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1. 发明申请

WO2011088333A2 SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL 审中-公开
标题翻译：疼痛控制的固体局部麻醉配方
公开(公告)号：WO2011088333A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021318
申请日：2011-01-14
申请人： ZARS PHARMA, INC. , NIU, Suyi , HULL, Wade , ZHANG, Jie
发明人： NIU, Suyi , HULL, Wade , ZHANG, Jie
CPC分类号： A61K31/167 , A61K9/0014 , A61K31/136 , A61K47/32 , A61K2300/00
摘要： Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
摘要翻译：用于疼痛控制的固体形成局部麻醉剂制剂可以包括利多卡因碱和丁卡因碱，聚乙烯醇，水和乳化剂。该制剂可以制备成在施用到皮肤表面之前处于半固体状态，可以在施用后形成软凝固层，并且当施用到靠近疼痛部位的皮肤表面时可以提供疼痛缓解。

2. 发明申请

WO2008106220A1 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERY WITH CONTROLLED HEAT 审中-公开
标题翻译：用控制热量输送的超导药物输送系统
公开(公告)号：WO2008106220A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002700
申请日：2008-02-28
申请人： ZARS PHARMA, INC. , ZHANG, Jie , WARNER, Kevin, S. , NUI, Suyi , STRONG, Nathan , NELSON, Randal , VAWDRY, Alan , IVERSON, Matt , WESSMAN, Mike
发明人： ZHANG, Jie , WARNER, Kevin, S. , NUI, Suyi , STRONG, Nathan , NELSON, Randal , VAWDRY, Alan , IVERSON, Matt , WESSMAN, Mike
IPC分类号： A61K9/70 , A61F7/00
CPC分类号： A61K9/7061 , A61K9/0004 , A61K31/192
摘要： Systems and methods for transdermal drug delivery with controlled heat are provided Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover.The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. The systems can further include a drug-containing layer that includes a drug.The drug-containing layer can have a surface area of about 50 cm2 to about 400 cm2.The systems of the present invention can deliver ketoprofen in an amount sufficient to produce a mean blood plasma concentration of ketoprofen in a human subject of at least 45 ng/ml within four hours after initial application of the system to a skin surface.
摘要翻译：提供具有受控热的透皮药物递送的系统和方法这样的系统可以包括加热装置，其包括通常以个体加热元件形式的放热化学组成。加热装置可以通过盖暴露于环境氧气。与不存在盖时相比，该盖可以减少能够接触化学成分的环境氧的量。该系统可以进一步包括含药物的层，药物含有层可以具有约50cm 2至约400cm 2的表面积。本发明的系统可以以足以产生在将该系统初次应用于皮肤表面后的四小时内，人受试者中酮洛芬的平均血药浓度至少为45ng / ml。

3. 发明申请

WO2009089361A3 SYSTEMS METHODS AND FORMULATION FOR TOPICALLY TREATING NAIL FUNGAL INFECTION AND NAIL PSORIASIS 审中-公开
标题翻译：用于主要治疗指甲真菌感染和指甲病的系统方法和配方
公开(公告)号：WO2009089361A3
公开(公告)日：2009-10-01
申请号：PCT/US2009030452
申请日：2009-01-08
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN , KUMAR PROMOD , ALIYAR HYDER
发明人： ZHANG JIE , WARNER KEVIN , KUMAR PROMOD , ALIYAR HYDER
IPC分类号： A61K31/74
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/08 , A61K47/32
摘要： The present invention is drawn to systems, methods, and formulations for treating nail disorders. The system comprises an active agent formulation and a first barrier film. The active agent formulation includes an active agent and an aqueous liquid component. The first barrier film is configured to form a sheath over at least a portion of a finger or toe on which the nail is located. An optional second barrier film, with lower moisture vapor transmission rate than the first barrier film, is placed between the first barrier film and the active agent formulation (or between the active agent formulation and the external environment) to reduce the water evaporation from the active agent formulation. The sheath is configured to be capable of securing and retaining the active agent formulation within the sheath on a finger nail or toe nail while reducing evaporation of the liquid component of the aqueous liquid component of the active agent formulation. The active agent formulation can be a 'slow-molding' hydrogel formulation that can slowly flow into the exact shape of the diseased nail to assure intimate contact and continuous delivery of the drug, while cannot be squeezed out of the position during the application.
摘要翻译：本发明涉及用于治疗指甲疾病的系统，方法和制剂。该系统包含活性剂制剂和第一阻挡膜。活性剂制剂包括活性剂和水性液体组分。第一阻挡膜被配置成在指甲所在的手指或脚趾的至少一部分上形成护套。在第一阻挡膜和活性剂制剂之间（或活性剂制剂和外部环境之间）放置具有比第一阻挡膜低的水蒸气透过率的任选的第二阻挡膜，以减少活性物质的水蒸发代理配方。鞘被构造成能够将活性剂制剂固定并保持在手指指甲或脚趾指甲内的鞘内，同时减少活性剂制剂的水性液体组分的液体组分的蒸发。活性剂制剂可以是“慢速成型”水凝胶制剂，其可以缓慢地流入患病钉的确切形状，以确保药物的紧密接触和连续递送，同时在施用期间不能被挤出位置。

4. 发明申请

WO2008150995A2 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERING ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：用于递送抗炎药物的转运药物递送系统
公开(公告)号：WO2008150995A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065285
申请日：2008-05-30
申请人： ZARS PHARMA, INC. , ZHANG, Jie , WARNER, Kevin, S.
发明人： ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61K9/70 , A61F7/08
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug, and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36 0 C to 42 0 C, and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置为将人皮肤部位加热到特定温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5小时的时间。

5. 发明申请

WO2011088333A3 SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL 审中-公开
标题翻译：用于疼痛控制的固体局部麻醉制剂
公开(公告)号：WO2011088333A3
公开(公告)日：2011-11-24
申请号：PCT/US2011021318
申请日：2011-01-14
申请人： ZARS PHARMA INC , NIU SUYI , HULL WADE , ZHANG JIE
发明人： NIU SUYI , HULL WADE , ZHANG JIE
IPC分类号： A61K31/16 , A61K9/107 , A61K31/167 , A61K31/216 , A61K31/24 , A61K31/245 , A61K47/30 , A61P23/02
CPC分类号： A61K31/167 , A61K9/0014 , A61K31/136 , A61K47/32 , A61K2300/00
摘要： Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
摘要翻译：用于疼痛控制的固体形成局部麻醉剂制剂可以包括利多卡因碱和丁卡因碱，聚乙烯醇，水和乳化剂。制剂可以在施用于皮肤表面之前制备为半固体状态，在施用后可以形成柔软的固化层，并且当施加到疼痛部位附近的皮肤表面时可以提供疼痛缓解。

6. 发明申请

WO2011028542A2 METHODS OF TREATING PAIN ASSOCIATED WITH COMPLEX REGIONAL PAIN SYNDROME 审中-公开
标题翻译：治疗与复合区域疼痛综合征相关的疼痛的方法
公开(公告)号：WO2011028542A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/046523
申请日：2010-08-24
申请人： ZARS PHARMA, INC. , ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
发明人： ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
IPC分类号： A61K31/245 , A61K31/24 , A61K31/165 , A61K31/167 , A61P17/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/165 , A61K31/167 , A61K31/24 , A61K31/245 , A61K2300/00
摘要： The present invention is drawn to methods for treating pain associated with complex regional pain syndrome. Specifically, a method for treating pain associated with complex regional pain syndrome includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36°C to 42°C.
摘要翻译：本发明涉及用于治疗与复杂性区域性疼痛综合征相关的疼痛的方法。具体地说，用于治疗与复杂的局部疼痛综合征有关的疼痛的方法包括将镇痛系统施用于经历疼痛的受试者的皮肤表面，并将止痛系统保持在皮肤表面上至少30分钟的时间。应用于皮肤表面的镇痛系统可以包括加热组分和包括至少一种局部麻醉剂的局部麻醉剂制剂。加热组件能够将皮肤表面加热至36℃至42℃的温度。

7. 发明申请

WO2009017767A3 COMPOSITIONS AND METHODS FOR DERMALLY TREATING NEUROPATHY WITH MINOXIDIL 审中-公开
标题翻译：用奥昔地尔皮肤治疗神经病变的组合物和方法
公开(公告)号：WO2009017767A3
公开(公告)日：2009-12-30
申请号：PCT/US2008009222
申请日：2008-07-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
发明人： ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
IPC分类号： A01N43/54 , A61K8/00 , A61K31/505
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含米诺地尔的胶粘剂固化制剂，其可用于治疗包括糖尿病性神经病在内的神经病。该制剂可以包含一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，所述挥发性溶剂能够促进米诺地尔在持续的一段时间内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，该配制剂可以具有适合施用于皮肤表面的粘度。当施用于皮肤时，在至少一部分挥发性溶剂体系蒸发后，制剂可形成固化层。

8. 发明申请

WO2008150995A3 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERING ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：用于递送抗炎药物的转运药物递送系统
公开(公告)号：WO2008150995A3
公开(公告)日：2009-03-05
申请号：PCT/US2008065285
申请日：2008-05-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S
发明人： ZHANG JIE , WARNER KEVIN S
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug, and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36 0C to 42 0C, and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置为将人皮肤部位加热到特定温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5小时的时间。

9. 发明申请

WO2009017767A2 COMPOSITIONS AND METHODS FOR DERMALLY TREATING NEUROPATHY WITH MINOXIDIL 审中-公开
标题翻译：用迷迭香治疗神经病变的组合物和方法
公开(公告)号：WO2009017767A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/009222
申请日：2008-07-30
申请人： ZARS PHARMA, INC. , SANJAY, Sharma , ZHANG, Jie , WARNER, Kevin, S.
发明人： SANJAY, Sharma , ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56 , A61K9/12 , A61P17/00
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含有可用于治疗包括糖尿病性神经病变神经病变的米诺地尔的粘合剂固化制剂。制剂可以包括一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种能够在持续的时间内以治疗有效速率递送米诺地尔的至少一种非挥发性溶剂的非挥发性溶剂体系。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

10. 发明申请

WO2011140236A3 TRIAMCINOLONE ACETONIDE FORMULATIONS FOR TREATING DERMATITIS AND PSORIASIS 审中-公开
公开(公告)号：WO2011140236A3
公开(公告)日：2011-11-10
申请号：PCT/US2011/035216
申请日：2011-05-04
申请人： ZARS PHARMA, INC. , ALIYAR, Hyder , ZHANG, Jie
发明人： ALIYAR, Hyder , ZHANG, Jie
IPC分类号： A61K9/06 , A61K47/30 , A61K47/34 , A61K31/56 , A61K31/57 , A61P17/00
摘要： The present invention is drawn to formulations and related methods for treating dermatitis or psoriasis. The formulation can include triamcinolone acetonide, a polymer selected from the group of a poly(2-hydroxyalkylacrylate), a poly(2-hydroxyalkylmethacrylate), and combinations thereof. The formulation also includes a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent.

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