or FKBP52 enhance the aggregation of α-SYN. Moreover, it was found that the effect of FKBP on α-SYN aggregation has its origin in the PPIase activity of the enzyme. Immunophilin ligands, specific inhibitors of the activity of FKBPs, inhibit stimulation of the aggregation of a α-SYN by FKBPs.

9. 发明申请

WO0249422A3 NON-HUMAN ANIMAL DISEASE MODELS 审中-公开
标题翻译：非人类动物疾病模型
公开(公告)号：WO0249422A3
公开(公告)日：2002-11-14
申请号：PCT/BE0100216
申请日：2001-12-18
申请人： LEUVEN K U RES & DEV , DEBYSER ZEGER , LAUWERS ERWIN , NUTTIN BART , BAEKELANDT VEERLE , DE STROOPER BART
发明人： DEBYSER ZEGER , LAUWERS ERWIN , NUTTIN BART , BAEKELANDT VEERLE , DE STROOPER BART
IPC分类号： A01K67/027 , A61K48/00 , A61K49/00 , C07K14/47 , C12N15/85 , C12N15/867 , C12N5/10 , G01N33/50
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A61K48/00 , A61K49/0008 , C07K14/47 , C12N15/86 , C12N2503/02 , C12N2740/16043 , C12N2830/48 , C12N2840/203
摘要： The invention involves a method of stereotactic and viral vector-mediated gene transfer to produce animals harboring in their neural tissue a polynucleotide sequence, an allelic variant, minigene or a homolog thereof, that encodes for alpha -synuclein or functional homologues thereof and overexpresses alpha -synuclein or functional homologues thereof locoregional in said neural tissue. Overexpression of alpha -synuclein is associated with locoregional pathology in the neural tissue as evidenced by histology and neurodegeneration as evidenced by histology. These animals can be used in pharmaceutical screening and for in vivo modelling of alpha -synuclein biochemistry.
摘要翻译：本发明涉及一种立体定向和病毒载体介导的基因转移的方法，以产生在其神经组织中携带编码α-突触核蛋白或其功能同系物并且过表达α-突触核蛋白或其功能同系物的多核苷酸序列，等位基因变体，小基因或其同源物的动物，突触核蛋白或其功能同源物在所述神经组织中的局部区域。 α-突触核蛋白的过度表达与神经组织中的局部病理学相关，如通过组织学证实的组织学和神经变性所证实的。这些动物可用于药物筛选和α-突触核蛋白生物化学的体内建模。

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