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1. 发明申请

WO2003065971A2 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS 审中-公开
标题翻译：具有类型性的非骨髓性多发性骨髓瘤治疗
公开(公告)号：WO2003065971A2
公开(公告)日：2003-08-14
申请号：PCT/IL2002/000467
申请日：2002-06-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , SLAVIN, Shimon , MORECKI, Shoshana , LEVITZKI, Alexander , GAZIT, Aviv
发明人： SLAVIN, Shimon , MORECKI, Shoshana , LEVITZKI, Alexander , GAZIT, Aviv
IPC分类号： A61K
CPC分类号： A61K49/0004 , A61K31/277 , A61K31/404 , A61K31/50 , A61K31/517 , A61K31/519 , A61K39/00 , A61K39/001 , A61K39/39 , A61K41/00 , A61K2039/55511 , A61K2300/00
摘要： A method of inducing immune tolerance in a first mammal to antigens of a second, non-syngeneic, mammal, is disclosed. The method is utilized to minimize graft rejection and/or reduce graft-versus-host diseases in transplantation procedures and to produce hematopoietic mixed chimeras. Methods of determining the activity of tyrphostins and the optimal concentration thereof in this method are also disclosed.
摘要翻译：公开了一种在第一种哺乳动物中诱导免疫耐受的方法，该方法是第二种非同系哺乳动物的抗原。该方法用于在移植过程中最小化移植物排斥和/或减少移植物抗宿主病，并产生造血混合嵌合体。还公开了确定酪氨酸磷酸酶活性的方法及其在该方法中的最佳浓度。

2. 发明申请

WO2003065971A3 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS 审中-公开
公开(公告)号：WO2003065971A3
公开(公告)日：2003-08-14
申请号：PCT/IL2002/000467
申请日：2002-06-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , SLAVIN, Shimon , LEVITZKI, Alexander , GAZIT, Aviv , MORECKI, Shoshana
发明人： SLAVIN, Shimon , LEVITZKI, Alexander , GAZIT, Aviv , MORECKI, Shoshana
IPC分类号： A61K48/00
摘要： A method of inducing immune tolerance in a first mammal to antigens of a second, non-syngeneic, mammal, is disclosed. The method is utilized to minimize graft rejection and/or reduce graft-versus-host diseases in transplantation procedures and to produce hematopoietic mixed chimeras. Methods of determining the activity of tyrphostins and the optimal concentration thereof in this method are also disclosed.

3. 发明申请

WO2005077348A1 TREATING OR PREVENTING DIABETES WITH CANNABIDIOL 审中-公开
标题翻译：用甘露糖治疗或预防糖尿病
公开(公告)号：WO2005077348A1
公开(公告)日：2005-08-25
申请号：PCT/IL2005/000196
申请日：2005-02-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , WEISS, Lola , ZEIRA, Michael , MECHOULAM, Raphael , SLAVIN, Shimon , GALLILY, Ruth
发明人： WEISS, Lola , ZEIRA, Michael , MECHOULAM, Raphael , SLAVIN, Shimon , GALLILY, Ruth
IPC分类号： A61K31/05
CPC分类号： A61K31/05 , A61K36/185
摘要： Use of a cannabidiol for the manufacture of a medicament identified for the treatment or prevention of diabetes and/or insulitis.
摘要翻译：使用大麻二醇来制造用于治疗或预防糖尿病和/或胰岛炎的药物。

4. 发明申请

WO2006087718A1 EXTENSION OF LIFESPAN WITH DRUGS 审中-公开
标题翻译：延长寿命与药物
公开(公告)号：WO2006087718A1
公开(公告)日：2006-08-24
申请号：PCT/IL2006/000205
申请日：2006-02-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , SLAVIN, Shimon , GAZIT, Aviv
发明人： SLAVIN, Shimon , GAZIT, Aviv
IPC分类号： A61K31/277 , C07C255/40 , C07C255/41 , C07C255/42 , C07C317/46 , C07C327/44 , A61P43/00
CPC分类号： C07C255/40 , C07C255/37 , C07C317/46 , C07C323/60 , C07C327/44
摘要： New compounds, inhibiting protein tyrosine kinases (PTKs) or steroid-related enzymes (SREs), which affect apoptosis in malignant tissues, and can be used in the preparation of medicaments for treating various disorders, and for elongating the lifespan of a subject while sustaining that subject in good health. Further, a method and antiaging compositions are provided for extending the lifespan.
摘要翻译：新化合物，抑制蛋白酪氨酸激酶（PTK）或类固醇相关酶（SREs），其影响恶性组织中的细胞凋亡，并且可用于制备用于治疗各种疾病的药物并延长受试者的寿命，同时维持那个问题身体健康。此外，提供了延长使用寿命的方法和抗衰老组合物。

5. 发明申请

WO2009060457A1 NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS 审中-公开
标题翻译：新型合成类似物
公开(公告)号：WO2009060457A1
公开(公告)日：2009-05-14
申请号：PCT/IL2008/001472
申请日：2008-11-09
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , DAGAN, Arieh , SLAVIN, Shimon , GATT, Shimon , ZAHAVI, Jeremy
发明人： DAGAN, Arieh , SLAVIN, Shimon , GATT, Shimon , ZAHAVI, Jeremy
IPC分类号： C07C215/10 , A61P35/00 , A61P43/00
CPC分类号： C07C215/12 , A61K31/133 , A61K31/4745 , A61K31/513 , C07C215/10 , Y02A50/409 , Y02A50/411
摘要： The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
摘要翻译：本发明提供了新的表示为式（II）化合物的神经酰胺类似物。这些新型类似物表现出显着的抗癌作用，因此作为治疗细胞增殖性疾病，神经变性疾病，代谢相关病症，感染性疾病和免疫相关疾病的药物组合物提供。本发明还提供组合的组合物和试剂盒，其将式（II）的新型神经酰胺类似物与另外的治疗剂组合。

6. 发明申请

WO2007105210A3 THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS 审中-公开
公开(公告)号：WO2007105210A3
公开(公告)日：2007-09-20
申请号：PCT/IL2007/000319
申请日：2007-03-13
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WEISS, Lola , MEINER, Vardiella , LEITERSDORF, Eran , SLAVIN, Shimon , MECHOULAM, Raphael , GALLILY, Ruth , LOTAN, Chaim , DURST, Ronen , PUGATSCH, Thea
发明人： WEISS, Lola , MEINER, Vardiella , LEITERSDORF, Eran , SLAVIN, Shimon , MECHOULAM, Raphael , GALLILY, Ruth , LOTAN, Chaim , DURST, Ronen , PUGATSCH, Thea
IPC分类号： A61K31/35
摘要： The present invention provides the use of a Cannabidiol (CBD) compound for the preparation of a pharmaceutical composition for treatment as well as for the prevention of at least one fundamental parameter affecting a vascular system selected from (a) the cardiovascular system; (b) the peripheral vascular system; or (c) a combination of (a) and (b); as well as pharmaceutical compositions and therapeutic methods for treating the above. A fundamental parameter may include blood/plasma lipid profile; atherosclerosis plaque load; size of heart scar; thickness of heart scar; and cardiac function in general. In accordance with a preferred embodiment the invention concerns treatment of heart scars as well as the preventing the formation of heart scars.

7. 发明申请

WO2004022120A1 COMPOSITIONS COMPRISING BONE MARROW CELLS, DEMINERALIZED BONE MATRIX AND RTG POLYMERS FOR USE IN THE INDUCTION OF BONE AND CARTILAGE FORMATION 审中-公开
标题翻译：包含骨髓细胞，脱骨骨基质和RTG聚合物的组合物用于诱导骨和骨形成
公开(公告)号：WO2004022120A1
公开(公告)日：2004-03-18
申请号：PCT/IL2002/000736
申请日：2002-09-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
IPC分类号： A61L27/38
CPC分类号： A61L27/3645 , A61K35/28 , A61K35/32 , A61K38/1875 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/3821 , A61L27/3834 , A61L27/3843 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) or demineralized tooth matrix (DTM), together with a reverse thermogelating polymer (RTG), optionally further comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint or a cranio-facial-maxillary bone, alveolar bone of maxilla and mandibula, spine, pelvis or long bones, or for construction or reconstruction of any extra skeletal bone, including for mechanical or biological support of artificial implants to the joint or of the joint or to the bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure.The BMC-DBM-RTG composition of the invention may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, primary or secondary malignant bone or cartilage disorders, metabolic bone diseases, or lesions caused by trauma, infection, any inflammatory process due to unknown or autoimmune etiology, conditions involving bone or cartilage deformities and Paget's disease. The composition may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including any artificial or musculoskeletal implants. The composition may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage, subchondral, and/or any other part of the bone.A kit is provided for performing transplantation of the composition into a joint, maxillary or mandibular alveolar bone or any bony structure of a mammal, including support of artificial implants.
摘要翻译：包含骨髓细胞（BMC）和脱矿质骨基质（DBM）或脱矿质牙质基质（DTM）的组合物，以及反向热凝胶聚合物（RTG），任选地还包含骨形态发生蛋白（BMP）和/或其它活性物质特别是用于将间充质祖细胞移植到关节或头颅面上颌骨，上颌骨和下颌骨，脊柱，骨盆或长骨的牙槽骨中，或用于构建或重建任何额外的骨骼骨，包括用于人造植入物对关节或关节或骨骼的机械或生物支持，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。本发明的BMC-DBM-RTG组合物可以是用于治疗遗传性或获得性骨骼疾病，遗传性或获得性软骨疾病，原发性或继发性恶性骨或软骨疾病，代谢性骨疾病或病变由于创伤，感染，由于未知或自身免疫性病因引起的任何炎症过程，涉及骨或软骨畸形的病症和佩吉特氏病引起。组合物还可用于矫正复合骨折，骨替代和塑性或性手术中新骨形成，以支持关节植入物，颅面上颌骨或其他肌骨骼植入物，包括任何人造骨骼或肌肉骨骼植入物。该组合物还可用于治疗与软骨，软骨下和/或骨的任何其他部分的畸形和/或功能障碍相关的损伤关节或退行性关节病。提供用于将组合物移植到关节中的试剂盒，上颌骨或下颌骨牙槽骨或哺乳动物的任何骨结构，包括人造植入物的支撑。

8. 发明申请

WO2009060445A1 SYNTHETIC SPHINGOLIPID ANALOGS 审中-公开
标题翻译：合成弹性体类似物
公开(公告)号：WO2009060445A1
公开(公告)日：2009-05-14
申请号：PCT/IL2008/001459
申请日：2008-11-06
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , DAGAN, Arieh , GATT, Shimon , SLAVIN, Shimon
发明人： DAGAN, Arieh , GATT, Shimon , SLAVIN, Shimon
IPC分类号： C07C321/28 , A61P3/10 , A61P25/28 , A61P31/04 , A61P31/12 , A61P33/06 , A61P37/08 , A61P43/00
CPC分类号： C07C323/32 , C07C381/12
摘要： Therapeutic compounds based on synthetic sphingolipid analogs are provided, particularly alkylthiophenyl substituted ceramide analogs, suitable for treating degenerative, infectious, and other diseases.
摘要翻译：提供了基于合成鞘脂类似物的治疗化合物，特别是烷基硫代苯基取代的神经酰胺类似物，其适于治疗退行性，感染性和其它疾病。

9. 发明申请

WO2004022121A1 COMPOSITIONS COMPRISING BONE MARROW CELLS, DEMINERALIZED BONE MATRIX AND VARIOUS SITE-REACTIVE POLYMERS FOR USE IN THE INDUCTION OF BONE AND CARTILAGE FORMATION 审中-公开
标题翻译：包含骨髓细胞，脱骨骨基质和各种位点反应性聚合物的组合物用于诱导骨和骨形成
公开(公告)号：WO2004022121A1
公开(公告)日：2004-03-18
申请号：PCT/IL2003/000728
申请日：2003-09-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
IPC分类号： A61L27/38
CPC分类号： A61L27/3645 , A61K35/28 , A61K35/32 , A61K38/1875 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/3821 , A61L27/3834 , A61L27/3843 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) or demineralized tooth matrix (DTM), together with a site-responsive polymer, optionally further comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint or a cranio-facial-maxillary bone, alveolar bone of maxilla and mandibula, spine, pelvis or long bones, or for construction or reconstruction of any extra skeletal bone, including for mechanical or biological support of artificial implants to the joint or of the joint or to the bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. A kit is provided for performing transplantation of the composition into a joint, maxillary or mandibular alveolar bone or any bony structure of a mammal, including support of artificial implants.
摘要翻译：包含骨髓细胞（BMC）和脱矿质骨基质（DBM）或软化牙基质（DTM）的组合物与位点应答聚合物一起，任选地还包含骨形态发生蛋白（BMP）和/或其它活性剂，特别是用于将间充质祖细胞移植到关节或头颅面上颌骨，上颌骨和下颌骨，脊柱，骨盆或长骨的牙槽骨中，或用于构建或重建任何额外的骨骼骨，包括用于机械或人造植入物对关节或关节或骨骼的生物支持，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。提供了用于将组合物移植到关节，上颌骨或下颌骨牙槽骨或哺乳动物的任何骨结构（包括人造植入物的支撑）中的试剂盒。

10. 发明申请

WO2006051538A2 CELLS ISOLATED FROM PLACENTA, DEVICE FOR ISOLATING SAME, AND USES THEREOF 审中-公开
标题翻译：从PLACENTA分离的细胞，用于分离的装置及其用途
公开(公告)号：WO2006051538A2
公开(公告)日：2006-05-18
申请号：PCT/IL2005/001184
申请日：2005-11-10
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , SLAVIN, Shimon , KILEMNIK, Ido, J.
发明人： SLAVIN, Shimon , KILEMNIK, Ido, J.
IPC分类号： A61K35/48 , A61K35/50 , C12N5/073 , C12N5/0789
CPC分类号： C12N5/0605 , A61K35/48 , A61K35/50 , A61L27/3604 , A61L27/3804 , A61L27/3839 , C12N5/0647 , C12N2506/02
摘要： A method of processing an organ is disclosed. The method comprises: (a) placing an organ in a sealable container; (b) disrupting the structure of said organ to yield a cell suspension; and (c) transferring said cell suspension to a sealable cell-suspension storage container, thereby isolating cells of said organ, wherein said sealable container, wherein said disrupting and said transferring are all performed substantially in a continuous vessel.
摘要翻译：公开了一种处理器官的方法。该方法包括：（a）将器官放置在可密封的容器中; （b）破坏所述器官的结构以产生细胞悬液; 和（c）将所述细胞悬浮液转移到可密封的细胞悬浮液储存容器中，由此分离所述器官的细胞，其中所述可密封容器，其中所述破坏和所述转移全部基本上在连续容器中进行。

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