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1. 发明申请

WO2016205361A1 NOVEL BIODEGRADABLE AND NON-BIODEGRADABLE 3D PRINTED IMPLANTS AS A DRUG DELIVERY SYSTEM 审中-公开
标题翻译：新型可生物降解和非生物降解3D印刷植物作为药物输送系统
公开(公告)号：WO2016205361A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037614
申请日：2016-06-15
申请人： ROWAN UNIVERSITY
发明人： RANGANATHAN, Shivakumar, Iyer , KIM, Tae Won, Benjamin , CAMPBELL, Daniel, Joseph , SMITH, Garrett, Christopher
IPC分类号： A61F2/28 , A61B17/80
CPC分类号： A61F2/28 , A61B5/0064 , A61B17/80 , A61B17/8052 , A61F2/30942 , A61F2/3859 , A61F2/3886 , A61F2/389 , A61F2002/2817 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30677 , A61F2002/3068 , A61F2002/30784 , A61F2002/30878 , A61F2002/30884 , A61F2002/30952 , A61F2002/30962 , A61F2002/30985 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61K31/4178 , A61K31/7036 , A61L31/022 , A61L31/06 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/406 , A61L2430/02 , A61L2430/24 , A61M31/002
摘要： The present invention is directed to a medical implant, methods of use and making of such implants. A method of making an implantable device may include obtaining an anatomical model in a computer aided design (CAD) system, customizing the anatomical model per patient specific parameters and creating a virtual image of the anatomical model, incorporating at least one microchannel geometry within said anatomical model, adjusting the density infill to a measurement ranging per patient specific parameters, and using three-dimensional printing to form the implantable device based on the anatomical model. The implant can be made of suitable metallic or polymeric material, such as PLA.
摘要翻译：本发明涉及医用植入物，使用和制造这种植入物的方法。一种制造可植入装置的方法可包括获得计算机辅助设计（CAD）系统中的解剖模型，根据患者的特定参数定制解剖模型并创建解剖模型的虚拟图像，将所述解剖学模型中的至少一个微通道几何结构模型，将密度填充调整到每个患者特定参数的测量范围，以及基于解剖模型使用三维印刷形成可植入装置。植入物可以由合适的金属或聚合物材料制成，例如PLA。

2. 发明申请

WO2014152533A1 POSTERIOR-STABILIZED KNEE IMPLANT COMPONENTS AND INSTRUMENTS 审中-公开
标题翻译：稳定稳定的卡尼尔植入部件和仪器
公开(公告)号：WO2014152533A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027446
申请日：2014-03-14
申请人： CONFORMIS, INC.
发明人： SLAMIN, John , BOJARSKI, Raymond , STEINES, Daniel , LANG, Philipp , WONG, Terrance , FITZ, Wolfgang
IPC分类号： A61F2/38
CPC分类号： A61F2/3886 , A61B17/155 , A61B17/1675 , A61B17/1764 , A61F2/30942 , A61F2/3859 , A61F2230/0063 , A61F2230/0095 , A61F2240/002 , G06F17/50 , G06F2217/02
摘要： Patient-adapted articular repair systems, including implants, instruments, and surgical plans, and methods of making and using such systems, are disclosed herein. In particular, various embodiments include knee joint articular repair systems designed for posterior stabilization, including patient-adapted posterior-stabilizing features.
摘要翻译：本文公开了患者适应的关节修复系统，包括植入物，器械和手术计划，以及制造和使用这种系统的方法。特别地，各种实施例包括设计用于后稳定的膝关节关节修复系统，包括患者适应的后稳定特征。

3. 发明申请

WO2014143538A1 KNEE PROSTHESIS INCLUDING ROTATABLE SPINE 审中-公开
标题翻译： KNEE PROSTHESIS包括可旋转的脊椎
公开(公告)号：WO2014143538A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/018228
申请日：2014-02-25
申请人： WASIELEWSKI, Ray C.
发明人： WASIELEWSKI, Ray C.
IPC分类号： A61F2/38 , A61F2/30
CPC分类号： A61F2/385 , A61F2/3836 , A61F2/3859 , A61F2/3868 , A61F2/3886 , A61F2/389 , A61F2002/30332 , A61F2002/30364 , A61F2002/30474 , A61F2002/30604 , A61F2210/0076
摘要： A knee joint prosthesis is disclosed. The knee joint prosthesis can include a tibial baseplate, a tibial insert, and a spine. The tibial baseplate can include a tibial plateau, having a proximal surface and an opposing distal surface, and a tibial stem extending from the distal surface of the tibial plateau. The tibial insert can be located on the proximal surface of the tibial plateau and can include an aperture. The spine can extend through the aperture of the tibial insert and into a cavity of the tibial stem, from the proximal surface of the tibial plateau. The spine can be rotatable with respect to the tibial baseplate and the tibial insert. The knee joint prosthesis can further include a femoral component including a posteriorly-located femoral cam. The posteriorly-located femoral cam can engage the spine during movement of the knee joint prosthesis.
摘要翻译：公开了一种膝关节假体。膝关节假体可以包括胫骨基板，胫骨插入物和脊柱。胫骨基板可以包括具有近端表面和相对远端表面的胫骨平台，以及从胫骨平台的远端表面延伸的胫骨柄。胫骨插入件可以位于胫骨平台的近端表面上并且可以包括孔。脊柱可以从胫骨平台的近端表面延伸穿过胫骨插入物的孔并进入胫骨柄的空腔。脊柱可相对于胫骨基板和胫骨插入物旋转。膝关节假体还可包括股骨部件，其包括位于后部的股骨凸轮。在膝关节假体运动期间，位于后方的股骨凸轮能够与脊柱接合。

4. 发明申请

WO2013009966A2 METHODS AND DEVICES FOR KNEE JOINT REPLACEMENT WITH ANTERIOR CRUCIATE LIGAMENT SUBSTITUTION 审中-公开
标题翻译：用于KNEE联合替换的方法和设备与前列腺切除术
公开(公告)号：WO2013009966A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046430
申请日：2012-07-12
申请人： THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL , MURATOGLU, Orhun, K. , VARADARAJAN, Kartik, Mangudi , LI, Guoan , RUBASH, Harry, E. , ZUMBRUNN, Thomas
发明人： MURATOGLU, Orhun, K. , VARADARAJAN, Kartik, Mangudi , LI, Guoan , RUBASH, Harry, E. , ZUMBRUNN, Thomas
IPC分类号： A61B17/56 , A61F2/46 , A61F2/38 , A61B17/11
CPC分类号： A61F2/3836 , A61F2/08 , A61F2/0811 , A61F2/3886 , A61F2002/30688
摘要： Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can al low a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a medial or lateral femoral implant, a femoral intercondylar notch structure, a medial or lateral tibial insert, and an ACL-substitution member. The ACL-substitution member can be configured to engage with the femoral intercondylar notch structure during a full range of knee motion and/or during only early knee flexion.
摘要翻译：提供用于膝关节置换前交叉韧带（ACL）替代的方法和装置。通常，方法和装置可以将膝关节部分或全部替换为膝盖关节的ACL的替代。在一个实施例中，膝关节置换假体可以包括内侧或外侧股骨植入物，股骨髁间隙结构，内侧或外侧胫骨插入物和ACL取代构件。 ACL取代构件可以被构造成在全膝关节运动范围和/或仅在早期膝关节屈曲期间与股骨髁间隙结构接合。

5. 发明申请

WO2012173705A1 FEMORAL COMPONENT FOR A KNEE PROSTHESIS WITH IMPROVED ARTICULAR CHARACTERISTICS 审中-公开
公开(公告)号：WO2012173705A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/035691
申请日：2012-04-27
申请人： ZIMMER, INC. , PARISI, Raymond, C. , DRURY, Nick , BALDRIDGE, Charles, A.
发明人： PARISI, Raymond, C. , DRURY, Nick , BALDRIDGE, Charles, A.
IPC分类号： A61F2/38
CPC分类号： A61F2/3859 , A61F2/3877 , A61F2/3886 , A61F2002/30616 , A61F2002/30878 , A61F2002/30889
摘要： An orthopaedic knee prosthesis includes a femoral component (20, 120, 220) which exhibits enhanced articular features, minimizes removal of healthy bone stock from the distal femur, and minimizes the impact of the prosthesis on adjacent soft tissues of the knee.

6. 发明申请

WO2012018567A1 ASYMMETRIC TIBIAL COMPONENTS FOR A KNEE PROSTHESIS 审中-公开
标题翻译：用于膝假体的非对称性胫骨组件
公开(公告)号：WO2012018567A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/045083
申请日：2011-07-22
申请人： ZIMMER, INC. , WENTORF, Mary, S.S.
发明人： WENTORF, Mary, S.S.
IPC分类号： A61F2/38
CPC分类号： A61F2/389 , A61F2/3868 , A61F2/3886 , A61F2002/30326 , A61F2002/30387 , A61F2002/30616 , A61F2002/30883 , A61F2220/0025
摘要： An orthopaedic tibial prosthesis includes a tibial baseplate with an asymmetric periphery which promotes proper positioning and orientation on a resected tibia, while also facilitating enhanced kinematics, soft-tissue interaction, and long-term fixation of the complete knee prosthesis. The asymmetric baseplate periphery is sized and shaped to substantially match portions of the periphery of a typical resected proximal tibial surface, such that proper location and orientation is evident by resting the baseplate on the tibia. The baseplate periphery provides strategically positioned relief and/or clearance between the baseplate periphery and bone periphery, such as in the posterior-medial portion to prevent deep-flexion component impingement, and in the anterior-lateral portion to avoid undue interaction between the anatomic iliotibial band and prosthesis components.
摘要翻译：矫形胫骨假体包括具有不对称周边的胫骨基板，其促进了在切除的胫骨上的适当定位和定向，同时还促进增强的运动学，软组织相互作用以及完整的长期固定膝假体。不对称底板周边的尺寸和形状被设定为基本匹配典型切除的近侧胫骨表面的周边的部分，使得通过将底板搁置在胫骨上而使适当的位置和取向明显。底板周边在底板周边和骨周边之间提供策略性定位的凸起和/或间隙，例如在内后部以防止深度弯曲部件撞击，并且在前 - 外部分中避免解剖学髂骨之间的过度相互作用带和假肢组件。

7. 发明申请

WO2011066227A2 INSTRUMENTATION FOR MOBILE BEARING PROSTHETICS 审中-公开
标题翻译：仪器仪表移动轴承修复
公开(公告)号：WO2011066227A2
公开(公告)日：2011-06-03
申请号：PCT/US2010057642
申请日：2010-11-22
申请人： RIES MICHAEL D , MEDICINELODGE INC DBA IMDS CO INNOVATION , MOORADIAN MARK J , BUTTERS JOSHUA A
发明人： RIES MICHAEL D , MOORADIAN MARK J , BUTTERS JOSHUA A
IPC分类号： A61B17/88 , A61F2/38 , A61F2/46
CPC分类号： A61F2/461 , A61F2/3868 , A61F2/3886 , A61F2002/4627
摘要： Knee prosthesis instrumentation including an insertion tool and a removal tool. The insertion tool may include an offset to provide clearance from a femoral component of the knee prosthesis. The removal tool may be wedge shaped to at least partially encircle a post of the knee prosthesis for removal. A mallet may be used with the instruments to provide additional force for prosthesis insertion or removal. A slide hammer may be incorporated into the instruments themselves.
摘要翻译：膝假体器械包括插入工具和移除工具。插入工具可以包括偏置以从膝假体的股骨部件提供间隙。移除工具可以是楔形的，以至少部分地包围膝关节假体的柱以便移除。槌可以与器械一起使用以为假体插入或移除提供额外的力。仪器本身可以包含滑锤。

8. 发明申请

WO2011059759A2 IMPLANTABLE MOBILE BEARING PROSTHETICS 审中-公开
标题翻译：可移动的移动轴承优势
公开(公告)号：WO2011059759A2
公开(公告)日：2011-05-19
申请号：PCT/US2010054534
申请日：2010-10-28
申请人： MEDICINELODGE INC DBA IMDS CO INNOVATION , RIES MICHAEL D , MOORADIAN MARK J , JUSTIN DANIEL F , BUTTERS JOSHUA A
发明人： RIES MICHAEL D , MOORADIAN MARK J , JUSTIN DANIEL F , BUTTERS JOSHUA A
CPC分类号： A61F2/3868 , A61F2/385 , A61F2/3886 , A61F2002/30133 , A61F2002/30163 , A61F2002/30878 , A61F2002/30892
摘要： A knee prosthesis including a femoral implant, a tibial implant, a tibial insert and a cam post. The femoral implant is secured to a femur and has a gap for receiving a natural PCL. The tibial implant is secured to a tibia. The tibial insert comprises a medial cavity with a rotational axis. The tibial insert has articulating surfaces that match the contours of the condyles of the femoral implant and a notch for retaining the natural PCL. The tibial insert has a medial boss that aligns with the medial cavity allowing it to rotate about the rotational axis. A post is secured to the tibial implant and enters a hole of the tibial insert providing anterior and posterior stops for the rotation of the tibial insert about the rotational axis.
摘要翻译：包括股骨植入物，胫骨植入物，胫骨插入物和凸轮柱的膝关节假体。股骨植入物被固定到股骨上并具有用于接收天然PCL的间隙。胫骨植入物被固定到胫骨上。胫骨插入物包括具有旋转轴线的中间腔。胫骨插入物具有与股骨植入物的髁的轮廓匹配的关节表面和用于保持天然PCL的凹口。胫骨插入物具有与中间空间对准的中间凸起，允许其围绕旋转轴线旋转。将柱固定到胫骨植入物并进入胫骨插入物的孔，其提供前部和后部止动件，用于使胫骨插入物绕旋转轴线旋转。

9. 发明申请

WO2011003621A2 KNEE JOINT PROSTHESIS AND RELATED METHOD 审中-公开
标题翻译： KNEE JOINT PROSTHESIS和相关方法
公开(公告)号：WO2011003621A2
公开(公告)日：2011-01-13
申请号：PCT/EP2010/004195
申请日：2010-07-09
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER , RICHTER, Berna , HURSCHLER, Christof , OSTERMEIER, Sven
发明人： RICHTER, Berna , HURSCHLER, Christof , OSTERMEIER, Sven
IPC分类号： A61F2/38 , A61F2/30 , B24B31/00
CPC分类号： A61F2/3886 , A61F2/3094 , A61F2/3868 , A61F2/468 , A61F2002/30365 , A61F2002/30369 , A61F2002/30528 , A61F2002/30934 , A61F2002/3895 , A61F2220/0025 , A61F2220/0033 , A61F2310/00203 , A61F2310/00239 , B24B31/003 , Y10T29/49826
摘要： The present invention relates to a knee joint prosthesis (1) having: a tibial component (2) and a femoral component (3). The tibial component (2) includes a fixation portion (10) adapted to be fixed to an upper end of a prepared tibia (T) in a patient, and a ceramic bearing portion (30) presenting at least one articulation surface (32). The femoral component (3) is adapted to be fixed to a lower end of a prepared femur (F) in a patient, and comprises a ceramic body portion (50) presenting at least one articulation surface (56) for engagement with the respective articulation surface(s) of the tibial component (2). The articulation surfaces (32, 56) of the tibial and femoral components (2, 3) are configured for essentially congruent engagement over a full range of movement of the prosthesis, and the bearing portion (30) of the tibial component (2) is adapted for movement relative to the fixation portion (10). The invention also provides a method of finishing articulation surfaces (32, 56) of ceramic components of a knee joint prosthesis, including the steps of combining the ceramic bearing portion (30) and the ceramic body portion (50) such that respective articulation surfaces (32, 56) are brought into engagement with a working substance (S) provided between them; and imparting relative movement to the bearing portion (30) and/or the body portion (50) such that the articulation surfaces (32, 56) repeatedly slide over one another, whereby friction forces generated between the articulation surfaces (32, 56) and the working substance (S) act to finish the surfaces simultaneously.
摘要翻译：膝关节假体（1）本发明涉及一种具有胫骨部件（2）和股骨部件（3）的膝关节假体（1）。胫骨部件（2）包括适于固定在患者中的制备的胫骨（T）的上端的固定部分（10）和呈现至少一个关节表面（32）的陶瓷轴承部分（30）。股骨部件（3）适于固定在患者体内的预备的股骨（F）的下端，并且包括陶瓷主体部分（50），其呈现至少一个关节表面（56），用于与相应的关节胫骨组件（2）的表面。胫骨和股骨部件（2,3）的关节表面（32,56）构造成用于在假体的整个运动范围上基本上一致地接合，并且胫骨部件（2）的支承部分（30）是适于相对于固定部分（10）移动。本发明还提供了一种完成膝关节假体的陶瓷部件的关节表面（32,56）的方法，包括以下步骤：将陶瓷轴承部分（30）和陶瓷体部分（50）组合，使得相应的关节表面 32,56）与设置在它们之间的工作物质（S）接合; 并且相对于轴承部分（30）和/或主体部分（50）相对运动，使得铰接表面（32,56）彼此重复地滑动，由此在铰接表面（32,56）和工作物质（S）同时完成表面。

10. 发明申请

WO2010151564A1 PATIENT-ADAPTED AND IMPROVED ORTHOPEDIC IMPLANTS, DESIGNS AND RELATED TOOLS 审中-公开
标题翻译：患者适应和改进的对位植入物，设计和相关工具
公开(公告)号：WO2010151564A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/039587
申请日：2010-06-23
申请人： BOJARSKI, Raymond, A. , LANG, Philipp , CHAO, Nam , FITZ, Wolfgang , SLAMIN, John , STEINES, Daniel
发明人： BOJARSKI, Raymond, A. , LANG, Philipp , CHAO, Nam , FITZ, Wolfgang , SLAMIN, John , STEINES, Daniel
IPC分类号： A61F2/38
CPC分类号： A61B34/10 , A61B17/155 , A61B17/157 , A61B17/1764 , A61B2034/107 , A61B2034/108 , A61F2/30942 , A61F2/384 , A61F2/3859 , A61F2/3886 , A61F2/389 , A61F2/5046 , A61F2002/30324 , A61F2002/30327 , A61F2002/30952 , A61F2002/3895 , B33Y80/00
摘要： Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.
摘要翻译：公开了关于改进的关节模型，植入物部件和相关的引导工具和程序的方法和装置。此外，公开了包括源自患者数据的一个或多个特征的关节模型，植入物部件和/或相关引导工具和过程的方法和装置，例如患者关节的图像。这些数据可用于创建一个分析患者关节的模型，并设计和评估一个纠正措施。该数据还可用于创建患者适应的植入物部件和相关工具和程序。

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