专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006047362A2 TRANSDERMAL DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2006047362A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038086
申请日：2005-10-21
申请人： DURECT CORP , YUM SU II , THEEUWES FELIX
发明人： YUM SU II , THEEUWES FELIX
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。该系统含有足够量的舒芬太尼，以在应用于受试者时诱导和维持恒定的止痛状态。该系统的特征在于具有一个或多个特征，包括对来自系统的舒芬太尼通量的高度剂量率控制，来自系统通过皮肤的高舒芬太尼净通量，缺乏渗透促进剂，展示粘合剂构件优越的剪切时间，来自系统的舒芬太尼的净通量的低变化系数，高的递送效率以及来自系统的舒芬太尼的基本恒定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时长时间诱导和维持镇痛的方法。

2. 发明申请

WO2004067062A3 EXPANDABLE BORE INJECTION NEEDLE 审中-公开
标题翻译：可膨胀的注射针
公开(公告)号：WO2004067062A3
公开(公告)日：2006-05-04
申请号：PCT/US2004002447
申请日：2004-01-28
申请人： DURECT CORP
发明人： GILLIS EDWARD M , FILICE JAMES A , BROWN JIM , RAMPERSAUD CHARLES , POUTIATINE ANDREW , ARGONZA DANNY
IPC分类号： A61B17/34 , A61M20060101 , A61M5/178
CPC分类号： A61B17/3468 , A61B17/3439
摘要： The present invention is a trocar/cannula assembly that is capable of delivering large-diameter objects/fluids into a body cavity interior, while minimizing the puncture footprint left after insertion. Generally, the invention could be a composite needle (12) having a composite wall (18) forming a trocar shaft (18) with at least two rigid elements (20), and flexible material (26) therebetween, which together at least partially define a trocar bore having a diameter, and a puncture tip (30). Together these elements enable the composite wall to flex outward so as to increase the diameter of the trocar bore. Additionally, the present invention could also be described as an expandable bore trocar/cannula that is made up of an expandable cannula body (40) having an interior channel that is capable of flexing radially outward, and a trocar tip associated with the cannula body to facilitate the insertion of the trocar/cannula into a patient.
摘要翻译：本发明是一种套管针/套管组件，其能够将大直径物体/流体输送到体腔内部，同时最小化插入后留下的穿刺足迹。通常，本发明可以是具有形成具有至少两个刚性元件（20）的套管针轴（18）的复合壁（18）和其间的柔性材料（26）的复合针（12），其一起至少部分地限定具有直径的套管针孔和穿刺尖端（30）。这些元件一起使得复合壁向外弯曲，从而增加套管针孔的直径。另外，本发明还可以被描述为由可扩张的套管主体（40）构成的可扩展的套管针/套管，其具有能够径向向外弯曲的内部通道，以及与插管主体相关联的套针针头有助于套管针/套管插入患者体内。

3. 发明申请

WO2004022130A3 AUTONOMOUS PATCH FOR COMMUNICATION WITH AN IMPLANTABLE DEVICE, AND MEDICAL KIT FOR USING SAID PATCH 审中-公开
标题翻译：用于与植入式装置通信的自动补丁，以及用于使用所述补丁的医疗工具包
公开(公告)号：WO2004022130A3
公开(公告)日：2004-05-13
申请号：PCT/US0327862
申请日：2003-09-05
申请人： DURECT CORP
发明人： GASS VOLKER , GILLIS EDWARD M
IPC分类号： A61M20060101 , A61N1/08 , A61N1/372 , A61N1/378
CPC分类号： A61N1/37235 , A61N1/3787
摘要： The present invention is directed to a self contained control patch for an implanted medical device, comprising a housing capable of being removably associated with an external surface of a patient, a transmitter for transmitting at least one of a transcutaneous power signal and a transcutaneous control signal to an implanted device; and a pre-programmed storage device containing at least one control program, wherein the control program dictates the nature of the signal from the transmitting means. Additionally, the present invention is directed to a system of such patches comprising two or more patches, with each patch being pre-programmed with a discrete set of instructions. Methods for using the patches are additionally disclosed.
摘要翻译：本发明涉及一种用于植入的医疗装置的独立控制贴片，其包括能够可移除地与患者的外表面相关联的壳体，用于发送经皮功率信号和经皮控制信号中的至少一个的发射器到植入装置; 以及包含至少一个控制程序的预先编程的存储设备，其中控制程序指示来自发送装置的信号的性质。另外，本发明涉及这种贴片的系统，其包括两个或更多个贴片，每个贴片用一组离散的指令预先编程。另外公开了使用贴剂的方法。

4. 发明申请

WO0228366A9 DEVICES AND METHODS FOR MANAGEMENT OF INFLAMMATION 审中-公开
标题翻译：用于管理炎症的装置和方法
公开(公告)号：WO0228366A9
公开(公告)日：2003-02-13
申请号：PCT/US0131652
申请日：2001-10-09
申请人： DURECT CORP , CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
发明人： CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
IPC分类号： A61K9/00 , A61K9/22 , A61K31/352 , A61K31/37
CPC分类号： A61K9/0024 , A61K31/352
摘要： Devices and methods for the sustained release into a subject of an inhibitor of mast cell-mediated inflammation, specifically sustained-release of sodium cromoglycate as a prophylactic to prevent acute asthma attacks.
摘要翻译：用于持续释放到肥大细胞介导的炎症抑制剂的受试者的装置和方法，特别是缓释色甘酸钠作为预防性急性哮喘发作的预防剂。

5. 发明申请

WO0243800A2 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于从药物递送装置进行控制的装置和方法
公开(公告)号：WO0243800A2
公开(公告)日：2002-06-06
申请号：PCT/US0143143
申请日：2001-11-21
申请人： DURECT CORP , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
发明人： BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00 , A61M39/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

6. 发明申请

WO0168140A3 OPIOID FORMULATIONS 审中-公开
标题翻译：阿片类制剂
公开(公告)号：WO0168140A3
公开(公告)日：2001-12-13
申请号：PCT/US0106955
申请日：2001-03-02
申请人： DURECT CORP , LITMANOVITZ DANA , LAIDLAW BARBARA J F
发明人： LITMANOVITZ DANA , LAIDLAW BARBARA J F
IPC分类号： C07D211/58 , A61K9/00 , A61K31/4468 , A61K31/4515 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61P25/02 , A61P25/04 , A61P29/00 , C07D409/06 , A61P23/00
CPC分类号： A61K9/0014 , A61K9/0019 , A61K31/4468 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.
摘要翻译：本发明提供阿片样物质的高浓度制剂，例如芬太尼或芬太尼同源物。本发明的制剂包含芬太尼或芬太尼同源物，其浓度显着超过常规制剂，例如约为常规制剂约2倍至约10,000倍，例如目前可商购的制剂。这些制剂对长期递送给患有疼痛的对象特别有用。本发明进一步提供了包含高浓度阿片样物质制剂的药物递送装置，并且还提供了减轻受试者疼痛的方法，包括将所述高浓度制剂给予有需要的受试者。

7. 发明申请

WO2006033948A2 CONTROLLED DELIVERY SYSTEM 审中-公开
标题翻译：控制输送系统
公开(公告)号：WO2006033948A2
公开(公告)日：2006-03-30
申请号：PCT/US2005032863
申请日：2005-09-15
申请人： DURECT CORP , VERITY NEIL A
发明人： VERITY NEIL A
IPC分类号： A61K47/26 , A61K9/08 , A61K31/445 , B60C27/10
CPC分类号： A61K31/445 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/107 , A61K9/7015 , A61K45/06 , A61K47/22 , A61K47/26
摘要： The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.
摘要翻译：本发明涉及含有非聚合物载体材料和麻醉剂的新型麻醉剂组合物，其中组合物适于提供持续的局部麻醉而没有初始爆发并具有约24小时或更长时间的持续时间。还提供了包括第一麻醉剂和第二麻醉剂的某些组合物。在这种组合物中，第二麻醉剂是用于第一麻醉剂的溶剂，并且在给予受试者时提供初始麻醉效果。非聚合物载体可以任选地是高粘度液体载体材料，例如合适的糖酯。组合物还可以包括一种或多种另外的成分，包括活性和非活性材料。还提供了使用本发明组合物在受试者的部位产生持续麻醉效果的方法。

8. 发明申请

WO2004049919A3 IMPLANT ANCHOR AND METHODS OF USE 审中-公开
标题翻译：植入锚和使用方法
公开(公告)号：WO2004049919A3
公开(公告)日：2004-09-02
申请号：PCT/US0338549
申请日：2003-12-04
申请人： DURECT CORP , POUTIATINE ANDREW I
发明人： POUTIATINE ANDREW I
IPC分类号： A61B20060101 , A61F2/06 , A61M25/04
CPC分类号： A61M25/04 , A61F2/848
摘要： An implant anchor (26) that holds an implant (18) in place by fibrotic encapsulation or inclusion of surrounding tissue into the anchor. The apparatus of the invention comprises an anchor (26) configured to couple to an implant (18) and which has at least one fibrous surface or portion capable of becoming fibrously encapsulated or included by surrounding tissue. The methods of the invention comprise providing an anchor (26) having at least one porous surface or portion thereon, attaching the anchor (26) to an implant (18), positioning the implant (18) and attached anchor (26) in a patient incision, and fibrotically encapsulating the anchor (26).
摘要翻译：通过纤维化包封或将周围组织包含在锚中而将植入物（18）保持在适当位置的植入物锚固件（26）。本发明的装置包括构造成联接到植入物（18）并且具有至少一个纤维表面或部分能够被纤维状包封或由周围组织包围的锚定件（26）。本发明的方法包括提供在其上具有至少一个多孔表面或部分的锚固件（26），将锚固件（26）附接到植入物（18），将植入物（18）和附着的锚固件（26）定位在患者体内切口，以及纤维封装锚（26）。

9. 发明申请

WO02102278A2 DEVICE AND METHOD FOR DELIVERING MICRODOSES OF AGENT TO THE EAR 审中-公开
标题翻译：用于将药剂微粒体递送至耳朵的装置和方法
公开(公告)号：WO02102278A2
公开(公告)日：2002-12-27
申请号：PCT/US0219290
申请日：2002-06-17
申请人： DURECT CORP , ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
发明人： ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
IPC分类号： A61F11/00 , A61F
CPC分类号： A61F11/00
摘要： The present invention provides devices and methods for delivery of very low dosages to the inner ear. The device is a self-contained unit that reproducibly and consistently delivers a dose of therapeutic agent that is effective, yet below the ototoxic threshold for that agent. The invention further provides therapeutic methods using the device of the invention.
摘要翻译：本发明提供了用于将非常低剂量递送到内耳的装置和方法。该装置是一种独立的单元，其可重复地和一致地递送有效剂量的治疗剂，但低于该药剂的耳毒性阈值。本发明还提供了使用本发明的装置的治疗方法。

10. 发明申请

WO0141858A3 CATHETER WITH STYLET LUMEN 审中-公开
标题翻译：带有白炽灯的导管
公开(公告)号：WO0141858A3
公开(公告)日：2002-01-31
申请号：PCT/US0033476
申请日：2000-12-07
申请人： DURECT CORP , GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
发明人： GILLIS EDWARD M , FILICE JAMES A , THEEUWES FELIX
IPC分类号： A61M25/00 , A61M25/01 , A61M25/14
CPC分类号： A61M25/0102 , A61M2025/0034 , A61M2025/0037 , A61M2025/0039
摘要： The present invention features a catheter suitable for drug delivery. The catheter comprises a catheter body comprising a proximal and a distal end, and defining a drug delivery lumen and a stylet lumen. The stylet lumen comprises a distal end configured to permit a stylet to abut the stylet lumen distal end, and a proximal aperture which is distal to the proximal end of the catheter, providing entry of the stylet into the side of the catheter. The stylet lumen is adapted for slidably receiving a stylet which can be used to guide the catheter to the intended site in the body of a subject and thus to facilitate implantation of the catheter.
摘要翻译：本发明的特征在于适于药物递送的导管。导管包括导管主体，其包括近端和远端，并且限定药物输送腔和探针管腔。探针管腔包括构造成允许探针邻接探针管腔远端的远端，以及远离导管近端的近端孔，提供探针进入导管侧。探针腔适于可滑动地容纳可用于将导管引导到受试者身体中预期部位的探针，并因此便于植入导管。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式