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1. 发明申请

WO2012103424A9 DIAGNOSTIC AND PROGNOSTIC MARKERS FOR METASTASIS 审中-公开
标题翻译：用于METASTASIS的诊断和预防标记
公开(公告)号：WO2012103424A9
公开(公告)日：2012-10-18
申请号：PCT/US2012022876
申请日：2012-01-27
申请人： UNIV VIRGINIA COMMONWEALTH , FISHER PAUL B , DAS SWADESH
发明人： FISHER PAUL B , DAS SWADESH
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/57407 , G01N2333/4745 , G01N2800/56
摘要： Methods for monitoring cancer metastasis and/or monitoring the response of a patient to cancer therapy directed against metastatic cancer are provided. The methods involve measuring Insulin Growth Factor Binding Protein-2 (IGFBP-2) and/or other biomarkers in biological (e.g., blood, plasma, serum) samples from the patient.

2. 发明申请

WO2004060269A3 MDA-7 AND FREE RADICALS IN THE TREATMENT OF CANCER 审中-公开
标题翻译： MDA-7和自由基在治疗癌症中的作用
公开(公告)号：WO2004060269A3
公开(公告)日：2004-10-14
申请号：PCT/US0328512
申请日：2003-09-09
申请人： UNIV COLUMBIA , UNIV VIRGINIA COMMONWEALTH , FISHER PAUL B , GOPALKRISHNAN RAHUL , LEBEDEVA IRINA , GRANT STEVEN , YACOUB ADLY , DENT PAUL
发明人： FISHER PAUL B , GOPALKRISHNAN RAHUL , LEBEDEVA IRINA , GRANT STEVEN , YACOUB ADLY , DENT PAUL
IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C12N15/861 , A01N37/18 , A01N43/04 , C07H21/04 , C07K1/00 , C12N15/00 , C12N15/63
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K2319/23 , C12N2710/10343 , C12N2810/00
摘要： The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda-7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda-7 gene, or by stabilization of the mda-7 mRNA. Generation of one or more free radicals in a cancer cell can occur by exposing the cancer cell to an effective amount of ionizing radiation, a free radical, a generator of a free radical, a ROS, a generator of a ROS, or a disruptor of mitochondrial membrane potential.
摘要翻译：本发明涉及治疗受试者的癌症的方法，其包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。本发明进一步涉及抑制受试者癌细胞增殖或促进死亡的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。通过向癌细胞施用有效量的mda-7核酸，MDA-7蛋白，这些分子中的任一个的功能等价物，通过上调内源性mda-7基因，可以产生有效量的MDA-7 ，或通过稳定mda-7 mRNA。通过将癌细胞暴露于有效量的电离辐射，自由基，自由基的生成物，ROS，ROS的生成物或干扰物的干扰物，可以发生癌细胞中的一种或多种自由基线粒体膜电位。

3. 发明申请

WO2011123427A9 TREATMENT OF CANCER BY INHIBITING ACTIVITY OR EXPRESSION OF LATE SV-40 FACTOR 审中-公开
标题翻译：通过抑制活性或表达最初的SV-40因子来治疗癌症
公开(公告)号：WO2011123427A9
公开(公告)日：2011-12-15
申请号：PCT/US2011030293
申请日：2011-03-29
申请人： UNIV VIRGINIA COMMONWEALTH , SARKAR DEVANAND , FISHER PAUL B
发明人： SARKAR DEVANAND , FISHER PAUL B
IPC分类号： A61K48/00 , A61K31/7105 , A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： A61K31/7105 , A61K2039/505 , C07K16/18 , C07K16/303 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57438

4. 发明申请

WO2010062975A3 SUPPRESSOR OF AP-1 审中-公开
标题翻译： AP-1的抑制剂
公开(公告)号：WO2010062975A3
公开(公告)日：2010-10-14
申请号：PCT/US2009065958
申请日：2009-11-25
申请人： UNIV VIRGINIA COMMONWEALTH , FISHER PAUL B , SU ZAO-ZHONG , LEE SEOK-GEUN , SARKAR DEVANAND
发明人： FISHER PAUL B , SU ZAO-ZHONG , LEE SEOK-GEUN , SARKAR DEVANAND
IPC分类号： C07H21/04 , C07K14/00 , C12P21/06
CPC分类号： A61K48/005 , C12N15/113 , C12N2799/022 , C12N2799/06 , C12N2830/008
摘要： Methods, compositions, and therapeutic products for use in the field of oncology and specifically, for the treatment of cancer and other diseases in which SARI is ameliorative or therapeutic and/or small molecule screening for anti-cancer drugs are provided. Cancer specific gene expression using the CCN1 promoter, which is negatively regulated by SARI, for targeting therapeutic molecules in tumors is also provided.
摘要翻译：提供了用于肿瘤学领域的方法，组合物和治疗产品，特别是用于治疗癌症和其它SARI改善或治疗和/或小分子筛选抗癌药物的疾病。还提供了使用由SARI负调节的CCN1启动子用于靶向肿瘤中的治疗分子的癌症特异性基因表达。

5. 发明申请

WO2014197598A3 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS 审中-公开
标题翻译：三磷酸核苷酸核酸结构
公开(公告)号：WO2014197598A3
公开(公告)日：2015-06-04
申请号：PCT/US2014040912
申请日：2014-06-04
申请人： UNIV JOHNS HOPKINS , UNIV VIRGINIA COMMONWEALTH
发明人： FISHER PAUL B , DAS SWADESH K , MENEZES MITCHELL E , SARKAR DEVANAND , POMPER MARTIN G
IPC分类号： A61K48/00
CPC分类号： A61K48/0058 , A61K9/0019 , A61K38/20 , A61K41/0028 , A61K41/0033 , A61K49/0013 , A61K49/0045 , A61K49/0054 , A61K51/00 , A61K51/0491 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/10043 , C12N2710/10343 , C12N2710/16143 , C12N2710/16171 , C12N2830/008 , C12Q1/6897
摘要： The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
摘要翻译：目前公开的主题通常涉及其用于癌症成像，癌症治疗和组合成像和治疗方案中的遗传构建体和方法。特别地，目前公开的主题涉及允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方式癌症核糖核酸构建体。

6. 发明申请

WO2004005481A3 METHODS FOR IDENTIFYING MODULATORS OF MDA-7 MEDIATED APOPTOSIS 审中-公开
标题翻译：用于鉴定MDA-7介导的病毒的调节剂的方法
公开(公告)号：WO2004005481A3
公开(公告)日：2004-12-29
申请号：PCT/US0321237
申请日：2003-07-03
申请人： UNIV COLUMBIA , FISHER PAUL B , SARKAR DEVANAND , GOPALKRISHNAN RAHUL V , SAUANE MOIRA
发明人： FISHER PAUL B , SARKAR DEVANAND , GOPALKRISHNAN RAHUL V , SAUANE MOIRA
IPC分类号： C07K14/47 , C07K14/54 , C12N15/09 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , A01N43/04 , A61K31/70 , G01N33/48
CPC分类号： G01N33/5011 , C07K14/54 , G01N33/5041 , G01N2510/00
摘要： The present invention relates to the discoveries that apoptotic effects of the melanoma differentiation associated gene mda-7 (also known as interleukin-24, "IL-24") on malignant cells occur via the p38 MAPK pathway and members of the Growth Arrest and DNA Damage ("GADD") gene family but are substantially independent of the JAK/STAT pathway. Accordingly, the invention provides for methods for identifying apoptosis-modulating agents using assay methods which determine the ability of a test agent to increase or decrease expression of constituents of the mda-7 apoptosis pathway, preferably in a JAK/STAT substantially independent manner. Such agents may be small molecules or may be fragments, variants and/or derivatives of native MDA-7.
摘要翻译：本发明涉及黑色素瘤分化相关基因mda-7（也称为白细胞介素-24，“IL-24”）对恶性细胞的凋亡作用通过p38MAPK途径发生，并且生长滞留和DNA的成员损伤（“GADD”）基因家族，但基本上独立于JAK / STAT途径。因此，本发明提供了使用确定测试试剂增加或减少mda-7凋亡途径的成分表达的能力的测定方法，优选以JAK / STAT基本上独立的方式来鉴定凋亡调节剂的方法。这样的试剂可以是小分子，也可以是天然MDA-7的片段，变体和/或衍生物。

7. 发明申请

WO2004016732A3 ASTROCYTE MODULATED GENES AND USES THEREOF 审中-公开
标题翻译： ASTROCYTE MODULATED GENES AND ANDESES THEREOF
公开(公告)号：WO2004016732A3
公开(公告)日：2005-03-10
申请号：PCT/US0311887
申请日：2003-04-17
申请人： UNIV COLUMBIA , FISHER PAUL B , SU ZAO-ZHONG , KANG DONG-CHUL
发明人： FISHER PAUL B , SU ZAO-ZHONG , KANG DONG-CHUL
IPC分类号： A01K67/027 , C07H21/04 , C07K14/47 , C12N5/06 , C12N7/00 , C12N15/12 , C12Q1/70 , C12N15/00
CPC分类号： C07K14/47
摘要： The present invention relates to Astrocyte Modulated Genes (AMGs). AMGs are genes whose expression are modulated in human astrocytes grown in primary cell culture following the exposure of these cells to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp120. AMGs comprise both Astrocyte Enhanced Genes (AEGs) and Astrocyte Suppressed Genes (ASGs). Thus, the present invention further relates to Astrocyte Enhanced Genes (AEGs), the expression of which are up-regulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gpl20, and to Astrocyte Suppressed Genes (ASGs), the expression of which are downregulated in human astrocytes grown in primary cell culture that are exposed to either the human immunodeficiency virus HIV-1 or to the HIV-1 protein gp 120. Because they may playa role in HIV-associated dementia ("HAD"), AMGs may be used as markers in methods for screening for drugs that treat or prevent HAD.
摘要翻译：本发明涉及星形胶质细胞调节基因（AMG）。 AMG是在将这些细胞暴露于人类免疫缺陷病毒HIV-1或HIV-1蛋白gp120后在原代细胞培养物中生长的人星形胶质细胞中表达的基因。 AMGs包括星形胶质细胞增强基因（AEG）和星形胶质细胞抑制基因（ASGs）。因此，本发明还涉及星形胶质细胞增强型基因（AEG），其表达在暴露于人类免疫缺陷病毒HIV-1或HIV-1蛋白的原代细胞培养物中生长的人星形胶质细胞中上调 gpl20和Astrocyte Suppressed Genes（ASG），其表达在暴露于人类免疫缺陷病毒HIV-1或HIV-1蛋白gp 120的原代细胞培养物中生长的人类星形胶质细胞中下调。因为它们可能在艾滋病相关性痴呆（“HAD”）中发挥作用，AMG可用作筛选治疗或预防HAD的药物的方法中的标记。

8. 发明申请

WO03016499A2 COMBINATORIAL METHODS FOR INDUCING CANCER CELL DEATH 审中-公开
标题翻译：用于诱导癌细胞死亡的组合方法
公开(公告)号：WO03016499A2
公开(公告)日：2003-02-27
申请号：PCT/US0226454
申请日：2002-08-19
申请人： UNIV COLUMBIA , FISHER PAUL B
发明人： FISHER PAUL B
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N15/113 , C12Q1/02 , C12N
CPC分类号： C12N15/1135 , A61K38/1709 , A61K48/00 , A61K48/0083 , C07K14/4703 , C12N15/86 , C12N2310/111 , C12N2710/10343 , C12N2799/021 , G01N33/5011 , G01N2510/00
摘要： The present invention relates to methods and compositions for inhibiting proliferation and inducing cell death in a population of cancer cells by (i) increasing the amount of the differentiation associated protein MDA-7, and (ii) decreasing RAS activity within the population. It is based, at least in part, on the discovery that decreasing expression of a mutated, activated K-ras gene, together with introducing an expressible mda-7 gene, in pancreatic cancer cells had a synergistic growth-inhibitory and anti-survival effect, and abolished tumorigenicity of the cells in athymic nude mice. The methods of the invention may be directed to the therapy of pancreatic cancer and other malignancies.
摘要翻译：本发明涉及通过（i）增加分化相关蛋白MDA-7的量和（ii）降低群体内的RAS活性来抑制癌细胞群体增殖和诱导细胞死亡的方法和组合物。至少部分基于以下发现，即在胰腺癌细胞中减少突变的活化的K-ras基因的表达以及引入可表达的mda-7基因具有协同生长抑制和抗生存效应，并消除无胸腺裸鼠中细胞的致瘤性。本发明的方法可以涉及胰腺癌和其他恶性肿瘤的治疗。

9. 发明申请

WO9954466A3 COLON CANCER-ASSOCIATED ANTIGENS AND THEIR DIAGNOSTIC AND THERAPEUTIC USES 审中-公开
标题翻译：结肠癌相关抗原及其诊断和治疗用途
公开(公告)号：WO9954466A3
公开(公告)日：2000-02-17
申请号：PCT/US9908672
申请日：1999-04-20
申请人： HUANG FEI , FISHER PAUL B , GOLDSTEIN NEIL I
发明人： HUANG FEI , FISHER PAUL B , GOLDSTEIN NEIL I
IPC分类号： A61K39/00 , C07K14/47 , C12N15/12 , A61K31/70 , A61K35/14 , A61K38/17 , A61K39/395 , C07K16/18 , C12N15/11 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/5156
摘要： Compositions and methods for the detection and therapy of cancer are disclosed. The compounds provided include tumor-associated proteins, and portions and variants thereof, as well as polynucleotides that encode such polypeptides. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for cancer prevention and treatment. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring cancer progression in a patient.
摘要翻译：公开了用于癌症检测和治疗的组合物和方法。提供的化合物包括肿瘤相关蛋白及其部分和变体，以及编码这些多肽的多核苷酸。还提供了包含这些化合物的疫苗和药物组合物，并且可以用于例如癌症预防和治疗。多肽也可用于生产抗体，其可用于诊断和监测患者的癌症进展。

10. 发明申请

WO9950289A3 TRANSFORMATION PROGRESSION-RELATED GENES AND THEIR USE 审中-公开
标题翻译：转化进展相关基因及其使用
公开(公告)号：WO9950289A3
公开(公告)日：2000-01-20
申请号：PCT/US9907187
申请日：1999-03-31
申请人： ZHANG NAN , FISHER PAUL B
发明人： ZHANG NAN , FISHER PAUL B
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , A61K39/395 , C12N5/10 , C12N15/12 , C12P21/00 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： Compositions and methods for cancer diagnosis, monitoring and therapy are disclosed. The compounds provided are progression-related proteins, and portions and variants thereof, as well as polynucleotides that encode such polypeptides, antibodies that bind to such polypeptides and agents that modulate expression of such polypeptides. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for cancer prevention and treatment. The polypeptides may also be used as markers for monitoring cancer progression in a patient.
摘要翻译：公开了用于癌症诊断，监测和治疗的组合物和方法。所提供的化合物是进展相关蛋白，其部分和变体，以及编码这种多肽的多核苷酸，结合这些多肽的抗体和调节这些多肽表达的试剂。还提供了包含这些化合物的疫苗和药物组合物，并且可以用于例如癌症预防和治疗。多肽也可以用作监测患者癌症进展的标志物。

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