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1. 发明申请

WO2016210402A1 GUIDED ORTHODONTIC BRACKET APPLICATION 审中-公开
标题翻译：引导正交支架应用
公开(公告)号：WO2016210402A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039516
申请日：2016-06-27
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： GRAVENSTEIN, Nikolaus , DOLCE, Calogero , LAMPOTANG, Samsun , LIZDAS, David, Erik
IPC分类号： A61C7/14 , A61C19/04 , A61C7/00 , G06F19/00
CPC分类号： A61C7/002 , A61C7/146 , A61C7/28 , G06F19/00 , G16H20/40
摘要： A computer-implemented method and system for guiding the placement of orthodontic brackets are provided. The system can include an at least one indexing tool designed to conform to at least a portion of a patient's teeth or alveolar process. The system can receive signals from a sensor at the indexing tool as well as signals from a sensor at a bracket positioning tool in order to track spatial location -and/or orientation of one or more brackets relative to the surface of the patient's actual or modeled teeth. A method for guiding the placement of orthodontic brackets involves detecting the location and/or orientation of a bracket with respect to at least one tooth of a patient and notifying the orthodontist that the actual bracket position and/or orientation meets specified criteria with respect to planned placement coordinates for the bracket. The method can further include collecting the planned placement coordinates for each bracket tooth combo during a planning phase.
摘要翻译：提供了一种用于指导正畸托架放置的计算机实现的方法和系统。该系统可以包括设计成符合患者牙齿或肺泡过程的至少一部分的至少一个分度工具。该系统可以在分度工具处接收来自传感器的信号以及来自支架定位工具处的传感器的信号，以便跟踪一个或多个支架相对于患者的实际或建模表面的空间位置和/或取向牙齿。用于引导正畸托架放置的方法包括检测支架相对于患者的至少一个牙齿的位置和/或方位，并通知正畸医生实际支架位置和/或方位符合规划的指定标准支架的放置坐标。该方法还可以包括在规划阶段收集每个支架齿组合的计划放置坐标。

2. 发明申请

WO2012033906A2 CONTEXT-SENSITIVE FLOW INTERRUPTER AND DRAINAGE OUTFLOW OPTIMIZATION SYSTEM 审中-公开
标题翻译：语境敏感的中断和排水外流优化系统
公开(公告)号：WO2012033906A2
公开(公告)日：2012-03-15
申请号：PCT/US2011/050810
申请日：2011-09-08
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. , LAMPOTANG, Samsun , GRAVENSTEIN, Nikolaus , SCHWAB, Wilhelm, K. , LIZDAS, David, E. , ENNEKING, Francesca, K.
发明人： LAMPOTANG, Samsun , GRAVENSTEIN, Nikolaus , SCHWAB, Wilhelm, K. , LIZDAS, David, E. , ENNEKING, Francesca, K.
IPC分类号： A61M1/00 , A61M27/00 , A61M39/08 , A61M39/28 , A61J1/05
CPC分类号： A61M25/0017 , A61M1/0021 , A61M39/08 , A61M39/28 , A61M39/284
摘要： Embodiments of the invention provide methods and devices for improved drainage systems and tubing. In one embodiment, a context-sensitive flow interrupter is provided that inhibits or facilitates flow of fluid when engaged with a mating holder. In another embodiment, outflow is optimized through control of the pressure in gas pockets in a tube, drainage tube or assembly. In one such embodiment, gas pockets are vented to inhibit excessive back-pressure or suction on an organ, vessel or cavity being drained. In another such embodiment, loops in the tubes are avoided by using a mechanical template in the form of a groove or peg assembly to thread the slack in the drainage tube to generate a monotonic gradient. In another embodiment, such as for active drainage systems, a bypass channel is provided that allows an applied vacuum to go around an obstruction created by the collection of fluid in an undrained dependent loop.
摘要翻译：本发明的实施例提供了用于改进的排水系统和管道的方法和装置。在一个实施例中，提供了当与配合保持器接合时抑制或促进流体流动的上下文敏感流动中断器。在另一个实施例中，通过控制管，引流管或组件中的气囊中的压力来优化流出。在一个这样的实施例中，气囊被排出以抑制在排出的器官，血管或腔体上的过度背压或抽吸。在另一个这样的实施例中，通过使用凹槽或钉组件的形式的机械模板来避免管中的环以将松弛部分穿入引流管中以产生单调梯度。在另一个实施例中，例如对于主动排水系统，提供了旁路通道，其允许施加的真空环绕由在不排水的依赖回路中的流体收集产生的障碍物周围。

3. 发明申请

WO2011146806A1 METHODS FOR REDUCING ANESTHETIC-INDUCIBLE EPILEPTOGENIC AND NEUROTOXIC EFFECTS 审中-公开
标题翻译：降低麻醉诱导性肾上腺皮质激素和神经毒性作用的方法
公开(公告)号：WO2011146806A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/037289
申请日：2011-05-20
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MARTYNYUK, Anatoly, Eugeny , SEUBERT, Christoph, Nikolaus , GRAVENSTEIN, Nikolaus
发明人： MARTYNYUK, Anatoly, Eugeny , SEUBERT, Christoph, Nikolaus , GRAVENSTEIN, Nikolaus
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A61K31/585 , A61K31/08 , A61K38/11 , A61K45/06 , A61K2300/00
摘要： The disclosure encompasses methods of reducing a neural activity in an animal or human subject. The neural activity may be a seizure that may be, but is not necessarily, an inducible side-effect of an anesthetic in an animal or human subject. The methods include administering to an animal or human subject an anesthetic together with a therapeutic agent selected from an inhibitor of the Na + -K + -2Cl - symport ion co-transporter 1 (NKCC1)agent, a mineralcorticoid receptor (MR) antagonist, or an agonist of an oxytocin receptor or a derivative thereof. The therapeutic agent can be be administered before or with an anesthetic, thereby reducing the likelihood of the onset of a non-anesthesizing effect of the anesthetic or the severity thereof. A suitable mineralcorticoid receptor (MR) antagonist can be 17-spironolactone, and the oxytocin receptor agonist can be, but not limited to, oxytocin, carbetocin, and the like. The neural activity reduced by the methods of the disclosure can include the onset or level of a seizure, a neurotoxicity, a behavioral effect, a cognitive effect.
摘要翻译：本公开内容包括减少动物或人类受试者的神经活性的方法。神经活动可以是可能但并不一定是麻醉剂在动物或人类受试者中的诱导性副作用的发作。所述方法包括向动物或人类受试者施用麻醉剂，其与选自Na + -K + -2Cl-对称离子共转运蛋白1（NKCC1）抑制剂，盐皮质激素受体（MR）拮抗剂或催产素受体或其衍生物的激动剂。治疗剂可以在麻醉之前或与麻醉剂一起施用，从而降低麻醉剂非麻醉作用发生的可能性或其严重性。合适的皮质激素受体（MR）拮抗剂可以是17-安体舒通内酯，催产素受体激动剂可以是但不限于催产素，卡贝缩酮等。通过本公开的方法减少的神经活动可以包括发作的发作或水平，神经毒性，行为效应，认知效应。

4. 发明申请

WO2011127379A2 INTERACTIVE MIXED REALITY SYSTEM AND USES THEREOF 审中-公开
标题翻译：互动混合现实系统及其用途
公开(公告)号：WO2011127379A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031738
申请日：2011-04-08
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. , LAMPOTANG, Samsun , GRAVENSTEIN, Nikolaus , LIZDAS, David, Erik , LURIA, Isaac, Thomas , PETERSON, Matthew, James
发明人： LAMPOTANG, Samsun , GRAVENSTEIN, Nikolaus , LIZDAS, David, Erik , LURIA, Isaac, Thomas , PETERSON, Matthew, James
IPC分类号： G09B9/00 , G09B23/28 , G09B5/02
CPC分类号： G06T19/006 , B33Y80/00 , G06F3/011 , G06F3/017 , G06F3/02 , G06T7/20 , G06T7/70 , G06T19/20 , G06T2207/10028 , G09B9/00 , G09B23/28 , G09B23/285 , G09B23/286 , G09B23/30
摘要： An interactive mixed reality simulator is provided that includes a virtual 3D model of internal or hidden features of an object; a physical model or object being interacted with; and a tracked instrument used to interact with the physical object. The tracked instrument can be used to simulate or visualize interactions with internal features of the physical object represented by the physical model. In certain embodiments, one or more of the internal features can be present in the physical model. In another embodiment, some internal features do not have a physical presence within the physical model.
摘要翻译：提供了一种交互式混合现实模拟器，其包括对象的内部或隐藏特征的虚拟3D模型; 与之相互作用的物理模型或物体; 以及用于与物理对象交互的跟踪仪器。跟踪的仪器可用于模拟或可视化与物理模型表示的物理对象的内部特征的交互。在某些实施例中，一个或多个内部特征可以存在于物理模型中。在另一个实施例中，一些内部特征在物理模型中不具有物理存在。

5. 发明申请

WO2006020171A1 METHODS AND MATERIALS FOR TREATING MENTAL ILLNESS 审中-公开
标题翻译：治疗精神错乱的方法和材料
公开(公告)号：WO2006020171A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/025357
申请日：2005-07-18
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MARTYNYUK, Anatoly, E. , DENNIS, Donn, M. , GRAVENSTEIN, Nikolaus , GLUSHAKOV, Alexander, V. , YAROTSKKY, Viktor , SUMNERS, Colin , SEUBERT, Christoph
发明人： MARTYNYUK, Anatoly, E. , DENNIS, Donn, M. , GRAVENSTEIN, Nikolaus , GLUSHAKOV, Alexander, V. , YAROTSKKY, Viktor , SUMNERS, Colin , SEUBERT, Christoph
IPC分类号： A61K31/198
CPC分类号： A61K31/198 , A61K31/382 , A61K31/445 , A61K31/505 , A61K31/54 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The subject invention pertains to methods of treating mental illnesses or conditions characterized by a decreased function of NMDA receptors and/or excessively enhanced glutamate release and activity of non-NMDA receptors (AMPA and/or kainate). Specifically disclosed are methods utilizing BrPhe, or isomers of analogs thereof, for treating or preventing mental illness or conditions such as schizophrenia.
摘要翻译：本发明涉及治疗精神疾病或特征在于NMDA受体功能降低和/或过度增强的非NMDA受体（AMPA和/或红藻氨酸）的谷氨酸释放和活性的方法。具体公开的是使用BrPhe或其类似物的异构体用于治疗或预防精神疾病或诸如精神分裂症的病症的方法。

6. 发明申请

WO2016196743A1 METHODS AND SYSTEMS FOR DETECTING MELANOMA 审中-公开
标题翻译：用于检测MELANOMA的方法和系统
公开(公告)号：WO2016196743A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035442
申请日：2016-06-02
申请人： THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： GRAVENSTEIN, Nikolaus , SHAW, Christiana, M. , COSTANZO, Michael, T. , YOST, Rick , ULMER, Candice, Z. , SEARCY, Louis
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N33/5743 , G01N2405/00 , G01N2560/00
摘要： The present disclosure provides methods and systems for detecting melanoma in a host. The methods include non-invasive methods of detecting melanoma and methods and systems for providing a molecular signature and/or melanoma biomarker signature for a host.
摘要翻译：本公开提供了用于检测宿主中黑素瘤的方法和系统。所述方法包括检测黑素瘤的非侵入性方法以及用于为宿主提供分子标记和/或黑素瘤生物标志物签名的方法和系统。

7. 发明申请

WO2008154494A1 HANDWASHING COMPLIANCE DETECTION SYSTEM 审中-公开
标题翻译：手洗合格检测系统
公开(公告)号：WO2008154494A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/066329
申请日：2008-06-09
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. , MELKER, Richard , GRAVENSTEIN, Nikolaus , DENNIS, Donn, Michael , BATICH, Christopher, D.
发明人： MELKER, Richard , GRAVENSTEIN, Nikolaus , DENNIS, Donn, Michael , BATICH, Christopher, D.
IPC分类号： G08B23/00 , A61G21/00
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用以确定是否符合手部卫生指南。洗手剂提供有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。在洗手事件之后，将受试者的手暴露于检测器（例如徽章），其包括能够检测挥发性化合物的传感器，以及指示挥发性化合物的检测，指示使用洗手剂和手卫生合规。

8. 发明申请

WO2022204459A1 METHODS AND COMPOSITIONS FOR TREATMENT OF LOW CIRCULATING TESTOSTERONE CONDITIONS 审中-公开
公开(公告)号：WO2022204459A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/021852
申请日：2022-03-25
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： MARTYNYUK, Anatoly, Eugeny , JU, Lingsha , MOREY, Timothy, E. , GRAVENSTEIN, Nikolaus , SEUBERT, Christoph, N.
IPC分类号： A61K31/02 , A61K31/08 , A61P23/00
摘要： In one aspect, the disclosure relates to methods of treating a subject having a clinical condition associated with low circulating levels of testosterone, comprising: administering to the subject a therapeutically effective dose of sevoflurane, thereby treating the clinical condition associated with low circulating levels of testosterone. In some aspects, the sevoflurane can be administered nasally or by inhalation. In another aspect, exposure to sevoflurane results in long-term increase in serum levels of testosterone in the subject (e.g., 60 days to 120 days). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

9. 发明申请

WO2009045374A3 NOVEL METHODS AND DEVICES FOR NONINVASIVE MEASUREMENT OF ENERGY ABSORBERS IN BLOOD 审中-公开
公开(公告)号：WO2009045374A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/011276
申请日：2008-09-29
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. , GRAVENSTEIN, Dietrich , RICE, Mark, J. , LAMPOTANG, Samsun , GRAVENSTEIN, Nikolaus , DEITTE, Lori
发明人： GRAVENSTEIN, Dietrich , RICE, Mark, J. , LAMPOTANG, Samsun , GRAVENSTEIN, Nikolaus , DEITTE, Lori
IPC分类号： G01N33/72 , G01N33/48
摘要： Various embodiments of the present invention include devices for use in determining the concentration of a tissue energy absorber (e.g., hemoglobin) in an individual's blood. In particular embodiments, the device includes a photometric device (e.g., a pulse oximeter) and an imaging device (e.g., an ultrasound imaging device or other suitable imaging device), and the device is adapted for: (A) using the photometric device to measure a change in mass of the tissue energy absorber within a particular volume of the individual's blood between a first point in time and a second point in time, the particular volume of blood being blood within a particular portion of at least one vascular structure, the vascular structure comprising at least one of the individual's vessels (e.g., at least one of the individual's arteries); (B) using an ultrasound imaging device to measure a change in interior volume, between the first point in time and the second point in time, of the particular portion of the vascular structure; and (C) using both the measured change in the mass of the tissue energy absorber, and the measured change in interior volume to determine at least an approximate blood total concentration of the tissue energy absorber within the individual's blood.

10. 发明申请

WO2009003169A2 DISPLAY-BASED INTERACTIVE SIMULATION WITH DYNAMIC PANORAMA 审中-公开
标题翻译：基于显示的动态全景相互作用模拟
公开(公告)号：WO2009003169A2
公开(公告)日：2008-12-31
申请号：PCT/US2008/068580
申请日：2008-06-27
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , LAMPOTANG, Samsun , LIZDAS, David, Erik , TUMINO, John, Joseph , GRAVENSTEIN, Nikolaus
发明人： LAMPOTANG, Samsun , LIZDAS, David, Erik , TUMINO, John, Joseph , GRAVENSTEIN, Nikolaus
IPC分类号： G06T15/00
CPC分类号： G06F3/011 , G06T15/205 , G06T19/003 , G09B23/28
摘要： The subject invention provides a panoramic, interactive, seamless, intuitive, high-resolution and yet extensive simulation tool capable of simulating dynamic events that alter the panoramic view in response to the user's actions or inaction. The dynamic panorama simulation can generate and display novel scenes that are not limited to static "canned" content that has been previously photographed, rendered, recorded, captured or filmed thus providing great flexibility, contextual authenticity and liveliness and, in some instances, unanticipated and surprising but accurate developments in the simulation.
摘要翻译：本发明提供了全景，交互式，无缝，直观，高分辨率和广泛的仿真工具，能够模拟响应于用户的动作或不行动而改变全景的动态事件。动态全景模拟可以生成和显示新颖的场景，不仅限于以前拍摄，呈现，记录，拍摄或拍摄的静态“罐头”内容，从而提供极大的灵活性，背景真实性和活力，并且在某些情况下，意外和令人惊讶但准确的发展在模拟。

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