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1. 发明申请

WO2008033461A3 METHODS FOR THE IDENTIFICATION, EVALUATION AND TREATMENT OF PATIENTS HAVING CC-CHEMOKINE RECEPTOR 2(CCR-2) MEDIATED DISORDERS 审中-公开
标题翻译：用CC-chemokine受体2（CCR-2）介导的疾病患者进行鉴定，评估和治疗的方法
公开(公告)号：WO2008033461A3
公开(公告)日：2008-10-30
申请号：PCT/US2007019926
申请日：2007-09-13
申请人： MILLENNIUM PHARM INC , PARKER ALEXANDER N , DONALDSON DEBRA D
发明人： PARKER ALEXANDER N , DONALDSON DEBRA D
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention is directed to the identification of predictive genotypes, e g, predictive single nucleotide polymorphisms (SNPs), and markers that can be used to determine whether a patient having a CC-Chemokine Receptor 2 (CCR-2) mediated disorders is likely to be responsive or non-responsive to a therapeutic regimen. For example, the present invention is directed, in part, to the use of certain individual and/or combinations of SNPs, wherein the expression of particular alleles at particular SNPs, or combinations of alleles at loci in linkage disequilibrium with a particular SNP, correlate with responsiveness or non-responsiveness to a therapeutic regimen. The present invention is also directed to the use of certain individual and/or combinations of predictive markers which correlate with responsiveness or non-responsiveness to a therapeutic regimen. Thus, by examining allelic expression at particular SNPs, combinations of alleles at loci in linkage disequilibrium with a particular SNP, or expression levels of individual predictive markers and/or predictive markers comprising a marker set, it is possible to determine whether a patient having a CCR-2 mediated disorder will likely respond or not respond to a therapeutic regimen.
摘要翻译：本发明涉及预测性基因型（例如预测性单核苷酸多态性（SNP））的鉴定，以及可用于确定具有CC-趋化因子受体2（CCR-2）介导的疾病的患者是否可能对治疗方案有反应或无反应。例如，本发明部分地涉及SNP的某些个体和/或组合的用途，其中特定SNP处的特定等位基因的表达或与特定SNP处于连锁不平衡中的基因座处等位基因的组合关联对治疗方案有反应或无反应。本发明还涉及使用与治疗方案的响应性或非响应性相关的某些个体和/或预测标记组合。因此，通过检查特定SNP处的等位基因表达，与特定SNP处于连锁不平衡中的基因座处等位基因的组合，或单个预测性标记和/或包含标记组的预测性标记的表达水平，可以确定具有 CCR-2介导的疾病可能对治疗方案有反应或无反应。

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