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1. 发明申请

WO2004022120A1 COMPOSITIONS COMPRISING BONE MARROW CELLS, DEMINERALIZED BONE MATRIX AND RTG POLYMERS FOR USE IN THE INDUCTION OF BONE AND CARTILAGE FORMATION 审中-公开
标题翻译：包含骨髓细胞，脱骨骨基质和RTG聚合物的组合物用于诱导骨和骨形成
公开(公告)号：WO2004022120A1
公开(公告)日：2004-03-18
申请号：PCT/IL2002/000736
申请日：2002-09-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
IPC分类号： A61L27/38
CPC分类号： A61L27/3645 , A61K35/28 , A61K35/32 , A61K38/1875 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/3821 , A61L27/3834 , A61L27/3843 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) or demineralized tooth matrix (DTM), together with a reverse thermogelating polymer (RTG), optionally further comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint or a cranio-facial-maxillary bone, alveolar bone of maxilla and mandibula, spine, pelvis or long bones, or for construction or reconstruction of any extra skeletal bone, including for mechanical or biological support of artificial implants to the joint or of the joint or to the bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure.The BMC-DBM-RTG composition of the invention may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, primary or secondary malignant bone or cartilage disorders, metabolic bone diseases, or lesions caused by trauma, infection, any inflammatory process due to unknown or autoimmune etiology, conditions involving bone or cartilage deformities and Paget's disease. The composition may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including any artificial or musculoskeletal implants. The composition may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage, subchondral, and/or any other part of the bone.A kit is provided for performing transplantation of the composition into a joint, maxillary or mandibular alveolar bone or any bony structure of a mammal, including support of artificial implants.
摘要翻译：包含骨髓细胞（BMC）和脱矿质骨基质（DBM）或脱矿质牙质基质（DTM）的组合物，以及反向热凝胶聚合物（RTG），任选地还包含骨形态发生蛋白（BMP）和/或其它活性物质特别是用于将间充质祖细胞移植到关节或头颅面上颌骨，上颌骨和下颌骨，脊柱，骨盆或长骨的牙槽骨中，或用于构建或重建任何额外的骨骼骨，包括用于人造植入物对关节或关节或骨骼的机械或生物支持，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。本发明的BMC-DBM-RTG组合物可以是用于治疗遗传性或获得性骨骼疾病，遗传性或获得性软骨疾病，原发性或继发性恶性骨或软骨疾病，代谢性骨疾病或病变由于创伤，感染，由于未知或自身免疫性病因引起的任何炎症过程，涉及骨或软骨畸形的病症和佩吉特氏病引起。组合物还可用于矫正复合骨折，骨替代和塑性或性手术中新骨形成，以支持关节植入物，颅面上颌骨或其他肌骨骼植入物，包括任何人造骨骼或肌肉骨骼植入物。该组合物还可用于治疗与软骨，软骨下和/或骨的任何其他部分的畸形和/或功能障碍相关的损伤关节或退行性关节病。提供用于将组合物移植到关节中的试剂盒，上颌骨或下颌骨牙槽骨或哺乳动物的任何骨结构，包括人造植入物的支撑。

2. 发明申请

WO2004022121A1 COMPOSITIONS COMPRISING BONE MARROW CELLS, DEMINERALIZED BONE MATRIX AND VARIOUS SITE-REACTIVE POLYMERS FOR USE IN THE INDUCTION OF BONE AND CARTILAGE FORMATION 审中-公开
标题翻译：包含骨髓细胞，脱骨骨基质和各种位点反应性聚合物的组合物用于诱导骨和骨形成
公开(公告)号：WO2004022121A1
公开(公告)日：2004-03-18
申请号：PCT/IL2003/000728
申请日：2003-09-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , COHN, Daniel , SOSNIK, Alejandro
IPC分类号： A61L27/38
CPC分类号： A61L27/3645 , A61K35/28 , A61K35/32 , A61K38/1875 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/3821 , A61L27/3834 , A61L27/3843 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) or demineralized tooth matrix (DTM), together with a site-responsive polymer, optionally further comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint or a cranio-facial-maxillary bone, alveolar bone of maxilla and mandibula, spine, pelvis or long bones, or for construction or reconstruction of any extra skeletal bone, including for mechanical or biological support of artificial implants to the joint or of the joint or to the bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. A kit is provided for performing transplantation of the composition into a joint, maxillary or mandibular alveolar bone or any bony structure of a mammal, including support of artificial implants.
摘要翻译：包含骨髓细胞（BMC）和脱矿质骨基质（DBM）或软化牙基质（DTM）的组合物与位点应答聚合物一起，任选地还包含骨形态发生蛋白（BMP）和/或其它活性剂，特别是用于将间充质祖细胞移植到关节或头颅面上颌骨，上颌骨和下颌骨，脊柱，骨盆或长骨的牙槽骨中，或用于构建或重建任何额外的骨骼骨，包括用于机械或人造植入物对关节或关节或骨骼的生物支持，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。提供了用于将组合物移植到关节，上颌骨或下颌骨牙槽骨或哺乳动物的任何骨结构（包括人造植入物的支撑）中的试剂盒。

3. 发明申请

WO2002070023A2 COMPOSITIONS COMPRISING BONE MARROW CELLS TOGETHER WITH DEMINERALIZED AND/OR MINERALIZED BONE MATRIX AND USES THEREOF IN THE INDUCTION OF BONE AND CARTILAGE FORMATION 审中-公开
标题翻译：包含骨髓基质细胞与成骨细胞和/或矿化骨骼基质的组合物及其在诱导骨骼和骨髓形成中的用途
公开(公告)号：WO2002070023A2
公开(公告)日：2002-09-12
申请号：PCT/IL2002/000172
申请日：2002-03-05
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , PRIGOZHINA, Tatyana
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , PRIGOZHINA, Tatyana
IPC分类号： A61L
CPC分类号： A61K35/32 , A61K35/28 , A61K38/1875 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and/or a cranio-facial-maxillary bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage and/or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.
摘要翻译：包含骨髓细胞（BMC）和去矿化骨基质（DBM）和/或矿化骨基质（MBM）和任选地包含骨形态发生蛋白（BMP）和/或其他活性剂的组合物，特别是用于移植间充质祖细胞进入关节和/或头颅面上颌骨，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。本发明的组合物及其使用方法可用于治疗遗传性或获得性骨病，遗传性或获得性软骨疾病，恶性骨或软骨疾病，代谢性骨病，骨感染，涉及骨或软骨畸形的病症和佩吉特病。组合物和方法还可用于矫正复合骨折，骨替代和塑性或性手术中新骨形成，以支持关节植入物，颅面上颌骨或其他肌骨骼植入物，包括人造植入物。本发明的方法还可用于治疗与软骨和/或软骨下骨的畸形和/或功能障碍相关的损伤关节或退行性关节病。提供用于进行移植到本发明组合物的哺乳动物的关节或头颅面上颌骨中的试剂盒。

4. 发明申请

WO2002070023A3 COMPOSITIONS COMPRISING BONE MARROW CELLS TOGETHER WITH DEMINERALIZED AND/OR MINERALIZED BONE MATRIX AND USES THEREOF IN THE INDUCTION OF BONE AND CARTILAGE FORMATION 审中-公开
公开(公告)号：WO2002070023A3
公开(公告)日：2002-09-12
申请号：PCT/IL2002/000172
申请日：2002-03-05
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , PRIGOZHINA, Tatyana
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan, Gowda, S. , PRIGOZHINA, Tatyana
IPC分类号： A61K35/32
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and/or a cranio-facial-maxillary bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage and/or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.

5. 发明申请

WO2009060457A1 NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS 审中-公开
标题翻译：新型合成类似物
公开(公告)号：WO2009060457A1
公开(公告)日：2009-05-14
申请号：PCT/IL2008/001472
申请日：2008-11-09
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , DAGAN, Arieh , SLAVIN, Shimon , GATT, Shimon , ZAHAVI, Jeremy
发明人： DAGAN, Arieh , SLAVIN, Shimon , GATT, Shimon , ZAHAVI, Jeremy
IPC分类号： C07C215/10 , A61P35/00 , A61P43/00
CPC分类号： C07C215/12 , A61K31/133 , A61K31/4745 , A61K31/513 , C07C215/10 , Y02A50/409 , Y02A50/411
摘要： The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.
摘要翻译：本发明提供了新的表示为式（II）化合物的神经酰胺类似物。这些新型类似物表现出显着的抗癌作用，因此作为治疗细胞增殖性疾病，神经变性疾病，代谢相关病症，感染性疾病和免疫相关疾病的药物组合物提供。本发明还提供组合的组合物和试剂盒，其将式（II）的新型神经酰胺类似物与另外的治疗剂组合。

6. 发明申请

WO2009060445A1 SYNTHETIC SPHINGOLIPID ANALOGS 审中-公开
标题翻译：合成弹性体类似物
公开(公告)号：WO2009060445A1
公开(公告)日：2009-05-14
申请号：PCT/IL2008/001459
申请日：2008-11-06
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. , DAGAN, Arieh , GATT, Shimon , SLAVIN, Shimon
发明人： DAGAN, Arieh , GATT, Shimon , SLAVIN, Shimon
IPC分类号： C07C321/28 , A61P3/10 , A61P25/28 , A61P31/04 , A61P31/12 , A61P33/06 , A61P37/08 , A61P43/00
CPC分类号： C07C323/32 , C07C381/12
摘要： Therapeutic compounds based on synthetic sphingolipid analogs are provided, particularly alkylthiophenyl substituted ceramide analogs, suitable for treating degenerative, infectious, and other diseases.
摘要翻译：提供了基于合成鞘脂类似物的治疗化合物，特别是烷基硫代苯基取代的神经酰胺类似物，其适于治疗退行性，感染性和其它疾病。

7. 发明申请

WO2002069988A3 COMPOSITIONS COMPRISING BONE MARROW CELLS TOGETHER WITH DEMINERALIZED AND/OR MINERALIZED BONE MATRIX AND THEIR USE IN BONE MARROW TRANSPLANTATION 审中-公开
公开(公告)号：WO2002069988A3
公开(公告)日：2002-09-12
申请号：PCT/IL2002/000171
申请日：2002-03-05
申请人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan Gowda S. , PRIGOZHINA, Tatyana
发明人： SLAVIN, Shimon , GUREVITCH, Olga , KURKALLI, Basan Gowda S. , PRIGOZHINA, Tatyana
IPC分类号： A61K35/32
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM), optionally comprising bone morphogenetic protein (BMP), particularly for use in bone marrow transplantation, into bone marrow cavity or into extraskeletal sites, and methods of transplantation/implantation thereof. The composition and methods of the invention enable restoring and/or enhancing the formation of hematopoietic microenvironment originating from the transplanted BMC, and are useful in the treatment of hematopoietic disorders, such as deficiency of stem cells and/or their products, genetic conditions resulting in abnormal stem cells and/or products, or hematopoietic disorders of malignant or non-malignant origin. The composition and method of the invention may also be used for the induction of graft tolerance, for the prevention of graft-v.-host disease. It is mostly important that the compositions and methods of the invention may be applied for the treatment of diseases affecting primarily or secondarily the stromal microenvironment that supports and regulates hematopoiesis. Further provided is a kit for transplantation into a mammal of BMC in admixture with DBM and/or MBM.

8. 发明申请

WO2006087718A1 EXTENSION OF LIFESPAN WITH DRUGS 审中-公开
标题翻译：延长寿命与药物
公开(公告)号：WO2006087718A1
公开(公告)日：2006-08-24
申请号：PCT/IL2006/000205
申请日：2006-02-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , SLAVIN, Shimon , GAZIT, Aviv
发明人： SLAVIN, Shimon , GAZIT, Aviv
IPC分类号： A61K31/277 , C07C255/40 , C07C255/41 , C07C255/42 , C07C317/46 , C07C327/44 , A61P43/00
CPC分类号： C07C255/40 , C07C255/37 , C07C317/46 , C07C323/60 , C07C327/44
摘要： New compounds, inhibiting protein tyrosine kinases (PTKs) or steroid-related enzymes (SREs), which affect apoptosis in malignant tissues, and can be used in the preparation of medicaments for treating various disorders, and for elongating the lifespan of a subject while sustaining that subject in good health. Further, a method and antiaging compositions are provided for extending the lifespan.
摘要翻译：新化合物，抑制蛋白酪氨酸激酶（PTK）或类固醇相关酶（SREs），其影响恶性组织中的细胞凋亡，并且可用于制备用于治疗各种疾病的药物并延长受试者的寿命，同时维持那个问题身体健康。此外，提供了延长使用寿命的方法和抗衰老组合物。

9. 发明申请

WO2007105210A3 THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS 审中-公开
公开(公告)号：WO2007105210A3
公开(公告)日：2007-09-20
申请号：PCT/IL2007/000319
申请日：2007-03-13
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WEISS, Lola , MEINER, Vardiella , LEITERSDORF, Eran , SLAVIN, Shimon , MECHOULAM, Raphael , GALLILY, Ruth , LOTAN, Chaim , DURST, Ronen , PUGATSCH, Thea
发明人： WEISS, Lola , MEINER, Vardiella , LEITERSDORF, Eran , SLAVIN, Shimon , MECHOULAM, Raphael , GALLILY, Ruth , LOTAN, Chaim , DURST, Ronen , PUGATSCH, Thea
IPC分类号： A61K31/35
摘要： The present invention provides the use of a Cannabidiol (CBD) compound for the preparation of a pharmaceutical composition for treatment as well as for the prevention of at least one fundamental parameter affecting a vascular system selected from (a) the cardiovascular system; (b) the peripheral vascular system; or (c) a combination of (a) and (b); as well as pharmaceutical compositions and therapeutic methods for treating the above. A fundamental parameter may include blood/plasma lipid profile; atherosclerosis plaque load; size of heart scar; thickness of heart scar; and cardiac function in general. In accordance with a preferred embodiment the invention concerns treatment of heart scars as well as the preventing the formation of heart scars.

10. 发明申请

WO2005077348A1 TREATING OR PREVENTING DIABETES WITH CANNABIDIOL 审中-公开
标题翻译：用甘露糖治疗或预防糖尿病
公开(公告)号：WO2005077348A1
公开(公告)日：2005-08-25
申请号：PCT/IL2005/000196
申请日：2005-02-16
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , WEISS, Lola , ZEIRA, Michael , MECHOULAM, Raphael , SLAVIN, Shimon , GALLILY, Ruth
发明人： WEISS, Lola , ZEIRA, Michael , MECHOULAM, Raphael , SLAVIN, Shimon , GALLILY, Ruth
IPC分类号： A61K31/05
CPC分类号： A61K31/05 , A61K36/185
摘要： Use of a cannabidiol for the manufacture of a medicament identified for the treatment or prevention of diabetes and/or insulitis.
摘要翻译：使用大麻二醇来制造用于治疗或预防糖尿病和/或胰岛炎的药物。

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