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1. 发明申请

WO2016106328A1 NANOPARTICLES FOR LIPID HOMEOSTASIS 审中-公开
标题翻译：用于脂肪家族成员的纳米脂
公开(公告)号：WO2016106328A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/067403
申请日：2015-12-22
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , MARRACHE, Sean , WEN, Ru , BANIK, Bhabatosh
发明人： DHAR, Shanta , MARRACHE, Sean , WEN, Ru , BANIK, Bhabatosh
IPC分类号： A61K9/51 , A61K35/00
CPC分类号： A61K9/5153 , A61K9/1275 , A61K9/282 , A61K38/10 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/6927 , A61K47/6937 , A61K49/1824 , B82Y5/00
摘要： Nanoparticles include a polymeric core and a high density lipoprotein (HDL) component where the ratio by weight of the HDL component to the polymeric core is in a range from about 1:9 to about 9:1, such as about 75:25 or less or about 7:3 or less. The nanoparticles may also include a mitochondria targeting moiety. The nanoparticles may be used to treat or prevent atherosclerosis or to maintain lipid homeostasis.
摘要翻译：纳米颗粒包括聚合物芯和高密度脂蛋白（HDL）组分，其中HDL组分与聚合物芯的重量比在约1:9至约9:1的范围内，例如约75:25或更低或约7：3或更少。纳米颗粒还可以包括线粒体靶向部分。纳米颗粒可用于治疗或预防动脉粥样硬化或维持脂质体内平衡。

2. 发明申请

WO2016022462A1 THERAPEUTIC NANOPARTICLES FOR ACCUMULATION IN THE BRAIN 审中-公开
标题翻译：用于在脑中积累的治疗性纳米颗粒
公开(公告)号：WO2016022462A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043398
申请日：2015-08-03
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. , DHAR, Shanta , WYATT, Emily, L. , MARRACHE, Sean , WEST, Franklin, D.
发明人： DHAR, Shanta , WYATT, Emily, L. , MARRACHE, Sean , WEST, Franklin, D.
IPC分类号： A61K35/30 , A61K38/43 , A61K31/573
CPC分类号： A61K9/5153 , A61K9/0019 , A61K31/122 , A61K31/573 , A61K47/02 , A61K47/48192 , A61K47/48953 , A61K47/59 , A61K47/6937 , A61K49/0067 , A61K2300/00
摘要： Nanoparticles containing a mitochondrial that are capable of crossing the blood-brain barrier and that have a targeting moiety, an antioxidant and an anti-inflammatory agent may be useful for treatment of traumatic brain injury.
摘要翻译：能够穿过血脑屏障并具有靶向部分的线粒体的纳米粒子，抗氧化剂和抗炎剂可用于治疗创伤性脑损伤。

3. 发明申请

WO2015138992A1 MITOCHONDRIAL DELIVERY OF 3-BROMOPYRUVATE 审中-公开
标题翻译： 3-BROMOPYRUVATE的MITOCHONDRIAL DELIVERY
公开(公告)号：WO2015138992A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020591
申请日：2015-03-13
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , MARRACHE, Sean
发明人： DHAR, Shanta , MARRACHE, Sean
IPC分类号： A61K31/66
CPC分类号： A61K31/19 , A61K31/194 , A61K31/416 , A61K31/7004 , A61K41/0042 , A61K41/0057 , A61K47/48084 , A61K47/48861 , A61K47/54 , A61K47/548 , A61K47/6907 , A61K47/6923 , A61N5/062 , A61N2005/067
摘要： A mitochondria targeted gold nanoparticle (T-3-BP-AuNP) decorated with 3- bromopyruvate (3 -BP) and delocalized lipophilic triphenylphosphonium (TPP) cations to target the mitochondrial membrane potential (Δ ψ m) was developed for delivery of 3 -BP to cancer cell mitochondria by taking advantage of higher Δ ψ m in cancer cell compared to normal cells. This construct showed remarkable anticancer activity in prostate cancer cells compared to non-targeted construct NT-3-BP-AuNP and free 3- BP. Anticancer activity of T-3-BP-AuNP was further enhanced upon laser irradiation by exciting the surface plasmon resonance band of AuNP and thereby utilizing a combination of 3 -BP chemotherapeutic and AuNP photothermal effects. T-3-BP- AuNPs showed markedly enhanced ability to alter cancer cell metabolism by inhibiting glycolysis and demolishing mitochondrial oxidative phosphorylation in prostate cancer cells. Our findings demonstrated that mitochondria targeted and concerted chemo-photothermal treatment of glycolytic cancer cells with a single NP may have promise as a new anticancer therapy.
摘要翻译：开发了用3-溴丙酮酸（3-BP）和离域亲脂性三苯基鏻（TPP）阳离子装饰的靶向线粒体膜电位（Δψm）的线粒体靶向金纳米颗粒（T-3-BP-AuNP），用于将3 -BP递送至与正常细胞相比，通过利用癌细胞中更高的Δψm来利用癌细胞线粒体。与非靶向构建体NT-3-BP-AuNP和游离3-BP相比，该构建体在前列腺癌细胞中显示出显着的抗癌活性。激光照射后，通过激发AuNP的表面等离子体共振带，从而利用3 -BP化学治疗和AuNP光热效应的组合，T-3-BP-AuNP的抗癌活性进一步提高。 T-3-BP-AuNPs通过抑制糖酵解和排除前列腺癌细胞中的线粒体氧化磷酸化显示出显着提高的癌细胞代谢能力。我们的研究结果表明线粒体靶向和一致的化学光热治疗糖酵解癌细胞与单一的NP可能有希望作为一种新的抗癌治疗。

4. 发明申请

WO2015157409A1 MITOCHONDRIA-TARGETING PLATINUM(IV) PRODRUG 审中-公开
标题翻译：麻醉剂针对白领（IV）PRODRUG
公开(公告)号：WO2015157409A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/024909
申请日：2015-04-08
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , PATHAK, Rakesh , MARRACHE, Sean
发明人： DHAR, Shanta , PATHAK, Rakesh , MARRACHE, Sean
IPC分类号： A61K31/282
CPC分类号： C07F15/0093 , A61K9/51 , A61K31/282 , A61K31/555 , A61K33/24 , A61K47/54 , A61K47/6923 , A61K47/6929
摘要： Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based compound. Upon reduction, the mitochondrial targeting moieties are released resulting in a Pt(II) therapeutic agent. Pt(IV) compounds including a mitochondria targeting moiety can be included in nanoparticles. The compounds or nanoparticles can be used to treat, for example, cancer.
摘要翻译： Pt（IV）化合物包括线粒体靶向部分。具有线粒体靶向部分的Pt（IV）化合物的一个实例是基于顺铂的铂（IV）化合物。在还原后，释放线粒体靶向部分，得到Pt（II）治疗剂。包括线粒体靶向部分的Pt（IV）化合物可以包括在纳米颗粒中。化合物或纳米颗粒可用于治疗例如癌症。

5. 发明申请

WO2013033513A1 APOPTOSIS-TARGETING NANOPARTICLES 审中-公开
公开(公告)号：WO2013033513A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/053307
申请日：2012-08-31
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , MARRACHE, Sean
发明人： DHAR, Shanta , MARRACHE, Sean
IPC分类号： A61K9/14
CPC分类号： A61K38/1709 , A61K31/315 , A61K38/08 , A61K45/06 , A61K47/54 , A61K47/549 , A61K47/6921 , A61K47/6935 , A61K47/6937 , A61K49/0067 , A61K49/0093 , A61K49/1881
摘要： Nanoparticles include a core and one or more targeting moieties, as well as one or more contrast agents or one or more therapeutic agents. The contrast agents or therapeutic agents may be contained or embedded within the core. If the nanoparticle includes therapeutic agents, the agents are preferably released from the core at a desired rate. The core may be biodegradable and may release the agents as the core is degraded or eroded. The targeting moieties preferably extend outwardly from the core so that they are available for interaction with cellular components, which interactions will target the nanoparticles to the appropriate cells, such as apoptotic cells; organelles, such as mitochondria; or the like. The targeting moieties may be tethered to the core or components that interact with the core.
摘要翻译：纳米颗粒包括核心和一个或多个靶向部分，以及一种或多种造影剂或一种或多种治疗剂。造影剂或治疗剂可以包含或嵌入核心内。如果纳米颗粒包括治疗剂，则试剂优选以所需的速率从芯中释放。核心可以是可生物降解的，并且当核心被降解或侵蚀时可释放药剂。靶向部分优选从核心向外延伸，使得它们可用于与细胞组分相互作用，所述相互作用将靶向纳米颗粒至合适的细胞，例如凋亡细胞; 细胞器，如线粒体; 或类似物。靶向部分可以连接到与核相互作用的核心或组分。

6. 发明申请

WO2013012628A2 IMMUNE-STIMULATING PHOTOACTIVE HYBRID NANOPARTICLES 审中-公开
标题翻译：免疫刺激光敏混合纳米颗粒
公开(公告)号：WO2013012628A2
公开(公告)日：2013-01-24
申请号：PCT/US2012/046171
申请日：2012-07-11
申请人： THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , DHAR, Shanta , CHOI, Joshua , MARRACHE, Sean
发明人： DHAR, Shanta , CHOI, Joshua , MARRACHE, Sean
IPC分类号： A61K47/48 , A61K9/16 , A61K9/14 , A61K47/30 , A61P35/00
CPC分类号： A61K47/48915 , A61K41/0071
摘要： Provides is a therapeutic technology that combines the phototoxic and immune- stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform. For example, zinc pthalocyanine, which is a long-wavelength absorbing photosensitizer, integrated into a polymeric nanoparticle core made up of poly(D, L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). The outside surface of the core can be coated with metallic nanoparticles, which are then modified with CpG- ODN. Metastatic mouse breast carcinoma cells showed significant photocytotoxicity of the hybrid after irradiation with a 660 nm LASER light and this activity was remarkably better than either treatment alone. Treatment of mouse bone marrow derived dendritic cells with the photodynamic therapy-killed 4T1 cell lysate showed that the combination of photodynamic therapy with a synerg istic immunostimulant in a single nanoparticle system resulted in an immune response suitable for the treatment of such as a metastatic cancer.
摘要翻译：提供一种治疗技术，将光动力治疗的光毒性和免疫刺激能力与免疫系统广泛有效降低癌细胞和肿瘤的生存能力结合起来。本公开的纳米颗粒组合物使用纳米颗粒递送平台将免疫刺激剂与光敏剂结合。例如，作为长波长吸收光敏剂的酞菁锌整合到由聚（D，L-乳酸 - 共 - 乙醇酸）-b-聚（乙二醇）（PLGA-b-聚乙二醇）构成的聚合物纳米颗粒核中， PEG）。核心的外表面可以用金属纳米粒子涂覆，然后用CpG-ODN修饰。在用660nm LASER光照射后，转移性小鼠乳腺癌细胞显示杂种显着的光细胞毒性，并且该活性显着优于单独的任一种处理。用光动力疗法杀死的4T1细胞裂解物处理小鼠骨髓衍生的树突细胞表明，光动力疗法与协同免疫刺激剂在单一纳米颗粒系统中的组合导致适合于治疗例如转移性癌症的免疫应答。

7. 发明申请

WO2014124425A1 GENERATION OF FUNCTIONAL DENDRITIC CELLS 审中-公开
标题翻译：功能性细胞的产生
公开(公告)号：WO2014124425A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/015744
申请日：2014-02-11
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
发明人： DHAR, Shanta , MARRACHE, Sean , HARN, Donald, A. , TUNDUP, Smanla
IPC分类号： G01N33/551 , G01N33/574 , G01N33/50
CPC分类号： A61K31/555 , A61K39/0011 , A61K41/0057 , A61K41/0071 , A61K47/48084 , A61K47/48215 , A61K47/48915 , A61K47/548 , A61K47/60 , A61K47/6937 , A61K2039/5154 , A61K2039/55555 , C08G63/08 , C12N5/0639 , C12N2501/999 , C12N2529/10 , G01N33/5047 , G01N33/54346 , G01N33/57415 , G01N33/582
摘要： Nanoparticles containing a photosensitizer configured to generate a reactive oxygen species when exposed to an appropriate wavelength of light can be used to enhance immunogenicity of cancer cells, such as breast cancer cells. Such enhanced immunogenicity cancer cells, or supernatants thereof, can be used to activate dendritic cells or cause dendritic cells to produce INF-gamma. Nanoparticles having mitochondria-targeting moieties are more effective at enhancing the immunogenicity of the cancer cells, or causing the dendritic cells to produce IFN-gamma, than nanoparticle lacking mitochondria-targeting moieties or free photosensitizer.
摘要翻译：包含配置成当暴露于适当波长的光时产生活性氧物质的光敏剂的纳米颗粒可用于增强癌细胞如乳腺癌细胞的免疫原性。这种增强的免疫原性癌细胞或其上清液可用于激活树突状细胞或引起树突状细胞产生INF-γ。具有线粒体靶向部分的纳米颗粒比不含缺乏线粒体靶向部分的纳米粒子或自由光敏剂更有效地增强癌细胞的免疫原性或引起树突状细胞产生IFN-γ。

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