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1. 发明申请

WO2017011668A1 GEL DELIVERY CATHETERS, SYSTEMS, AND METHODS 审中-公开
标题翻译：凝胶输送管，系统和方法
公开(公告)号：WO2017011668A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/042300
申请日：2016-07-14
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： FLANAGAN, Aiden , BANNISTER, Philip
IPC分类号： A61B17/00
CPC分类号： A61M5/155 , A61B17/3478 , A61B2017/00495 , A61B2090/064 , A61M5/19 , A61M5/3294 , A61M25/0074 , A61M2005/14513 , A61M2202/0007 , A61M2202/09 , A61M2210/125
摘要： An injection catheter system is disclosed. The system includes a catheter defining a first pressure transfer lumen adapted to retain a pressure transfer material, an actuator at a proximal end of the catheter adapted to deliver a pressure from a proximal end to a distal end of the first pressure transfer lumen via the pressure transfer material, a distal section defining at least a first internal chamber adapted to retain a therapeutic gel component, at least a first plunger retained in the first internal chamber, and an injection port for delivering a therapeutic gel component into a treatment location from the first internal chamber when the actuator is used to deliver a pressure via the pressure transfer material to move the first plunger to deliver a therapeutic gel component through the injection port.
摘要翻译：公开了一种注射导管系统。所述系统包括限定适于保持压力转移材料的第一压力传递腔的导管，所述导管的近端处的致动器适于经由所述压力将压力从所述第一压力传递腔的近端输送到远端转移材料，限定至少一个适于保持治疗性凝胶组分的第一内室的远侧部分，至少保留在第一内室中的第一柱塞和用于将治疗性凝胶组分从第一内部输送到治疗位置的注射口当致动器用于经由压力转移材料输送压力以移动第一柱塞以通过注射端口输送治疗性凝胶组分时，内腔室内。

2. 发明申请

WO2013188931A1 CONTAINER FILLED WITH A LOCAL ANAESTHETIC AND METHOD FOR PREPARING A MIXTURE OF A LOCAL ANAESTHETIC AND A SECOND LIQUID 审中-公开
标题翻译：用本地麻醉剂填充的容器和制备本地麻醉剂和第二液体的混合物的方法
公开(公告)号：WO2013188931A1
公开(公告)日：2013-12-27
申请号：PCT/BE2013/000028
申请日：2013-06-07
申请人： VERMEYLEN, Jan Gustaaf M.
发明人： VERMEYLEN, Jan Gustaaf M.
IPC分类号： A61M5/24 , A61M5/32
CPC分类号： A61M5/2448 , A61M5/3294
摘要： Container (1) that is intended to store a first liquid (13) and a second liquid (14) separately in separate chambers (4,5) and which is intended to let the liquids (13, 14) flow simultaneously out of the container (1), that is filled with a first liquid (13) and second liquid (14) in the separate chambers (4,5), characterised in that the first liquid (13) is a solution of a local anaesthetic and the second liquid (14) is an agent to adjust the pH of the first liquid (13).
摘要翻译：用于将第一液体（13）和第二液体（14）分别存储在分开的室（4,5）中并且旨在使液体（13,14）同时流出容器的容器（1）（1），其在分隔室（4,5）中填充有第一液体（13）和第二液体（14），其特征在于，第一液体（13）是局部麻醉剂和第二液体（14）是调节第一液体（13）的pH的试剂。

3. 发明申请

WO2013104665A1 CARTRIDGE HUB WITH ACTIVE VALVE 审中-公开
标题翻译：带主动阀的盒式集线器
公开(公告)号：WO2013104665A1
公开(公告)日：2013-07-18
申请号：PCT/EP2013/050297
申请日：2013-01-09
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： MOORE, David
IPC分类号： A61M5/19 , A61M5/20
CPC分类号： A61M5/3294 , A61M5/14244 , A61M5/14566 , A61M5/16827 , A61M5/19 , A61M5/20 , A61M5/2448 , A61M5/345 , A61M2005/2407 , A61M2005/2474 , A61M2005/2481 , A61M2005/2496 , A61M2005/3117 , A61M2205/10 , A61M2205/50 , F04C2270/0421
摘要： The invention is related to a dispense interface (402) for a drug delivery device for delivering at least two drug agents, wherein the dispense interface (402) is configured to be coupled to a cartridge holder of the drug delivery device, wherein the cartridge holder is configured to hold at least two cartridges (416, 418), wherein the dispense interface (402) comprises at least two inlet channels (404, 406), each comprising a fluid inlet opening (408, 412), wherein each fluid inlet opening (408, 412) is configured to receive fluid from a respective cartridge of the at least two cartridges (416, 418) when the dispense interface (402) is axially coupled to the cartridge holder, an outlet channel (424) comprising a fluid outlet opening (426), a valve structure (420) configured to be selectively moved into any one of a plurality of positions, wherein in at least one position the valve structure (420) selectively permits or prevents fluid flow from any of the at least two inlet channels (404, 406) to the outlet channel (424). The invention is further related to a drug delivery device for delivering at least two drug agents comprising a dispense interface (402) of the aforementioned kind.
摘要翻译：本发明涉及用于递送至少两种药物的药物递送装置的分配界面（402），其中分配界面（402）被配置为联接到药物递送装置的药筒保持器，其中药筒保持器配置为容纳至少两个盒（416,418），其中所述分配接口（402）包括至少两个入口通道（404,406），每个入口通道包括流体入口开口（408,412），其中每个流体入口开口（408,412）被配置成当所述分配接口（402）轴向联接到所述盒保持器时，从所述至少两个盒（416,418）的相应盒中接收流体;出口通道（424），包括流体出口开口（426），阀结构（420），其被配置为选择性地移动到多个位置中的任何一个位置，其中在至少一个位置中，所述阀结构（420）选择性地允许或阻止流体从所述至少两个入口通道（4 04,406）连接到出口通道（424）。本发明进一步涉及用于递送至少两种药剂的药物递送装置，其包括上述类型的分配界面（402）。

4. 发明申请

WO2013030224A1 ARRANGEMENT FOR SEQUENTIAL DELIVERY OF FLUID VOLUMES 审中-公开
标题翻译：顺序输送流体体积的安排
公开(公告)号：WO2013030224A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066755
申请日：2012-08-29
申请人： NOVO NORDISK A/S , BENDIX, Klaus , LINDBLAD, Thomas , SMARTT, Nick
发明人： BENDIX, Klaus , LINDBLAD, Thomas , SMARTT, Nick
IPC分类号： A61M5/32 , A61M5/315
CPC分类号： A61M5/31561 , A61M5/31525 , A61M5/3155 , A61M5/31551 , A61M5/31555 , A61M5/31585 , A61M5/31596 , A61M5/3291 , A61M5/3294 , A61M2005/1787
摘要： The present invention relates to a reservoir unit (40, 140, 240) for a drug delivery arrangement (1, 100, 200), the reservoir unit (40, 140, 240) comprising: a housing (41, 141, 241) adapted to accommodate a fluid substance and comprising a displaceable wall (43, 143, 243), a fluid transport member (50, 150, 250) comprising a fluid outlet (52, 152, 252), first fluid communication means (53, 153, 253) for providing fluid communication with an interior of another reservoir, and second fluid communication means (54, 154, 254) for providing fluid communication with an interior (44, 144, 244) of the housing (41, 141, 241), and coupling means (45, 145, 245) adapted for connection with mating coupling means associated with the other reservoir. The invention further relates to a drug delivery arrangement (1, 100, 200) employing the reservoir unit (40, 140, 240). The fluid transport member being a needle (50) fixedly retained by the outlet portion (42) and having a side hole (54) in the needle body (51) just proximally of the outlet portion (42).
摘要翻译：本发明涉及一种用于药物输送装置（1,100,200）的储存器单元（40,140,240），所述储存器单元（40,140,240）包括：适于以容纳流体物质并且包括可移动壁（43,43,243），包括流体出口（52,152,252）的流体输送构件（50,150,250），第一流体连通装置（53,153，用于提供与另一容器的内部的流体连通的第二流体连通装置（54,154,254），用于提供与壳体（41,141,241）的内部（44,144,244）的流体连通，以及适于与与另一储存器相关联的配合联接装置连接的联接装置（45,145,245）。本发明还涉及采用储存器单元（40,140,240）的药物输送装置（1,100,200）。所述流体输送构件是由所述出口部分（42）固定地保持并且在所述针体（51）中的靠近所述出口部分（42）的近侧具有侧孔（54）的针（50）。

5. 发明申请

WO2012143434A2 MEDICATED MODULE WITH AUTOMATIC RESERVOIR ENGAGEMENT AND LOCK MECHANISM 审中-公开
标题翻译：具有自动储存和锁定机构的药物模块
公开(公告)号：WO2012143434A2
公开(公告)日：2012-10-26
申请号：PCT/EP2012057150
申请日：2012-04-19
申请人： SANOFI AVENTIS DEUTSCHLAND , CROSS JOHN DAVID , BAINTON MICHAEL , KOUYOUMJIAN GAREN , MERCER DAVID RICHARD , BOYD MALCOLM STANLEY
发明人： CROSS JOHN DAVID , BAINTON MICHAEL , KOUYOUMJIAN GAREN , MERCER DAVID RICHARD , BOYD MALCOLM STANLEY
IPC分类号： A61M5/00 , A61M5/24 , A61M5/32
CPC分类号： A61M5/2448 , A61M5/002 , A61M5/2466 , A61M5/3146 , A61M5/31533 , A61M5/326 , A61M5/3272 , A61M5/3294 , A61M2005/1787 , A61M2005/2073 , A61M2005/3267 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584
摘要： A module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks before and after an injection,and locks after dose delivery. Restraining features are present on the module to prevent the needle guard from moving relative to the device, in a trigger locked position.
摘要翻译：公开了一种用于共同递送至少两种药物的注射系统的模块，其中包含主要药物的主要递送装置接受含有单剂量次级药物的模块，并且其中两种药物通过中空针头递送。模块不需要用户手动地接合包含辅助药剂的储存器。相反，当针护罩缩回时，偏置构件自动启动储存器。针头防护装置防止注射前后的意外针刺，并在给药后锁定。在模块中存在限制功能，以防止针护罩相对于设备移动，处于触发器锁定位置。

6. 发明申请

WO2012059452A3 MEDICATED MODULE FOR A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于药物递送装置的药物模块
公开(公告)号：WO2012059452A3
公开(公告)日：2012-06-28
申请号：PCT/EP2011069097
申请日：2011-10-31
申请人： SANOFI AVENTIS DEUTSCHLAND , DAVIES JAMES ALEXANDER , WIMPENNY STEVEN
发明人： DAVIES JAMES ALEXANDER , WIMPENNY STEVEN
IPC分类号： A61M5/24 , A61M5/32
CPC分类号： A61M5/31596 , A61M5/2053 , A61M5/2425 , A61M5/2448 , A61M5/2466 , A61M5/31511 , A61M5/329 , A61M5/3294 , A61M2005/1787
摘要： A system for sequentially dispensing a non-user settable dose of one medicament followed by a user- settable dose of a primary medicament. The system may include a dual cross - section, floating piston (210, 310) arranged to facilitate first delivering all or substantially all of a given medicament (e.g., a secondary medicament) through an output needle (208, 308) and then thereafter delivering yet another medicament (e.g., a primary medicament) through the same output needle in a single injection step. The dual cross - section, floating piston of the system also reduces or limits ullage left in the medicated module relative to the amount of the secondary medicament dispensed from the system.
摘要翻译：一种用于顺序地分配非用户可设置剂量的一种药物，然后是用户可设置剂量的初级药物的系统。该系统可以包括双横截面浮动活塞（210,310），其布置成便于首先通过输出针（208,308）首先输送给定药物（例如，次级药物）的全部或基本上全部，然后输送在单次注射步骤中通过相同输出针的另一种药物（例如，初级药物）。系统的双横截面，浮动活塞还相对于从系统分配的次级药剂的量减少或限制了药物模块中留下的残留物。

7. 发明申请

WO2012059460A1 NEEDLE ASSEMBLY FOR THE DELIVERY OF AT LEAST TWO MEDICAMENTS 审中-公开
标题翻译：用于交付至少两种药物的针头大会
公开(公告)号：WO2012059460A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069109
申请日：2011-10-31
申请人： Sanofi-Aventis Deutschland GmbH , FRANKE, Beate , CERMAN, Zdenek
发明人： FRANKE, Beate , CERMAN, Zdenek
IPC分类号： A61M5/24 , A61M5/32
CPC分类号： A61M5/19 , A61M5/2448 , A61M5/284 , A61M5/31596 , A61M5/326 , A61M5/3294 , A61M5/347 , A61M5/50 , A61M5/5086 , A61M2005/1787 , A61M2005/3128 , A61M2005/3247 , A61M2005/3267
摘要： Various embodiments of needle assemblies for use with a drug delivery device to deliver two or more medicaments are provided. Additionally, various embodiments of methods for delivering two or medicaments are provided. In one embodiment, a needle assembly comprises an injection needle (2), a proximal housing member (11), a distal housing member (12), and a medicament transfer element. The proximal housing member contains a first medicament and is configured to attach to a drug delivery device containing a second medicament. The distal housing member is movably engaged with the proximal housing member such that relative axial movement between the proximal and distal housing members causes the first medicament to be delivered. Upon activation of the drug delivery device (e.g., activation of a dose button of the drug delivery device) the second medicament is transferred, via the medicament transfer feature, from the drug delivery device to the injection needle of the needle assembly such that the second medicament can be delivered.
摘要翻译：提供了用于与药物递送装置一起递送两种或更多种药物的针组件的各种实施方案。另外，提供用于递送两种或多种药物的方法的各种实施方案。在一个实施例中，针组件包括注射针（2），近侧壳体构件（11），远侧壳体构件（12）和药物转移元件。近端壳体构件包含第一药剂并被构造成附着于含有第二药物的药物递送装置。远侧壳体构件与近侧壳体构件可移动地接合，使得近侧和远侧壳体构件之间的相对轴向运动导致第一药物被输送。在激活药物递送装置（例如，激活药物递送装置的剂量按钮）时，第二药物经由药物转运特征从药物递送装置转移到针组件的注射针，使得第二药物可以递送药物。

8. 发明申请

WO2012059459A1 MEDICATED MODULE WITH INTERLOCK 审中-公开
标题翻译：具有互锁的药物模块
公开(公告)号：WO2012059459A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069108
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , DAVIES, James Alexander , CROSS, John David , BOYD, Malcolm Stanley , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas , BILTON, Simon Lewis , REKAYA, Naceur
发明人： DAVIES, James Alexander , CROSS, John David , BOYD, Malcolm Stanley , WIMPENNY, Steven , DE SAUSMAREZ LINTELL, Daniel Thomas , BILTON, Simon Lewis , REKAYA, Naceur
IPC分类号： A61M5/24 , A61M5/32 , A61M5/50 , A61M5/31 , A61M5/178
CPC分类号： A61M5/50 , A61M5/24 , A61M5/32 , A61M5/326 , A61M5/3294 , A61M2005/1787 , A61M2005/3142 , A61M2205/583
摘要： A medicated module attachable to a drug delivery device comprising a connecting body configured for attachment to the drug delivery device. A first needle held within a first needle hub of the connecting body and a second needle fixed within a second needle hub of the connecting body. A recess within the connecting body defining a reservoir. The reservoir containing at least one dose of a medicament and configured for fluid communication with the first needle. The connecting body further comprises a lockout feature that prevents the medicated module from being reconnected to the drug delivery device after the medicated module has been connected to the drug delivery device a first time.
摘要翻译：一种可附接到药物递送装置的药物模块，包括构造成附接到药物递送装置的连接体。保持在连接体的第一针座内的第一针和固定在连接体的第二针座内的第二针。连接体内的凹部限定了一个储存器。所述储存器包含至少一剂剂量的药物，并且被配置为与第一针流体连通。连接体还包括锁定特征，其在药物模块已经第一次连接到药物递送装置之后防止药物模块重新连接到药物递送装置。

9. 发明申请

WO2012059456A1 NEEDLE CANNULA CONTAINING MEDICAMENT 审中-公开
标题翻译：针灸包含药物
公开(公告)号：WO2012059456A1
公开(公告)日：2012-05-10
申请号：PCT/EP2011/069105
申请日：2011-10-31
申请人： SANOFI-AVENTIS DEUTSCHLAND GmbH , DE SAUSMAREZ LINTELL, Daniel Thomas
发明人： DE SAUSMAREZ LINTELL, Daniel Thomas
IPC分类号： A61M5/32 , A61M5/24 , A61M5/28 , A61M5/178
CPC分类号： A61M5/19 , A61M5/2448 , A61M5/284 , A61M5/329 , A61M5/3291 , A61M5/3294 , A61M2005/1787
摘要： A method and system of delivering a first medicament to a first injection depth and a second medicament to a second injection depth using a single dispense interface. A medicated module (202, 500) is attachable to a drug delivery device (100), where the drug delivery device includes a drug reservoir (230) holding a first medicament (232). The medicated module includes a needle cannula (206, 400, 502) having a sidewall (314, 416), at least one micro-hole (308, 310, 312, 406, 410, 412, 414, 504, 506) in the sidewall of the needle cannula, and a flexible membrane (316) sealably fixed to an inner surface (318) of the needle cannula. The flexible membrane holds a second medicament (320, 420) between the flexible membrane and a portion of the sidewall having the at least one micro-hole. The first and second medicaments can be delivered to two, axially separate injection depths.
摘要翻译：一种使用单个分配界面将第一药剂输送到第一注射深度并将第二药物输送到第二注射深度的方法和系统。药物模块（202,500）可附接到药物递送装置（100），其中药物递送装置包括容纳第一药物（232）的药物储存器（230）。所述药物模块包括具有侧壁（314,416）的至少一个微孔（308,310,312,406,410,412,414,504,506）的针插管（206,400,502）针插管的侧壁和可密封地固定到针插管的内表面（318）的柔性膜（316）。柔性膜在柔性膜和具有至少一个微孔的侧壁的一部分之间保持第二药物（320,420）。第一和第二药物可以输送到两个轴向分离的注射深度。

10. 发明申请

WO2012011909A1 NEEDLE ASSEMBLY FOR MIXING OF SUBSTANCES 审中-公开
标题翻译：用于混合物质的针头组件
公开(公告)号：WO2012011909A1
公开(公告)日：2012-01-26
申请号：PCT/US2010/042876
申请日：2010-07-22
申请人： BECTON, DICKINSON AND COMPANY , MARTIN, Frank , KLUG, Richard, J. , HAIDER, M., Ishaq
发明人： MARTIN, Frank , KLUG, Richard, J. , HAIDER, M., Ishaq
IPC分类号： A61M5/178
CPC分类号： A61M5/3294 , A61M5/2448 , A61M5/346 , A61M5/347 , A61M2005/2474
摘要： In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.
摘要翻译：在本发明的一个方面，提供一种针组件，其包括：主体，其具有近端，远端和位于其间的通道，所述主体被配置为安装到注射器; 所述针固定到所述主体，所述针具有近端和远端，所述远端从所述主体的远端向远侧延伸并且被形成为用于插入到患者体内，所述针的近端与所述通道连通; 以及设置在针的近端的近侧的通道中的过滤器。有利地，提供针组件，其允许混合至少两种物质以准备注射，而不改变相关联的注射器。

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