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1. 发明申请

WO2006033948A2 CONTROLLED DELIVERY SYSTEM 审中-公开
标题翻译：控制输送系统
公开(公告)号：WO2006033948A2
公开(公告)日：2006-03-30
申请号：PCT/US2005032863
申请日：2005-09-15
申请人： DURECT CORP , VERITY NEIL A
发明人： VERITY NEIL A
IPC分类号： A61K47/26 , A61K9/08 , A61K31/445 , B60C27/10
CPC分类号： A61K31/445 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/107 , A61K9/7015 , A61K45/06 , A61K47/22 , A61K47/26
摘要： The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.
摘要翻译：本发明涉及含有非聚合物载体材料和麻醉剂的新型麻醉剂组合物，其中组合物适于提供持续的局部麻醉而没有初始爆发并具有约24小时或更长时间的持续时间。还提供了包括第一麻醉剂和第二麻醉剂的某些组合物。在这种组合物中，第二麻醉剂是用于第一麻醉剂的溶剂，并且在给予受试者时提供初始麻醉效果。非聚合物载体可以任选地是高粘度液体载体材料，例如合适的糖酯。组合物还可以包括一种或多种另外的成分，包括活性和非活性材料。还提供了使用本发明组合物在受试者的部位产生持续麻醉效果的方法。

2. 发明申请

WO2006033948A3 SUSTAINED LOCAL ANESTHETIC COMPOSITION CONTAINING PREFERABLY A SUGAR ESTER SUCH AS SAIB 审中-公开
公开(公告)号：WO2006033948A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/032863
申请日：2005-09-15
申请人： DURECT CORPORATION , VERITY, Neil, A.
发明人： VERITY, Neil, A.
IPC分类号： A61K47/26 , A61K9/08 , A61K31/445
摘要： The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided. Preferably the composition contains bupivacaine and a sugar ester such as saib.

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