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1. 发明申请

WO2016182790A1 THREE-DIMENSION PRINTER WITH MECHANICALLY SCANNED CATHODE-COMB 审中-公开
标题翻译：三维打印机与机械扫描CATHODE-COMB
公开(公告)号：WO2016182790A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/030537
申请日：2016-05-03
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： MACKIE, Thomas, Rockwell , WALKER, Brandon, Joseph
IPC分类号： B29C67/00 , B33Y30/00 , B33Y50/02 , B33Y40/00
CPC分类号： B22F3/1055 , B22F2003/1057 , B33Y30/00 , B33Y50/02 , Y02P10/295
摘要： A 3-D printer scalable to large sizes employs a combination of mechanical and electrical scanning of a linear array of electron beams that operate to melt material of a powder bed. A housing holding the electron beam sources may be maintained at a high vacuum and positioned close to a print, surface to minimize electron travel in a softer vacuum surrounding a print bed.
摘要翻译：可扩展到大尺寸的3-D打印机采用操作以熔化粉末床材料的电子束线性阵列的机械和电子扫描的组合。保持电子束源的壳体可以保持在高真空并且靠近印刷表面定位，以使围绕打印床的较软真空中的电子传播最小化。

2. 发明申请

WO2022271453A1 HIGH ENERGY 3-D PRINTER EMPLOYING CONTINUOUS PRINT PATH 审中-公开
公开(公告)号：WO2022271453A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/032785
申请日：2022-06-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： WALKER, Brandon, Joseph , MACKIE, Thomas, Rockwell , SCHUMACHER, Nathan, Donald
IPC分类号： B22F10/28 , B22F12/50 , B22F12/00 , B22F12/41 , B22F12/30 , B22F10/80 , B33Y10/00 , B33Y30/00 , B33Y50/00 , B33Y70/00 , B22F12/20 , B22F12/37 , B22F12/45 , B33Y40/10
摘要： High-throughput printing, possible with multiple electron beams, is facilitated by a continuous powder bed preparation process operating in parallel to apply and pre-sinter the powder along a continuous helical path. The sintered powder may be self-supporting to allow unconstrained expansion in the radial direction when high energy is used for powder fusion.

3. 发明申请

WO2014126623A2 DRY PHASE REACTOR FOR GENERATING MEDICAL ISOTOPES 审中-公开
标题翻译：用于产生医用同位素的干相反应器
公开(公告)号：WO2014126623A2
公开(公告)日：2014-08-21
申请号：PCT/US2013/070750
申请日：2013-11-19
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： MACKIE, Thomas, Rockwell , HELTEMES, Thad, Alexander
IPC分类号： G21C1/00
CPC分类号： G21G1/001 , G21G1/06 , G21G2001/0036
摘要： An apparatus for generating medical isotopes provides for the irradiation of dry-phase, granular uranium compounds which are then dissolved in a solvent for separation of the medical isotope from the irradiated compound. Once the medical isotope is removed, the dissolved compound may be reconstituted in dry granular form for repeated irradiation.
摘要翻译：用于生成医用同位素的装置提供了干相颗粒状铀化合物的照射，然后将其溶解在用于将医用同位素与被照射的化合物分离的溶剂中。一旦医用同位素被去除，溶解的化合物可以以干燥的颗粒形式重构用于反复照射。

4. 发明申请

WO1994028974A2 MULTI-LEAF RADIATION ATTENUATOR FOR RADIATION THERAPY WITH VERIFICATION SYSTEM 审中-公开
标题翻译：用于具有验证系统的辐射治疗的多叶辐射衰减器
公开(公告)号：WO1994028974A2
公开(公告)日：1994-12-22
申请号：PCT/US1994006487
申请日：1994-06-08
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： WISCONSIN ALUMNI RESEARCH FOUNDATION , SWERDLOFF, Stuart , MACKIE, Thomas, Rockwell , HOLMES, Timothy
IPC分类号： A61N05/10
CPC分类号： A61N5/1042 , A61N5/1048 , C08F234/02 , G21K1/04 , G21K1/046 , G21K5/04 , G21K5/10
摘要： A radiation therapy apparatus includes a compensator with moving leaves to attenuate a radiation beam and a compensator verification system to determine if the attenuating leaves are moving in accordance with desired position signals. Two radiation intensity monitoring chambers, one chamber on either side of a patient within a radiation beam, produce beam fluence data used by a computer to construct radiation absorption images and to evaluate the functionality of the compensator. The absorption image can be used for both radiation dose verification and planning of suitable subsequent therapy sessions. The compensator may include a first plurality of radiation attenuating leaves and a second plurality of radiation attenuating leaves. The first plurality of leaves may be spaced with gaps between adjacent leaves within a radiation beam so that the leaves and the gaps therebetween divide the radiation beam into rays. The second plurality of leaves may be disposed directly under gaps in the first plurality of leaves so that each ray of the beam can be occluded by a leaf in either the first or second plurality. The gaps eliminate interference between leaves; the staggering prevents radiation leakage between leaves. Each leaf, in both groups, may be moved between a first open state on one side of the beam, a closed state within the beam thus occluding one ray of the beam, and a second open state on the other side of the beam.
摘要翻译：放射线治疗装置包括具有移动叶片以补偿辐射束的补偿器和补偿器验证系统，以根据期望的位置信号确定衰减叶片是否正在移动。两个辐射强度监测室，辐射束内患者任一侧的一个腔室产生计算机使用的波束注量数据，以构建辐射吸收图像并评估补偿器的功能。吸收图像可以用于辐射剂量验证和规划合适的后续治疗会话。补偿器可以包括第一多个辐射衰减叶和第二多个辐射衰减叶。第一多个叶片可以与辐射束内的相邻叶片之间的间隙间隔开，使得叶片和其间的间隙将辐射束分成射线。第二多个叶片可以直接设置在第一多个叶片中的间隙下方，使得束的每个射线可以被第一或第二多个叶片中的叶片遮挡。差距消除叶间的干扰; 惊人的防止叶片之间的辐射泄漏。两组中的每个叶片可以在梁的一侧上的第一打开状态之间移动，光束内的闭合状态，从而遮挡一束光束，在光束的另一侧上移动第二打开状态。

5. 发明申请

WO2020236455A1 THREE-DIMENSIONAL PRINTER LAMINATING FUSIBLE SHEETS 审中-公开
公开(公告)号：WO2020236455A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/032421
申请日：2020-05-12
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： MACKIE, Thomas, Rockwell , WALKER, Brandon, Joseph , SCHUMACHER, Nathan, Donald
IPC分类号： B22F3/105 , B33Y70/00 , B33Y10/00 , B33Y30/00 , B33Y40/00
摘要： A 3D printer successively fuses sheet material in a stack to form a three- dimensional object. The sheet material may provide a mesh separating islands of material that will be fused to produce the desired three-dimensional object. The mesh provides support for the island material during the fusing process and may be removed afterwards.

6. 发明申请

WO1994029882A1 DYNAMIC BEAM FLATTENING APPARATUS FOR RADIATION THERAPY 审中-公开
标题翻译：用于辐射治疗的动态光束平铺装置
公开(公告)号：WO1994029882A1
公开(公告)日：1994-12-22
申请号：PCT/US1994006489
申请日：1994-06-08
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： WISCONSIN ALUMNI RESEARCH FOUNDATION , SWERDLOFF, Stuart , MACKIE, Thomas, Rockwell , HOLMES, Timothy
IPC分类号： G21K01/04
CPC分类号： G21K1/093 , A61N5/1042 , G21K1/04 , G21K1/046 , G21K5/04 , G21K5/10
摘要： A radiation therapy apparatus includes a compensator having a plurality of leaves to divide a radiation beam into rays each of which may be effectively and individually attenuated over a range of attenuations by controlling the ratio of time in which each leaf is in the open and closed states. The compensator is used to compensate for the non-uniform source fluence profile of the radiation beam. In a second embodiment, a radiation therapy apparatus includes an oscillating means for oscillating an electron stream along a line on a radiation generating target so that the resulting field of radiation emanating from the target within the plane of oscillation is uniform over time. The invention eliminates the need for beam flattening filters and thus more effectively uses the energy of the radiation beam.
摘要翻译：放射治疗装置包括具有多个叶片的补偿器，用于将辐射束分成射线，每个辐射束可以通过控制每个叶片处于打开和关闭状态的时间的比例在衰减范围内被有效地和单独地衰减。补偿器用于补偿辐射束的不均匀源能量密度分布。在第二实施例中，放射治疗装置包括用于使辐射线上的电子流振荡的振荡装置，使得在振荡平面内从目标发出的辐射场随时间均匀。本发明消除了对光束平坦化滤光器的需要，从而更有效地使用辐射束的能量。

7. 发明申请

WO1994028971A2 RADIATION THERAPY SYSTEM 审中-公开
标题翻译：辐射治疗系统
公开(公告)号：WO1994028971A2
公开(公告)日：1994-12-22
申请号：PCT/US1994006488
申请日：1994-06-08
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： WISCONSIN ALUMNI RESEARCH FOUNDATION , SWERDLOFF, Stuart , MACKIE, Thomas, Rockwell , HOLMES, Timothy
IPC分类号： A61N05/01
CPC分类号： A61B6/00 , A61B6/027 , A61B6/032 , A61N5/01 , A61N5/1042 , G21K1/04 , G21K1/046
摘要： A radiation therapy machine having constrained angular freedom to produce a beam only within a gantry plane. A radiation shield may be stationary and not attached to the gantry or rotating to always block the primary beam. The constrained motion reduces the risk of patient/gantry collision and provides for extremely accurate radiation therapy planning. The therapy machine, so constrained, may include a tomographic imaging system on a single gantry. The two systems cooperate and employ many of the same hardware components to both plan and carry out therapy sessions in which irregularly shaped treatment volumes are accurately irradiated while tissue surrounding those volumes is minimally irradiated. The therapy machine also may include a collimator that changes the width of a fan beam of radiation as a treatment volume of the patient crosses the volume exposed by the beam so as to minimize the irradiation of healthy tissue at the front and back of the tumor. The width of the fan beam may be controlled to treat multiple adjacent, similar slices of the patient at one time reducing the treatment duration.
摘要翻译：辐射治疗机具有约束的角度自由度，仅在机架平面内产生束。辐射屏蔽件可以是静止的并且不附接到台架或旋转以总是阻挡主梁。受约束的运动减少患者/龙门架碰撞的风险，并提供非常精确的放射治疗计划。治疗机器受到限制，可以包括在单个机架上的断层成像系统。两个系统协调并采用了许多相同的硬件组件来规划和执行治疗阶段，其中不规则形状的治疗体积被精确地照射，同时围绕这些体积的组织被最少地照射。治疗机还可以包括准直器，其随着患者的治疗体积横过由梁暴露的体积而改变辐射束的宽度，以便最小化肿瘤前后的健康组织的照射。可以控制扇形束的宽度以一次治疗患者的多个相邻的相似切片，从而减少治疗持续时间。

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