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1. 发明申请

WO2009089361A3 SYSTEMS METHODS AND FORMULATION FOR TOPICALLY TREATING NAIL FUNGAL INFECTION AND NAIL PSORIASIS 审中-公开
标题翻译：用于主要治疗指甲真菌感染和指甲病的系统方法和配方
公开(公告)号：WO2009089361A3
公开(公告)日：2009-10-01
申请号：PCT/US2009030452
申请日：2009-01-08
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN , KUMAR PROMOD , ALIYAR HYDER
发明人： ZHANG JIE , WARNER KEVIN , KUMAR PROMOD , ALIYAR HYDER
IPC分类号： A61K31/74
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/08 , A61K47/32
摘要： The present invention is drawn to systems, methods, and formulations for treating nail disorders. The system comprises an active agent formulation and a first barrier film. The active agent formulation includes an active agent and an aqueous liquid component. The first barrier film is configured to form a sheath over at least a portion of a finger or toe on which the nail is located. An optional second barrier film, with lower moisture vapor transmission rate than the first barrier film, is placed between the first barrier film and the active agent formulation (or between the active agent formulation and the external environment) to reduce the water evaporation from the active agent formulation. The sheath is configured to be capable of securing and retaining the active agent formulation within the sheath on a finger nail or toe nail while reducing evaporation of the liquid component of the aqueous liquid component of the active agent formulation. The active agent formulation can be a 'slow-molding' hydrogel formulation that can slowly flow into the exact shape of the diseased nail to assure intimate contact and continuous delivery of the drug, while cannot be squeezed out of the position during the application.
摘要翻译：本发明涉及用于治疗指甲疾病的系统，方法和制剂。该系统包含活性剂制剂和第一阻挡膜。活性剂制剂包括活性剂和水性液体组分。第一阻挡膜被配置成在指甲所在的手指或脚趾的至少一部分上形成护套。在第一阻挡膜和活性剂制剂之间（或活性剂制剂和外部环境之间）放置具有比第一阻挡膜低的水蒸气透过率的任选的第二阻挡膜，以减少活性物质的水蒸发代理配方。鞘被构造成能够将活性剂制剂固定并保持在手指指甲或脚趾指甲内的鞘内，同时减少活性剂制剂的水性液体组分的液体组分的蒸发。活性剂制剂可以是“慢速成型”水凝胶制剂，其可以缓慢地流入患病钉的确切形状，以确保药物的紧密接触和连续递送，同时在施用期间不能被挤出位置。

2. 发明申请

WO2011140236A2 TRIAMCINOLONE ACETONIDE FORMULATIONS FOR TREATING DERMATITIS AND PSORIASIS 审中-公开
标题翻译：用于治疗牙龈萎缩症的三氰菊酯乙酰胆碱配方
公开(公告)号：WO2011140236A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035216
申请日：2011-05-04
申请人： ZARS PHARMA INC , ALIYAR HYDER , ZHANG JIE
发明人： ALIYAR HYDER , ZHANG JIE
IPC分类号： A61K9/06 , A61K31/56 , A61K31/57 , A61K47/30 , A61K47/34 , A61P17/00
CPC分类号： A61K31/58 , A61K9/0014 , A61K31/57 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to formulations and related methods for treating dermatitis or psoriasis. The formulation can include triamcinolone acetonide, a polymer selected from the group of a poly(2-hydroxyalkylacrylate), a poly(2-hydroxyalkylmethacrylate), and combinations thereof. The formulation also includes a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent.
摘要翻译：本发明涉及用于治疗皮炎或牛皮癣的制剂和相关方法。制剂可以包括曲安奈德，选自聚（2-羟烷基丙烯酸酯），聚（2-羟烷基甲基丙烯酸酯）和其组合的聚合物。该制剂还包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。

3. 发明申请

WO2011088333A3 SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL 审中-公开
标题翻译：用于疼痛控制的固体局部麻醉制剂
公开(公告)号：WO2011088333A3
公开(公告)日：2011-11-24
申请号：PCT/US2011021318
申请日：2011-01-14
申请人： ZARS PHARMA INC , NIU SUYI , HULL WADE , ZHANG JIE
发明人： NIU SUYI , HULL WADE , ZHANG JIE
IPC分类号： A61K31/16 , A61K9/107 , A61K31/167 , A61K31/216 , A61K31/24 , A61K31/245 , A61K47/30 , A61P23/02
CPC分类号： A61K31/167 , A61K9/0014 , A61K31/136 , A61K47/32 , A61K2300/00
摘要： Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
摘要翻译：用于疼痛控制的固体形成局部麻醉剂制剂可以包括利多卡因碱和丁卡因碱，聚乙烯醇，水和乳化剂。制剂可以在施用于皮肤表面之前制备为半固体状态，在施用后可以形成柔软的固化层，并且当施加到疼痛部位附近的皮肤表面时可以提供疼痛缓解。

4. 发明申请

WO2009017767A3 COMPOSITIONS AND METHODS FOR DERMALLY TREATING NEUROPATHY WITH MINOXIDIL 审中-公开
标题翻译：用奥昔地尔皮肤治疗神经病变的组合物和方法
公开(公告)号：WO2009017767A3
公开(公告)日：2009-12-30
申请号：PCT/US2008009222
申请日：2008-07-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
发明人： ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
IPC分类号： A01N43/54 , A61K8/00 , A61K31/505
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含米诺地尔的胶粘剂固化制剂，其可用于治疗包括糖尿病性神经病在内的神经病。该制剂可以包含一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，所述挥发性溶剂能够促进米诺地尔在持续的一段时间内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，该配制剂可以具有适合施用于皮肤表面的粘度。当施用于皮肤时，在至少一部分挥发性溶剂体系蒸发后，制剂可形成固化层。

5. 发明申请

WO2008150995A3 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERING ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：用于递送抗炎药物的转运药物递送系统
公开(公告)号：WO2008150995A3
公开(公告)日：2009-03-05
申请号：PCT/US2008065285
申请日：2008-05-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S
发明人： ZHANG JIE , WARNER KEVIN S
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug, and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36 0C to 42 0C, and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置为将人皮肤部位加热到特定温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5小时的时间。

6. 发明申请

WO2011028542A3 METHODS OF TREATING PAIN ASSOCIATED WITH COMPLEX REGIONAL PAIN SYNDROME 审中-公开
标题翻译：治疗与复合性局部疼痛综合征有关的疼痛的方法
公开(公告)号：WO2011028542A3
公开(公告)日：2011-07-21
申请号：PCT/US2010046523
申请日：2010-08-24
申请人： ZARS PHARMA INC , ZHANG JIE , CROCKETT ANDREW , RIGBY LARRY
发明人： ZHANG JIE , CROCKETT ANDREW , RIGBY LARRY
IPC分类号： A61K31/245 , A61K31/165 , A61K31/167 , A61K31/24 , A61P17/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/165 , A61K31/167 , A61K31/24 , A61K31/245 , A61K2300/00
摘要： The present invention is drawn to methods for treating pain associated with complex regional pain syndrome. Specifically, a method for treating pain associated with complex regional pain syndrome includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36°C to 42°C.
摘要翻译：本发明涉及治疗与复杂区域性疼痛综合征相关的疼痛的方法。具体而言，用于治疗与复合区域性疼痛综合征相关的疼痛的方法包括将镇痛系统应用于经历疼痛的受试者的皮肤表面并将该镇痛系统维持在皮肤表面上至少30分钟的时间段。应用于皮肤表面的止痛系统可以包括加热部件和包含至少一种局部麻醉剂的局部麻醉剂。加热部件能够将皮肤表面加热至36℃至42℃的温度。

7. 发明申请

WO2012138425A3 LAMINAR COMPOSITE TOILET LID AND SEAT 审中-公开
标题翻译： LAMINAR复合厕所盖和座椅
公开(公告)号：WO2012138425A3
公开(公告)日：2013-05-10
申请号：PCT/US2012025864
申请日：2012-02-21
申请人： TOPSEAT INTERNATIONAL INC , WU CHENGDONG , ZHANG JIE
发明人： WU CHENGDONG , ZHANG JIE
IPC分类号： B32B27/00
CPC分类号： B32B21/02 , A47K13/02 , B32B27/308 , B32B2307/412 , B32B2317/12 , B32B2317/16 , B32B2333/12 , B32B2509/00 , Y10T428/24802
摘要： Embodiments of the present disclosure include a laminate composite toilet lid (202) and seat (204) and a method of manufacturing thereof. The toilet lid includes a core structural layer (306) having a shape and size associated with the toilet lid. The toilet lid also includes a first decorative graphic layer (304) disposed on a first surface of the core structural layer. The toilet lid further includes a plurality of exterior layers (302, 310) disposed on exterior surfaces of the core structural layer and the first decorative graphic layer, the exterior layers configured to envelop the toilet lid.
摘要翻译：本公开的实施例包括层压复合马桶盖（202）和座（204）及其制造方法。马桶盖包括具有与马桶盖相关联的形状和尺寸的芯结构层（306）。马桶盖还包括设置在芯结构层的第一表面上的第一装饰图形层（304）。所述马桶盖还包括设置在所述芯结构层和所述第一装饰图形层的外表面上的多个外层（302,310），所述外层被配置为包封所述马桶盖。

8. 发明申请

WO2007050427A3 PATH DETERMINATION FACILITATION METHOD 审中-公开
标题翻译：路线确定方法
公开(公告)号：WO2007050427A3
公开(公告)日：2009-04-16
申请号：PCT/US2006040893
申请日：2006-10-19
申请人： MOTOROLA INC , GYORFI JULIUS S , GAMOTA DANIEL R , MOK SWEE M , SZCZECH JOHN B , TOLOO MANSOUR , ZHANG JIE
发明人： GYORFI JULIUS S , GAMOTA DANIEL R , MOK SWEE M , SZCZECH JOHN B , TOLOO MANSOUR , ZHANG JIE
IPC分类号： G06F15/18 , G06N3/00 , G06N3/12
CPC分类号： G06N3/126
摘要： One facilitates determination of a path that comprises a plurality of specific locations (Fig 1, Bl 101). in an optional though preferred embodiment these specific locations comprise locations where a given functional ink will preferably be printed using a continuous printing spray. Also in an optional though preferred embodiment this path will also avoid at least one predetermined area (Fig 1. Bl 102) where such a functional ink should not be printed. In a preferred approach this process generally provides for identifying these specific locations and further identifying, when applicable, the one or more predetermined areas to be avoided. This process then preferably uses a processor to effect at least one (and preferably both) of using a genetic algorithm to identify a preferred path that includes the plurality of specific locations and using an A* algorithm to process a candidate path to provide a selected path that includes the plurality of specific locations while also avoiding the at least one predetermined area (Fig 1, Bl 104).
摘要翻译：有利于确定包括多个特定位置的路径（图1，B1101）。在可选的但优选的实施方案中，这些具体位置包括优选使用连续印刷喷涂印刷给定功能油墨的位置。同样在可选的但优选实施例中，该路径还将避免不应打印这种功能性油墨的至少一个预定区域（图1B122）。在优选的方法中，该方法通常提供识别这些特定位置，并且在适用时进一步识别要避免的一个或多个预定区域。该过程然后优选地使用处理器来实现使用遗传算法来识别包括多个特定位置的优选路径的至少一个（并且优选地两者），并且使用A *算法来处理候选路径以提供选择的路径其包括多个特定位置，同时还避免至少一个预定区域（图1，B1104）。

9. 发明申请

WO2007051119A8 METHODS AND COMPOSITIONS OF PARP INHIBITORS AS POTENTIATORS IN CANCER THERAPY 审中-公开
标题翻译： PARP抑制剂作为癌症治疗中的潜在剂量的方法和组合
公开(公告)号：WO2007051119A8
公开(公告)日：2007-11-22
申请号：PCT/US2006060219
申请日：2006-10-25
申请人： MGI GP INC , FERRARIS DANA VICTOR , LI JIA-HE , KALISH VINCENT , ZHANG JIE
发明人： FERRARIS DANA VICTOR , LI JIA-HE , KALISH VINCENT , ZHANG JIE
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K45/06 , A61K31/4745 , A61K2300/00
摘要： The present disclosure relates generally to a series of compounds which are derivatives of tricyclic compounds which inhibit poly (ADP-ribose) polymerase (PARP) and their use in the potentiation of cancer therapies. The disclosure relates more particularly to uses of azaphenanthridone compounds to chemosensitize cancers to the cytotoxic effects of chemopharmaceutical agents.
摘要翻译：本公开一般涉及一系列化合物，其是抑制聚（ADP-核糖）聚合酶（PARP）的三环化合物的衍生物及其在增强癌症疗法中的用途。本公开更具体地涉及氮代苯并噻吩酮化合物对癌症化学敏感化学药剂的细胞毒性作用的用途。

10. 发明申请

WO2006029107A2 HEAT-RADIATING DEVICE WITH A GUIDE STRUCTURE 审中-公开
标题翻译：具有导向结构的热辐射装置
公开(公告)号：WO2006029107A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031602
申请日：2005-09-06
申请人： MOLEX INC , ZHANG JIE
发明人： ZHANG JIE
CPC分类号： G06F1/20 , F28F3/02 , F28F13/06 , H01L23/3672 , H01L2924/0002 , H01L2924/00
摘要： A heat-radiating device with a guide includes a radiator and a fan. The radiator includes a base and a plurality of radiating fins protruding upward from the top surface of the base. The fan is mounted to one side of the radiator, the air flow from the fan passes through the air gap between two adjacent radiating fins so as to flow out from the side opposite the fan. These radiating fins is protruded bently toward its one side to form a guide structure which inclines from the further side of the base to the closer side of the base in the air flow direction so that the air flow flows downward to the heated electronic elements to radiate heat for them. The guide structure of the present invention is formed integrally with the radiating fins, thus advantages of low cost and easy manufacture are obtained.
摘要翻译：具有导轨的散热装置包括散热器和风扇。散热器包括基座以及从基座的上表面向上突出的多个散热片。风扇安装在散热器的一侧，来自风扇的气流经过两个相邻散热片之间的气隙，从而从风扇对面的一侧流出。这些散热片向其一侧倾斜地突出以形成引导结构，该引导结构从空气流动方向上的基座的另一侧向基座的较近侧倾斜，使得气流向下流动到加热的电子元件以辐射为他们加热。本实用新型的导向结构与散热片一体成型，具有低成本，易于制造的优点。

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