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    • 4. 发明申请
    • LIQUID-LIQUID INTERFACIAL NANOPARTICLE ASSEMBLIES
    • 液体液体纳米材料组件
    • WO2004063705A2
    • 2004-07-29
    • PCT/US2004/000291
    • 2004-01-08
    • UNIVERSITY OF MASSACHUSETTSEMRICK, ToddRUSSEL, TomDINSMORE, AnthonySKAFF, HabibLIN, YaoBÖKER, Alexander
    • EMRICK, ToddRUSSEL, TomDINSMORE, AnthonySKAFF, HabibLIN, YaoBÖKER, Alexander
    • G01N
    • A61K9/5089A61K9/501B01J13/14Y10S977/787
    • Self-assembly of nanoparticles at the interface between two fluids, and methods to control such self-assembly process, e.g., the surface density of particles assembling at the interface; to utilize the assembled nanoparticles and their ligands in fabrication of capsules, where the elastic properties of the capsules can be varied from soft to tough; to develop capsules with well defined porosities for ultimate use as delivery systems; and to develop chemistries whereby multiple ligands or ligands with multiple functionalities can be attached to the nanoparticles to promote the interfacial segregation and assembly of the nanoparticles. Certain embodiments use cadmium selenide (CdSe) nanoparticles, since the photoluminescence of the particles provides a convenient means by which the spatial location and organization of the particles can be probed. However, the systems and methodologies presented here are general and can, with suitable modification of the chemistries, be adapted to any type of nanoparticle.
    • 纳米颗粒在两种流体之间的界面处的自组装,以及控制这种自组装过程的方法,例如在界面处组装的颗粒的表面密度; 在胶囊的制造中利用组装的纳米颗粒及其配体,其中胶囊的弹性性质可以从柔软变为韧性; 开发具有明确定义的孔隙度的胶囊,以最终用作输送系统; 并且开发化学物质,由此具有多个官能团的多个配体或配体可以连接到纳米颗粒以促进纳米颗粒的界面分离和组装。 某些实施方案使用硒化镉(CdSe)纳米颗粒,因为颗粒的光致发光提供了可以探测颗粒的空间位置和组织的便利手段。 然而,这里呈现的系统和方法是通用的,并且可以通过适当的化学修饰来适应任何类型的纳米颗粒。