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1. 发明申请

WO2008052845A3 PLUG CONNECTOR, PARTICULARLY FOR SENSOR-/ACTUATORLINES 审中-公开
标题翻译： CONNECTOR，尤其适用于传感器/执行器电缆
公开(公告)号：WO2008052845A3
公开(公告)日：2009-12-03
申请号：PCT/EP2007059918
申请日：2007-09-19
申请人： WEIDMUELLER INTERFACE , DIEKMANN JOERG , SCHUMACHER RALF , PUESCHNER KLAUS , STORM SIEGFRIED , TAPPE THOMAS , SCHNATWINKEL MICHAEL , MEIER RENE , HANNING WALTER , MEYER MICHAEL , HOEING MICHAEL
发明人： DIEKMANN JOERG , SCHUMACHER RALF , PUESCHNER KLAUS , STORM SIEGFRIED , TAPPE THOMAS , SCHNATWINKEL MICHAEL , MEIER RENE , HANNING WALTER , MEYER MICHAEL , HOEING MICHAEL
IPC分类号： H01R4/24
CPC分类号： H01R9/031 , H01R4/2433 , H01R13/506 , H01R13/582 , H01R13/6271 , H01R13/6658 , H01R25/00
摘要： The invention relates to a plug connector (1), comprising a first plug connector part designed as a plug part (2), and a second plug connector part (3) designed as a socket part (3), wherein at least one of the plug connector parts is designed for connecting a cable (7) with at least one or preferably several insulated conductors (19) embedded in a cable sleeve. The plug connector part (2) comprises at least one or several insulation-piercing contacts (17) per conductor (19) and an actuating element (12) for contacting the conductors with the insulation-piercing contacts (17). The actuating element (12) comprises at least one or several accommodating contours (25) for accommodating the conductors, having a tapered shape for centering the conductor (19) to be contacted.
摘要翻译：插头连接（1），包括被设计为插接件（2）的第一连接器部分，并且其被设计为阴型部件的第二连接器部件（3），其中，所述连接器部件中的至少一个被配置用于电缆的连接（7）具有至少一个或优选多个嵌入在电缆护套绝缘导体（19），其中所述连接器部分（2）具有至少每一个导体（19）的一个或多个绝缘刺穿触头（17）和用于导体与绝缘刺穿接触的致动器（12）触点（17），其中所述致动元件（12）具有至少一个或多个安装轮廓（25），用于容纳导体，具有用于定心各导体的锥形形状，以接触（19）/有。

2. 发明申请

WO2005113592A2 INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES 审中-公开
标题翻译：干扰素多肽和结合蛋白
公开(公告)号：WO2005113592A2
公开(公告)日：2005-12-01
申请号：PCT/US2005017471
申请日：2005-05-18
申请人： MAXYGEN INC , HOFFMANN LA ROCHE , PATTEN PHILLIP A , VISWANATHAN SRIDHAR , NISSEN TORBEN LAUESGAARD , VOGT ANNE , KROPSHOFER HARALD , SCHUMACHER RALF , FISCHER STEPHAN , SEEBER STEFAN , GROSSMANN ADELBERT , HESSE FRIEDERIKE , SCHAUBMAR ANDREAS , FALKENSTEIN ROBERTO , KOLL HANS , DEMBOWSKI MARKUS
发明人： PATTEN PHILLIP A , VISWANATHAN SRIDHAR , NISSEN TORBEN LAUESGAARD , VOGT ANNE , KROPSHOFER HARALD , SCHUMACHER RALF , FISCHER STEPHAN , SEEBER STEFAN , GROSSMANN ADELBERT , HESSE FRIEDERIKE , SCHAUBMAR ANDREAS , FALKENSTEIN ROBERTO , KOLL HANS , DEMBOWSKI MARKUS
IPC分类号： A61K38/21 , A61K47/48 , C07H21/04 , C07K14/555 , C07K14/56 , C12P21/02 , C12Q1/68
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译：本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。

3. 发明申请

WO2005005635A3 ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF 审中-公开
标题翻译：针对胰岛素样生长因子的抗体我接受并使用它
公开(公告)号：WO2005005635A3
公开(公告)日：2005-08-25
申请号：PCT/EP2004007562
申请日：2004-07-09
申请人： HOFFMANN LA ROCHE , GRAUS YVO , KOPETZKI ERHARD , KUENKELE KLAUS-PETER , MUNDIGL OLAF , PARREN PAUL , REBERS FRANK , SCHUMACHER RALF , VAN DE WINKEL JAN , VRIESEMA-VAN VUGT MARTINE
发明人： GRAUS YVO , KOPETZKI ERHARD , KUENKELE KLAUS-PETER , MUNDIGL OLAF , PARREN PAUL , REBERS FRANK , SCHUMACHER RALF , VAN DE WINKEL JAN , VRIESEMA-VAN VUGT MARTINE
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , C12N5/16
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a) is ofIgG1 isotype, b) shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c) inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody, and d) shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 µM in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum (FCS) when compared to such an assay without said antibody has improved properties in antitumor therapy.
摘要翻译：结合IGF-1R并抑制IGF-1和IGF-II与IGF-1R结合的抗体，其特征在于所述抗体是a）是IgG1同种型，b）显示结合抑制的IC 50值的IGF-I与IGF-1R对IG-II与IGF-1R的结合的抑制为1：3至3：1，c）在5nM的浓度下，抑制至少80％的IGF-1β磷酸化与没有所述抗体的此类测定相比，使用在含有0.5％热失活的胎牛血清（FCS）的培养基中提供400,000至600,000个分子IGF-IR /细胞的细胞磷酸化测定，以及d）未显示IGF-IR刺激活性在细胞磷酸化测定中以10μM的浓度用IGF-IR磷酸化测量，使用3T3在与含有0.5％热失活的胎牛血清（FCS）的培养基中提供400,000至600,000个分子IGF-IR /细胞没有所述抗体的测定法在抗肿瘤治疗中具有改善的性质。

4. 发明申请

WO2004087756A3 ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗胰岛素样生长因子Ⅰ受体的抗体及其用途
公开(公告)号：WO2004087756A3
公开(公告)日：2005-01-06
申请号：PCT/EP2004003442
申请日：2004-04-01
申请人： HOFFMANN LA ROCHE , GRAUS YVO , KOPETZKI ERHARD , KUENKELE KLAUS-PETER , MUNDIGL OLAF , PARREN PAUL , REBERS FRANK , SCHUMACHER RALF , VAN DE WINKEL JAN , VAN VUGT MARTINE
发明人： GRAUS YVO , KOPETZKI ERHARD , KUENKELE KLAUS-PETER , MUNDIGL OLAF , PARREN PAUL , REBERS FRANK , SCHUMACHER RALF , VAN DE WINKEL JAN , VAN VUGT MARTINE
IPC分类号： A61P35/00 , C07K16/28 , C12N5/20 , C12N15/13 , A61K39/395 , C12N5/10 , C12N15/85
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565
摘要： An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IG-RI which is characterized in that said antibody is of human IgG1 isotype, and shows a ratio of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IGF-II to IGF-IR of 1:3 to 3:1, and induces celle death of 20% or more cells of a preparation of IGF-IR expressing cells after 24 hours at a concentration of said antibody of 100 nM by ADCC; has improved properties in antitumor therapy.
摘要翻译：结合IGF-1R并抑制IGF-1和IGF-II与IG-RI结合的抗体，其特征在于所述抗体是人IgG1同种型，并且显示IGF-I与IGF-I结合的抑制比 IGF-IR抑制IGF-II与IGF-IR的结合为1:3至3:1，并且在浓度24小时后诱导表达IGF-1R的细胞制剂的20％或更多细胞的纤丝死亡的所述抗体为100nM; 具有改善抗肿瘤治疗的特性。

5. 发明申请

WO2006029879A2 ANTI-OX40L ANTIBODIES 审中-公开
标题翻译：抗OX40L抗体
公开(公告)号：WO2006029879A2
公开(公告)日：2006-03-23
申请号：PCT/EP2005009968
申请日：2005-09-16
申请人： HOFFMANN LA ROCHE , ENDL JOSEF , EUGUI ELSIE , FUENTES MARIA , GRAUS YVO , LABRIJN ARAN , LANZENDOERFER MARTIN , PARREN PAUL , REBERS FRANK , SCHUMACHER RALF , SEEBER STEFAN , VAN DE WINKEL JAN , VAN VUGT MARTINE
发明人： ENDL JOSEF , EUGUI ELSIE , FUENTES MARIA , GRAUS YVO , LABRIJN ARAN , LANZENDOERFER MARTIN , PARREN PAUL , REBERS FRANK , SCHUMACHER RALF , SEEBER STEFAN , VAN DE WINKEL JAN , VAN VUGT MARTINE
IPC分类号： C07K16/46
CPC分类号： C07K16/2875 , C07K2317/21 , C07K2317/52 , C07K2317/56
摘要： This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
摘要翻译：本发明涉及抗OX40L抗体，并且特别涉及抗OX40L抗体及其变体，其含有衍生自人来源的Fc部分并且不结合补体因子C1q。这些抗体具有新的和创造性的特性，对患有炎性疾病的患者有益。

6. 发明申请

WO2009155955A8 ROLLING BOOT WITH TRANSITION REGION 审中-公开
标题翻译：滚动引导与过渡区域
公开(公告)号：WO2009155955A8
公开(公告)日：2010-04-01
申请号：PCT/EP2008006656
申请日：2008-08-13
申请人： GKN DRIVELINE INT GMBH , HOETS LUKAS , DEISINGER MARKUS , SCHUMACHER RALF
发明人： HOETS LUKAS , DEISINGER MARKUS , SCHUMACHER RALF
IPC分类号： B31B50/56 , F16D3/84 , F16J3/04
CPC分类号： F16D3/845 , F16J3/043
摘要： To achieve the object of making available a rolling boot which is of compact design, there is proposed a rolling boot having a first fastening region and a fold region with at least a first fold having a first fold peak region and a first fold flank near the first fastening region and, opposite this first fold flank, a second fold flank which is adjoined by a fold trough, wherein a transition region having a base surface is arranged between the first fastening region and fold region, and an angle a having a range from approximately 90° to approximately 140° is formed between the base surface and an outer side of the first fold flank, and the fold trough has a depth T which is at most approximately 65 percent of a height H of the first fold.
摘要翻译：为了实现具有紧凑设计的滚动靴的目的，提出了一种具有第一紧固区域和折叠区域的滚动靴，其具有至少第一折叠，具有第一折叠峰值区域和靠近第一折叠峰值区域的第一折叠侧面第一紧固区域和与该第一折叠侧面相对的第二折叠侧面，其与折叠槽相邻，其中具有基面的过渡区域布置在第一紧固区域和折叠区域之间，角度a的范围从在基部表面和第一折叠侧面的外侧之间形成约90°至约140°，并且折叠槽的深度T至多为第一折叠的高度H的约65％。

7. 发明申请

WO2009077082A3 CONTROLLABLE AIR CHANNELS FOR FEEDING ADDITIONAL COMBUSTION AIR INTO THE AREA OF FLUE GAS CHANNELS OF COKING CHAMBER FURNACES 审中-公开
标题翻译：可控空气通道，用于在厨房烟道烟气通道中供应额外的燃烧空气
公开(公告)号：WO2009077082A3
公开(公告)日：2009-11-05
申请号：PCT/EP2008010243
申请日：2008-12-04
申请人： UHDE GMBH , RONALD KIM , SCHUMACHER RALF
发明人： RONALD KIM , SCHUMACHER RALF
IPC分类号： C10B15/02 , C10B21/10 , C10B41/00
CPC分类号： C10B15/02 , C10B21/10 , C10B41/00
摘要： The invention relates to a device for feeding and controlling secondary air from secondary air channels into flue gas channels of horizontal coking chamber ovens. The flue gas channels are thereby located under the coking chamber floor on which coking takes place. The flue gas channels serve for combusting partially combusted coking gases from the coking chamber. The partially combusted coking gases are combusted using secondary air, whereby the coke cake is also heated from below for uniform coking. The secondary air comes from the secondary air channels connected to outside air and to the flue gas channels. Control elements are installed in the connection channels between the flue gas channels and the secondary air channels and can precisely control the air flow in the flue gas channels. Significantly more uniform heating and heat distribution can thus be achieved in coking chamber furnaces. The actual control devices in the connecting channels can be formed by rotatable tube segments, bricks, or metal dampers. A stool-like device can also be used particularly advantageously, said device sitting in the secondary channels and having a hump plate having a central opening slid under the corresponding branch for controlling the gas flow. The control mechanism can be manually, electrically, or pneumatically actuated. The control device can thereby also be automated.
摘要翻译：本发明涉及一种用于从卧式炼焦炉的烟道中的二次风管供给和调节二次空气的装置。烟气管道位于发生焦化的焦炉室底板下方。烟气管道用于燃烧来自焦炉室的部分燃烧的焦化气体。部分燃烧的焦化气体用二次空气燃烧，这意味着焦炭饼从下面加热以便均匀焦化。二次空气来自二次空气管道，二次空气管道连接到外部空气和烟气管道。在烟气管道和二次风管之间的连接通道上安装了控制元件，可以精确控制进入烟气管道的空气流量。这样可以在焦炉到达范围内实现更均匀的加热和热量分配。连接通道中的实际控制装置可以由可旋转的管件，砖或金属片形成。特别有利的是，您还可以使用坐在第二通道中的凳子状装置，并且具有带中央开口的凳板，该中央开口被推动以控制适当分支下的气流。控制机构可以手动，电动或气动操作。控制装置由此也可以是自动的。

8. 发明申请

WO2007115814A3 ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗胰岛素样生长因子Ⅰ受体的抗体及其用途
公开(公告)号：WO2007115814A3
公开(公告)日：2008-01-10
申请号：PCT/EP2007003165
申请日：2007-04-10
申请人： HOFFMANN LA ROCHE , HANSEN SILKE , KUENKELE KLAUS-PETER , REUSCH DIETMAR , SCHUMACHER RALF
发明人： HANSEN SILKE , KUENKELE KLAUS-PETER , REUSCH DIETMAR , SCHUMACHER RALF
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/41 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An antibody binding to IGF-IR, being of human IgG1 or IgG3 type and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/ or the amount of N-terminal alpha-1,3- galactose is 1% or less has improved properties in antitumor therapy.
摘要翻译：结合IGF-1R的抗体是人IgG1或IgG3型并且在Asn297处被糖链糖基化的抗体，所述抗体的特征在于所述糖链内的岩藻糖的量至少为99％，另外还有量的NGNA为1％以下，和/或N-末端α-1,3-半乳糖的量为1％以下具有改善的抗肿瘤治疗性能。

9. 发明申请

WO2006103100A2 ANTIBODIES AGAINST CCR5 AND USES THEREOF 审中-公开
标题翻译：抗CCR5的抗体及其用途
公开(公告)号：WO2006103100A2
公开(公告)日：2006-10-05
申请号：PCT/EP2006002974
申请日：2006-03-31
申请人： HOFFMANN LA ROCHE , BRANDT MICHAEL , SANKURATRI SURYANARAYANA , SCHUMACHER RALF , SEEBER STEFAN
发明人： BRANDT MICHAEL , SANKURATRI SURYANARAYANA , SCHUMACHER RALF , SEEBER STEFAN
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/52 , C07K2317/565
摘要： An antibody binding to human CCR5 comprising a variable heavy chain and a variable light chain, characterized in that the variable heavy chain comprises CDR sequences CDRl, CDR2 and CDR3 and CDRl being selected from the group consisting of SEQ ID NOs: 9, 10, 11, 12, CDR2 being selected from the group consisting of SEQ ID NOs: 13, 14, 15, CDR3 being selected from the group consisting of SEQ ID NOs: 16, 17, wherein said CDRs are selected independently of each other, or is a chimeric, humanized variant or a fragment of said antibody, has advantageous properties for the treatment of immunosuppressive diseases.
摘要翻译：结合人CCR5的抗体，其包含可变重链和可变轻链，其特征在于所述可变重链包含CDR序列CDR1，CDR2和CDR3，并且CDR1选自SEQ ID NO：9,10,11 12，CDR2选自SEQ ID NO：13,14,15，CDR3选自SEQ ID NO：16,17，其中所述CDR彼此独立地选择，或者是嵌合的，人源化的变体或所述抗体的片段，具有治疗免疫抑制性疾病的有利特性。

10. 发明申请

WO0130940A9 METHOD AND DEVICE FOR EVACUATING HOT RAW GASES FROM COKE OVENS 审中-公开
标题翻译：方法和装置排放热KOKSOFENROHGASEN的
公开(公告)号：WO0130940A9
公开(公告)日：2002-06-27
申请号：PCT/EP0008577
申请日：2000-09-02
申请人： THYSSEN KRUPP ENCOKE GMBH , SCHUMACHER RALF , TOLL HERMANN , WORBERG RAINER
发明人： SCHUMACHER RALF , TOLL HERMANN , WORBERG RAINER
IPC分类号： C10B27/00 , C10B27/06
CPC分类号： C10B27/00 , C10B27/06
摘要： The invention relates to a method and a device for evacuating hot raw gases which occur in the oven chambers of a coke oven battery during coking. The oven gases are lead from the oven chambers into a hot gas collector. The pressure in the oven chambers is controlled by shut-off and throttling devices which are arranged in the hot gas streams between the raw gas outlet of the oven chambers and the hot gas collector. The positions of said devices are controlled according to the pressure that is measured in the allocated oven chamber. The gas of the hot gas collector is supplied to a steam boiler firing or a fission reactor.
摘要翻译：本发明涉及一种方法和用于引导在炼焦炉组的炉室焦化过程中产生的热原料气的装置。炉内气体从在热模板炉室引入的。在炉室中的压力由切断和节流构件，其被设置在热气体中的Rohgasauslass之间流动的炉室和热收集和他们的位置在在相关的炉腔的压力测量的依赖性受控控制。从热模板的气体被供给到一个Dampfkesselfeuerung或裂变反应堆。

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