专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013040295A2 DIVALENT-METAL COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION 审中-公开
标题翻译：用金属包覆纳米粒子将组合物送入中枢神经系统的鼻夹心
公开(公告)号：WO2013040295A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055306
申请日：2012-09-14
申请人： UNIVERSITY OF SOUTH FLORIDA , SANCHEZ-RAMOS, Juan , SAVA, Vasyl , SONG, Shijie , MOHAPATRA, Shyam, S. , MOHAPATRA, Subhra
发明人： SANCHEZ-RAMOS, Juan , SAVA, Vasyl , SONG, Shijie , MOHAPATRA, Shyam, S. , MOHAPATRA, Subhra
IPC分类号： A61K33/06 , A61K33/30 , A61K33/34 , A61K31/722 , A61K48/00 , A61K9/16 , A61K47/48 , A61K47/30
CPC分类号： C12N15/113 , A61K9/0043 , A61K9/1075 , A61K9/1611 , A61K9/1652 , A61K9/1658 , A61K9/50 , A61K9/501 , A61K9/5115 , A61K31/7088 , A61K31/713 , A61K47/541 , A61K47/547 , A61K47/6939 , A61K48/00 , A61K49/1881 , C12N15/88 , C12N15/895 , C12N2310/14 , C12N2320/32
摘要： The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation- containing nanoparticles to all regions of brain. It has been found that such divalent cation- containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs. The present disclosure encompasses embodiments of nanoparticle-based compositions and methods for the use thereof for the delivery of genes, oligonucleotides, including but not limited to small interfering RNA, and other small molecule drugs, into the brain by nasal insufflation.
摘要翻译：本公开的组合物和方法特别靶向在嗅觉神经末梢上表达的二价金属转运蛋白以将二价阳离子包被的或含阳离子的纳米颗粒转运至脑的全部区域。已经发现这种含二价阳离子的纳米颗粒，包括那些包含锰的纳米颗粒，对金属转运受体蛋白具有亲和力。虽然该受体对锰具有特别的亲和力，但可以设想，其它二价离子，包括镁，钙等也可以与这些受体结合，导致纳米颗粒转运到胞内细胞质中。因此，纳米粒子已经被开发用作胃肠外递送基因，蛋白质和药物的载体。本公开内容涵盖基于纳米粒子的组合物的实施方案及其用于通过鼻腔吹入将基因，寡核苷酸（包括但不限于小干扰RNA和其它小分子药物）递送到脑中的方法。

2. 发明申请

WO2009073527A2 METHODS AND COMPOSITIONS FOR REDUCING ACTIVITY OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR AND FOR TREATMENT OF DISEASES 审中-公开
标题翻译：降低ATRIAL NATRIURETIC PEPTIDE RECEPTOR活性和治疗疾病的方法和组合物
公开(公告)号：WO2009073527A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/084908
申请日：2008-11-26
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , XU, Weidong , KONG, Xiaoyuan , WANG, Xiaoqin , MOHAPATRA, Subhra, S.
发明人： MOHAPATRA, Shyam, S. , XU, Weidong , KONG, Xiaoyuan , WANG, Xiaoqin , MOHAPATRA, Subhra, S.
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： C12N15/1138 , A61K9/0019 , A61K9/0034 , A61K9/0043 , A61K9/0073 , A61K9/5161 , A61K31/711 , A61K31/713 , A61K47/61 , A61K47/6935 , A61K47/6939 , A61K48/0008 , A61K48/005 , A61K49/0008 , B82Y5/00 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2320/30
摘要： Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan. chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery. Delivery permits cell and tissue specific targeting of gene therapies resulting in expression of a natriuretic peptide or down regulation of natriuretic peptide receptor. A variety of cancers, asthma and viral diseases can be treated therapeutically using the methods and compositions of the present invention.
摘要翻译：本发明提供了降低利尿钠肽受体活性和其他信号的方法，组合物和装置。通过使用编码利尿钠肽的多核苷酸或通过调节利尿钠肽受体（如NPRA和NPRC）的表达或这些疗法的组合来提供治疗性治疗。用于递送编码利尿钠肽的多核苷酸的路线，或例如下调调节利尿钠肽受体的siRNA包括皮下注射，口服管饲，经皮和鼻内递送途径。组合物可以包括壳聚糖。壳聚糖衍生物和壳聚糖衍生物和脂质。透皮给药可以使用透皮霜。鼻内输送可以使用滴管或吸气器来传送雾。口服管子相当于口服输送。交付允许基因治疗的细胞和组织特异性靶向导致利尿钠肽的表达或利尿钠肽受体的下调。可以使用本发明的方法和组合物治疗多种癌症，哮喘和病毒性疾病。

3. 发明申请

WO2013082591A1 COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS 审中-公开
标题翻译：用于调节麦芽糖衍生抑制细胞的组合物和方法
公开(公告)号：WO2013082591A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/067586
申请日：2012-12-03
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , NAGARAJ, Srinivas , MOHAPATRA, Subhra
发明人： MOHAPATRA, Shyam, S. , NAGARAJ, Srinivas , MOHAPATRA, Subhra
IPC分类号： C12Q1/68 , C12N5/071 , C12N5/077 , C12N15/11
CPC分类号： C12N15/113 , A61K47/6807 , A61K47/6849 , A61K47/6929 , C12N5/0639 , C12N5/0645 , C12N5/0647 , C12N15/111 , C12N2310/141 , C12N2310/17 , C12N2320/30 , C12N2501/65 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC.
摘要翻译：提供了用于调节骨髓来源的抑制细胞（MDSC）的分化的方法和组合物。特别地，本文描述了可用于调节MDSC的分化的miR-142多核苷酸和miR-223多核苷酸。可以通过增加MDSC中的miR-142和/或miR-223多核苷酸来实现MDSC群体或MDSC群体内的细胞的增加的分化。

4. 发明申请

WO2012151406A1 DIAGNOSIS AND TREATMENT OF TRAUMATIC BRAIN INJURY 审中-公开
标题翻译：诊断和治疗TRAUMATIC脑损伤
公开(公告)号：WO2012151406A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036335
申请日：2012-05-03
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Subhra , MOHAPATRA, Shyam, S. , PENNYPACKER, Keith, Ronald , DAS, Mahasweta , LEONARDO, Christopher, Charles
发明人： MOHAPATRA, Subhra , MOHAPATRA, Shyam, S. , PENNYPACKER, Keith, Ronald , DAS, Mahasweta , LEONARDO, Christopher, Charles
IPC分类号： A61K38/19
CPC分类号： G01N33/6863 , A61K45/06 , C07K16/24 , C12Q1/6883 , C12Q2600/158 , G01N2333/521 , G01N2500/00 , G01N2800/28
摘要： The subject invention identifies CC chemokine ligand 20 (CCL20) as a novel biomarker for diagnosis of traumatic brain injury and/or neurodegeneration is the brain. The subject invention also provides treatment methods for traumatic brain injury and/or neurodegeneration in the brain by modulating systemic and/or brain-specific CCL20-CC.R6 signaling. Also provided are uses of CCL20-CCR6 signaling a target for screening for therapeutic agents that are useful for treatment of traumatic brain injury.
摘要翻译：本发明鉴定CC趋化因子配体20（CCL20）作为用于诊断创伤性脑损伤和/或神经变性的新型生物标志物是脑。本发明还通过调节全身和/或脑特异性CCL20-CC.R6信号传导来提供脑外伤性脑损伤和/或神经变性的治疗方法。还提供了CCL20-CCR6的用途，其表达用于筛选可用于治疗创伤性脑损伤的治疗剂的靶标。

5. 发明申请

WO2007127487A2 MATERIALS AND METHODS FOR REDUCING INFLAMMATION BY INHIBITION OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 审中-公开
标题翻译：通过抑制ATRIAL NATRIURETIC PEPTIDE RECEPTOR抑制炎症的材料和方法
公开(公告)号：WO2007127487A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010572
申请日：2007-04-30
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , XU, Weidong , KONG, Xiaoyuan , WANG, Xiaoqin
发明人： MOHAPATRA, Shyam, S. , XU, Weidong , KONG, Xiaoyuan , WANG, Xiaoqin
IPC分类号： C07H21/04 , C12P21/06 , C12N5/10 , C12P21/08
CPC分类号： C12N15/1138 , C12N2310/14
摘要： This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject.
摘要翻译：本发明涉及用于减少与诸如哮喘，呼吸道合胞病毒（RSV）感染和癌症相关的许多人类疾病的炎症的小干扰RNA（siRNA）的心房钠尿肽受体A（NPRA）功能的抑制剂（例如黑素瘤，肺癌和/或卵巢癌）通过干扰NPRA基因表达或以其他方式降低受试者内的NPRA功能; 以及通过向受试者施用这种NPRA抑制剂来治疗患有或有风险发展为炎性疾病，呼吸性过敏（例如过敏性鼻炎和哮喘），病毒感染和/或癌症的受试者的方法。

6. 发明申请

WO2007127480A2 MATERIALS AND METHODS TO REDUCE LOW DENSITY LIPOPROTEIN CHOLESTEROL 审中-公开
标题翻译：减少低密度脂蛋白胆固醇的材料和方法
公开(公告)号：WO2007127480A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010496
申请日：2007-04-30
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , KUMAR, Arun
发明人： MOHAPATRA, Shyam, S. , KUMAR, Arun
IPC分类号： A61F2/02
CPC分类号： A61K9/5146 , A61K9/5161 , Y10S977/739 , Y10S977/746 , Y10S977/747 , Y10S977/90
摘要： The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density lipoprotein (LDL), attached to the core. The invention also concerns methods for reducing LDL cholesterol in a human or animal subject by administering nanoparticles of the invention. In a preferred embodiment, both circulating LDL and plasma cholesterol levels are reduced in the subject.
摘要翻译：本发明涉及包含具有7-α羟化酶或其酶活性片段，特异于低密度脂蛋白（LDL）的烟酰胺腺嘌呤二核苷酸（NADH）和抗体或抗体片段的金属和/或聚合物核心的纳米颗粒，，附在核心。本发明还涉及通过施用本发明的纳米颗粒来降低人或动物受试者中的LDL胆固醇的方法。在优选的实施方案中，受试者中循环LDL和血浆胆固醇水平都降低。

7. 发明申请

WO2005056021A1 POLYNUCLEOTIDES FOR REDUCING RESPIRATORY SYNCYTIAL VIRUS GENE EXPRESSION 审中-公开
标题翻译：用于减少呼吸道同源病毒基因表达的多核苷酸
公开(公告)号：WO2005056021A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/040727
申请日：2004-12-06
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , ZHANG, Weidong
发明人： MOHAPATRA, Shyam, S. , ZHANG, Weidong
IPC分类号： A61K31/70
CPC分类号： A61K31/713 , A61K31/70 , C07H21/02 , C07H21/04 , C12N15/1131 , C12N2310/111 , C12N2310/14
摘要： This invention pertains to polynucleotides, such as small interfering RNA (siRNA), useful for reducing the expression of respiratory syncytial virus (RSV) genes within a subject; and methods for treating a patient suffering from, or at risk of developing, an RSV infection by administering such polynucleotides to the subject.
摘要翻译：本发明涉及可用于减少受试者内呼吸道合胞病毒（RSV）基因表达的多核苷酸，例如小干扰RNA（siRNA）; 以及通过向受试者施用这种多核苷酸来治疗患有或有发展为RSV感染风险的患者的方法。

8. 发明申请

WO2008157834A1 MATERIALS AND METHODS FOR DIAGNOSIS OF ASTHMA 审中-公开
标题翻译：用于诊断ASTHMA的材料和方法
公开(公告)号：WO2008157834A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067920
申请日：2008-06-23
申请人： UNIVERSITY OF SOUTH FLORIDA , THE NEMOURS FOUNDATION , MOHAPATRA, Shyam, S. , LIMA, John, J.
发明人： MOHAPATRA, Shyam, S. , LIMA, John, J.
IPC分类号： C12Q1/68 , G01N33/53 , C12N15/09
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , G01N2333/58 , G01N2800/122
摘要： The present invention pertains to materials and methods for diagnosing and/or determining the prognosis and likelihood of developing asthma. In one embodiment, methods of the invention comprise the use of single nucleotide polymorphic markers of asthma. Markers of the invention are present in the atria natriuretic peptide (NPPA) gene, and serve as a marker for genetic susceptibility of a person or animal in developing asthma.
摘要翻译：本发明涉及用于诊断和/或确定哮喘发展的预后和可能性的材料和方法。在一个实施方案中，本发明的方法包括使用哮喘的单核苷酸多态标志物。本发明的标记物存在于心房利钠肽（NPPA）基因中，并且作为人或动物发展中的哮喘的遗传易感性的标记物。

9. 发明申请

WO2008048272A2 METHOD OF DRUG DELIVERY BY CARBON NANOTUBE-CHITOSAN NANOCOMPLEXES 审中-公开
标题翻译：通过碳纳米管 - 壳聚糖纳米复合物递送药物的方法
公开(公告)号：WO2008048272A2
公开(公告)日：2008-04-24
申请号：PCT/US2006/041570
申请日：2006-10-23
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , KUMAR, Arun
发明人： MOHAPATRA, Shyam, S. , KUMAR, Arun
IPC分类号： A61K48/00
CPC分类号： A61K48/0041
摘要： Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells.
摘要翻译：与纳米壳聚糖复合的功能化单壁碳纳米管（SWCNT）用于递送生物影响物质和诊断应用。与壳聚糖NG042复合的fSWCNT用于递送编码DNA的EGFP报道蛋白和肽。结果表明，所示的CNT-壳聚糖杂化纳米颗粒在体内的转染效率显着高于单独的壳聚糖。此外，功能化的纳米管被测试以将肽转移到HEK293细胞中。结果显示混合纳米颗粒有效地转移肽。总之，这些结果表明杂交SWCNT-壳聚糖颗粒增加DNA和肽转移到细胞中。

10. 发明申请

WO2004076664A2 VECTORS FOR REGULATING GENE EXPRESSION 审中-公开
标题翻译：用于调节基因表达的载体
公开(公告)号：WO2004076664A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005566
申请日：2004-02-23
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , ZHANG, Weidong
发明人： MOHAPATRA, Shyam, S. , ZHANG, Weidong
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , A61K48/005 , A61K48/0058 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2750/14143
摘要： The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression cassette encodes a polypeptide of interest, and wherein the gene suppressing cassette encodes a short interfering RNA (siRNA) molecule that reduces expression of a target gene by RNA interference. The present invention further includes vectors that contain suppressor cassettes in conjunction with cassettes upregulating gene expression regulated by either a constitutive promoter, such as a general CMV promoter, or a tissue specific promoter. The present invention further includes vectors that contain Dengue virus gene suppression cassettes. The present invention further includes pharmaceutical compositions containing such vectors, methods of modulating the expression of genes in a host using such vectors, and method of producing such vectors.
摘要翻译：本发明涉及用于调节基因表达的载体，所述载体具有至少一个表达基因的盒和至少一个基因抑制盒，其中所述基因表达盒编码目的多肽，并且其中所述基因抑制盒编码短干扰RNA（siRNA）通过RNA干扰降低靶基因表达的分子。本发明还包括载体，其含有与上调由组成型启动子如一般CMV启动子或组织特异性启动子调节的基因表达的盒结合的抑制盒。本发明还包括含有登革热病毒基因抑制盒的载体。本发明还包括含有这些载体的药物组合物，使用这种载体调节宿主中基因表达的方法，以及生产这种载体的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式