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1. 发明申请

WO2022056155A1 RECOMBINANT ALGAE HAVING HIGH LIPID PRODUCTIVITY 审中-公开
公开(公告)号：WO2022056155A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/049708
申请日：2021-09-09
申请人： SYNTHETIC GENOMICS, INC.
发明人： IMAM, Saheed , MOELLERING, Eric R. , PEACH, Luke , LAMBERT, William F. , WEIR, Jessica
IPC分类号： C07H21/04 , C07K14/405 , C12N1/12 , C12N1/13 , C12N1/36
摘要： The invention provides recombinant algal organisms that have a genetic modification to a gene or nucleic acid sequence encoding an RNA binding domain. In some embodiments the genetic modification can be a functional deletion or attenuation of the gene. The genetic modification results in a mutant organism with increased lipid productivity and/or higher biomass productivity. The lipid products of these mutants can be utilized as biofuels or to manufacture other specialty products. The recombinant mutants can also, optionally, have a genetic modification to a gene encoding an SGI1 polypeptide. Methods of making and using the recombinant algal mutants and methods of producing lipids are also disclosed.

2. 发明申请

WO2019143949A2 INDUCE AND ENHANCE IMMUNE RESPONSES USING RECOMBINANT REPLICON SYSTEMS 审中-公开
公开(公告)号：WO2019143949A2
公开(公告)日：2019-07-25
申请号：PCT/US2019/014210
申请日：2019-01-18
申请人： SYNTHETIC GENOMICS, INC.
发明人： KAMRUD, Kurt, Iver , WANG, Nathaniel, Stephen , ALIAHMAD, Parinaz , DEHART, Jason
IPC分类号： A61K39/12
摘要： The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.

3. 发明申请

WO2018075235A1 RECOMBINANT VIRUS REPLICON SYSTEMS AND USES THEREOF 审中-公开
标题翻译：重组病毒复制系统及其用途
公开(公告)号：WO2018075235A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/054928
申请日：2017-10-03
申请人： SYNTHETIC GENOMICS, INC.
发明人： KAMRUD, Kurt, Iver
IPC分类号： C12N15/86
摘要： The present disclosure generally relates to viral-based expression systems suitable for the production of molecules of interest. The disclosure relates to nucleic acid constructs, such as expression vectors, containing a modified replicon RNA which includes a modified 5 '-unstranslated region (5' -UTR) and, optionally, at least some of its original viral sequence encoding structural proteins having been deleted. Also disclosed are methods for producing polypeptides of interest.
摘要翻译：本公开总体涉及适用于产生感兴趣的分子的基于病毒的表达系统。本公开内容涉及包含修饰的复制子RNA的核酸构建体，例如表达载体，所述修饰的复制子RNA包含修饰的5'非翻译区（5'-UTR）以及任选地至少一些其编码结构蛋白的原始病毒序列删除。还公开了生产感兴趣多肽的方法。

4. 发明申请

WO2018039639A1 GENETICALLY ENGINEERED VIBRIO SP. AND USES THEREOF 审中-公开
标题翻译：基因工程VIBRIO SP。并使用它
公开(公告)号：WO2018039639A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048743
申请日：2017-08-25
申请人： SYNTHETIC GENOMICS, INC.
发明人： WEINSTOCK, Matthew T. , WILSON, Christopher, M.
IPC分类号： A61K39/02 , C12N15/63 , C12N15/90
摘要： The present disclosure provides engineered Vibrio sp . organisms. The organisms can be engineered to have an altered Chromosome II so that the altered Chromosome II can be used in Vibrio sp . and other organisms for the cloning or amplification of nucleic acid molecules and for the expression and production of proteins and peptides in a Vibrio sp. organism. One or more genetic elements have been deleted from Chromosome II and/or relocated from Chromosome II to Chromosome I. The engineered Vibrio sp . organisms of the invention can also have signal sequences fused to proteins or peptides to be secreted from the cell. In some embodiments the engineered Vibrio sp . organisms can have sequences that enable them to retain viability after incubation at low temperatures.
摘要翻译：本公开提供了工程化的弧菌sp。生物。生物体可以被改造成具有改变的染色体II，从而改变的染色体II可以用于弧菌属。和用于克隆或扩增核酸分子以及用于在弧菌中表达和生产蛋白质和肽的其他生物体。生物。一种或多种遗传元件已从染色体II中删除和/或从染色体II重新定位至染色体I.工程化的弧菌属sp。本发明的生物体也可具有与从细胞分泌的蛋白质或肽融合的信号序列。在一些实施方案中，工程化的Vibrio sp 。生物体可以具有序列，使得它们能够在低温孵育后保留生存力。

5. 发明申请

WO2017132407A1 PROTEIN CONTAINING MATERIAL BIOMASS AND METHODS OF PRODUCTION 审中-公开
标题翻译：含蛋白质的材料生物质和生产方法
公开(公告)号：WO2017132407A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/015177
申请日：2017-01-26
申请人： SYNTHETIC GENOMICS, INC.
发明人： SCHOLTEN, Johannes , LAKSHMANASWAMY, Arun , BURKE, Joel , RUTT, George, C.
IPC分类号： A23J3/20 , C12N1/06
CPC分类号： A23J3/20 , A23J1/006 , A23J1/009 , C12N1/12
摘要： The present invention provides methods and protein compositions having advantageous properties, such as a high uncorrected limiting amino acid score as well as favorable amounts of essential amino acids, branched chain amino acids, as well as other amino acids more difficult to find in the regular diet. The protein composition is obtainable as taught herein from algal or microbial biomass. The protein composition produced according to the methods of the invention provides a proteinaceous food or food ingredient that is more nutritionally balanced (and therefore nutritionally superior) to protein compositions otherwise available. The protein material is advantageously used as a food or food ingredient for humans and/or animals. Also provided are methods of producing the protein material from biomass sources.
摘要翻译：本发明提供了具有有利特性的方法和蛋白质组合物，例如高的未校正限制性氨基酸评分以及有利量的必需氨基酸，支链氨基酸以及其他氨基酸在正常饮食中更难找到。如本文教导的，蛋白质组合物可以从藻类或微生物生物质获得。根据本发明的方法产生的蛋白质组合物提供了蛋白质食物或食物成分，该蛋白质食物或食物成分在其他方面可获得的蛋白质组合物中更加营养平衡（并且因此在营养上更好）。蛋白质材料有利地用作人和/或动物的食物或食物成分。还提供了从生物质来源生产蛋白质材料的方法。

6. 发明申请

WO2017095960A1 COMPOSITIONS AND METHODS FOR EXPRESSING GENES IN ALGAE 审中-公开
标题翻译：在藻类中表达基因的组合物和方法
公开(公告)号：WO2017095960A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064275
申请日：2016-11-30
申请人： SYNTHETIC GENOMICS, INC.
发明人： MOELLERING, Eric, R. , EDWARDS, Amanda, R. , BAUMAN, Nicholas
IPC分类号： A01H1/00 , A61K31/7088 , C12N1/13 , C12N9/22
CPC分类号： C12N15/8216 , C07K14/405 , C12N15/79 , C12N15/8209 , C12N15/8218 , C12N15/8247 , C12N15/8269
摘要： The present application provides novel regulatory elements including promoter sequences from microorganisms. The application further discloses DNA constructs containing these novel regulatory elements, and recombinant microorganisms comprising these regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory elements and transformation methods disclosed herein are particularly suited for use in Parachlorella and other microalgae.
摘要翻译：本申请提供了新的调控元件，包括来自微生物的启动子序列。本申请还公开了含有这些新调控元件的DNA构建体，以及包含这些调控元件的重组微生物。还公开了修饰，产生和使用调控元件的方法。本文公开的调控元件和转化方法特别适用于小球藻和其他微藻。

7. 发明申请

WO2016015013A1 PROTEIN RICH FOOD INGREDIENT FROM BIOMASS AND METHODS OF PREPARATION 审中-公开
标题翻译：蛋白质丰富的食物成分从生物量和制备方法
公开(公告)号：WO2016015013A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/042113
申请日：2015-07-24
申请人： SYNTHETIC GENOMICS, INC.
发明人： RUTT, George, C. , FLATT, James, H. , DOMAILLE, Peter , TOLEDO, Gerardo, V.
IPC分类号： A23J3/20 , C12N1/06 , C12N1/12
CPC分类号： A23J3/20 , A23J1/008
摘要： The present invention provides a protein material and food ingredient from a sustainable and stable source. The sustainable and stable source of the food or food ingredient is biomass, for example an algal or microbial biomass. The invention discloses that the biomass can be subjected to a series of steps to derive the protein material and food or food ingredient, which has high nutritional content without the unacceptable organoleptic properties that typically accompany proteins and food ingredients from these sources.
摘要翻译：本发明提供了可持续和稳定的来源的蛋白质材料和食品成分。食物或食品成分的可持续和稳定的来源是生物量，例如藻类或微生物生物量。本发明公开了生物质可以进行一系列步骤以得到具有高营养含量的蛋白质材料和食品或食品成分，而没有通常伴随这些来源的蛋白质和食物成分的不可接受的感官特性。

8. 发明申请

WO2015179844A3 LABYRINTHULOMYCETE STRAINS FOR PRODUCING DOCOSAHEXAENOIC ACID 审中-公开
标题翻译：用于生产DOCOSAHEXAENOIC酸的乳酸菌菌株
公开(公告)号：WO2015179844A3
公开(公告)日：2016-01-14
申请号：PCT/US2015032308
申请日：2015-05-22
申请人： SYNTHETIC GENOMICS INC
发明人： RADAKOVITS RANDOR R , CHAMPAGNE MICHELE L
IPC分类号： C12P7/64 , C10G3/00 , C11B1/00
CPC分类号： C12N1/00 , A23D9/00 , A23K20/158 , C07C53/126 , C07C57/03 , C12N1/10 , C12N1/36 , C12N15/01 , C12P7/6409 , C12P7/6427 , C12P7/649 , C12R1/00 , C12R1/90 , Y02E50/13 , Y02P30/20
摘要： Improved labyrinthulomycetes strains that produce microbial oils having increased docosahexaenoic acid (DHA) content are disclosed. The strains have increased productivity with respect to a wild type strain. Also provided are microbial oil compositions having increased DHA content. Methods of improving strains for the production of lipid, such as DHA, are also included.
摘要翻译：公开了产生具有增加的二十二碳六烯酸（DHA）含量的微生物油的改进的迷路囊霉菌菌株。菌株相对于野生型菌株具有提高的生产力。还提供了具有增加的DHA含量的微生物油组合物。还包括改善用于生产脂质的菌株如DHA的方法。

9. 发明申请

WO2015077443A3 METHODS FOR PRODUCING DICARBOXYLIC ACIDS 审中-公开
标题翻译：生产二羧酸的方法
公开(公告)号：WO2015077443A3
公开(公告)日：2015-11-12
申请号：PCT/US2014066595
申请日：2014-11-20
申请人： SYNTHETIC GENOMICS INC
发明人： GRIFFIN BENJAMIN M , KAMBOURAKIS SPIROS
IPC分类号： C12P7/44 , C12N9/00 , C12P7/64
CPC分类号： C12P7/6409 , C12N9/001 , C12N9/0071 , C12Y114/14001
摘要： The present invention provides methods of producing dicarboxylic acids. The methods involve incubating a fatty acid or hydrocarbon substrate with an enzyme to produce a dicarboxylic acid product. The enzyme acts on the substrate to produce a product that has been both over-oxidized and has undergone cleavage of a C-C bond. In some embodiments the enzymes having these useful characteristics are mutants of a cytochrome P450 enzyme, for example an enzyme of the class CYP102 or a mutant thereof. The invention provides enzymes where these desirable characteristics can be found in a single enzyme, and thus in some embodiments the methods can be performed through the action of a single enzyme.
摘要翻译：本发明提供了生产二羧酸的方法。该方法包括将脂肪酸或烃底物与酶一起温育以产生二羧酸产物。该酶作用于底物以产生既已过氧化又已经经历C-C键裂解的产物。在一些实施方案中，具有这些有用特征的酶是细胞色素P450酶的突变体，例如CYP102类的酶或其突变体。本发明提供了可在单一酶中发现这些所需特征的酶，因此在一些实施方式中，所述方法可通过单一酶的作用进行。

10. 发明申请

WO2015143381A2 COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF 审中-公开
标题翻译：用于生产化学品及其衍生物的组合物和方法
公开(公告)号：WO2015143381A2
公开(公告)日：2015-09-24
申请号：PCT/US2015/021848
申请日：2015-03-20
申请人： SYNTHETIC GENOMICS, INC.
发明人： KAMBOURAKIS, Spiros , GRIFFIN, Benjamin, M. , MARTIN, Kevin, V.
IPC分类号： C12P7/58 , C12P17/04
CPC分类号： C12P7/58 , C12P7/44 , C12P17/06
摘要： The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention.
摘要翻译：本发明提供了生产一种或多种酶途径的产物的方法。用于本发明方法的途径包括一个或多个转化步骤，例如将古罗糖醛酸酶促转化成D-葡糖二酸（步骤7）; 将5-酮葡萄糖酸（5-KGA）酶促转化成L-阿魏酸（步骤15）; 步骤7b）中L-赖康酸转化成Idaric酸的酶促转化; 并将5-酮基葡萄糖酸酯酶促转化成4,6-二羟基2,5-二酮己酸酯（2,5-DDH）（步骤16）。在一些实施方案中，本发明的方法产生作为产物的2,5-呋喃二羧酸（FDCA）。所述方法包括作为步骤的酶和化学转化。还提供了将葡萄糖转化为5-脱氢-4-脱氧葡糖二酸（DDG）和将葡萄糖转化为2,5-呋喃二羧酸（FDCA）的各种途径。该方法还涉及使用以高特异性和高效率进行反应的工程化酶。可以生产的其它产品包括代谢产物，例如但不限于古洛糖醛酸，L-艾杜糖醛酸，id酸，葡糖二酸。可以使用葡萄糖作为底物或在本发明的任何方法或途径中使用任何中间体来生产任何产物。

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