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1. 发明申请

WO0068382A9 PrP-LIKE GENE 审中-公开
标题翻译： PrP-like基因
公开(公告)号：WO0068382A9
公开(公告)日：2002-08-29
申请号：PCT/US0013099
申请日：2000-05-11
申请人： UNIV CALIFORNIA , UNIV TORONTO , UNIV WASHINGTON , PRUSINER STANLEY B , TREMBLAY PATRICK , MOORE RICHARD , WESTAWAY DAVID , HOOD LEROY E , LEE INYOUL
发明人： PRUSINER STANLEY B , TREMBLAY PATRICK , MOORE RICHARD , WESTAWAY DAVID , HOOD LEROY E , LEE INYOUL
IPC分类号： A01K67/027 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47
摘要： The present invention provides nucleic acids encoding the Doppel ("Dpl") protein, Dpl peptides, and assays utilizing the Dpl nucleic acids and/or peptides. In related aspects the invention features expression vectors and host cells comprising nucleic acids that encode a human Dpl polypeptide. The present invention also relates to antibodies that bind specifically to a human Dpl polypeptide, methods for producing human Dpl polypeptides, methods for identifying cells expressing Dpl, methods for using the Dpl gene and the Dpl polypeptide to alter cellular function and prion infectivity in culture or in vivo , and identification of individuals at risk for prion disorders by detecting alteration in Dpl coding and regulatory sequences and Dpl expression levels.
摘要翻译：本发明提供编码多巴巴（“Dpl”）蛋白，Dpl肽的核酸和利用Dpl核酸和/或肽的测定。在相关方面，本发明的特征在于包含编码人Dpl多肽的核酸的表达载体和宿主细胞。本发明还涉及与人Dpl多肽特异性结合的抗体，用于产生人Dpl多肽的方法，用于鉴定表达Dpl的细胞的方法，使用Dpl基因和Dpl多肽来改变培养物中的细胞功能和朊病毒感染性的方法，或通过检测Dpl编码和调节序列和Dpl表达水平的变化来鉴定朊病毒病风险的个体。

2. 发明申请

WO2005055803A2 MULTI-SEGMENT CONE-BEAM RECONSTRUCTION SYSTEM AND METHOD FOR TOMOSYNTHESIS IMAGING 审中-公开
标题翻译：多分段锥束重建系统及其成像方法
公开(公告)号：WO2005055803A2
公开(公告)日：2005-06-23
申请号：PCT/US2004039913
申请日：2004-11-29
申请人： GEN HOSPITAL CORP , WU TAO , MOORE RICHARD , KOPANS DANIEL
发明人： WU TAO , MOORE RICHARD , KOPANS DANIEL
IPC分类号： A61B20060101 , A61B6/00 , A61B6/02 , A61B6/03 , A61B6/04 , A61B
CPC分类号： A61B6/504 , A61B6/025 , G06T11/005 , G06T2211/436
摘要： A tomosynthesis method for creating a three-dimensional reconstruction of a target element volume acquires radiation absorbance images of the target element volume through a limited plurality of positions. The target element volume is divided into a plurality of volume segments and a reconstruction algorithm is applied to each segment to generate a three-dimensional reconstruction of each volume segment. The three-dimensional reconstruction of each volume segment is then merged to create a three-dimensional reconstruction of the target volume. A tomosynthesis system and a computer program product for carrying out tomosynthesis are also provided.
摘要翻译：用于创建目标元素体积的三维重建的断层合成方法通过有限的多个位置获取目标元素体积的辐射吸收图像。目标元素体积被分成多个音量段，并且将重建算法应用于每个段以产生每个音量段的三维重建。然后将每个卷段的三维重建合并，以创建目标体积的三维重建。还提供了用于进行断层合成的断层合成系统和计算机程序产品。

3. 发明申请

WO2004043236A3 DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES 审中-公开
标题翻译：使用生物标志物轮廓诊断食物或SIRS
公开(公告)号：WO2004043236A3
公开(公告)日：2005-07-28
申请号：PCT/US0336025
申请日：2003-11-12
申请人： BECTON DICKINSON CO , IVEY RICHARD , GENTLE THOMAS , MOORE RICHARD , TOWNS MICHAEL , BACHUR NICHOLAS , ROSENSTEIN ROBERT , GOLDENBAUM PAUL , SHI SONG , COPERTINO DONALD , GARRETT JAMES , TICE GREGORY
发明人： IVEY RICHARD , GENTLE THOMAS , MOORE RICHARD , TOWNS MICHAEL , BACHUR NICHOLAS , ROSENSTEIN ROBERT , GOLDENBAUM PAUL , SHI SONG , COPERTINO DONALD , GARRETT JAMES , TICE GREGORY
IPC分类号： C12Q1/68 , G01N33/68 , C07H21/04 , C12Q1/70
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , G01N33/6893 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.
摘要翻译：败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。使用分子诊断方法实现早期预测或诊断，其包括将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较，其可包括发生败血症的群体。识别个体生物标志物特征的特征是脓毒症发作的特征，允许临床医生在单个时间点从个体分离的体液诊断败血症的发作。因此，避免在一段时间内监测患者的必要性，有利地允许在脓毒症严重症状发作之前进行临床干预。

4. 发明申请

WO2007081767A3 USE OF HE4 AND OTHER BIOCHEMICAL MARKERS FOR ASSESSMENT OF ENDOMETRIAL AND UTERINE CANCERS 审中-公开
标题翻译：使用HE4和其他生物化学标记物评估子宫内膜癌和子宫癌
公开(公告)号：WO2007081767A3
公开(公告)日：2008-04-24
申请号：PCT/US2007000215
申请日：2007-01-04
申请人： FUJIREBIO AMERICA INC , MOORE RICHARD , SOMERS ELIZABETH , ALLARD JEFFREY W
发明人： MOORE RICHARD , SOMERS ELIZABETH , ALLARD JEFFREY W
IPC分类号： C12Q1/25 , G01N33/50 , G01N33/574
CPC分类号： G01N33/57442 , C07K16/3069
摘要： The disclosure relates to use of the HE4/HE4a marker(s) to assess endometrial and uterine cancer in a patient. The disclosure also relates to using tumors marks for diagnosis, grading and staging of endometrial and uterine cancers. The disclosure also relates to determining prognosis and treatment effectiveness of a patient who has been diagnosed with endometrial or uterine cancer.
摘要翻译：本公开涉及使用HE4 / HE4a标记来评估患者中的子宫内膜和子宫癌。本公开还涉及使用肿瘤标记来诊断，分级和分期子宫内膜和子宫癌。本公开还涉及确定已被诊断患有子宫内膜或子宫癌的患者的预后和治疗有效性。

5. 发明申请

WO2011025684A1 AUTOMATIC TERMINATION PATH CONFIGURATION 审中-公开
标题翻译：自动终止路径配置
公开(公告)号：WO2011025684A1
公开(公告)日：2011-03-03
申请号：PCT/US2010045592
申请日：2010-08-16
申请人： LEVEL 3 COMMUNICATIONS LLC , DECONCILIS MICHAEL F , MOORE RICHARD
发明人： DECONCILIS MICHAEL F , MOORE RICHARD
IPC分类号： H04M3/42
CPC分类号： H04Q3/66 , H04M7/128 , H04Q2213/13141 , H04Q2213/13353
摘要： Herein, an improved technique for processing a substrate is disclosed. In one particular exemplary embodiment, the technique may be achieved using a mask for processing the substrate. The mask may be incorporated into a substrate processing system such as, for example, an ion implantation system. The mask may comprise one or more first apertures disposed in a first row; and one or more second apertures disposed in a second row, each row extending along a width direction of the mask, wherein the one or more first apertures and the one or more second apertures are non-uniform.
摘要翻译：本文中公开了一种用于处理衬底的改进技术。在一个特定的示例性实施例中，可以使用用于处理衬底的掩模来实现该技术。掩模可以并入基板处理系统中，例如离子注入系统。掩模可以包括设置在第一排中的一个或多个第一孔; 以及设置在第二排中的一个或多个第二孔，每排沿着所述掩模的宽度方向延伸，其中所述一个或多个第一孔和所述一个或多个第二孔是不均匀的。

6. 发明申请

WO2005031304A3 QUANTIFICATION OF ANALYTES USING INTERNAL STANDARDS 审中-公开
标题翻译：使用内部标准的分析员的数量
公开(公告)号：WO2005031304A3
公开(公告)日：2005-06-02
申请号：PCT/US2004031046
申请日：2004-09-22
申请人： BECTON DICKINSON CO , GENTLE THOMAS , MOORE RICHARD , WINEGAR THOMAS , SHI SONG , JIN ZHE
发明人： GENTLE THOMAS , MOORE RICHARD , WINEGAR THOMAS , SHI SONG , JIN ZHE
IPC分类号： C12Q1/68 , G01N20060101 , G01N24/00 , G01N33/00 , G01N33/53 , H01J49/16 , H01J49/40
CPC分类号： H01J49/0009 , Y10T436/143333
摘要： The present invention pertains to methods and compositions for quantifying the levels of at least one biomolecular analyte in a sample or extract by mass spectrometry using at least one dendrimer internal standard, as shown in Figure 1. Examples of suitable dendrimer standards are poly(ethylene glycol) (PEG dendrimer and poly(amidoamine) (PAMAM) dendrimer. In one embodiment a labile internal standard sensitive to heat or protease is used together with the dendrimer standard.
摘要翻译：本发明涉及通过使用至少一种树枝状大分子内标的质谱法来量化样品或提取物中至少一种生物分子分析物的水平的方法和组合物，如图1所示。合适的树枝状聚合物标准物的实例是聚（乙二醇）（PEG树枝状聚合物和聚（酰氨基胺）（PAMAM）树枝状聚合物。在一个实施方案中，对热或蛋白酶敏感的不稳定内标与树枝状大分子标准一起使用。

7. 发明申请

WO2004010729A3 PORTABLE AUDIO PLAYBACK DEVICE WITH BASS ENHANCEMENT 审中-公开
标题翻译：便携式音频播放装置，具有强化功能
公开(公告)号：WO2004010729A3
公开(公告)日：2004-07-22
申请号：PCT/IB0302793
申请日：2003-07-14
申请人： SONY ERICSSON MOBILE COMM AB , MOORE RICHARD
发明人： MOORE RICHARD
IPC分类号： H04R5/02 , H04B5/00
CPC分类号： H04R3/14 , H04R5/04 , H04R2420/07 , H04S2400/07
摘要： Wirelessly linking a portable audio device to an external audio system permits the external audio system to generate audible signals that enhance local playback of audio by the portable device. For example, the portable device wirelessly transmits lower frequency components of an audio signal to a subwoofer system for reproduction of bass frequencies extending below the playback capability of the portable device. In this manner, the external audio system provides bass enhancement for the portable audio device. Wireless transmissions between the portable audio device and the external audio system may be, but are not limited to, optical or radio frequency (RF) transmissions. Where RF signaling is used, the wireless link may be based on wireless network links, such as those supported by Bluetooth and 802.11b standards, or based on, for example, dedicated RF interfaces.
摘要翻译：将便携式音频设备无线链接到外部音频系统允许外部音频系统生成可听信号，以增强便携式设备对音频的本地回放。例如，便携式设备将音频信号的较低频率分量无线传输到超低音扬声器系统，以再现低于便携式设备的回放能力的低音频率。以这种方式，外部音频系统为便携式音频设备提供低音增强。便携式音频设备和外部音频系统之间的无线传输可以是但不限于光学或射频（RF）传输。在使用RF信令的情况下，无线链路可以基于无线网络链路，例如由蓝牙和802.11b标准支持的链路，或基于例如专用RF接口。

8. 发明申请

WO2007081768A3 USE OF HE4 AND OTHER BIOCHEMICAL MARKERS FOR ASSESSMENT OF OVARIAN CANCERS 审中-公开
标题翻译：使用HE4和其他生物化学标记物评估OVARIAN癌症
公开(公告)号：WO2007081768A3
公开(公告)日：2008-04-24
申请号：PCT/US2007000216
申请日：2007-01-04
申请人： FUJIREBIO AMERICA INC , MOORE RICHARD , SOMERS ELIZABETH
发明人： MOORE RICHARD , SOMERS ELIZABETH
IPC分类号： C12Q1/25 , G01N33/50 , G01N33/574
CPC分类号： G01N33/57442 , C07K16/3069
摘要： The disclosure relates to use of the HE4/HE4a marker(s) together with one or more other markers to assess ovarian cancers in a patient.
摘要翻译：本公开涉及使用HE4 / HE4a标记物与一种或多种其它标记物来评估患者中的卵巢癌。

9. 发明申请

WO2007038758A2 DETECTION OF LYSOPHOSPHATIDYLCHOLINE FOR PROGNOSIS OR DIAGNOSIS OF A SYSTEMIC INFLAMMATORY CONDITION 审中-公开
标题翻译：用于预防或诊断系统性炎症症状的赖氨酸衍生物的检测
公开(公告)号：WO2007038758A2
公开(公告)日：2007-04-05
申请号：PCT/US2006038177
申请日：2006-09-27
申请人： BECTON DICKINSON CO , SHI SONG , GENTLE THOMAS , MOORE RICHARD
发明人： SHI SONG , GENTLE THOMAS , MOORE RICHARD
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , C12Q1/26 , C12Q1/44 , G01N2800/26
摘要： The present invention provides methods and compositions useful for the diagnosis or prognosis of a systemic inflammatory condition such as sepsis.
摘要翻译：本发明提供了用于诊断或预后诸如败血症的全身性炎症病症的方法和组合物。

10. 发明申请

WO2004044556A3 DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES 审中-公开
标题翻译：使用生物标志物特征诊断脓肿或S DI症
公开(公告)号：WO2004044556A3
公开(公告)日：2005-09-09
申请号：PCT/US0336021
申请日：2003-11-12
申请人： BECTON DICKINSON CO , IVEY RICHARD , GENTLE THOMAS , MOORE RICHARD , TOWNS MICHAEL , BACHUR NICHOLAS , ROSENSTEIN ROBERT , GOLDENBAUM PAUL , SHI SONG , COPERTINO DONALD , GARRETT JAMES , TICE GREGORY
发明人： IVEY RICHARD , GENTLE THOMAS , MOORE RICHARD , TOWNS MICHAEL , BACHUR NICHOLAS , ROSENSTEIN ROBERT , GOLDENBAUM PAUL , SHI SONG , COPERTINO DONALD , GARRETT JAMES , TICE GREGORY
IPC分类号： C12Q1/68 , G01N33/68 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , G01N33/6893 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.
摘要翻译：脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。早期预测或诊断是使用分子诊断方法完成的，涉及将个体的生物标志物表达谱与从一个或多个对照或参照群（其可包括发生败血症的群体）获得的谱相比较。识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断个体在单个时间点分离的体液中脓毒症的发作。因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。

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