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1. 发明申请

WO2003008552A3 MLL TRANSLOCATIONS SPECIFY A DISTINCT GENE EXPRESSION PROFILE, DISTINGUISHING A UNIQUE LEUKEMIA 审中-公开
公开(公告)号：WO2003008552A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/022823
申请日：2002-07-17
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , DANA-FARBER CANCER INSTITUTE, INC. , GOLUB, Todd, R. , ARMSTRONG, Scott, A. , KORSMEYER, Stanley, J.
发明人： GOLUB, Todd, R. , ARMSTRONG, Scott, A. , KORSMEYER, Stanley, J.
IPC分类号： C12Q1/68
摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myellgenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes indentified herein as targets.

2. 发明申请

WO03008552A9 MLL TRANSLOCATIONS SPECIFY A DISTINCT GENE EXPRESSION PROFILE, DISTINGUISHING A UNIQUE LEUKEMIA 审中-公开
标题翻译： MLL TRANSLATIONS规定了一个不同的基因表达谱，分辨出一个独特的亮点
公开(公告)号：WO03008552A9
公开(公告)日：2004-01-15
申请号：PCT/US0222823
申请日：2002-07-17
申请人： WHITEHEAD BIOMEDICAL INST , DANA FARBER CANCER INST INC , GOLUB TODD R , ARMSTRONG SCOTT A , KORSMEYER STANLEY J
发明人： GOLUB TODD R , ARMSTRONG SCOTT A , KORSMEYER STANLEY J
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34 , G01N33/53
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N2333/475 , G01N2800/52
摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myellgenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes indentified herein as targets.
摘要翻译：本发明涉及根据来自个体的样品的基因表达谱的混合谱系白血病（MLL），急性成淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）的诊断，以及治疗和利用本文中所标识的基因作为靶标的筛选。

3. 发明申请

WO1995005750A1 CELL DEATH REGULATOR 审中-公开
标题翻译：细胞死亡调节剂
公开(公告)号：WO1995005750A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009701
申请日：1994-08-24
申请人： WASHINGTON UNIVERSITY , KORSMEYER, Stanley, J.
发明人： WASHINGTON UNIVERSITY
IPC分类号： A23J01/00
CPC分类号： C07K14/82 , A01K2217/05 , C07K14/4747 , Y10S435/81 , Y10S530/827
摘要： The invention provides a bcl-2 related protein, bcl-2 muteins, and uses thereof.
摘要翻译：本发明提供了一种bcl-2相关蛋白，bcl-2突变蛋白及其用途。

4. 发明申请

WO2005044839A2 STABILIZED ALPHA HELICAL PEPTIDES AND USES THEREOF 审中-公开
标题翻译：稳定的α螺旋肽及其用途
公开(公告)号：WO2005044839A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/038403
申请日：2004-11-05
申请人： DANA-FARBER CANCER INSTITUTE, INC. , WALENSKY, Loren, D. , KORSMEYER, Stanley, J. , VERDINE, Gregory
发明人： WALENSKY, Loren, D. , KORSMEYER, Stanley, J. , VERDINE, Gregory
IPC分类号： C07K
CPC分类号： C07K7/08 , A61K38/00 , C07K1/113 , C07K1/1136 , C07K7/64 , C07K14/001 , C07K14/435 , C07K14/4747
摘要： Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
摘要翻译：本文描述了新多肽及其制备和使用方法。多肽包括交联（“碳氢化合物钉”）部分以在两个氨基酸部分之间提供束缚，这限制了多肽的二级结构。本文所述的多肽可用于治疗以过度或不足细胞死亡为特征的疾病。

5. 发明申请

WO0006187A9 MODULATION OF APOPTOSIS 审中-公开
标题翻译：调节细胞凋亡
公开(公告)号：WO0006187A9
公开(公告)日：2000-12-14
申请号：PCT/US9917276
申请日：1999-07-30
申请人： UNIV WASHINGTON , KORSMEYER STANLEY J , SCHLESINGER PAUL H
发明人： KORSMEYER STANLEY J , SCHLESINGER PAUL H
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61P9/10 , A61P15/00 , A61P17/02 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/47 , C12N5/06 , G01N33/15 , A61P37/02
CPC分类号： C07K14/4747 , A61K38/00
摘要： Methods and compositions for modulating apoptosis in cells and patients are provided. One method comprises selecting a compound which affects the ability of a channel comprised of a member of the BCL-2 family to allow passage of cytochrome c, then administering the compound to the cell or patient. Another method comprises selecting a compound which changes ion conductance properties of the channel, then administering the compound to the cell or patient. Compounds which affect these channel characteristics are also provided. Additionally, methods for identifying apoptosis-modulating compounds using lipid bilayers are provided. One method involves contacting a compound of interest with a lipid bilayer which contains an ion-channel formed by an anti-apoptotic or pro-apoptotic polypeptide of the BCL-2 family and assaying for changes in the ability of the pore to allow passage of cytochrome c. Changes in ion conductance properties of the channel, including ion selectivity, single channel conductance and rectification are also useful characteristics for identifying apoptosis-modulating compounds. A second method identifies compounds which can form ion channels in planar lipid bilayers and determines the ability to allow passage of cytochrome c, the ion selectivity and the pH dependence of such channels, where apoptosis modulating activity is predicted based on comparing these channel forming characteristics with those of BCL-2 family members.
摘要翻译：提供了用于调节细胞和患者细胞凋亡的方法和组合物。一种方法包括选择影响由BCL-2家族的成员组成的通道允许细胞色素c通过的能力的化合物，然后将化合物施用于细胞或患者。另一种方法包括选择改变通道的离子电导特性的化合物，然后将该化合物施用于细胞或患者。还提供了影响这些通道特性的化合物。另外，提供了使用脂双层鉴定凋亡调节化合物的方法。一种方法包括使感兴趣的化合物与含有由BCL-2家族的抗细胞凋亡或促凋亡多肽形成的离子通道的脂质双层接触，并测定孔允许细胞色素通过的能力的变化 C。通道离子电导特性的变化，包括离子选择性，单通道电导和精馏也是识别凋亡调节化合物的有用特征。第二种方法鉴定可在平面脂质双层中形成离子通道并确定细胞色素c通过的能力，离子选择性和这些通道的pH依赖性的化合物，其中基于将这些通道形成特征与那些BCL-2家庭成员。

6. 发明申请

WO1996013614A1 BCL-X/BCL-2 ASSOCIATED CELL DEATH REGULATOR 审中-公开
标题翻译： BCL-X / BCL-2相关细胞死亡调节剂
公开(公告)号：WO1996013614A1
公开(公告)日：1996-05-09
申请号：PCT/US1995014246
申请日：1995-10-31
申请人： WASHINGTON UNIVERSITY , KORSMEYER, Stanley, J.
发明人： WASHINGTON UNIVERSITY
IPC分类号： C12Q01/68
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4747 , C07K2319/00
摘要： The invention provides novel compositions, methods, and uses of Bad polypeptides and polynucleotides.
摘要翻译：本发明提供了坏多肽和多核苷酸的新型组合物，方法和用途。

7. 发明申请

WO2003008552A2 MLL TRANSLOCATIONS SPECIFY A DISTINCT GENE EXPRESSION PROFILE, DISTINGUISHING A UNIQUE LEUKEMIA 审中-公开
标题翻译： MLL TRANSLOCATIONS指定独特的基因表达谱，区分独特的白血病
公开(公告)号：WO2003008552A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/022823
申请日：2002-07-17
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , DANA-FARBER CANCER INSTITUTE, INC. , GOLUB, Todd, R. , ARMSTRONG, Scott, A. , KORSMEYER, Stanley, J.
发明人： GOLUB, Todd, R. , ARMSTRONG, Scott, A. , KORSMEYER, Stanley, J.
IPC分类号： C12N
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N2333/475 , G01N2800/52
摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myellgenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes indentified herein as targets.
摘要翻译：本发明涉及根据来自个体的样品的基因表达谱来诊断混合谱系白血病（MLL），急性成淋巴细胞性白血病（ALL）和急性原始细胞性白血病（AML）以及利用本文鉴定的基因作为靶点的治疗和筛选方法。

8. 发明申请

WO0205835A3 MODULATION OF APOPTOSIS 审中-公开
标题翻译：疫苗调节
公开(公告)号：WO0205835A3
公开(公告)日：2003-01-03
申请号：PCT/US0120169
申请日：2001-06-25
申请人： UNIV WASHINGTON , KORSMEYER STANLEY J , SCHLESINGER PAUL H
发明人： KORSMEYER STANLEY J , SCHLESINGER PAUL H
IPC分类号： A61K38/17 , G01N33/68
CPC分类号： A61K38/1761
摘要： Methods and compositions for modulating apoptosis in cells and patients are provided. One method comprises selecting a compound which affects the formation of large channels comprised of multiple molecules of a pro-apoptotic member of the BCL-2 family, then administering the compound to the cell or patient. Another method comprises selecting a compound which affects the formation of a channel that includes at least four molecules of a pro-apoptotic BCL-2 family member polypeptide, then administering the compound to the cell or patient. Compounds which affect these channel characterictics are also provided. Additionally, methods for identifying apoptosis-modulating compounds using lipid membranes are provided. One method involves contacting a compound of interest with a lipid membrane which contains an ion-channel formed by an anti-apoptotic or pro-apoptotic polypeptide of the BCL-2 family and assaying for changes in the size of the pore. Changes in ion conductance properties of the channel, including ion selectivity, the ability to allow the passage of cytochrome c and/or FD10, single channel conductance and rectification are also useful characteristics for identifying apoptosis-modulating compounds.
摘要翻译：提供了调节细胞和患者细胞凋亡的方法和组合物。一种方法包括选择影响由BCL-2家族的促凋亡成员的多个分子构成的大通道的形成的化合物，然后将该化合物给予细胞或患者。另一种方法包括选择影响形成通道的化合物，该化合物包括至少四个分子的促凋亡BCL-2家族成员多肽，然后将该化合物给予细胞或患者。还提供影响这些通道特征的化合物。另外，提供了使用脂质膜鉴定凋亡调节化合物的方法。一种方法包括使感兴趣的化合物与含有由BCL-2家族的抗凋亡或促凋亡多肽形成的离子通道的脂质膜接触并测定孔的大小变化。通道的离子传导性质的变化，包括离子选择性，允许细胞色素c和/或FD10通过的能力，单通道电导和整流也是鉴定凋亡调节化合物的有用特征。

9. 发明申请

WO0006187A2 MODULATION OF APOPTOSIS 审中-公开
标题翻译：疫苗调节
公开(公告)号：WO0006187A2
公开(公告)日：2000-02-10
申请号：PCT/US9917276
申请日：1999-07-30
申请人： UNIV WASHINGTON , KORSMEYER STANLEY J , SCHLESINGER PAUL H
发明人： KORSMEYER STANLEY J , SCHLESINGER PAUL H
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61P9/10 , A61P15/00 , A61P17/02 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/47 , C12N5/06 , G01N33/15 , A61P37/02
CPC分类号： C07K14/4747 , A61K38/00
摘要： Methods and compositions for modulating apoptosis in cells and patients are provided. One method comprises selecting a compound which affects the ability of a channel comprised of a member of the BCL-2 family to allow passage of cytochrome c, then administering the compound to the cell or patient. Another method comprises selecting a compound which changes ion conductance properties of the channel, then administering the compound to the cell or patient. Compounds which affect these channel characteristics are also provided. Additionally, methods for identifying apoptosis-modulating compounds using lipid bilayers are provided. One method involves contacting a compound of interest with a lipid bilayer which contains an ion-channel formed by an anti-apoptotic or pro-apoptotic polypeptide of the BCL-2 family and assaying for changes in the ability of the pore to allow passage of cytochrome c. Changes in ion conductance properties of the channel, including ion selectivity, single channel conductance and rectification are also useful characteristics for identifying apoptosis-modulating compounds. A second method identifies compounds which can form ion channels in planar lipid bilayers and determines the ability to allow passage of cytochrome c, the ion selectivity and the pH dependence of such channels, where apoptosis modulating activity is predicted based on comparing these channel forming characteristics with those of BCL-2 family members.
摘要翻译：提供了调节细胞和患者细胞凋亡的方法和组合物。一种方法包括选择影响由BCL-2家族成员构成的通道的能力的化合物，以允许细胞色素c通过，然后将该化合物给予细胞或患者。另一种方法包括选择改变通道的离子传导性质的化合物，然后将化合物给予细胞或患者。还提供影响这些通道特性的化合物。另外，提供了使用脂质双层鉴定凋亡调节化合物的方法。一种方法包括使感兴趣的化合物与含有由BCL-2家族的抗凋亡或促凋亡多肽形成的离子通道的脂质双层接触，并测定孔的能力变化以允许细胞色素通过 C。通道的离子传导特性的变化，包括离子选择性，单通道电导和整流也是鉴定凋亡调节化合物的有用特征。第二种方法鉴定了可以在平面脂双层中形成离子通道的化合物，并确定允许细胞色素c通过的能力，这种通道的离子选择性和pH依赖性，其中基于将这些通道形成特征与 BCL-2家庭成员。

10. 发明申请

WO9916787A9 CELL DEATH AGONISTS 审中-公开
标题翻译：细胞死亡激素
公开(公告)号：WO9916787A9
公开(公告)日：1999-06-24
申请号：PCT/US9819765
申请日：1998-09-22
申请人： UNIV WASHINGTON , KORSMEYER STANLEY J
发明人： KORSMEYER STANLEY J
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K7/00 , A61K38/04 , A61K38/16 , C07H21/02 , C07H21/04 , C07K14/00 , C12N15/11
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00
摘要： Small polypeptides and peptides of 5 to 50 amino acids having cell death agonist activity are provided. The polypeptides are at least 9 amino acids in length and contain the BH3 domain of a pro-apoptotic BCL-2 family member. The peptides contain 5 to 8 amino acids from the BH3 domain. Methods of promoting apoptosis with these cell death agonist polypeptides and peptides and their encoding polynucleotides are also provided.
摘要翻译：提供具有细胞死亡激动剂活性的5至50个氨基酸的小多肽和肽。多肽长度至少为9个氨基酸，并含有促凋亡BCL-2家族成员的BH3结构域。肽含有5至8个氨基酸，从BH3结构域。还提供了用这些细胞死亡激动剂多肽和肽及其编码多核苷酸促进凋亡的方法。

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