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1. 发明申请

WO2008091724A1 METHOD OF AND APPARATUS FOR INK JET PRINTING ADHESIVES 审中-公开
标题翻译：喷墨印刷胶粘剂的方法和装置
公开(公告)号：WO2008091724A1
公开(公告)日：2008-07-31
申请号：PCT/US2008/050355
申请日：2008-01-07
申请人： 3M INNOVATIVE PROPERTIES COMPANY , BOYD, Scott A. , LEE, Jennifer L. , SEVERANCE, Richard L. , WEAVER, Billy L.
发明人： BOYD, Scott A. , LEE, Jennifer L. , SEVERANCE, Richard L. , WEAVER, Billy L.
IPC分类号： B05D1/16 , B05C3/02
CPC分类号： B05D1/28 , B05B7/2483 , B05D3/042 , B05D5/10
摘要： An improved adhesive applicator or fluid delivery system (1) immerses a wire in a reservoir of adhesive for a period of time sufficient to allow the wire to be coated with the adhesive, (2) places the coated wire in close proximity to a designated medium onto which the adhesive will be applied, and (3) directs a stream of gas to contact the coated wire and to thereby cause at least some of the adhesive on the wire to be deposited onto the designated medium. The speed of the wire and the force of the air stream may be digitally controlled by a processor, controller, microprocessor, or other computing device to ensure that a desired image resolution is achieved. Because the fluid delivery system is free of most of the mechanical limitations of traditional ink jet print heads, the system is compatible with adhesive application. When compared to the traditional coating operations for adhesives, the fluid delivery system allows controlled delivery, both in terms of location on the print medium and drop size (and thus coat weight). The system thus allows for greater positional and coat weight control of adhesives on the print medium or substrate, which is especially useful where precise control is desired.
摘要翻译：改进的粘合剂施加器或流体输送系统（1）将线浸入粘合剂储存器中足以允许电线被粘合剂涂覆的时间段，（2）将涂覆的电线放置在靠近指定介质将粘合剂施加到其上，以及（3）引导气流与涂覆的丝接触，从而导致线上的至少一些粘合剂沉积在指定的介质上。线的速度和空气流的力可由处理器，控制器，微处理器或其他计算设备数字地控制，以确保实现所需的图像分辨率。由于流体输送系统没有传统喷墨打印头的大部分机械限制，所以该系统与粘合剂应用相兼容。当与传统的粘合剂涂层操作相比时，流体输送系统允许在打印介质上的位置和液滴尺寸（以及因此涂层重量）方面受到控制的传送。因此，该系统允许对打印介质或基底上的粘合剂进行更大的位置和涂层重量控制，这在需要精确控制时尤其有用。

2. 发明申请

WO2007049017A2 TUMOR NECROSIS FACTOR RECEPTOR 1 ANTAGONISTS FOR TREATING RESPIRATORY DISEASES 审中-公开
标题翻译：肿瘤坏死因子受体1治疗呼吸道疾病的拮抗剂
公开(公告)号：WO2007049017A2
公开(公告)日：2007-05-03
申请号：PCT/GB2006003935
申请日：2006-10-23
申请人： DOMANTIS LTD , ARGENTA DISCOVERY LTD , DE WILDT RUDOLF M T , HOLMES STEVE , TOMLINSON IAN M , WINTER GREGORY P , FITZGERALD MARY F , FOX JUSTIAN CRAIG , SEPP ARMIN , LEE JENNIFER , WOOLVEN BENJAMIN P
发明人： DE WILDT RUDOLF M T , HOLMES STEVE , TOMLINSON IAN M , WINTER GREGORY P , FITZGERALD MARY F , FOX JUSTIAN CRAIG , SEPP ARMIN , LEE JENNIFER , WOOLVEN BENJAMIN P
IPC分类号： A61K39/00 , C07K16/28
CPC分类号： C07K16/2875 , A61K9/0043 , A61K9/007 , A61K39/3955 , C07K16/28 , C07K16/2878 , C07K2317/31 , C07K2317/569 , C07K2317/76
摘要： Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFRl for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g., inhaler, intranasal delivery device) for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.
摘要翻译：公开了结合肺组织中的靶标以制备用于局部递送至肺组织的长效或长治疗窗口制剂的试剂（例如，抗体片段，拮抗剂，配体，dAb单体）的用途，以及用于施用将肺组织中的靶标结合到受试者以在肺组织中产生长治疗窗口的试剂。该制剂用于，并且该方法包括局部给予肺组织。还公开了TNFR1的拮抗剂在制备用于治疗，预防或抑制肺部炎症或呼吸系统疾病的制剂或药物中的用途，以及治疗这些疾病的方法。还公开了使用试剂a来制造用于治疗或预防肺部炎症或呼吸系统疾病的输送装置（例如，吸入器，鼻内递送装置），以及用于治疗或预防肺部炎症或包含本文所述的药剂的呼吸系统疾病。

3. 发明申请

WO2003106452A2 ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 审中-公开
标题翻译：梅毒素浓度HORMONE受体拮抗剂
公开(公告)号：WO2003106452A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018346
申请日：2003-06-11
申请人： MILLENNIUM PHARMACEUTICALS, INC. , BLACKBURN, Christopher , LAI, Su-jen , LEE, Jennifer, G. , MAGUIRE, Martin , PATANE, Michael, A. , LAMARCHE, Matthew, J. , CULLIS, Courtney, A. , BROWN, James , VASUDEVAN, Anil , FREEMAN, Jennifer, C. , MULHERN, Mathew, M. , LYNCH, John, K. , GAO, Ju , WODKA, Dariusz , SOUERS, Andrew, J. , IYENGAR, Rajesh
发明人： BLACKBURN, Christopher , LAI, Su-jen , LEE, Jennifer, G. , MAGUIRE, Martin , PATANE, Michael, A. , LAMARCHE, Matthew, J. , CULLIS, Courtney, A. , BROWN, James , VASUDEVAN, Anil , FREEMAN, Jennifer, C. , MULHERN, Mathew, M. , LYNCH, John, K. , GAO, Ju , WODKA, Dariusz , SOUERS, Andrew, J. , IYENGAR, Rajesh
IPC分类号： C07D405/00
CPC分类号： C07D405/14 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14
摘要： This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R 9 )-, R 1 , R 2 , R 3 , R 4 , R 5 , R 9 , and Ring A are defined in the specification. Coumarin and quinolone compounds where R 1 and R 2 together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.
摘要翻译：本发明提供了作为黑色素浓缩激素受体-1（MCH-R1）的拮抗剂的化合物。化合物由式（I）表示：其中m为0或1，n为0至2，Y为氧或-N（R 9） - ，R 1，R 2，R 3 >，R 4，R 5，R 9和环A在本说明书中定义。其中R 1和R 2一起形成稠合的苯并环的香豆素和喹诺酮化合物是优选的。本发明还提供其中香豆素部分被喹唑啉酮环代替的式（Ⅵ）化合物。所述化合物可用于治疗MCH-R1相关疾病，特别是肥胖症，包括肥胖症。

4. 发明申请

WO1998000045A1 A METHOD AND APPARATUS FOR REMOVING EXCESS APPLIQUE FROM AN APPLICATOR 审中-公开
标题翻译：一种从应用程序中移除超级应用程序的方法和装置
公开(公告)号：WO1998000045A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011312
申请日：1997-07-01
申请人： LEE, Jennifer, Paulson
发明人： UTLEY, George, D., III
IPC分类号： A45D40/00
CPC分类号： A46B3/18 , A45D40/268 , A45D2034/005 , A46B15/00 , A46B15/0095 , A46B2200/1053 , B44D3/006
摘要： This invention is a method for removing an excess amount of applique from an applicator (20), including the steps of applying a force to a flexible structure (120), and pulling the applicator (20) through the flexible structure (120) to engage the applicator (20) with the flexible structure (120). The device for removing excess applique has a flexible segment (120) which is manually squeezed by the user to engage the flexible segment (120) with the applicator (20) to remove excess applique from the applicator (20) upon passing the applicator (20) through the flexible segment (120). In one embodiment, the flexible segment (120) includes at least one projection (412) extending from an aperture wall which engages the applicator (20) as the applicator (20) is pulled through the deformed aperture in the flexible segment (120). In a preferred embodiment, the applique is mascara and the applicator (20) is a mascara brush.
摘要翻译：本发明是用于从施用器（20）上去除过量的贴花的方法，包括以下步骤：向柔性结构（120）施加力，并且通过柔性结构（120）拉动施用器（20）以接合所述施用器（20）具有柔性结构（120）。用于去除多余贴花的装置具有柔性部分（120），其被使用者手动挤压以使柔性部分（120）与施加器（20）接合，以在通过涂抹器（20）时从施用器（20）移除多余的贴花）通过柔性段（120）。在一个实施例中，柔性段（120）包括至少一个突出部（412），该突出部（412）从施加器（20）的孔壁延伸，当施加器（20）被拉动穿过柔性段（120）中的变形的孔时。在优选实施例中，贴花是睫毛膏，并且施用器（20）是睫毛膏刷。

5. 发明申请

WO2011163353A3 ON-DEMAND DUAL FREQUENCY LASER SOURCES FOR NON-LINEAR OPTICAL MICROSCOPY AND MICRO-SPECTROSCOPY IMAGING SYSTEMS 审中-公开
标题翻译：用于非线性光学显微镜和微光谱成像系统的双频激光源
公开(公告)号：WO2011163353A3
公开(公告)日：2012-02-23
申请号：PCT/US2011041441
申请日：2011-06-22
申请人： HARVARD COLLEGE , CORNELL RES FOUNDATION INC , XU CHRIS , XIE XIAOLIANG SUNNEY , FREUDIGER CHRISTIAN W , WANG KE , SAAR BRIAN G , LEE JENNIFER H
发明人： XU CHRIS , XIE XIAOLIANG SUNNEY , FREUDIGER CHRISTIAN W , WANG KE , SAAR BRIAN G , LEE JENNIFER H
IPC分类号： G01J3/10 , G01N21/01
CPC分类号： G01N21/65 , G01J3/10 , G01N2021/655
摘要： An illumination system is disclosed for use in non-linear modulation transfer microscopy and micro-spectroscopy. The illumination system includes a laser system for providing a first train of pulses at a center optical frequency ?1, and an optical assembly for collinearly combining a first train of pulses with a second train of pulses having a center optical frequency of ?2 as synchronized excitation fields for non¬ linear modulation transfer microscopy and micro-spectroscopy. The laser system includes a continuous wave laser for providing a first continuous wave field, a first chirp modulator system comprising a means to receive the first continuous wave field, a means to receive a trigger signal, a first phase modulator and a first electro-optic modulator; and a first pulse compression unit.
摘要翻译：公开了用于非线性调制转移显微镜和微光谱的照明系统。照明系统包括用于提供中心光频率λ1的第一脉冲序列的激光系统，以及用于将第一脉冲串与第二脉冲序列共线组合的光学组件，所述第二脉冲序列具有同步的中心光频率ω2 用于非线性调制转移显微镜和微光谱的激发场。激光系统包括用于提供第一连续波场的连续波激光器，包括接收第一连续波场的装置的第一线性调频系统，接收触发信号的装置，第一相位调制器和第一电光调制器; 和第一脉冲压缩单元。

6. 发明申请

WO2011163353A2 ON-DEMAND DUAL FREQUENCY LASER SOURCES FOR NON-LINEAR OPTICAL MICROSCOPY AND MICRO-SPECTROSCOPY IMAGING SYSTEMS 审中-公开
标题翻译：用于非线性光学显微镜和微光谱成像系统的双频激光源
公开(公告)号：WO2011163353A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041441
申请日：2011-06-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CORNELL RESEARCH FOUNDATION, INC. , XU, Chris , XIE, Xiaoliang, Sunney , FREUDIGER, Christian, W. , WANG, Ke , SAAR, Brian, G. , LEE, Jennifer, H.
发明人： XU, Chris , XIE, Xiaoliang, Sunney , FREUDIGER, Christian, W. , WANG, Ke , SAAR, Brian, G. , LEE, Jennifer, H.
IPC分类号： G01J3/10 , G01N21/01
CPC分类号： G01N21/65 , G01J3/10 , G01N2021/655
摘要： An illumination system is disclosed for use in non-linear modulation transfer microscopy and micro-spectroscopy. The illumination system includes a laser system for providing a first train of pulses at a center optical frequency ω 1 , and an optical assembly for collinearly combining a first train of pulses with a second train of pulses having a center optical frequency of ω 2 as synchronized excitation fields for non¬ linear modulation transfer microscopy and micro-spectroscopy. The laser system includes a continuous wave laser for providing a first continuous wave field, a first chirp modulator system comprising a means to receive the first continuous wave field, a means to receive a trigger signal, a first phase modulator and a first electro-optic modulator; and a first pulse compression unit.
摘要翻译：公开了用于非线性调制转移显微镜和微光谱的照明系统。照明系统包括用于提供中心光频率λ1的第一脉冲序列的激光系统，以及用于将第一脉冲串与第二脉冲序列共线组合的光学组件，所述第二脉冲序列具有同步的中心光频率ω2 用于非线性调制转移显微镜和微光谱的激发场。激光系统包括用于提供第一连续波场的连续波激光器，包括接收第一连续波场的装置的第一线性调频系统，接收触发信号的装置，第一相位调制器和第一电光调制器; 和第一脉冲压缩单元。

7. 发明申请

WO2006038027A2 ANTAGONISTS AND METHODS OF USE THREFOR 审中-公开
标题翻译： ANGEONISTS和使用方法
公开(公告)号：WO2006038027A2
公开(公告)日：2006-04-13
申请号：PCT/GB2005/003873
申请日：2005-10-07
申请人： DOMANTIS LIMITED , BREWIS, Neil, D. , WOOLVEN, Benjamin, P. , HOLMES, Steve , TOMLINSON, Ian, M. , LEE, Jennifer , ENEVER, Carolyn , BASRAN, Amrik , JONES, Kate , WILDT, Ruud de , TUNA, Mihriban
发明人： BREWIS, Neil, D. , WOOLVEN, Benjamin, P. , HOLMES, Steve , TOMLINSON, Ian, M. , LEE, Jennifer , ENEVER, Carolyn , BASRAN, Amrik , JONES, Kate , WILDT, Ruud de , TUNA, Mihriban
IPC分类号： A61K39/395 , C07K16/18 , C07K16/24 , C07K16/28 , C07K16/40 , C12N15/13 , C12N15/62 , C12N15/63
CPC分类号： C07K16/18 , A61K47/60 , A61K2039/505 , C07K16/241 , C07K16/2866 , C07K16/2878 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/40 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12N2799/021
摘要： The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.
摘要翻译：本发明提供了治疗炎性疾病（例如慢性炎性疾病）的方法，其包括施用肿瘤坏死因子受体1拮抗剂。本发明还提供了含有结合肿瘤坏死因子的免疫球蛋白单可变结构域（结构域抗体，dAb）单体的配体受体1以及使用配体的方法。还提供了编码配体的核酸，重组宿主细胞和制备配体的方法。

8. 发明申请

WO2003106452A3 ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 审中-公开
公开(公告)号：WO2003106452A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018346
申请日：2003-06-11
申请人： MILLENNIUM PHARMACEUTICALS, INC. , BLACKBURN, Christopher , LAI, Su-jen , LEE, Jennifer, G. , MAGUIRE, Martin , PATANE, Michael, A. , LAMARCHE, Matthew, J. , CULLIS, Courtney, A. , BROWN, James , VASUDEVAN, Anil , FREEMAN, Jennifer, C. , MULHERN, Mathew, M. , LYNCH, John, K. , GAO, Ju , WODKA, Dariusz , SOUERS, Andrew, J. , IYENGAR, Rajesh
发明人： BLACKBURN, Christopher , LAI, Su-jen , LEE, Jennifer, G. , MAGUIRE, Martin , PATANE, Michael, A. , LAMARCHE, Matthew, J. , CULLIS, Courtney, A. , BROWN, James , VASUDEVAN, Anil , FREEMAN, Jennifer, C. , MULHERN, Mathew, M. , LYNCH, John, K. , GAO, Ju , WODKA, Dariusz , SOUERS, Andrew, J. , IYENGAR, Rajesh
IPC分类号： C07D405/14
摘要： This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R 9 )-, R 1 , R 2 , R 3 , R 4 , R 5 , R 9 , and Ring A are defined in the specification. Coumarin and quinolone compounds where R 1 and R 2 together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

9. 发明申请

WO2012170744A3 SOLUTIONS FOR BRIDGING AND PRESSURE CONCENTRATION REDUCTION AT WOUND SITES 审中-公开
标题翻译：在网站上进行桥梁和压力浓度降低的解决方案
公开(公告)号：WO2012170744A3
公开(公告)日：2013-01-31
申请号：PCT/US2012041432
申请日：2012-06-07
申请人： SPIRACUR INC , WU KENNETH , NG DARREN , LEE JENNIFER , HU DEAN
发明人： WU KENNETH , NG DARREN , LEE JENNIFER , HU DEAN
IPC分类号： A61M1/00
CPC分类号： A61F13/0216 , A61F13/00068 , A61F2013/00174 , A61F2013/00412 , A61F2013/00536 , A61M1/0027 , A61M1/0086 , A61M1/0088
摘要： Disclosed herein are devices, systems and methods for delivering reduced pressure to a load-bearing wound site. The device can include a distal port configured to connect to a wound dressing positioned over the wound site; a proximal port located a distance from the distal port and configured to connect to a reduced pressure source, and a conduit body having an inner channel extending between the distal port and the proximal port. When the distal port is applied to the wound dressing positioned over the wound site the proximal port is positioned at a non-load bearing location remote from the wound dressing. The inner channel has a non-circular profile having a width larger than a height of the conduit body.
摘要翻译：本文公开了用于将减压递送到承载伤口部位的装置，系统和方法。该装置可以包括构造成连接到位于伤口部位上方的伤口敷料的远端口; 邻近端口，其远离远端口定位并且被配置为连接到减压源，以及导管本体，其具有在远端端口和近端口之间延伸的内部通道。当远端口被施加到位于伤口位置上的伤口敷料上时，近端口位于远离伤口敷料的非承载位置。内部通道具有宽度大于导管本体的高度的非圆形轮廓。

10. 发明申请

WO2008052155A3 SYSTEM FOR PRODUCING OPTICAL PULSES OF A DESIRED WAVELENGTH USING CHERENKOV RADIATION 审中-公开
标题翻译：使用CHERENKOV辐射产生所需波长的光学脉冲的系统
公开(公告)号：WO2008052155A3
公开(公告)日：2008-08-07
申请号：PCT/US2007082625
申请日：2007-10-26
申请人： CORNELL RES FOUNDATION INC , XU CHRIS , VAN HOWE JAMES , LEE JENNIFER
发明人： XU CHRIS , VAN HOWE JAMES , LEE JENNIFER
IPC分类号： H01S3/30
CPC分类号： G02F1/3513 , G01N21/6408 , G01N21/6458 , G01N2021/653 , G01N2201/0696 , G02B6/02009 , G02B6/02214 , G02B6/03644 , G02B21/06 , G02B21/16 , G02F2203/17 , G02F2203/26 , G02F2203/54
摘要： The present invention includes an apparatus and method for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher-order-mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by exciting Cherenkov radiation using the input optical pulses. The present invention also relates to a method of producing optical pulses having a desired wavelength, where the input optical pulses have a first wavelength and a first spatial mode and the output optical pulses have a second wavelength and a second spatial mode, which may be converted to another spatial mode.
摘要翻译：本发明包括用于产生所需波长的光脉冲的装置和方法。该装置包括可用于产生第一波长的输入光脉冲的光脉冲源。该装置还包括可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，此后通过使用输入光脉冲激发切伦科夫辐射来产生所需波长的输出光脉冲。本发明还涉及一种产生具有期望波长的光脉冲的方法，其中输入光脉冲具有第一波长和第一空间模式，并且输出光脉冲具有第二波长和第二空间模式，其可被转换到另一个空间模式。

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