专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012119265A1 NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES 审中-公开
标题翻译： 4,9-二羟基萘并[2,3-b]氟虫病治疗疾病新药
公开(公告)号：WO2012119265A1
公开(公告)日：2012-09-13
申请号：PCT/CN2011/000357
申请日：2011-03-04
申请人： ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. , JIANG, Zhiwei , WANG, Aijin , HU, Hongwei , XU, Jiali , HU, Yuesong , LI, Xian , YE, Yan , WANG, Jie , LI, Qinglong
发明人： JIANG, Zhiwei , WANG, Aijin , HU, Hongwei , XU, Jiali , HU, Yuesong , LI, Xian , YE, Yan , WANG, Jie , LI, Qinglong
IPC分类号： C07D307/92 , A61K31/343 , A61P3/04 , A61P3/10 , A61P3/00 , A61P25/28 , A61P35/00 , A61P43/00
CPC分类号： C07D307/92 , A61K31/343 , A61K31/665 , A61K45/06 , C07F9/65517
摘要： The present invention discloses esters of 4,9-dihydroxy-naphtho[2,3-b]furans and methods of making and using the same. The present invention also discloses conversion of the esters into therapeutically active 4,9-dihydroxy-naphtho[2,3-b]furans in vivo . The present invention furthermore discloses pharmaceutical compositions comprising the esters of 4,9- dihydroxy-naphtho[2,3-b]furans for the treatment of various indications including proliferative diseases.
摘要翻译：本发明公开了4,9-二羟基 - 萘并[2,3-b]呋喃的酯及其制备和使用方法。本发明还公开了在体内将酯转化为治疗活性的4,9-二羟基 - 萘并[2,3-b]呋喃。本发明还公开了包含4,9-二羟基 - 萘并[2,3-b]呋喃的酯的药物组合物，用于治疗各种适应症，包括增殖性疾病。

2. 发明申请

WO2012024818A1 NOVEL ANPHTHOQUINONES FOR DISEASE THERAPIES 审中-公开
标题翻译：用于疾病治疗的新型药物
公开(公告)号：WO2012024818A1
公开(公告)日：2012-03-01
申请号：PCT/CN2010/001288
申请日：2010-08-24
申请人： ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. , JIANG, Zhiwei , WANG, Aijin , LI, Xian , LI, Qinglong , HU, Hongwei , XU, Jiali , HU, Yuesong , YE, Yan
发明人： JIANG, Zhiwei , WANG, Aijin , LI, Xian , LI, Qinglong , HU, Hongwei , XU, Jiali , HU, Yuesong , YE, Yan
IPC分类号： C07D307/92 , C07D333/74 , A61K31/343 , A61K31/381 , A61P35/00
CPC分类号： A61K31/343 , A61K45/06 , C07D307/92
摘要： Naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]thiophene-4,9-diones, the preparation methods and uses thereof are disclosed. The pharmaceutical compositions comprising such compounds for the treatment of various indications including proliferative diseases are also disclosed.
摘要翻译：萘并[2,3-b]呋喃-4,9-二酮和萘并[2,3-b]噻吩-4,9-二酮，其制备方法和用途被公开。还公开了包含用于治疗包括增殖性疾病在内的各种适应症的化合物的药物组合物。

3. 发明申请

WO2013166618A1 PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE 审中-公开
标题翻译： 4,9-二羟基萘并[2,3-b]呋喃类抗癌多药耐药性的研究进展
公开(公告)号：WO2013166618A1
公开(公告)日：2013-11-14
申请号：PCT/CN2012/000618
申请日：2012-05-08
申请人： ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. , JIANG, Zhiwei , HU, Yuesong , WANG, Jie , YE, Yan , LI, Xian , XU, Hairong , YANG, Huanhuan , FU, Yaner
发明人： JIANG, Zhiwei , HU, Yuesong , WANG, Jie , YE, Yan , LI, Xian , XU, Hairong , YANG, Huanhuan , FU, Yaner
IPC分类号： C07D307/92 , A61K31/343 , A61P35/00
CPC分类号： A61K31/343
摘要： The present invention discloses use of prodrug of 4,9-dihydroxy-naphtho[2,3-b]furan derivative for circumventing cancer multidrug resistance. The present invention also discloses use of prodrug of 4,9-dihydroxy-naphtho[2,3-b]furan derivative for the treatment of various types of cancers exhibiting multidrug resistance phenomenon. The present invention further discloses use of the pharmaceutically acceptable composition comprising prodrug of 4,9- dihydroxy-naphtho[2,3-b]furan derivative and method of using said composition in the treatment of various types of cancers exhibiting multidrug resistance phenomenon.
摘要翻译：本发明公开了4,9-二羟基 - 萘并[2,3-b]呋喃衍生物的前药用于避免癌症多药耐药性。本发明还公开了4,9-二羟基 - 萘并[2,3-b]呋喃衍生物的前药用于治疗表现出多药耐药现象的各种类型的癌症。本发明还公开了包含4,9-二羟基 - 萘并[2,3-b]呋喃衍生物的前药的药学上可接受的组合物的用途和使用该组合物治疗表现出多药耐药现象的各种类型的癌症的方法。

4. 发明申请

WO2013120229A1 METHOD FOR PREPARING AQUEOUS MANO PARTICLE SUSPENSIONS OF DERIVATIVES OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURAN ALIPHATIC ACID ESTERS 审中-公开
标题翻译：制备4,9-二羟基 - 萘并[2,3-b]呋喃二酸酯衍生物的水溶性颗粒悬浮液的方法
公开(公告)号：WO2013120229A1
公开(公告)日：2013-08-22
申请号：PCT/CN2012/000190
申请日：2012-02-17
申请人： ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. , JIANG, Zhiwei , LI, Xian , XU, Hairong , YE, Yan , HU, Hongwei , YANG, Huanhuan
发明人： JIANG, Zhiwei , LI, Xian , XU, Hairong , YE, Yan , HU, Hongwei , YANG, Huanhuan
IPC分类号： A61K31/343 , A61K9/10 , A61J3/00 , C07D307/92 , A61P3/04 , A61P3/10 , A61P3/00 , A61P25/28 , A61P35/00 , A61P43/00
CPC分类号： A61K9/10 , A61K9/1075 , A61K9/5146 , A61K31/343 , C07D307/92
摘要： Disclosed is a method for preparing aqueous nanoparticle suspensions of derivatives of 4,9-dihydroxy-naphtho[2,3-b]furan aliphatic acid esters. The compositions and the uses of the aqueous nanoparticle suspensions prepared according to the method as described herein are also disclosed.
摘要翻译：公开了一种制备4,9-二羟基 - 萘并[2,3-b]呋喃脂肪酸酯衍生物的水性纳米颗粒悬浮液的方法。还公开了根据本文所述的方法制备的纳米颗粒水悬浮液的组合物和用途。

5. 发明申请

WO2018196003A1 MOTOR VENTILATION STRUCTURE AND MOTOR 审中-公开
公开(公告)号：WO2018196003A1
公开(公告)日：2018-11-01
申请号：PCT/CN2017/082616
申请日：2017-04-28
申请人： SIEMENS AKTIENGESELLSCHAFT , JIANG, Zhiwei
发明人： JIANG, Zhiwei
IPC分类号： H02K9/08 , F24F11/00 , H02K5/20 , F04D25/08 , F04D29/30
CPC分类号： H02K5/20 , H02K9/08
摘要： The motor ventilation structure (20) is disposed inside a housing (31) of the motor (30), and the motor (30) is provided with a drive end (301) and a non-drive end (302) opposite to the drive end. The motor ventilation structure (20) includes: a first air baffle (21), located on the drive end (301), where the first air baffle (21) is spaced from a side wall of the housing of the motor (30), so as to form an accommodation space (210) with the housing (31); a ventilation pipe (22), fixed on the first air baffle (21), where the ventilation pipe (22) extends from the non-drive end (302) of the motor (30) to the drive end (301) of the motor (30) and is in communication with the accommodation space (210); and a double-suction fan (23), fixedly sleeved on a rotation shaft (32) of the motor (30) and disposed on one side, close to the non-drive end (302), of the first air baffle (21), where the double-suction fan (23) is configured to extract air from the non-drive end (302) to the drive end (301), and extract air in the accommodation space (210) and air for axial-radial cooling out of the housing (31) of the motor (30). The motor ventilation structure (20) and the motor (30) may ensure that a bearing of the drive end of the motor (30) has an appropriate temperature, and may achieve relatively high heat dissipation efficiency.

6. 发明申请

WO2009036099A1 A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS 审中-公开
标题翻译： STAT3途径抑制剂和癌症干细胞途径抑制剂的新一代
公开(公告)号：WO2009036099A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075903
申请日：2008-09-10
申请人： BOSTON BIOMEDICAL, INC. , LI, Chiang, Jia , JIANG, Zhiwei , ROGOFF, Harry , LI, Youzhi , LIU, Jifeng , LI, Wei
发明人： LI, Chiang, Jia , JIANG, Zhiwei , ROGOFF, Harry , LI, Youzhi , LIU, Jifeng , LI, Wei
IPC分类号： A61K31/38
CPC分类号： C07D307/92 , A61K31/38 , C07D333/74 , Y02A50/465
摘要： The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regimen; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds.
摘要翻译：本发明涉及新型癌症干细胞途径（CSCP）抑制剂的应用; 涉及使用这些化合物治疗顽固性，复发性或转移性癌症的方法; 通过使用具有特定给药方案的这种化合物选择性杀死癌细胞的方法; 通过抑制Stat3途径靶向癌症干细胞的方法; 涉及使用新化合物治疗与异常Stat3途径活性相关的哺乳动物中的病症或病症的方法; 以及制备这些化合物及其中间体的方法，以及相关化合物的药物组合物以及这些化合物的具体给药方法。

7. 发明申请

WO2004045557A2 NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：新型拉帕酮化合物及其使用方法
公开(公告)号：WO2004045557A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/037219
申请日：2003-11-18
申请人： ARQULE, INC. , JIANG, Zhiwei , REDDY, Dasharatha , ACKERMAN, Samuel, K. , SALVESEN, June
发明人： JIANG, Zhiwei , REDDY, Dasharatha , ACKERMAN, Samuel, K. , SALVESEN, June
IPC分类号： A61K
CPC分类号： C07D335/08 , C07D307/92 , C07D311/92 , C07D327/06 , C07D333/74
摘要： The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of psoriasis or cancer or precancerous conditions.
摘要翻译：本发明提供了拉帕酮类似物和衍生物及其使用方法。这些化合物可以用于治疗或预防细胞增殖疾病的药物组合物中。这些化合物也可用于治疗或预防银屑病，癌症或癌前病变。

8. 发明申请

WO2009036059A3 NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS 审中-公开
公开(公告)号：WO2009036059A3
公开(公告)日：2009-03-19
申请号：PCT/US2008/075848
申请日：2008-09-10
申请人： BOSTON BIOMEDICAL, INC. , JIANG, Zhiwei , LI, Chiang, Jia , LI, Wei , LEGGETT, David
发明人： JIANG, Zhiwei , LI, Chiang, Jia , LI, Wei , LEGGETT, David
IPC分类号： A61K31/505 , A61K31/55 , A61K38/17
摘要： The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.

9. 发明申请

WO2003011224A2 PHARMACEUTICAL COMPOSITIONS CONTAINING BETA-LAPACHONE, OR DERIVATIVES OR ANALOGS THEREOF, AND METHODS OF USING SAME 审中-公开
标题翻译：含有β-Lapapone或其衍生物或类似物的药物组合物及使用该组合物的方法
公开(公告)号：WO2003011224A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024262
申请日：2002-07-31
申请人： CYCLIS PHARMACEUTICALS, INC. , JIANG, Zhiwei , REDDY, Dasharatha, G.
发明人： JIANG, Zhiwei , REDDY, Dasharatha, G.
IPC分类号： A61K
CPC分类号： A61K9/0019 , A61K31/337 , A61K31/352 , A61K47/10 , A61K47/24 , A61K47/32 , Y10S514/937 , Y10S514/941 , Y10S514/97 , A61K2300/00
摘要： Beta-lapachone, which is poorly soluble in most pharmaceutically acceptable solvents, has demonstrated significant antineoplastic activity against human cancer lines. The present invention overcomes this significant limitation by teaching novel pharmaceutical compositions comprising a therapeutically effective amount of Beta-lapachone, or a derivative or analog thereof, and a pharmaceutically acceptable solubilizing carrier molecule, which may be at water-solubilizing carrier molecule such as hydroxypropyl-β-cyclodextrin, or an oil-based solubilizing carrier molecule, for enhancing the solubility of Beta-lapachone in aqueous solution. The therapeutically effective amount of Beta-lapachone, or a derivative or analog thereof, may be complexed with the pharmaceutically acceptable solubilizing carrier molecule in aqueous solution. The novel pharmaceutical compositions may be administered with a second anticancer agent or in combination with radiation therapy. A formulation of Beta-lapachone or a derivative or analog thereof, complexed with a pharmaceutically acceptable solubilizing carrier molecule, wherein the complex can be freeze-dried and when subsequently reconstituted in aqueous solution is substantially soluble is also disclosed. Emulsions of Beta-Lapachone in a pharmaceutically acceptable fat emulsion vehicle are also provided. Also disclosed are methods for treating cancer by administering to a patient the novel pharmaceutical compositions and formulations. Pharmaceutical kits are also provided.
摘要翻译：在大多数药学上可接受的溶剂中难以溶解的β-拉帕醌已经显示出对人癌细胞系具有显着的抗肿瘤活性。本发明通过教导包含治疗有效量的β-拉帕醌或其衍生物或类似物以及药学上可接受的增溶载体分子的新颖药物组合物来克服这一显着限制，所述载体分子可以在水溶性载体分子如羟丙基 - β-环糊精或基于油的增溶载体分子，用于增强β-拉帕醌在水溶液中的溶解度。 β-拉帕醌或其衍生物或类似物的治疗有效量可以与药学上可接受的增溶载体分子在水溶液中复合。新型药物组合物可以与第二种抗癌剂一起给药或与放射疗法联合给药。与药学上可接受的增溶载体分子络合的β-拉帕醌或其衍生物或类似物的制剂，其中该络合物可以冷冻干燥，并且随后在水溶液中重构时基本上可溶。还提供了β-拉帕醌在药学上可接受的脂肪乳剂载体中的乳剂。还公开了通过向患者施用新药物组合物和制剂来治疗癌症的方法。还提供药品包。

10. 发明申请

WO2002059103A1 SYNTHESIS OF BETA-LAPACHONE AND ITS INTERMEDIATES 审中-公开
标题翻译： BETA-LAPACHONE及其中间体的合成
公开(公告)号：WO2002059103A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/002359
申请日：2002-01-23
申请人： CYCLIS PHARMACEUTICALS, INC. , JIANG, Zhiwei , HOGELAND, Jane
发明人： JIANG, Zhiwei , HOGELAND, Jane
IPC分类号： C07D311/72
CPC分类号： C07D311/78
摘要： A novel process for synthesizing β-lapachone (beta-lapachone), an agent that has demonstrated significant antineoplastic activity against human cancer lines. The process comprises the conversion of starting material, 2-hydroxy-1,4-naphothoquinone into β-lapachone intermediate, lapachol. The lapachol is then converted to β-lapachone by treatment with sulfuric acid and purified by recrystallization from ethanol. This novel process is extremely simple and provides β-lapachone in excellent quality and high yield.
摘要翻译： β-拉帕酮（β-lapachone）的合成新方法，该试验已显示出对人类癌细胞系具有显着的抗肿瘤活性。该方法包括将起始物质2-羟基-1,4-辛氧基醌转化为β-Lapapone中间体，Lapanhol。然后通过用硫酸处理将皮肤胆固醇转化成β-papone，并通过乙醇重结晶纯化。这种新颖的方法非常简单，提供了优质和高产量的β-lapachone。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式