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1. 发明申请

WO2009089361A3 SYSTEMS METHODS AND FORMULATION FOR TOPICALLY TREATING NAIL FUNGAL INFECTION AND NAIL PSORIASIS 审中-公开
标题翻译：用于主要治疗指甲真菌感染和指甲病的系统方法和配方
公开(公告)号：WO2009089361A3
公开(公告)日：2009-10-01
申请号：PCT/US2009030452
申请日：2009-01-08
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN , KUMAR PROMOD , ALIYAR HYDER
发明人： ZHANG JIE , WARNER KEVIN , KUMAR PROMOD , ALIYAR HYDER
IPC分类号： A61K31/74
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/08 , A61K47/32
摘要： The present invention is drawn to systems, methods, and formulations for treating nail disorders. The system comprises an active agent formulation and a first barrier film. The active agent formulation includes an active agent and an aqueous liquid component. The first barrier film is configured to form a sheath over at least a portion of a finger or toe on which the nail is located. An optional second barrier film, with lower moisture vapor transmission rate than the first barrier film, is placed between the first barrier film and the active agent formulation (or between the active agent formulation and the external environment) to reduce the water evaporation from the active agent formulation. The sheath is configured to be capable of securing and retaining the active agent formulation within the sheath on a finger nail or toe nail while reducing evaporation of the liquid component of the aqueous liquid component of the active agent formulation. The active agent formulation can be a 'slow-molding' hydrogel formulation that can slowly flow into the exact shape of the diseased nail to assure intimate contact and continuous delivery of the drug, while cannot be squeezed out of the position during the application.
摘要翻译：本发明涉及用于治疗指甲疾病的系统，方法和制剂。该系统包含活性剂制剂和第一阻挡膜。活性剂制剂包括活性剂和水性液体组分。第一阻挡膜被配置成在指甲所在的手指或脚趾的至少一部分上形成护套。在第一阻挡膜和活性剂制剂之间（或活性剂制剂和外部环境之间）放置具有比第一阻挡膜低的水蒸气透过率的任选的第二阻挡膜，以减少活性物质的水蒸发代理配方。鞘被构造成能够将活性剂制剂固定并保持在手指指甲或脚趾指甲内的鞘内，同时减少活性剂制剂的水性液体组分的液体组分的蒸发。活性剂制剂可以是“慢速成型”水凝胶制剂，其可以缓慢地流入患病钉的确切形状，以确保药物的紧密接触和连续递送，同时在施用期间不能被挤出位置。

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