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1. 发明申请

WO2009134786A2 QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES 审中-公开
标题翻译：质量控制方法和微/纳米通道设备
公开(公告)号：WO2009134786A2
公开(公告)日：2009-11-05
申请号：PCT/US2009041957
申请日：2009-04-28
申请人： UNIV TEXAS , GRATTONI ALESSANDRO , FERRARI MAURO , LIU XUEWU
发明人： GRATTONI ALESSANDRO , FERRARI MAURO , LIU XUEWU
IPC分类号： G01N3/12 , B81B7/00 , B82B3/00
CPC分类号： B81C99/005 , B81B2201/058 , B81B2203/0338 , G01N11/08 , G01N35/00663
摘要： Embodiments of the present invention comprise a quality control system and method for testing micro- or nano-channeled devices. The system and method can utilize a pressure- driven gas flow for the detection and quantification of structural defects. The test method and system are non-destructive and allow defects to be detected and classified quickly based on measured factors, such as mass flow rate for a given pressure differential.
摘要翻译：本发明的实施例包括用于测试微通道或纳米通道器件的质量控制系统和方法。该系统和方法可以利用压力驱动气流来检测和定量结构缺陷。测试方法和系统是非破坏性的，并且基于测量因素（例如给定压力差的质量流率）来快速检测和分类缺陷。

2. 发明申请

WO2010120817A2 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
标题翻译：纳米通道器件及相关方法
公开(公告)号：WO2010120817A2
公开(公告)日：2010-10-21
申请号：PCT/US2010030937
申请日：2010-04-13
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , GRATTONI ALESSANDRO , GOODALL RANDY , HUDON LEE
发明人： FERRARI MAURO , LIU XUEWU , GRATTONI ALESSANDRO , GOODALL RANDY , HUDON LEE
IPC分类号： A61K9/48 , A61K9/16 , A61K9/50 , A61P19/00 , A61P19/02
CPC分类号： A61M31/002 , A61K9/0097 , A61M5/14276 , A61M2209/045
摘要： A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.
摘要翻译：配置用于体内再灌注治疗剂的胶囊。在某些实施方案中，胶囊可以含有甲氨蝶呤。

3. 发明申请

WO2010056986A8 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
标题翻译：纳米通道装置和相关方法
公开(公告)号：WO2010056986A8
公开(公告)日：2010-08-05
申请号：PCT/US2009064376
申请日：2009-11-13
申请人： UNIV TEXAS , UNIV OHIO STATE RES FOUND , FERRARI MAURO , LIU XEUWU , GRATTONI ALESSANDRO , HOSALI SHARATH , GOODALL RANDY , MEDEMA RYAN , HUDSON LEE , FINE DANIEL
发明人： FERRARI MAURO , LIU XEUWU , GRATTONI ALESSANDRO , HOSALI SHARATH , GOODALL RANDY , MEDEMA RYAN , HUDSON LEE , FINE DANIEL
IPC分类号： A61M5/14 , A61M5/00 , A61M37/00
CPC分类号： A61M5/00 , A61K9/0097 , A61M5/14276 , A61M37/00 , B81B2201/058 , B81B2203/0338 , B81C1/00119 , B82Y5/00 , Y10T137/8593 , Y10T156/1064
摘要： A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
摘要翻译：纳米通道输送装置及其制造和使用方法。纳米通道递送装置包括入口，出口和纳米通道。纳米通道可以平行于纳米通道递送装置的主平面取向。入口和出口可以与纳米通道直接流体连通。

4. 发明申请

WO2010056986A2 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
标题翻译：纳米通道器件及相关方法
公开(公告)号：WO2010056986A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064376
申请日：2009-11-13
申请人： UNIV TEXAS , UNIV OHIO STATE RES FOUND , FERRARI MAURO , LIU XEUWU , GRATTONI ALESSANDRO , HOSALI SHARATH , GOODALL RANDY , MEDEMA RYAN , HUDSON LEE , FINE DANIEL
发明人： FERRARI MAURO , LIU XEUWU , GRATTONI ALESSANDRO , HOSALI SHARATH , GOODALL RANDY , MEDEMA RYAN , HUDSON LEE , FINE DANIEL
IPC分类号： A61M5/14 , A61M5/00 , A61M37/00
CPC分类号： A61M5/00 , A61K9/0097 , A61M5/14276 , A61M37/00 , B81B2201/058 , B81B2203/0338 , B81C1/00119 , B82Y5/00 , Y10T137/8593 , Y10T156/1064
摘要： A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
摘要翻译：一种纳米通道输送装置及其制造和使用方法。纳米通道递送装置包括入口，出口和纳米通道。纳米通道可以平行于纳米通道递送装置的主平面定向。入口和出口可以与纳米通道直接流体连通。

5. 发明申请

WO2011156028A2 POROUS AND NON-POROUS NANOSTRUCTURES 审中-公开
标题翻译：多孔和非多孔纳米结构
公开(公告)号：WO2011156028A2
公开(公告)日：2011-12-15
申请号：PCT/US2011027746
申请日：2011-03-09
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
发明人： FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
IPC分类号： H01L29/06 , H01L21/306 , H01L23/48 , H01L23/532
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L2924/0002 , H01L2924/00
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.
摘要翻译：公开了各种微观和纳米尺度的多孔和无孔线状结构。例如，公开的是包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。还公开了制造和使用这种结构的方法。例如，本发明提供了通过以下步骤制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将所述衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

6. 发明申请

WO2006108054A2 DIFFUSION DELIVERY SYSTEM AND METHODS OF FABRICATION 审中-公开
标题翻译：扩散输送系统和制造方法
公开(公告)号：WO2006108054A2
公开(公告)日：2006-10-12
申请号：PCT/US2006012700
申请日：2006-04-05
申请人： UNIV OHIO STATE , FERRARI MAURO , LIU XUEWU , SINHA PIYUSH MOHAN , SMITH BRYAN , SHARMA SADHANA
发明人： FERRARI MAURO , LIU XUEWU , SINHA PIYUSH MOHAN , SMITH BRYAN , SHARMA SADHANA
IPC分类号： H01R13/648
CPC分类号： A61K9/0097 , A61F2/022 , A61M31/002 , A61N1/306 , B82Y30/00
摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nano engineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.
摘要翻译：本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程装置。该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。本发明还涉及含有扩散递送系统的胶囊。本发明还涉及制造扩散递送系统的方法。

7. 发明申请

WO2008021908A3 MULTISTAGE DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：有效代理的多个交付
公开(公告)号：WO2008021908A3
公开(公告)日：2008-08-14
申请号：PCT/US2007075516
申请日：2007-08-08
申请人： UNIV TEXAS , TASCIOTTI ENNIO , FERRARI MAURO
发明人： FERRARI MAURO
IPC分类号： A61K9/14
CPC分类号： A61K9/50 , A61K9/127 , A61K9/1271 , A61K9/51 , A61K31/165 , A61K31/704 , A61K31/7088
摘要： Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
摘要翻译：公开了包括第一阶段颗粒和第二阶段颗粒的多阶段递送载体。第一级颗粒是含有第二级颗粒的微型或纳米颗粒。第二级粒子包括活性剂，例如治疗剂或成像剂。多级递送载体允许顺序克服或绕过生物屏障。作为包括多个车辆的组合物的一部分来管理多级输送车辆。还提供制造多级输送车辆的方法。

8. 发明申请

WO2008041970A3 METHODS AND COMPOSITIONS FOR TARGETING FENESTRATED VASCULATURE 审中-公开
标题翻译：用于靶向芬太尼血管的方法和组合物
公开(公告)号：WO2008041970A3
公开(公告)日：2009-04-30
申请号：PCT/US2006038196
申请日：2006-09-28
申请人： UNIV TEXAS , UNIV OHIO STATE RES FOUND , DECUZZI PAOLO , FERRARI MAURO
发明人： DECUZZI PAOLO , FERRARI MAURO
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K49/0002 , A61K31/00
摘要： Targeting of a fenestrated vasculature at a body site by micro or nanoparticles can be increased by using particles that have a radius substantially equal to a critical radius of a normal vasculature at the body site. The particles can be used for treating or monitoring a physiological condition responsible for the fenestrated vasculature. A method of improving an ability of micro or nanoparticles to target fenestrated blood vessels in a body site by selecting particles from a population of the micro or nanoparticles, where the selected particles have a radius that permits enhanced delivery into the fenestrated blood vessels.
摘要翻译：可以通过使用具有基本上等于身体部位正常脉管系统的临界半径的半径的粒子来增加通过微观或纳米颗粒在体部位置开窗口脉管系统的靶向。颗粒可用于治疗或监测负责开窗脉管系统的生理状况。通过从微粒或纳米颗粒的群体中选择颗粒来提高微粒体或纳米颗粒靶向体内部位的开孔血管的能力的方法，其中所选择的颗粒具有允许增强输送到开窗血管的半径。

9. 发明申请

WO2008067049A3 PARTICLES FOR CELL TARGETING 审中-公开
标题翻译：用于细胞靶向的颗粒
公开(公告)号：WO2008067049A3
公开(公告)日：2008-11-13
申请号：PCT/US2007081097
申请日：2007-10-11
申请人： UNIV TEXAS , DECUZZI PAOLO , FERRARI MAURO
发明人： DECUZZI PAOLO , FERRARI MAURO
IPC分类号： A61K9/14 , A61K49/00 , A61P43/00
CPC分类号： A61K9/1611 , A61K9/143 , A61K47/6923 , A61K47/6929 , A61K49/0002
摘要： Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.
摘要翻译：提供了包含扁平球形颗粒的组合物，其包含活性剂（例如治疗剂或成像剂），以及通过将组合物施用于有需要的受试者来治疗或监测生理状况（诸如疾病）的方法。还提供了制造颗粒的方法，所述颗粒的体积可以增强颗粒与受试者体内目标部位的粘附，以获得预选形状的颗粒，以及制备具有可增强颗粒粘附的形状的颗粒的方法到预先选定体积的颗粒的受试者体内的目标部位。

10. 发明申请

WO2007120248A2 NANOPOROUS SUBSTRATES FOR ANALYTICAL METHODS 审中-公开
标题翻译：用于分析方法的纳米基材
公开(公告)号：WO2007120248A2
公开(公告)日：2007-10-25
申请号：PCT/US2006048460
申请日：2006-12-20
申请人： UNIV OHIO STATE RES FOUND , UNIV TEXAS , FERRARI MAURO , CHENG MARK MING-CHENG , CUDA GIOVANNI , GASPARI MARCO , GEHO DAVID , LIOTTA LANCE , PETRICOIN EMMANUEL , ROBERTSON FREDIKA , TERRACCIANO ROSA
发明人： FERRARI MAURO , CHENG MARK MING-CHENG , CUDA GIOVANNI , GASPARI MARCO , GEHO DAVID , LIOTTA LANCE , PETRICOIN EMMANUEL , ROBERTSON FREDIKA , TERRACCIANO ROSA
CPC分类号： G01N1/405 , B01D15/00 , B01D15/08 , B01J20/103 , B01J20/2808 , B01J2220/54 , B01L3/5023 , B82Y5/00 , C07K1/30 , C07K1/34 , G01N33/6803 , Y10T436/2525 , Y10T436/255
摘要： Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
摘要翻译：可以使用纳米多孔材料来富集样品，以便随后分析样品中所含的物质。该方法显示为丰富低分子量蛋白质组中物种的产量，允许检测低纳摩尔范围内的小肽。

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