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    • 2. 发明申请
    • DEVICE TO BE IMPLANTED IN A HUMAN OR ANIMAL BODY FOR MATERIAL OR SIGNAL DELIVERY OR ACQUISITION WITHIN THE BODY
    • 在人体或动物体内进行材料或信号传递或收集的装置
    • WO2011029208A1
    • 2011-03-17
    • PCT/CH2010/000217
    • 2010-09-07
    • WOODWELDING AGMAYER, JörgFROESCH, BarbaraLEHMANN, MarioLANGHOFF, JensKNECHT, Thomas
    • MAYER, JörgFROESCH, BarbaraLEHMANN, MarioLANGHOFF, JensKNECHT, Thomas
    • A61B17/86A61K9/00
    • A61B5/6878A61B5/076A61B5/4839A61B17/3472A61B17/68A61B90/90A61B90/98A61B2017/00955A61B2017/561A61B2017/8655A61B2503/40A61B2562/164A61D7/00A61F2/30744A61F2002/2839A61N7/00A61N2007/0047
    • For fixedly implanting a device for material or signal delivery or acquisition or a part of such a device in a human or animal body, an opening is provided in hard tissue of the body, the opening reaching through a hard tissue layer, e.g. through a cortical bone layer (2) into cancellous bone (1 ) underneath. The device comprises a plug portion (P) and/or a cover portion (C) which comprises a ring (7) of a material having thermoplastic properties extending around the plug portion (P) or on a tissue facing surface of the cover portion (C). The opening (9) provided in the hard tissue has a cross section at least in the area of its mouth that is adapted to the plug or cover portion such that the plug portion (P) can be introduced through the mouth of the opening (9) or the cover portion (C) can be positioned over the mouth of the opening (9) such that the ring (7) extends around the opening, along its wall and/or on the hard tissue surface around its mouth. For implantation the device is positioned with the plug portion (P) in the mouth of the opening and/or the cover portion (C) over the opening, the material having thermoplastic properties is then liquefied e.g. through application of vibrational energy and is made to get into contact with the wall of the opening and/or with the hard tissue surface all around the opening. On resolidification the material having thermoplastic properties constitutes a sealing ring (11) between device and hard tissue. The device is e.g. equipped as drug delivery device for intra-osseous or intra-articular drug delivery and is implanted through the cortical bone layer in the vicinity of a Joint. The sealing ring (11) fully prevents migration of the drug or other undesired substances along the device surface through the cortical bone layer.
    • 为了将材料或信号传递或获取的装置或这种装置的一部分固定地植入人体或动物体内,在身体的硬组织中提供开口,所述开口通过硬组织层例如穿过。 通过皮质骨层(2)进入下面的松质骨(1)。 该装置包括插头部分(P)和/或盖部分(C),其包括具有围绕插塞部分(P)延伸的热塑性特性或覆盖部分的面向组织表面的材料的环(7) C)。 设置在硬组织中的开口(9)至少在其嘴部的适于插头或盖部分的区域中具有横截面,使得插塞部分(P)可以通过开口(9)的口引入 )或盖部分(C)可以定位在开口(9)的口部上方,使得环(7)围绕开口沿其壁和/或围绕其嘴部的硬组织表面延伸。 为了植入,装置定位成使塞子部分(P)位于开口的口部和/或盖部分(C)的开口上方,具有热塑性的材料然后被液化。 通过施加振动能量使其与开口的壁和/或与开口处的硬组织表面接触。 在重新固化时,具有热塑性的材料构成装置和硬组织之间的密封环(11)。 该装置是例如 作为用于骨内或关节内药物递送的药物递送装置,并且通过皮质骨层在关节附近植入。 密封环(11)完全防止药物或其它不需要的物质沿着装置表面通过皮层骨层迁移。