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1. 发明申请

WO2004063129A2 METHODS FOR NUCLEOPHILIC FLUOROMETHYLATION 审中-公开
标题翻译：用于核酸氟代甲基化的方法
公开(公告)号：WO2004063129A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000651
申请日：2004-01-13
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , PRAKASH, Surya, G., K. , HU, Jinbo , OLAH, George, A.
发明人： PRAKASH, Surya, G., K. , HU, Jinbo , OLAH, George, A.
IPC分类号： C07C
CPC分类号： C07D307/42 , C07C29/38 , C07C319/14 , C07C2603/74 , C07C323/03 , C07C33/46 , C07C31/38 , C07C35/52
摘要： A novel, convenient and efficient method for trifluoromethylation of substrate compounds is disclosed. Particularly, alkoxide and hydroxide induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides and other electrophiles, using phenyl trifluoromethyl sulfone PhSO2CF3 (or sulfoxide PhSOCF3) is disclosed. A method of both symmetrical and unsymmetrical anti-2,2-difluoropropan-1,3-diols with high diastereoselectivity (up to 94 % de) is disclosed using dufluoromethyl phenyl sulfone. This unusual type of high diastereoselectivity was obtained via an intramolecular charge-charge repulsion effect rather than the traditional steric control (based on the Cram's rule). Thus, difluoromethyl phenyl sulfone can be used as a novel difluoromethylene dianion species (`CF2""), which can couple two electrophiles (such as diphenyl disulfide or non-enolizable aldehydes) to give new difluoromethylenated products.
摘要翻译：公开了一种用于底物化合物三氟甲基化的新颖，方便和有效的方法。特别地，公开了使用苯基三氟甲基砜PhSO 2 CF 3（或亚砜PhSOCF 3）的羰基化合物，二硫化物和其它亲电子体的醇盐和氢氧化物的亲核三氟甲基化。使用二氟甲基苯基砜公开了具有高非对映选择性（高达94％de）的对称和不对称的2,2-二氟丙-1,3-二醇的方法。这种不寻常类型的高非对映选择性通过分子内电荷 - 排斥效应而不是传统的空间控制获得（基于Cram的规则）。因此，二氟甲基苯基砜可以用作新的二氟亚甲基二阴离子物质（“CF2”“），其可以偶合两种亲电子试剂（例如二苯基二硫化物或不可烯化的醛）以产生新的二氟亚甲基化产物。

2. 发明申请

WO2006113293A1 EFFICIENT AND SELECTIVE CONVERSION OF CARBON DIOXIDE TO METHANOL, DIMETHYL ETHER AND DERIVED PRODUCTS 审中-公开
标题翻译：二氧化碳对甲醇，二甲醚及其衍生物的有效选择性转化
公开(公告)号：WO2006113293A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/013742
申请日：2006-04-12
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , OLAH, George, A. , PRAKASH, Surya, G., K.
发明人： OLAH, George, A. , PRAKASH, Surya, G., K.
IPC分类号： C07C29/14 , C07C31/04 , C07C51/16 , C07C53/02 , C07C29/149
CPC分类号： C07C68/005 , C07C1/20 , C07C29/04 , C07C29/136 , C07C29/14 , C07C29/141 , C07C29/149 , C07C41/09 , C07C51/15 , C07C67/08 , C07C67/38 , C07C68/02 , C25B3/04 , C07C11/02 , C07C31/08 , C07C31/10 , C07C31/04 , C07C53/02 , C07C69/06 , C07C69/96 , C07C43/043
摘要： An environmentally beneficial method of producing methanol from varied sources of carbon dioxide including flue gases of fossil fuel burning powerplants, industrial exhaust gases or the atmosphere itself. Converting carbon dioxide by electrochemical reduction produces formic acid acid and some formaldehyde and methanol mixtures. The formic acid can be used as source of carbon as well as hydrogen to produce methanol, dimethyl ether and other products.
摘要翻译：一种从不同来源的二氧化碳生产甲醇的环保方法，包括化石燃料燃烧发电厂的烟气，工业废气或大气本身。通过电化学还原转化二氧化碳产生甲酸和一些甲醛和甲醇混合物。甲酸可用作碳源和氢气来生产甲醇，二甲醚和其他产品。

3. 发明申请

WO2006113294A1 SELECTIVE OXIDATIVE CONVERSION OF METHANE TO METHANOL, DIMETHYL ETHER AND DERIVED PRODUCTS 审中-公开
标题翻译：甲醇对甲醇，二甲醚和衍生产物的选择性氧化转化
公开(公告)号：WO2006113294A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/013743
申请日：2006-04-12
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , OLAH, George, A. , PRAKASH, Surya, G., K.
发明人： OLAH, George, A. , PRAKASH, Surya, G., K.
IPC分类号： C07C29/149 , C07C31/04 , C07C29/48
CPC分类号： C07C41/09 , C07C29/14 , C07C29/149 , C07C29/48 , C07C29/50 , C07C45/28 , C07C45/33 , C07C51/215 , C07C67/44 , C10G2300/1025 , C10G2300/1029 , C10G2400/20 , C10G2400/22 , C10G2400/30 , C10L1/023 , C10L1/026 , C25B3/04 , Y02P30/40 , Y02P30/42 , C07C47/04 , C07C53/02 , C07C69/06 , C07C31/04 , C07C43/043 , C07C31/08 , C07C31/10
摘要： The present invention relates to a method of producing methanol from a methane source by oxidizing methane under conditions sufficient to a mixture of methanol and formaldehyde while minimizing the formation of formic acid and carbon dioxide. The oxidation step is followed by treatment step in which formaldehyde is converted into methanol and formic acid which itself can further be converted into methanol via catalytic hydrogenation of intermediately formed methyl formate.
摘要翻译：本发明涉及通过在足以使甲醇和甲醛的混合物充分的甲烷下氧化甲烷，同时最小化甲酸和二氧化碳的形成而从甲烷源生产甲醇的方法。氧化步骤之后是将甲醛转化为甲醇和甲酸的处理步骤，其本身可以通过中间形成的甲酸甲酯的催化氢化进一步转化成甲醇。

4. 发明申请

WO2003048033A3 MAGNESIUM MEDIATED PREPARATION OF FLUORINATED ALKYLSILANES 审中-公开
公开(公告)号：WO2003048033A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038127
申请日：2002-11-27
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , PRAKASH, Surya, G., K. , HU, Jinbo , OLAH, George, A.
发明人： PRAKASH, Surya, G., K. , HU, Jinbo , OLAH, George, A.
IPC分类号： C07F7/04
摘要： An efficient method is disclosed for the preparation of trifluoromethyl- and difluoromethylsilanes using magnesium metal mediated reductive tri- and difluoromethylation of chlorosilanes with tri- and difluoromethy sulfides, sulfoxides, and sulfones. One byproduct of the process is diphenyl disulfide. Since phenyl trifluoromethyl sulfone, sulfoxide and sulfide are readily prepared from readily available trifluoromethane and diphenyl disulfide, the method can be considered "pseudo-catalytic" for the preparation of (trifluoromethyl)trimethylsilane from environmentally benign trifluoromethane.

5. 发明申请

WO2004050809A2 METHOD FOR EXPEDIENT SYNTHESIS OF [18F]-LABELED α-TRIFLUOROMETHYL KETONES 审中-公开
标题翻译：快速合成[18 F] - 标记的α-三氟甲基酮的方法
公开(公告)号：WO2004050809A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/037606
申请日：2003-11-26
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： PRAKASH, Surya, G., K. , ALAUDDIN, Mian, M. , HU, Jinbo , CONTI, Peter, S. , OLAH, George, A.
IPC分类号： C11D
CPC分类号： C07C49/813 , C07C45/511 , C07C49/80
摘要： The present invention is directed to a convenient method of synthesizing radiolabeled a-trifluoromethyl ketones by a fluorination reaction. The present invention also relates to imaging agents and markers for identifying cell proliferation, or viral infection. The markers and imaging agents including the radiolabeled α-trifluoromethyl ketones that are prepared by the present method.
摘要翻译：本发明涉及通过氟化反应合成放射性标记的α-三氟甲基酮的便利方法。本发明还涉及用于鉴定细胞增殖或病毒感染的显像剂和标记。标记和显像剂包括通过本发明方法制备的放射性标记的α-三氟甲基酮。

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