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1. 发明申请

WO1995005750A1 CELL DEATH REGULATOR 审中-公开
标题翻译：细胞死亡调节剂
公开(公告)号：WO1995005750A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009701
申请日：1994-08-24
申请人： WASHINGTON UNIVERSITY , KORSMEYER, Stanley, J.
发明人： WASHINGTON UNIVERSITY
IPC分类号： A23J01/00
CPC分类号： C07K14/82 , A01K2217/05 , C07K14/4747 , Y10S435/81 , Y10S530/827
摘要： The invention provides a bcl-2 related protein, bcl-2 muteins, and uses thereof.
摘要翻译：本发明提供了一种bcl-2相关蛋白，bcl-2突变蛋白及其用途。

2. 发明申请

WO1996013614A1 BCL-X/BCL-2 ASSOCIATED CELL DEATH REGULATOR 审中-公开
标题翻译： BCL-X / BCL-2相关细胞死亡调节剂
公开(公告)号：WO1996013614A1
公开(公告)日：1996-05-09
申请号：PCT/US1995014246
申请日：1995-10-31
申请人： WASHINGTON UNIVERSITY , KORSMEYER, Stanley, J.
发明人： WASHINGTON UNIVERSITY
IPC分类号： C12Q01/68
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4747 , C07K2319/00
摘要： The invention provides novel compositions, methods, and uses of Bad polypeptides and polynucleotides.
摘要翻译：本发明提供了坏多肽和多核苷酸的新型组合物，方法和用途。

3. 发明申请

WO1998017682A1 SERINE SUBSTITUTED MUTANTS OF BCL-XL/BCL-2 ASSOCIATED CELL DEATH REGULATOR 审中-公开
标题翻译： BCL-XL / BCL-2相关细胞死亡调节剂的丝氨酸取代基
公开(公告)号：WO1998017682A1
公开(公告)日：1998-04-30
申请号：PCT/US1997019175
申请日：1997-10-17
申请人： WASHINGTON UNIVERSITY , KORSMEYER, Stanley, J.
发明人： WASHINGTON UNIVERSITY
IPC分类号： C07K14/00
CPC分类号： C07K14/4747 , A61K38/00 , C07K2319/00
摘要： Novel forms of mutant BAD polypeptides or fragments thereof having an amino acid substitution for serine-112 and/or serine-136 are provided along with their encoding polynucleotides. Also disclosed are methods for preparation of the mutant BAD polypeptides and methods for treating disease conditions involving decreased apoptosis.
摘要翻译：提供具有丝氨酸-121和/或丝氨酸-136的氨基酸取代的突变体BAD多肽或其片段的新型形式及其编码多核苷酸。还公开了用于制备突变体BAD多肽的方法和用于治疗涉及凋亡减少的疾病状况的方法。

4. 发明申请

WO1998009643A1 MODULATION OF APOPTOSIS BY SERINE PHOSPHORYLATION OF BLC-XL/BLC-2 ASSOCIATED CELL DEATH REGULATOR 审中-公开
标题翻译： BLC-XL / BLC-2相关细胞死亡调节剂丝氨酸磷酸化调节
公开(公告)号：WO1998009643A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015871
申请日：1997-09-09
申请人： WASHINGTON UNIVERSITY , KORSMEYER, Stanley, J.
发明人： WASHINGTON UNIVERSITY
IPC分类号： A61K38/16
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4747
摘要： Novel forms of BAD polypeptide phosphorylated at serine-112 and/or serine-136 are provided along with methods for detecting and modulating intracellular levels.
摘要翻译：提供了在丝氨酸-121和/或丝氨酸-133磷酸化的BAD多肽的新形式以及用于检测和调节细胞内水平的方法。

5. 发明申请

WO1998010295A1 DIAGNOSTIC METHOD FOR ATHEROSCLEROSIS 审中-公开
标题翻译：诊断心脏病的诊断方法
公开(公告)号：WO1998010295A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015115
申请日：1997-09-03
申请人： WASHINGTON UNIVERSITY , HEINECKE, Jay, W.
发明人： WASHINGTON UNIVERSITY
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/323 , G01N2800/52 , Y10S436/811
摘要： A diagnostic method and screening test for atherosclerosis and analogous diseases involving activated phagocytes and/or inflammation is provided which comprises determining the presence of p-hydroxyphenylacetaldehyde-lysine in a test sample of a body fluid or tissue at a level which is elevated relative to the level in a normal patient.
摘要翻译：提供了一种用于动脉粥样硬化和涉及活化的吞噬细胞和/或炎症的类似疾病的诊断方法和筛选试验，其包括测定体液或组织的测试样品中对羟基苯乙醛 - 赖氨酸的存在，其水平相对于水平在正常的病人。

6. 发明申请

WO1997033601A1 INHIBITION OF INTRACELLULAR SIGNAL TRANSDUCTION BY 14-3-3-BINDING PEPTIDES 审中-公开
标题翻译：通过14-3-3结合肽抑制细胞内信号传导
公开(公告)号：WO1997033601A1
公开(公告)日：1997-09-18
申请号：PCT/US1997004298
申请日：1997-03-17
申请人： WASHINGTON UNIVERSITY
发明人： WASHINGTON UNIVERSITY , SHAW, Andrey, S. , MUSLIN, Anthony, J.
IPC分类号： A61K38/00
CPC分类号： C12N9/1205 , A61K38/00
摘要： Compositions and methods for inhibition of the intracellular activation of a signal transducing protein comprising phosphoserine containing peptides derived from the Raf-1 protein are disclosed. The peptides bind to 14-3-3 protein and thereby prevent its association with the signal transducing peptide to block signal transduction. Also provided is an assay method for identifying a pharmacologic agent that can bind 14-3-3 protein and block signal transduction.
摘要翻译：公开了用于抑制包含衍生自Raf-1蛋白的含磷酸丝氨酸肽的信号转导蛋白的细胞内活化的组合物和方法。肽与14-3-3蛋白结合，从而阻止其与信号转导肽的结合阻断信号转导。还提供了用于鉴定能结合14-3-3蛋白和阻断信号转导的药理学试剂的测定方法。

7. 发明申请

WO1996041158A1 METHOD AND APPARATUS FOR PREDICTING STRUCTURAL INTEGRITY BY ESTIMATING MODAL DAMPING FACTOR 审中-公开
标题翻译：通过估计模型阻尼因子预测结构完整性的方法和装置
公开(公告)号：WO1996041158A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008236
申请日：1996-05-31
申请人： WASHINGTON UNIVERSITY
发明人： WASHINGTON UNIVERSITY , DIMAROGONAS, Andrew, D.
IPC分类号： G01N29/04
CPC分类号： G01H1/16 , G01N3/30 , G01N3/32 , G01N29/045 , G01N29/11 , G01N29/12 , G01N2203/0055 , G01N2203/0073 , G01N2203/0688 , G01N2291/0235 , G01N2291/0258 , G01N2291/02827 , G01N2291/101 , G01N2291/267
摘要： The integrity of structures may be determined by either one of two methods. In a first method, an impulse of energy is introduced into the structure (20), such as by striking the structure (20), and the induced vibration is measured and the modal damping factor is calculated, the modal damping factor being directly related to the integrity of the structure (20). In a second method, a continous energy input is provided to the structure (20) for inducing a continous vibration in the structure (20). This continous vibration is measured with a transducer (28) and a modal damping factor is calculated with a computer (32). The computer uses an algorithm to estimate the modal damping factor of the structure by calculating a theoretical response of an idealized system from several assumed parameters and varying those parameters.
摘要翻译：结构的完整性可以通过两种方法之一来确定。在第一种方法中，例如通过撞击结构（20）将结构（20）中的能量脉冲引入到结构（20）中，并测量感应振动并计算模态阻尼系数，模态阻尼因子与结构的完整性（20）。在第二种方法中，向结构（20）提供连续能量输入，用于在结构（20）中引起连续的振动。用一个换能器（28）测量该连续振动，并用计算机（32）计算模态阻尼系数。计算机使用一种算法来估计结构的模态阻尼因子，通过从几个假定的参数和改变这些参数计算理想系统的理论响应。

8. 发明申请

WO1996026951A1 GENETICALLY ENGINEERED CELL LINES FOR DETECTING INFECTIOUS HERPESVIRUS AND METHODS THEREFOR 审中-公开
标题翻译：用于检测感染性肝炎病毒的遗传工程细胞系及其方法
公开(公告)号：WO1996026951A1
公开(公告)日：1996-09-06
申请号：PCT/US1996001939
申请日：1996-02-15
申请人： WASHINGTON UNIVERSITY
发明人： WASHINGTON UNIVERSITY , OLIVO, Paul, D.
IPC分类号： C07H19/00
CPC分类号： C12N9/0093 , C12Q1/04 , C12Q1/6897 , C12Q1/705 , G01N33/5091 , G01N2333/90209 , G01N2333/924 , G01N2333/938
摘要： A diagnostic assay for detecting the presence of an infectious herpesvirus in a specimen and a genetically engineered cell line for use in such assay are disclosed. The cell line used in the assay expresses a reporter gene only if infectious herpesvirus is present in the specimen. The assay involves inoculating a DNA-transfected cell line with a specimen suspected of containing a herpesvirus, allowing a sufficient period of time for the herpesvirus infectious cycle to proceed, and detecting and quantifying the number of herpesvirus-infected cells to determine the number of infectious herpesvirus virions in the specimen. The cell line is a DNA-transfected cell line susceptible to infection by a herpesvirus which is stably transformed with a chimeric gene comprising a herpesvirus inducible promoter and a gene coding for an enzyme, the expression of the enzyme being dependent upon and quantitatively proportional to the presence of herpesvirus. A kit for such assay is also provided.
摘要翻译：公开了用于检测样本中的感染性疱疹病毒的存在的诊断测定法和用于这种测定的基因工程细胞系。只有感染性疱疹病毒存在于样本中时，测定中使用的细胞系才能表达报告基因。该测定包括用疑似含有疱疹病毒的标本接种DNA转染的细胞系，允许疱疹病毒感染循环的足够的时间进行，并检测和定量疱疹病毒感染细胞的数量以确定感染的数量样本中的疱疹病毒病毒粒子。细胞系是由疱疹病毒感染易感染的DNA转染的细胞系，其用包含疱疹病毒诱导型启动子和编码酶的基因的嵌合基因稳定转化，所述酶的表达依赖于和与其成比例存在疱疹病毒。还提供了用于这种测定的试剂盒。

9. 发明申请

WO1996017059A2 RECEPTOR FOR CELL-BINDING DOMAIN OF THROMBOSPONDINS 审中-公开
标题翻译：血栓形成细胞结合域的受体
公开(公告)号：WO1996017059A2
公开(公告)日：1996-06-06
申请号：PCT/US1995014553
申请日：1995-11-21
申请人： WASHINGTON UNIVERSITY , FRAZIER, William, A. , GAO, Ai-Guo
发明人： WASHINGTON UNIVERSITY
IPC分类号： C12N15/12
CPC分类号： C07K14/78 , A61K38/00 , C07K14/705
摘要： A 52 kDa protein is disclosed, which is a receptor for the cell-binding peptide sequences of the cell-binding domain (CBD) of thrombospondin 1 (TS1), namely the 4N1s and 7N3 peptide sequences as well as the 4N1K and 4NK peptides.
摘要翻译：公开了一种52kDa蛋白，其是血小板反应蛋白1（TS1）的细胞结合结构域（CBD）的细胞结合肽序列的受体，即4N1和7N3肽序列以及4N1K和4NK肽。

10. 发明申请

WO1996009067A1 OSTEOCLAST-SPECIFIC GLYCOPROTEIN FOR DIAGNOSIS AND TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译： OSTEOCLAST特异性糖蛋白用于诊断和治疗OSTEOPOROSIS
公开(公告)号：WO1996009067A1
公开(公告)日：1996-03-28
申请号：PCT/US1994010700
申请日：1994-09-21
申请人： WASHINGTON UNIVERSITY , OSDOBY, Philip, A.
发明人： WASHINGTON UNIVERSITY
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K38/00 , G01N33/6893
摘要： Osteoclast associated antigen (47J) and monoclonal antibodies and methods for detecting and ameliorating osteoporotic disease are disclosed. The monoclonal antibodies are specifically reactive with epitopes present on 47J antigen, which is specific to osteoclasts.
摘要翻译：公开了破骨细胞相关抗原（47J）和用于检测和改善骨质疏松症的单克隆抗体和方法。单克隆抗体与存在于47J抗原上的表位具有特异性的活性，其是破骨细胞特异性的。

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