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1. 发明申请

WO2005123126A3 ANTIBODIES AGAINST HUMAN INTERLEUKIN-13 AND USES THEREFOR 审中-公开
标题翻译：抗体人类抗体13及其用途
公开(公告)号：WO2005123126A3
公开(公告)日：2007-07-12
申请号：PCT/US2005020160
申请日：2005-06-09
申请人： WYETH CORP , KASAIAN MARION T , TCHISTIAKOVA LIOUDMILA , VELDMAN GEERTRUIDA M , MARQUETTE KIMBERLY ANN , TAN XIANG-YANG , DONALDSON DEBRA D , LIN LAURA LONG , SHANE TANIA , TAM AMY SZEPUI , FEYFANT ERIC , WOOD NANCY L , FITZ LORI J , WIDOM ANGELA M , PARRIS KEVIN D , GOLDMAN SAMUEL J
发明人： KASAIAN MARION T , TCHISTIAKOVA LIOUDMILA , VELDMAN GEERTRUIDA M , MARQUETTE KIMBERLY ANN , TAN XIANG-YANG , DONALDSON DEBRA D , LIN LAURA LONG , SHANE TANIA , TAM AMY SZEPUI , FEYFANT ERIC , WOOD NANCY L , FITZ LORI J , WIDOM ANGELA M , PARRIS KEVIN D , GOLDMAN SAMUEL J
IPC分类号： A61K39/395 , C07K16/00 , C07K16/24 , G01N33/53
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译：本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途。本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性病症。

2. 发明申请

WO2006085938A3 IL-13 BINDING AGENTS 审中-公开
标题翻译： IL-13结合剂
公开(公告)号：WO2006085938A3
公开(公告)日：2009-04-30
申请号：PCT/US2005021454
申请日：2005-06-17
申请人： WYETH CORP , TCHISTIAKOVA LIOUDMILA , KASAIAN MARION T , DONALDSON DEBRA D , TAN XIANG-YANG , GILL DAVINDER , JACOBSON BRUCE , JIN MACY X , GOLDMAN SAMUEL J , KNOPF JOHN , WIDOM ANGELA M
发明人： TCHISTIAKOVA LIOUDMILA , KASAIAN MARION T , DONALDSON DEBRA D , TAN XIANG-YANG , GILL DAVINDER , JACOBSON BRUCE , JIN MACY X , GOLDMAN SAMUEL J , KNOPF JOHN , WIDOM ANGELA M
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译：公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。

3. 发明申请

WO2005112983A2 MODULATION OF IMMUNOGLOBULIN PRODUCTION AND ATOPIC DISORDERS 审中-公开
标题翻译：免疫球蛋白生产和原发性疾病的调节
公开(公告)号：WO2005112983A2
公开(公告)日：2005-12-01
申请号：PCT/US2005017514
申请日：2005-05-19
申请人： WYETH CORP , KASAIAN MARION T , WOOD NANCY L , DONALDSON DEBRA D , COLLINS MARY
发明人： KASAIAN MARION T , WOOD NANCY L , DONALDSON DEBRA D , COLLINS MARY
IPC分类号： A61K38/20 , G01N33/68
CPC分类号： G01N33/6869 , A61K38/13 , A61K38/20 , A61K48/00 , C07K16/244 , C07K16/2878 , C07K2317/75 , C07K2317/76 , G01N33/6854 , G01N2500/00 , G01N2800/20 , G01N2800/24 , A61K2300/00
摘要： An IL-21 polypeptide or other IL-21 pathway agonist can be used to treat atopic disorders, e.g., asthma.
摘要翻译： IL-21多肽或其它IL-21途径激动剂可用于治疗特应性疾病，例如哮喘。

4. 发明申请

WO2005089442A8 INHIBITORS OF GOB-4 PROTEIN AS ASTHMA THERAPEUTICS 审中-公开
标题翻译： GOB-4蛋白抑制剂作为ASTHMA治疗
公开(公告)号：WO2005089442A8
公开(公告)日：2007-02-01
申请号：PCT/US2005008946
申请日：2005-03-18
申请人： WYETH CORP , FOLLETTIE MAXIMILLIAN , DONALDSON DEBRA D
发明人： FOLLETTIE MAXIMILLIAN , DONALDSON DEBRA D
IPC分类号： C12Q1/00 , G01N33/68
CPC分类号： G01N33/6893 , G01N2400/40 , G01N2500/00 , G01N2500/04 , G01N2800/122
摘要： Methods of screening for agents for treating asthma are provided. The methods involve screening for agents that decrease the production or activity of a Gob-4 protein that has been discovered herein to play a role in producing the symptoms and pathological complications involved in asthma. Methods of treating asthma, as well as screening for and treating with inhibitors of a Gob-4 protein are also provided.
摘要翻译：提供了用于治疗哮喘的药物的筛选方法。该方法涉及筛选降低Gob-4蛋白的生产或活性的试剂，这些已发现本发明在产生与哮喘有关的症状和病理并发症中发挥作用。还提供了治疗哮喘的方法，以及用Gob-4蛋白抑制剂的筛选和治疗。

5. 发明申请

WO2005089442A3 INHIBITORS OF GOB-4 PROTEIN AS ASTHMA THERAPEUTICS 审中-公开
标题翻译： GOB-4蛋白作为哮喘治疗药物的抑制剂
公开(公告)号：WO2005089442A3
公开(公告)日：2005-12-08
申请号：PCT/US2005008946
申请日：2005-03-18
申请人： WYETH CORP , FOLLETTIES MAXIMILLIAN , DONALDSON DEBRA D
发明人： FOLLETTIE MAXIMILLIAN , DONALDSON DEBRA D
IPC分类号： C12Q1/00 , G01N33/68
CPC分类号： G01N33/6893 , G01N2400/40 , G01N2500/00 , G01N2500/04 , G01N2800/122
摘要： Methods of screening for agents for treating asthma are provided. The methods involve screening for agents that decrease the production or activity of a Gob-4 protein that has been discovered herein to play a role in producing the symptoms and pathological complications involved in asthma. Methods of treating asthma, as well as screening for and treating with inhibitors of a Gob-4 protein are also provided.
摘要翻译：提供了用于治疗哮喘的药剂的筛选方法。所述方法包括筛选降低本文中已经发现的Gob-4蛋白的产生或活性以在产生哮喘相关症状和病理并发症方面起作用的试剂。还提供了治疗哮喘以及筛选和用Gob-4蛋白抑制剂治疗的方法。

6. 发明申请

WO02055100A9 Method and composition for inhibition of tumor growth and enhancing an immune response 审中-公开
标题翻译：用于抑制肿瘤生长和增强免疫应答的方法和组合物
公开(公告)号：WO02055100A9
公开(公告)日：2006-05-11
申请号：PCT/US0151339
申请日：2001-10-22
申请人： BERZOFSKY JAY A , TERABE MASAKI , DONALDSON DEBRA D , MATSUI SO , NOBEN-TRAUTH NANCY , PAUL WILLIAM E , INST GENETICS LLC , US GOV HEALTH & HUMAN SERV
发明人： BERZOFSKY JAY A , TERABE MASAKI , DONALDSON DEBRA D , MATSUI SO , NOBEN-TRAUTH NANCY , PAUL WILLIAM E
IPC分类号： A61K47/34 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/02 , A61P37/04 , C07K14/54 , C07K16/24 , C07K16/28
CPC分类号： C07K16/244 , A61K38/1793 , A61K38/208 , A61K39/39 , A61K2039/505 , A61K2039/55516 , A61K2039/55538 , C07K16/2812 , C07K2319/30 , A61K2300/00
摘要： Provided is a method and composition for enhancing an immune response in a subject by administering to the subject an inhibitor of IL-13 or an inhibitor of an NK-T cell to the subject. The method can be used to prevent growth of a tumor in the subject, e.g., to inhibit tumor recurrence or metastasis. The method can also be used to enhance a response to a vaccine in a subject.
摘要翻译：本发明提供了一种通过向受试者施用IL-13抑制剂或NK-T细胞抑制剂来增强受试者的免疫应答的方法和组合物。该方法可用于预防受试者中肿瘤的生长，例如抑制肿瘤复发或转移。该方法还可用于增强对受试者中疫苗的反应。

7. 发明申请

WO0185792A8 MU-1, MEMBER OF THE CYTOKINE RECEPTOR FAMILY 审中-公开
标题翻译： MU-1，细胞因子受体家族成员
公开(公告)号：WO0185792A8
公开(公告)日：2002-05-23
申请号：PCT/US0115395
申请日：2001-05-11
申请人： GENETICS INST , DONALDSON DEBRA D , UNGER MICHELLE J , YOUNG DEBORAH A , WHITTERS MATTHEW J , LOWE LESLIE , COLLINS MARY
发明人： DONALDSON DEBRA D , UNGER MICHELLE J , YOUNG DEBORAH A , WHITTERS MATTHEW J , LOWE LESLIE , COLLINS MARY
IPC分类号： C12N15/09 , A61K38/00 , A61P37/04 , A61P37/06 , A61P37/08 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , A61K38/17 , C12N15/66
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/30
摘要： Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.
摘要翻译：公开了编码MU-1造血细胞因子受体超家族链及其片段的多核苷酸。还公开了MU-1蛋白质及其生产方法。

8. 发明申请

WO0185792A3 MU-1, MEMBER OF THE CYTOKINE RECEPTOR FAMILY 审中-公开
标题翻译： MU-1，细胞因子受体家族成员
公开(公告)号：WO0185792A3
公开(公告)日：2003-08-21
申请号：PCT/US0115395
申请日：2001-05-11
申请人： INST GENETICS LLC , DONALDSON DEBRA D , UNGER MICHELLE J , YOUNG DEBORAH A , WHITTERS MATTHEW J , LOWE LESLIE , COLLINS MARY
发明人： DONALDSON DEBRA D , UNGER MICHELLE J , YOUNG DEBORAH A , WHITTERS MATTHEW J , LOWE LESLIE , COLLINS MARY
IPC分类号： C12N15/09 , A61K38/00 , A61P37/04 , A61P37/06 , A61P37/08 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , A61K38/17 , C12N15/66
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/30
摘要： Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.
摘要翻译：公开了编码MU-1造血细胞因子受体超家族链及其片段的多核苷酸。还公开了MU-1蛋白质及其生产方法。

9. 发明申请

WO02055100A2 METHOD AND COMPOSITION FOR ENHANCING AN IMMUNE RESPONSE 审中-公开
标题翻译：增强免疫反应的方法和组合
公开(公告)号：WO02055100A2
公开(公告)日：2002-07-18
申请号：PCT/US0151339
申请日：2001-10-22
申请人： INST GENETICS LLC , US GOV HEALTH & HUMAN SERV , BERZOFSKY JAY A , TERABE MASAKI , DONALDSON DEBRA D , MATSUI SO , NOBEN-TRAUTH NANCY , PAUL WILLIAM E
发明人： BERZOFSKY JAY A , TERABE MASAKI , DONALDSON DEBRA D , MATSUI SO , NOBEN-TRAUTH NANCY , PAUL WILLIAM E
IPC分类号： A61K47/34 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/02 , A61P37/04 , C07K14/54 , C07K16/24 , C07K16/28
CPC分类号： C07K16/244 , A61K38/1793 , A61K38/208 , A61K39/39 , A61K2039/505 , A61K2039/55516 , A61K2039/55538 , C07K16/2812 , C07K2319/30 , A61K2300/00
摘要： Provided is a method and composition for enhancing an immune response in a subject by administering to the subject an inhibitor of IL-13 or an inhibitor of an NK-T cell to the subject. The method can be used to prevent growth of a tumor in the subject, e.g., to inhibit tumor recurrence or metastasis. The method can also be used to enhance a response to a vaccine in a subject.
摘要翻译：本发明提供了一种通过向受试者施用IL-13抑制剂或NK-T细胞抑制剂来对受试者增强受试者的免疫应答的方法和组合物。该方法可用于预防受试者中肿瘤的生长，例如抑制肿瘤复发或转移。该方法还可用于增强对受试者中疫苗的反应。

10. 发明申请

WO2008033461A3 METHODS FOR THE IDENTIFICATION, EVALUATION AND TREATMENT OF PATIENTS HAVING CC-CHEMOKINE RECEPTOR 2(CCR-2) MEDIATED DISORDERS 审中-公开
标题翻译：用CC-chemokine受体2（CCR-2）介导的疾病患者进行鉴定，评估和治疗的方法
公开(公告)号：WO2008033461A3
公开(公告)日：2008-10-30
申请号：PCT/US2007019926
申请日：2007-09-13
申请人： MILLENNIUM PHARM INC , PARKER ALEXANDER N , DONALDSON DEBRA D
发明人： PARKER ALEXANDER N , DONALDSON DEBRA D
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is directed to the identification of predictive genotypes, e g, predictive single nucleotide polymorphisms (SNPs), and markers that can be used to determine whether a patient having a CC-Chemokine Receptor 2 (CCR-2) mediated disorders is likely to be responsive or non-responsive to a therapeutic regimen. For example, the present invention is directed, in part, to the use of certain individual and/or combinations of SNPs, wherein the expression of particular alleles at particular SNPs, or combinations of alleles at loci in linkage disequilibrium with a particular SNP, correlate with responsiveness or non-responsiveness to a therapeutic regimen. The present invention is also directed to the use of certain individual and/or combinations of predictive markers which correlate with responsiveness or non-responsiveness to a therapeutic regimen. Thus, by examining allelic expression at particular SNPs, combinations of alleles at loci in linkage disequilibrium with a particular SNP, or expression levels of individual predictive markers and/or predictive markers comprising a marker set, it is possible to determine whether a patient having a CCR-2 mediated disorder will likely respond or not respond to a therapeutic regimen.
摘要翻译：本发明涉及预测性基因型（例如预测性单核苷酸多态性（SNP））的鉴定，以及可用于确定具有CC-趋化因子受体2（CCR-2）介导的疾病的患者是否可能对治疗方案有反应或无反应。例如，本发明部分地涉及SNP的某些个体和/或组合的用途，其中特定SNP处的特定等位基因的表达或与特定SNP处于连锁不平衡中的基因座处等位基因的组合关联对治疗方案有反应或无反应。本发明还涉及使用与治疗方案的响应性或非响应性相关的某些个体和/或预测标记组合。因此，通过检查特定SNP处的等位基因表达，与特定SNP处于连锁不平衡中的基因座处等位基因的组合，或单个预测性标记和/或包含标记组的预测性标记的表达水平，可以确定具有 CCR-2介导的疾病可能对治疗方案有反应或无反应。

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