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1. 发明申请

WO2004071502A1 FORMULATION LIQUIDE INJECTABLE DE PARACETAMOL 审中-公开
标题翻译： PARACETAMOL的注射液配方
公开(公告)号：WO2004071502A1
公开(公告)日：2004-08-26
申请号：PCT/CH2004/000085
申请日：2004-02-16
申请人： NGUYEN-XUAN, Tho
发明人： NGUYEN-XUAN, Tho
IPC分类号： A61K31/167
CPC分类号： A61K9/08 , A61K31/167 , Y10S514/97
摘要： L'invention concerne une nouvelle formulation pharmaceutique liquide injectable de paracétamol qui contient du paracétamol, un solvant aqueux, un agent tamponnant de pKa compris entre 4,5 et 6,5, un agent isotonisant et du dimère de paracétamol de formule (I) suivante, ainsi qu'un procédé pour préparer cette formulation, et l'utilisation de ce dimère pour stabiliser une formulation pharmaceutique liquide de paracétamol.
摘要翻译：本发明涉及一种新型的对乙酰氨基酚注射液体制剂，其包含水溶剂，pKa在4.5和6.5之间的缓冲剂，等渗剂和式（I）的扑热息痛的二聚体，制备所述制剂的方法和使用所述二聚体来稳定液体对乙酰氨基酚药物制剂。

2. 发明申请

WO2004047809A1 STABLE PHARMACEUTICAL COMPOSITIONS WITHOUT A STABILIZER 审中-公开
标题翻译：没有稳定剂的稳定的药物组合物
公开(公告)号：WO2004047809A1
公开(公告)日：2004-06-10
申请号：PCT/US2003/028976
申请日：2003-09-16
申请人： ANDRX PHARMACEUTICALS, INC.
发明人： LI, Boyong , CHENG, Xiu Xiu
IPC分类号： A61K9/20
CPC分类号： A61K31/137 , A61K9/2031 , A61K9/2054 , Y10S514/97
摘要： Stabilized controlled release pharmaceutical preparations are disclosed in which active ingredient degradation is prevented without the use of a stabilizer. The active ingredient is sealed away from excipients that can adversely affect stability by sealing the excipients rather than the active ingredient. The preparations are substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
摘要翻译：公开了稳定的控释药物制剂，其中在不使用稳定剂的情况下防止活性成分降解。通过密封赋形剂而不是活性成分，将活性成分从赋形剂中密封，这些赋形剂可以不利地影响稳定性。制剂基本上不受暴露于升高的温度和/或相对湿度升高的储存条件的影响。

3. 发明申请

WO2004014345A1 PHARMACEUTICAL PREPARATION CONTAINING A BENZIMIDAZOLE COMPOUND MIXED WITH MICROCRYSTALLINE CELLULOSE AND A METHOD FOR ITS PREPARATION 审中-公开
标题翻译：含有与微晶纤维素混合的苯并咪唑化合物的药物制剂及其制备方法
公开(公告)号：WO2004014345A1
公开(公告)日：2004-02-19
申请号：PCT/EP2003/007741
申请日：2003-07-16
申请人： RATIOPHARM GMBH , MUSKULUS, Frank , KRAASS, Peter , BURGENMEISTER, Andrea
发明人： MUSKULUS, Frank , KRAASS, Peter , BURGENMEISTER, Andrea
IPC分类号： A61K9/50
CPC分类号： A61K31/4439 , A61K9/2081 , A61K9/5078 , Y10S514/97
摘要： The present invention relates to oral pharmaceutical preparations in the form of pellets in which a benzimidazole compound is stabilized by combining it with microcrystalline cellulose.
摘要翻译：本发明涉及丸粒形式的口服药物制剂，其中苯并咪唑化合物通过与微晶纤维素结合而稳定化。

4. 发明申请

WO0226263A3 STABLE SOLID DOSAGE FORMS OF AMINO ACIDS AND PROCESSES FOR PRODUCING SAME 审中-公开
标题翻译：氨基酸的稳定剂量形式及其生产方法
公开(公告)号：WO0226263A3
公开(公告)日：2003-01-03
申请号：PCT/US0130095
申请日：2001-09-26
申请人： SIGMAPHARM INC , SPIREAS SPIRIDON
发明人： SPIREAS SPIRIDON
IPC分类号： A61K9/16 , A61K31/195 , A61K9/20 , A61K47/00
CPC分类号： A61K9/1647 , A61K9/1694 , Y10S514/97
摘要： Pharmaceutical formulations, adn processes for making same, comprising an amino acid which is liable to formation of an undesirable lactam, and a stabilizer comprising a volatile alcohol; a non-volatile alcohol; a water immiscible liquid or solid; a liquid with a relatively low dielectric constant; a liquid surface active agent; a solid surface active agent; an antioxidant; a ketone, an aldehyde; a solid polyethylene glycol of high molecular weight; polyvinylpyrrolidone; a derived cellulose; silicon dioxide; or a combination thereof.
摘要翻译：药物制剂及其制备方法，其包含易于形成不合需要的内酰胺的氨基酸和包含挥发性醇的稳定剂; 不挥发性酒精; 与水不混溶的液体或固体; 具有较低介电常数的液体; 液体表面活性剂; 固体表面活性剂; 抗氧化剂酮，醛; 高分子量的固体聚乙二醇; 聚乙烯吡咯烷酮; 衍生的纤维素; 二氧化硅; 或其组合。

5. 发明申请

WO01028332A1 LOW-TEMPERATURE-STABLE PRESERVATIVES 审中-公开
标题翻译：低温稳定的防腐剂
公开(公告)号：WO01028332A1
公开(公告)日：2001-04-26
申请号：PCT/IB2000/001489
申请日：2000-10-17
IPC分类号： A01N25/22 , A01N47/18
CPC分类号： A01N47/18 , Y10S514/937 , Y10S514/97 , Y10S514/971 , A01N25/22 , A01N25/02 , A01N2300/00
摘要： The invention relates to a liquid, cold-temperature-stabilized preservative based on carbendazim or a salt thereof, which comprises, as low-temperature stabilizer, at least one aromatic alcohol and/or at least one aromatic glycol ether and/or a pyrrolidone.
摘要翻译：本发明涉及一种基于多菌灵或其盐的液体，冷温稳定的防腐剂，其包含作为低温稳定剂的至少一种芳族醇和/或至少一种芳族二醇醚和/或吡咯烷酮。

6. 发明申请

WO00042849A1 COMPLEX OF RAS-FARNESYLTRANSFERASE INHIBITOR AND SULFOBUTYLETHER-7- beta -CYCLODEXTRIN OR 2-HYDROXYPROPYL- beta -CYCLODEXTRIN AND METHOD 审中-公开
标题翻译： RAS-FARNESYLTRANSFERASE抑制剂和SUFFOBUTYLETHER-7-β-环糊精或2-羟丙基-β-环糊精和方法的复合物
公开(公告)号：WO00042849A1
公开(公告)日：2000-07-27
申请号：PCT/US1999/030424
申请日：1999-12-21
IPC分类号： C07D403/06 , A61K9/08 , A61K31/55 , A61K31/5513 , A61K47/12 , A61K47/40 , A61K47/48 , A61P35/00 , C07D243/14 , C07D409/14 , A01N43/00
CPC分类号： B82Y5/00 , A61K47/6951 , Y10S514/97 , Y10S514/973
摘要： A ras-farnesyltransferase inhibitor complex formed of ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, of formula (I), wherein n is 0 or 1; R1 is selected from Cl, Br, phenyl, pyridyl or cyano; R2 is aralkyl; R3 is selected from lower alkyl, aryl or substituted aryl or heterocyclo; Z1 is selected from CO, SO2, CO2 or SO2NR5, R5 is selected from hydrogen, lower alkyl or substituted alkyl; and sulfobutylether-7- beta -cyclodextrin or 2-hydroxypropyl- beta -cyclodextrin is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor and is useful for its intravenous delivery to humans with cancer. Also provided is a method for forming the complex. The ras-farnesyltransferase inhibitors are useful as anti-tumor agents.
摘要翻译：由式（I）的ras-法呢基转移酶抑制剂或其药学上可接受的盐形成的ras-farnesyltransferase抑制剂复合物，其中n为0或1; R 1选自Cl，Br，苯基，吡啶基或氰基; R2是芳烷基; R3选自低级烷基，芳基或取代的芳基或杂环; Z1选自CO，SO2，CO2或SO2NR5，R5选自氢，低级烷基或取代烷基; 并提供磺基丁醚-7β-环糊精或2-羟丙基-β-环糊精。该复合物具有出乎意料的高法拉氏转移酶抑制剂的高溶解度，并且可用于其向癌症患者的静脉内递送。还提供了形成复合物的方法。拉法尼基转移酶抑制剂可用作抗肿瘤剂。

7. 发明申请

WO00035499A1 CONTACT LENS CLEANER COMPRISING BIGUANIDE, TYLOXAPOL, AND POLOXAMINE 审中-公开
标题翻译：接触透镜清洁剂，包含碧兰草，类粘土和聚酰胺
公开(公告)号：WO00035499A1
公开(公告)日：2000-06-22
申请号：PCT/US1999/028143
申请日：1999-11-29
IPC分类号： G02C13/00 , A61L2/18 , A61L12/14
CPC分类号： A61L12/142 , A61L12/141 , A61L12/145 , C11D3/0078 , C11D3/48 , Y10S134/901 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10S514/915 , Y10S514/97 , Y10S514/975
摘要： The present invention is directed to a biguanide-containing disinfecting solution containing tyloxapol in combination with a poloxamine for stabilizing the biguanide, which is especially useful for contact-lens solutions that provide enhanced disinfecting and enhanced cleaning efficacy. The method of the present invention comprises cleaning and disinfecting a contact lens with the above-described solution.
摘要翻译：本发明涉及一种含有双酚A的消毒溶液，其含有与用于稳定双胍的泊洛沙胺组合的泰洛沙泊，其特别适用于提供增强的消毒和增强的清洁功效的隐形眼镜溶液。本发明的方法包括用上述溶液清洁和消毒隐形眼镜。

8. 发明申请

WO00035289A1 HYDROGEN PEROXIDE DISINFECTANT WITH INCREASED ACTIVITY 审中-公开
标题翻译：氢过氧化物消毒剂具有增加的活性
公开(公告)号：WO00035289A1
公开(公告)日：2000-06-22
申请号：PCT/CA1999/001132
申请日：1999-11-26
IPC分类号： A61K9/08 , A01N25/02 , A01N25/30 , A01N59/00 , A61K33/40 , A61K33/42 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/20 , A61P31/02 , A01N25/22
CPC分类号： A01N59/00 , Y10S424/06 , Y10S514/97 , Y10S514/973 , A01N25/30 , A01N25/22 , A01N2300/00
摘要： An acidic aqueous hydrogen peroxide solution is provided, with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 % and as-used concentrations contain about 0.5 % peroxide. The solution also contains from 0.1 to 5.0 % of at least one acid compound, e.g. phosphoric and/or a phosphonate with from 1 to 5 phosphonic acid groups, and from 0.02 to 5 % of at least one anionic surfactant. The surfactant is selected from C8 to C16-alkyl aryl sulphonic acids, sulphonated C12 to C22 carboxylic acids, C8 to C22-alkyl diphenyl oxide sulphonic acids, naphthalene sulphonic acids, C8 to C22 alkyl sulphonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulphates, and mixtures thereof. Most preferably the solution has an emulsifier, e.g. a salt of an alkylated diphenyl oxide. The solution may also contain corrosion inhibitors and/or lower alcohols.
摘要翻译：提供酸性过氧化氢水溶液，具有改善的消毒剂活性。浓缩溶液优选含有高达约8％且所用浓度含有约0.5％的过氧化物。该溶液还含有0.1至5.0％的至少一种酸化合物，例如，具有1至5个膦酸基团的磷酸酯和/或膦酸酯，和0.02至5％的至少一种阴离子表面活性剂。表面活性剂选自C 8至C 16烷基芳基磺酸，磺化的C 12至C 22羧酸，C 8至C 22烷基二苯基氧基磺酸，萘磺酸，C 8至C 22烷基磺酸及其碱金属和铵盐，和碱金属C8至C18烷基硫酸盐，及其混合物。最优选地，溶液具有乳化剂，例如烷基化二苯基氧化物的盐。该溶液还可含有腐蚀抑制剂和/或低级醇。

9. 发明申请

WO00019981A1 SYNERGISTIC ANTIMICROBIAL, DERMATOLOGICAL AND OPHTHALMIC PREPARATIONS CONTAINING CHLORITE AND HYDROGEN PEROXIDE 审中-公开
标题翻译：含有氯化氢和过氧化氢的协同抗微生物，精神和眼科制剂
公开(公告)号：WO00019981A1
公开(公告)日：2000-04-13
申请号：PCT/US1999/023291
申请日：1999-10-06
IPC分类号： A01N59/00 , A61K9/00 , A61K33/40 , A61K47/02 , A61K9/127 , A01N25/00 , A01N59/08 , A01N59/14
CPC分类号： A61K33/40 , A01N59/00 , A61K9/0014 , A61K9/0048 , A61K9/06 , A61K9/127 , A61K33/14 , A61K33/20 , A61K47/02 , A61K47/38 , Y10S424/13 , Y10S514/944 , Y10S514/964 , Y10S514/969 , Y10S514/97 , A01N2300/00 , A61K2300/00
摘要： Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which include chlorite (e.g., a metal salt of a chlorite) in combination with a peroxy compound (e.g., hydrogen peroxide), and methods for using such preparations for disinfection of articles or surfaces (e.g., contact lenses, counter tops, etc.), antisepsis of skin or other body parts, prevention or deterrence of scar formation and/or treatment and prophylaxis of dermal (i.e., skin or mucous membrane) disorders (e.g., wounds, burns, infections, cold sores, ulcerations, psoriasis, acne, or other scar-forming lesions).
摘要翻译：包括亚氯酸盐（例如亚氯酸盐的金属盐）与过氧化合物（例如，过氧化氢）的组合的抗微生物剂/药物制剂（例如溶液，凝胶，软膏，霜剂，缓释制剂等）和方法使用这样的制品来消除物品或表面（例如隐形眼镜，台面等），皮肤或其他身体部位的消毒，防止或阻止瘢痕形成和/或治疗和预防皮肤（即，皮肤或粘膜）疾病（例如伤口，烧伤，感染，感冒，溃疡，牛皮癣，痤疮或其他瘢痕形成病变）。

10. 发明申请

WO00002586A1 PHARMACEUTICAL LEVOTHYROXINE PREPARATION 审中-公开
标题翻译：制药LEVOTHYROXINZUBEREITUNG
公开(公告)号：WO00002586A1
公开(公告)日：2000-01-20
申请号：PCT/EP1999/004485
申请日：1999-06-29
IPC分类号： A61K9/20 , A61K31/198 , A61K33/18 , A61K47/02 , A61K47/04 , A61K47/12 , A61K47/38 , A61K47/42
CPC分类号： A61K33/18 , Y10S514/951 , Y10S514/961 , Y10S514/97 , A61K2300/00
摘要： The invention relates to a pharmaceutical preparation containing levothyroxine sodium, potassium iodide, microcrystalline cellulose and binding agents free from antioxidizing agents or other adjuvants and to a method for production said preparation.
摘要翻译：本发明涉及一种药物制剂，其包含左甲状腺素钠，碘化钾，微晶纤维素和粘合剂，其不含抗氧化剂或其它助剂的对，以及它们的制备方法。

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