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1. 发明申请

WO2012006367A2 COMPOSITIONS AND METHODS FOR TREATING INFLUENZA 审中-公开
标题翻译：用于治疗流感的组合物和方法
公开(公告)号：WO2012006367A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043094
申请日：2011-07-06
申请人： VARIATION BIOTECHNOLOGIES, INC. , ANDERSON, David, E. , OGREL, Andrei , BOCH, Ronald, Erwin , BAXTER, Jeff
发明人： ANDERSON, David, E. , OGREL, Andrei , BOCH, Ronald, Erwin , BAXTER, Jeff
IPC分类号： A61K39/145
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1271 , A61K39/12 , A61K39/145 , A61K47/06 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： The present disclosure provides compositions and methods useful for treating influenza. As described herein, provided compositions and methods are based on the development of certain compositions that include an influenza virus hemagglutinin antigen in combination with lipid vesicles that include a non-ionic surfactant (NISVs) and optionally an adjuvant. In certain embodiments, provided compositions remain potent even when they are not stored in a standard cold-chain system (i.e., they are thermostable).
摘要翻译：本公开提供了可用于治疗流感的组合物和方法。如本文所述，提供的组合物和方法基于某些组合物的开发，所述组合物包括与包含非离子表面活性剂（NISV）和任选的佐剂的脂质囊泡组合的流感病毒血凝素抗原。在某些实施方案中，所提供的组合物即使不存储在标准冷链系统中（即它们是耐热的）也保持有效。

2. 发明申请

WO2010033812A1 COMPOSITIONS AND METHODS FOR TREATING HEPATITIS A. 审中-公开
标题翻译：治疗乙型肝炎的组合物和方法A.
公开(公告)号：WO2010033812A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057492
申请日：2009-09-18
申请人： VARIATION BIOTECHNOLOGIES, INC. , DIAZ-MITOMA, Francisco , LE, Thanh , ANDERSON, David, E.
发明人： DIAZ-MITOMA, Francisco , LE, Thanh , ANDERSON, David, E.
IPC分类号： A01N43/04
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5252 , A61K2039/542 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , C12N2770/32434 , Y02A50/464
摘要： The present application provides compositions and methods useful for treating hepatitis A. In particular, while hepatitis A vaccines are currently limited to parenteral administration routes (i.e., intramuscular injection), we have identified compositions that induce a protective response when administered orally.
摘要翻译：本申请提供了可用于治疗戊型肝炎的组合物和方法。特别地，虽然甲型肝炎疫苗目前仅限于肠胃外给药途径（即肌内注射），但是我们已经鉴定了当口服给药时诱导保护性应答的组合物。

3. 发明申请

WO2013144722A2 METHODS FOR DETECTION OF ANTI-CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES 审中-公开
标题翻译：检测抗中性粒细胞中性抗体的方法
公开(公告)号：WO2013144722A2
公开(公告)日：2013-10-03
申请号：PCT/IB2013/001021
申请日：2013-03-27
申请人： VARIATION BIOTECHNOLOGIES, INC.
发明人： ANDERSON, David, E. , BOZIC, Jasminka , ONTSOUKA, Barthelemy
IPC分类号： C12Q1/70
CPC分类号： C12Q1/70 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/70 , C12N2710/16134 , G01N33/5044 , G01N33/6854 , G01N2333/045 , G01N2469/20
摘要： The present disclosure provides methods useful for determining levels of HCMV infection in host cells and, by extension, determining levels of neutralizing antibodies present in a sample. The present disclosure encompasses the recognition that HCMV viruses that have a fluorescent moiety permit detection of viral infection (e.g., by assessing fluorescence in cells after contacting the host cell with the virus). In some embodiments, levels of HCMV infection are determined by fluorescence detection where the virus has been preincubated with a test sample (e.g., a serum sample) from a subject. In some embodiments, the subject has been administered a candidate HCMV vaccine.
摘要翻译：本公开提供了用于确定宿主细胞中HCMV感染水平的方法，并且延伸地确定样品中存在的中和抗体的水平。本公开包括认识到具有荧光部分的HCMV病毒允许检测病毒感染（例如通过在与宿主细胞接触病毒之后评估细胞中的荧光）。在一些实施方案中，HCMV感染的水平通过荧光检测来确定，其中病毒已经与来自受试者的测试样品（例如，血清样品）预孵育。在一些实施方案中，受试者已经施用候选HCMV疫苗。

4. 发明申请

WO2015128731A2 COMPOSITIONS AND METHODS FOR TREATMENT OF HEPATITIS C 审中-公开
标题翻译：用于治疗乙型肝炎的组合物和方法C
公开(公告)号：WO2015128731A2
公开(公告)日：2015-09-03
申请号：PCT/IB2015/000397
申请日：2015-02-24
申请人： VARIATION BIOTECHNOLOGIES, INC.
发明人： ANDERSON, David, E.
IPC分类号： C12N15/85
CPC分类号： C07K14/15 , A61K39/29 , A61K2039/5258 , C07K14/005 , C07K14/1833 , C07K2319/40 , C12N7/045 , C12N2740/13023 , C12N2740/13041 , C12N2770/24234
摘要： The present disclosure provides compositions and methods useful for treating HCV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCV epitopes, such as, for example, from HCV envelope glycoprotein El and/or E2 or variants thereof (e.g., E2G) and/or non-structural proteins NS3 and/or NS4A. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and interior non-structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).
摘要翻译：本公开提供了可用于治疗HCV感染的组合物和方法。如本文所述，组合物和方法基于免疫原性组合物的开发，所述免疫原性组合物包括包含一种或多种莫洛尼鼠白血病病毒（MMLV）核心蛋白的病毒样颗粒（VLP），并且包括一个或多个HCV表位，例如例如，来自HCV包膜糖蛋白E1和/或E2或其变体（例如E2G）和/或非结构蛋白NS3和/或NS4A。除其他之外，本发明包括认识到抗原（例如，包膜糖蛋白和内部非结构蛋白）的组合可导致有益的免疫应答，例如包括体液应答（例如产生中和抗体）和细胞反应（例如T细胞活化）。

5. 发明申请

WO2013068847A2 COMPOSITIONS AND METHODS FOR TREATMENT OF CYTOMEGALOVIRUS 审中-公开
标题翻译：用于治疗细胞色素瘤的组合物和方法
公开(公告)号：WO2013068847A2
公开(公告)日：2013-05-16
申请号：PCT/IB2012/002854
申请日：2012-11-09
申请人： VARIATION BIOTECHNOLOGIES, INC.
发明人： ANDERSON, David, E.
IPC分类号： C12N15/63 , A61K39/245 , A61K39/295 , A61P31/22 , A61P37/04 , C07K14/045 , C07K14/145 , C07K14/15 , C07K19/00 , C12N15/38 , C12N15/48 , C12N15/62 , C12N15/86 , C12N7/01 , C12N7/04
CPC分类号： C07K14/005 , A61K39/245 , A61K2039/5258 , A61K2039/70 , C07K2319/00 , C07K2319/03 , C12N2710/16134 , C12N2740/13023 , C12N2760/20234
摘要： The present disclosure provides compositions and methods useful for treating HCMV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCMV epitopes, such as, for example, from HCMV envelope glycoproteins gB and/or gH and/or tegument protein pp65. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).
摘要翻译：本公开提供了可用于治疗HCMV感染的组合物和方法。如本文所述，组合物和方法基于免疫原性组合物的开发，其包括包含一种或多种莫洛尼鼠白血病病毒（MMLV）核心蛋白的病毒样颗粒（VLP），并且包括一种或多种HCMV表位，例如例如，来自HCMV包膜糖蛋白gB和/或gH和/或凝胶蛋白pp65。除此之外，本发明包括认识到抗原（例如，包膜糖蛋白和结构蛋白）的组合可以导致有益的免疫应答，例如包括体液应答（例如产生中和抗体）和细胞反应（例如T细胞活化）。

6. 发明申请

WO2012097347A1 METHODS FOR PREPARING VESICLES AND FORMULATIONS PRODUCED THEREFROM 审中-公开
标题翻译：制备其生产的药剂和制剂的方法
公开(公告)号：WO2012097347A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/021389
申请日：2012-01-13
申请人： VARIATION BIOTECHNOLOGIES, INC. , ANDERSON, David, E. , PERRIE, Yvonne , WILKHU, Jitinder Singh , KIRCHMEIER, Marc
发明人： ANDERSON, David, E. , PERRIE, Yvonne , WILKHU, Jitinder Singh , KIRCHMEIER, Marc
IPC分类号： A61K9/127 , C12N9/98 , C12N1/04
CPC分类号： A61K9/10 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： The present disclosure provides methods for preparing vesicles. In one aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding the molten mixture of vesicle-forming lipids to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed, wherein in the step of adding the molten mixture of vesicle forming lipids is at a temperature of less than 120°C. In another aspect, the methods involve providing a molten mixture of vesicle-forming lipids and adding an aqueous solution comprising an antigen to the molten mixture of vesicle-forming lipids such that antigen-containing vesicles are formed, wherein the resulting mixture is placed under temperature-controlled conditions of less than 60°C. In yet another aspect, the methods involve providing a solution of vesicle forming lipids and adding the solution of vesicle-forming lipids to an aqueous solution comprising an antigen by injection such that antigen-containing vesicles are formed.
摘要翻译：本公开提供了制备囊泡的方法。在一个方面，所述方法包括提供形成囊泡的脂质的熔融混合物，并将形成囊泡的脂质的熔融混合物加入到包含抗原的水溶液中，使得形成含抗原的囊泡，其中在添加熔融囊泡形成脂质的混合物的温度低于120℃。在另一方面，所述方法包括提供形成囊泡的脂质的熔融混合物，并将含有抗原的水溶液加入到泡囊形成脂质的熔融混合物中，使得形成含抗原的囊泡，其中所得混合物置于温度控制条件低于60°C。另一方面，所述方法包括提供形成小泡的脂质溶液，并通过注射将含小泡形成脂质的溶液加入到包含抗原的水溶液中，使得形成含抗原的囊泡。

7. 发明申请

WO2011005772A1 METHODS FOR PREPARING VESICLES AND FORMULATIONS PRODUCED THEREFROM 审中-公开
标题翻译：制备其生产的药剂和制剂的方法
公开(公告)号：WO2011005772A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041081
申请日：2010-07-06
申请人： VARIATION BIOTECHNOLOGIES, INC. , ANDERSON, David, E. , DIAZ-MITOMA, Francisco , LE, Thanh
发明人： ANDERSON, David, E. , DIAZ-MITOMA, Francisco , LE, Thanh
IPC分类号： A61K9/127
CPC分类号： A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/55555 , C12N2770/24234
摘要： The present disclosure provides methods for preparing vesicles. In general, these methods include steps of providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen- containing vesicles are formed. The lyophilized lipid product is prepared by dissolving vesicle-forming lipids in a polar-protic water-miscible organic solvent to produce a lipid solution and then lyophilizing the lipid solution. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.
摘要翻译：本公开提供了制备囊泡的方法。通常，这些方法包括提供冻干的脂质产物并用包含抗原的水溶液再冻融冻干的脂质产物以使得形成含抗原的囊泡的步骤。冻干的脂质产物通过将溶解泡囊形成的脂质溶解在极性 - 水溶性水溶性有机溶剂中来制备脂质溶液，然后冻干脂质溶液。本公开还提供了使用这些方法制备的含抗原的囊泡制剂。本公开还提供了在第一容器中包含冻干的脂质产物和在第二容器中包含抗原的水溶液的试剂盒。

8. 发明申请

WO2009155489A2 COMPOSITIONS AND METHODS FOR TREATING INFLUENZA 审中-公开
标题翻译：用于治疗流感的组合物和方法
公开(公告)号：WO2009155489A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/047911
申请日：2009-06-19
申请人： VARIATION BIOTECHNOLOGIES, INC. , DIAZ-MITOMA, Francisco , OGREL, Andrei , TORRES, Jose, V. , ANDERSON, David, E.
发明人： DIAZ-MITOMA, Francisco , OGREL, Andrei , TORRES, Jose, V. , ANDERSON, David, E.
IPC分类号： A61K38/03 , A61K39/39 , A61P31/16
CPC分类号： A61K39/145 , A61K38/162 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/542 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , C07K7/08 , C07K14/00 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271
摘要： The present application provides compositions and methods useful for treating influenza. As described herein, the compositions and methods are based on the development of peptides and peptide combinations which exhibit immunogenic properties against influenza. In some embodiments, the peptide combinations induce a protective response against multiple strains of influenza, e.g., seasonal strains of influenza or even the new pandemic influenza A (H1N1) virus of swine origin.
摘要翻译：本申请提供了可用于治疗流感的组合物和方法。如本文所述，组合物和方法基于显示针对流感的免疫原性的肽和肽组合的开发。在一些实施方案中，肽组合诱导针对多种流感病毒株的保护性应答，例如季节性流感病毒株，甚至猪源的新型大流行性流感A（H1N1）病毒。

9. 发明申请

WO2014128568A2 COMPOSITIONS AND METHODS FOR TREATMENT OF HEPATITIS C 审中-公开
标题翻译：用于治疗乙型肝炎的组合物和方法C
公开(公告)号：WO2014128568A2
公开(公告)日：2014-08-28
申请号：PCT/IB2014/000815
申请日：2014-02-25
申请人： VARIATION BIOTECHNOLOGIES, INC.
发明人： ANDERSON, David, E. , KLATZMANN, David
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K2039/5258 , C07K2319/03 , C12N2740/16222 , C12N2770/24222 , C12N2770/24234
摘要： The present disclosure provides compositions and methods useful for treating HCV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCV epitopes, such as, for example, from HCV envelope glycoprotein El and/or E2 or variants thereof (e.g., E2G) and/or non-structural proteins NS3 and/or NS4A. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and interior non-structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).
摘要翻译：本公开提供了可用于治疗HCV感染的组合物和方法。如本文所述，组合物和方法基于免疫原性组合物的开发，所述免疫原性组合物包括包含一种或多种莫洛尼鼠白血病病毒（MMLV）核心蛋白的病毒样颗粒（VLP），并且包括一个或多个HCV表位，例如例如，来自HCV包膜糖蛋白E1和/或E2或其变体（例如E2G）和/或非结构蛋白NS3和/或NS4A。除其他之外，本发明包括认识到抗原（例如，包膜糖蛋白和内部非结构蛋白）的组合可导致有益的免疫应答，例如包括体液应答（例如产生中和抗体）和细胞反应（例如T细胞活化）。

10. 发明申请

WO2013111012A2 METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药物的方法和组合物
公开(公告)号：WO2013111012A2
公开(公告)日：2013-08-01
申请号：PCT/IB2013/000454
申请日：2013-01-25
申请人： VARIATION BIOTECHNOLOGIES, INC.
发明人： KIRCHMEIER, Marc, J. , ANDERSON, David, E.
IPC分类号： A61K47/28
CPC分类号： A61K47/14 , A61K9/1272 , A61K39/0015 , A61K39/12 , A61K39/165 , A61K39/20 , A61K39/295 , A61K39/39591 , A61K47/24 , A61K47/28 , A61K2039/5254 , A61K2039/55555 , A61K2039/70 , C07K16/32 , C12N7/00 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234 , Y02A50/388
摘要： The present disclosure provides inter alia compositions that comprise therapeutic agents (e.g., live attenuated viral antigens, therapeutic proteins, etc.) and a lipid component. The lipid component may comprise or consist of different types of lipid or lipids as described herein. In some embodiments the therapeutic agents are thermolabile. The present disclosure also provides methods for preparing compositions, including the aforementioned compositions (e.g., melt methods and spray injection methods among others).
摘要翻译：本公开尤其提供了包含治疗剂（例如活减毒病毒抗原，治疗性蛋白质等）和脂质组分的组合物。脂质组分可以包含或由本文所述的不同类型的脂质或脂质组成。在一些实施方案中，治疗剂是不耐热的。本公开还提供了制备组合物的方法，包括前述组合物（例如，熔融方法和喷射方法等）。

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